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La ricerca find articoli where soggetti phrase all words 'CDK-ACTIVATING KINASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 163 riferimenti
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    1. Roy, KK; Sausville, EA
      Early development of cyclin dependent kinase modulators

      CURRENT PHARMACEUTICAL DESIGN
    2. Stals, H; Inze, D
      When plant cells decide to divide

      TRENDS IN PLANT SCIENCE
    3. Wendland, J
      Comparison of morphogenetic networks of filamentous fungi and yeast

      FUNGAL GENETICS AND BIOLOGY
    4. Lawrie, AM; Tito, P; Hernandez, H; Brown, NR; Robinson, CV; Endicott, JA; Noble, MEM; Johnson, LN
      Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells

      PROTEIN EXPRESSION AND PURIFICATION
    5. Owa, T; Yoshino, H; Yoshimatsu, K; Nagasu, T
      Cell cycle regulation in the G1 phase: A promising target for the development of new chemotherapeutic anticancer agents

      CURRENT MEDICINAL CHEMISTRY
    6. Ronen, A; Glickman, BW
      Human DNA repair genes

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    7. Porter, DC; Zhang, N; Danes, C; McGahren, MJ; Harwell, RM; Faruki, S; Keyomarsi, K
      Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms

      MOLECULAR AND CELLULAR BIOLOGY
    8. Murray, S; Udupa, R; Yao, S; Hartzog, G; Prelich, G
      Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase

      MOLECULAR AND CELLULAR BIOLOGY
    9. Wu, LT; Chen, P; Shum, CH; Chen, C; Barsky, LW; Weinberg, KI; Jong, A; Triche, TJ
      MAT1-modulated CAK activity regulates cell cycle G(1) exit

      MOLECULAR AND CELLULAR BIOLOGY
    10. Larochelle, S; Chen, J; Knights, R; Pandur, J; Morcillo, P; Erdjument-Bromage, H; Tempst, P; Suter, B; Fisher, RP
      T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity

      EMBO JOURNAL
    11. Rossi, DJ; Londesborough, A; Korsisaari, N; Pihlak, A; Lehtonen, E; Henkemeyer, M; Makela, TP
      Inability to enter S phase and defective RNA polymerase IICTD phosphorylation in mice lacking Mat1

      EMBO JOURNAL
    12. Smits, VAJ; Medema, RH
      Checking out the G2/M transition

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    13. Ljungman, M; Paulsen, MT
      The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382

      MOLECULAR PHARMACOLOGY
    14. Chu, C; Khotz, DS
      Identification of the E2A gene products as regulatory targets of the G(1) cyclin-dependent kinases

      JOURNAL OF BIOLOGICAL CHEMISTRY
    15. Harper, JW; Adams, PD
      Cyclin-dependent kinases

      CHEMICAL REVIEWS
    16. Kim, JM; McGaughy, JT; Bogle, RK; Ravnik, SE
      Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse

      BIOLOGY OF REPRODUCTION
    17. Watanabe, Y; Fujimoto, H; Watanabe, T; Maekawa, T; Masutani, C; Hanaoka, F; Ohkuma, Y
      Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II

      GENES TO CELLS
    18. Bregman, DB; Pestell, RG; Kidd, VJ
      Cell cycle regulation and RNA polymerase II

      FRONTIERS IN BIOSCIENCE
    19. Depoortere, F; Pirson, I; Bartek, J; Dumont, JE; Roger, PP
      Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1)

      MOLECULAR BIOLOGY OF THE CELL
    20. McDonald, ER; El-Deiry, WS
      Cell cycle control as a basis for cancer drug development (review)

      INTERNATIONAL JOURNAL OF ONCOLOGY
    21. Yamaguchi, M; Fabian, T; Sauter, M; Bhalerao, RP; Schrader, J; Sandberg, G; Umeda, M; Uchimiya, H
      Activation of CDK-activating kinase is dependent on interaction with H-type cyclins in plants

      PLANT JOURNAL
    22. Araujo, SJ; Tirode, F; Coin, F; Pospiech, H; Syvaoja, JE; Stucki, M; Hubscher, U; Egly, JM; Wood, RD
      Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation byCAK

      GENES & DEVELOPMENT
    23. Liu, J; Kipreos, ET
      Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): Differential conservation of CAKs in yeast and metazoa

      MOLECULAR BIOLOGY AND EVOLUTION
    24. Hayashi, K; Yokozaki, H; Naka, K; Yasui, W; Yajin, K; Lotan, R; Tahara, E
      Effect of 9-cis-retinoic acid on oral squamous cell carcinoma cell lines

      CANCER LETTERS
    25. Yamashita, M
      Toward modeling of a general mechanism of MPF formation during oocyte maturation in vertebrates

      ZOOLOGICAL SCIENCE
    26. Masaki, T; Shiratori, Y; Rengifo, W; Igarashi, K; Matsumoto, K; Nishioka, M; Hatanaka, Y; Omata, M
      Hepatocellular carcinoma cell cycle: Study of Long-Evans Cinnamon rats

      HEPATOLOGY
    27. Ivanov, D; Kwak, YT; Guo, J; Gaynor, RB
      Domains in the SPT5 protein that modulate its transcriptional regulatory properties

      MOLECULAR AND CELLULAR BIOLOGY
    28. Price, DH
      P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymeraseII

      MOLECULAR AND CELLULAR BIOLOGY
    29. Farrell, A; Morgan, DO
      Cdc37 promotes the stability of protein kinases Cdc28 and Cak1

      MOLECULAR AND CELLULAR BIOLOGY
    30. Douziech, M; Coin, F; Chipoulet, JM; Arai, Y; Ohkuma, Y; Egly, JM; Coulombe, B
      Mechanism of promoter melting by the xeroderma pigmentosum complementationgroup B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking

      MOLECULAR AND CELLULAR BIOLOGY
    31. Nishiwaki, E; Turner, SL; Harju, S; Miyazaki, S; Kashiwagi, M; Koh, J; Serizawa, H
      Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation

      MOLECULAR AND CELLULAR BIOLOGY
    32. Yao, S; Neiman, A; Prelich, G
      BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo

      MOLECULAR AND CELLULAR BIOLOGY
    33. Reynard, GJ; Reynolds, W; Verma, R; Deshaies, RJ
      Cks1 is required for G(1) cyclin-cyclin-dependent kinase activity in budding yeast

      MOLECULAR AND CELLULAR BIOLOGY
    34. Chiariello, M; Gomez, E; Gutkind, JS
      Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G(1) phase

      BIOCHEMICAL JOURNAL
    35. Stals, H; Casteels, P; Van Montagu, M; Inze, D
      Regulation of cyclin-dependent kinases in Arabidopsis thaliana

      PLANT MOLECULAR BIOLOGY
    36. Schultz, P; Fribourg, S; Poterszman, A; Mallouh, V; Moras, D; Egly, JM
      Molecular structure of human TFIIH

      CELL
    37. Tannoch, VJ; Hinds, PW; Tsai, LH
      Cell cycle control

      CANCER GENE THERAPY
    38. Okamoto, H; Cujec, TP; Peterlin, BM; Okamoto, T
      HIV-1 replication is inhibited by a pseudo-substrate peptide that blocks Tat transactivation

      VIROLOGY
    39. Kahl, BF; Li, H; Paule, MR
      RNA melting and promoter clearance by eukaryotic RNA polymerase I

      JOURNAL OF MOLECULAR BIOLOGY
    40. Schang, LM; Hwang, GJH; Dynlacht, BD; Speicher, DW; Bantly, A; Schaffer, PA; Shilatifard, A; Ge, H; Shiekhattar, R
      Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    41. Cheng, AY; Kaldis, P; Solomon, MJ
      Dephosphorylation of human cyclin-dependent kinases by protein phosphatasetype 2C alpha and beta 2 isoforms

      JOURNAL OF BIOLOGICAL CHEMISTRY
    42. Bradsher, J; Coin, F; Egly, JM
      Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape

      JOURNAL OF BIOLOGICAL CHEMISTRY
    43. Smits, VAJ; Klompmaker, R; Vallenius, T; Rijksen, G; Makela, TP; Medema, RH
      p21 Inhibits Thr(161) phosphorylation of Cdc2 to enforce the G(2) DNA damage checkpoint

      JOURNAL OF BIOLOGICAL CHEMISTRY
    44. Kaldis, P; Solomon, MJ
      Analysis of CAK activities from human cells

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    45. Rank, KB; Evans, DB; Sharma, SK
      The N-terminal domains of cyclin-dependent kinase inhibitory proteins block the phosphorylation of cdk2/cyclin E by the cdk-activating kinase

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    46. Noguchi, T; Dobashi, Y; Minehara, H; Itoman, M; Kameya, T
      Involvement of cyclins in cell proliferation and their clinical implications in soft tissue smooth muscle tumors

      AMERICAN JOURNAL OF PATHOLOGY
    47. Senderowicz, AM; Sausville, EA
      Preclinical and clinical development of cyclin-dependent kinase modulators

      JOURNAL OF THE NATIONAL CANCER INSTITUTE
    48. Kaldis, P
      The cdk-activating kinase (CAK): from yeast to mammals

      CELLULAR AND MOLECULAR LIFE SCIENCES
    49. Janus, F; Albrechtsen, N; Dornreiter, I; Wiesmuller, L; Grosse, F; Deppert, W
      The dual role model for p53 in maintaining genomic integrity

      CELLULAR AND MOLECULAR LIFE SCIENCES
    50. Hirst, M; Kobor, MS; Kuriakose, N; Greenblatt, J; Sadowski, I
      GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8

      MOLECULAR CELL
    51. Zhang, H; Berger, JD
      A novel member of the cyclin-dependent kinase family in Paramecium tetraurelia

      JOURNAL OF EUKARYOTIC MICROBIOLOGY
    52. Reynaud, E; Lomeli, H; Vazquez, M; Zurita, M
      The Drosophila melanogaster homologue of the xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

      MOLECULAR BIOLOGY OF THE CELL
    53. Taylor, WR; DePrimo, SE; Agarwal, A; Agarwal, ML; Schonthal, AH; Katula, KS; Stark, GR
      Mechanisms of G2 arrest in response to overexpression of p53

      MOLECULAR BIOLOGY OF THE CELL
    54. Schulze-Gahmen, U; Jung, JU; Kim, SH
      Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6

      STRUCTURE WITH FOLDING & DESIGN
    55. Van Keymeulen, A; Bartek, J; Dumont, JE; Roger, PP
      Cyclin D3 accumulation and activity integrate and rank the comitogenic pathways of thyrotropin and insulin in thyrocytes in primary culture

      ONCOGENE
    56. Adnane, J; Shao, ZH; Robbins, PD
      Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulateSp1-mediated transcription

      ONCOGENE
    57. de Laat, WL; Jaspers, NGJ; Hoeijmakers, JHJ
      Molecular mechanism of nucleotide excision repair

      GENES & DEVELOPMENT
    58. Cheng, AY; Ross, KE; Kaldis, P; Solomon, MJ
      Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases

      GENES & DEVELOPMENT
    59. Batchelder, C; Dunn, MA; Choy, B; Suh, Y; Cassie, C; Shim, EY; Shin, TH; Mello, C; Seydoux, G; Blackwell, TK
      Transcriptional repression by the Caenorhabditis elegans germ-line proteinPIE-1

      GENES & DEVELOPMENT
    60. Shellman, YG; Svee, E; Sclafani, RA; Langan, TA
      Identification and characterization of individual cyclin-dependent kinase complexes from Saccharomyces cerevisiae

      YEAST
    61. Suzuki, M; Hosaka, Y; Matsushima, H; Goto, T; Kitamura, T; Kawabe, K
      Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines

      CANCER LETTERS
    62. Frit, P; Bergmann, E; Egly, JM
      Transcription factor IIH: A key player in the cellular response to DNA damage

      BIOCHIMIE
    63. Mateyak, MK; Obaya, AJ; Sedivy, JM
      c-Myc regulates cyclin D-Cdk4 and-Cdk6 activity but affects cell cycle progression at multiple independent points

      MOLECULAR AND CELLULAR BIOLOGY
    64. Kuhlman, TC; Cho, H; Reinberg, D; Hernandez, N
      The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter

      MOLECULAR AND CELLULAR BIOLOGY
    65. Kim, MK; Nikodem, VM
      hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation

      MOLECULAR AND CELLULAR BIOLOGY
    66. Coin, F; Bergmann, E; Tremeau-Bravard, A; Egly, JM
      Mutations in XPB and XPD helicases found in xeroderma pigmentosum patientsimpair the transcription function of TFIIH

      EMBO JOURNAL
    67. Vandel, L; Kouzarides, T
      Residues phosphorylated by TFIIH are required for E2F-1 degradation duringS-phase

      EMBO JOURNAL
    68. Albrecht, JH; Rieland, BM; Nelsen, CJ; Ahonen, CL
      Regulation of G(1) cyclin-dependent kinases in the liver: role of nuclear localization and p27 sequestration

      AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
    69. Senderowicz, AM
      Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

      INVESTIGATIONAL NEW DRUGS
    70. Lessard, P; Bouly, JP; Jouannic, S; Kreis, M; Thomas, M
      Identification of cdc2cAt: a new cyclin-dependent kinase expressed in Arabidopsis thaliana flowers

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    71. Ramanathan, Y; Reza, SM; Young, TM; Mathews, MB; Pe'ery, T
      Human and rodent transcription elongation factor P-TEFb: Interactions withhuman immunodeficiency virus type 1 Tat and carboxy-terminal domain substrate

      JOURNAL OF VIROLOGY
    72. Jin, KL; Nagayama, T; Chen, J; Stetler, AR; Kawaguchi, K; Simon, RP; Graham, SH
      Molecular cloning of a cell cycle regulation gene cyclin H from ischemic rat brain: Expression in neurons after global cerebral ischemia

      JOURNAL OF NEUROCHEMISTRY
    73. Gross, SD; Loijens, JC; Anderson, RA
      The casein kinase I alpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism

      JOURNAL OF CELL SCIENCE
    74. Patturajan, M; Conrad, NK; Bregman, DB; Corden, JL
      Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    75. Bochar, DA; Pan, ZQ; Knights, R; Fisher, RP; Shilatifard, A; Shiekhattar, R
      Inhibition of transcription by the trimeric cyclin-dependent kinase 7 complex

      JOURNAL OF BIOLOGICAL CHEMISTRY
    76. Brown, NR; Noble, MEM; Lawrie, AM; Morris, MC; Tunnah, P; Divita, G; Johnson, LN; Endicott, JA
      Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

      JOURNAL OF BIOLOGICAL CHEMISTRY
    77. Walker, GJ; Gabrielli, BG; Castellano, M; Hayward, NK
      Functional reassessment of p16 variants using a transfection-based assay

      INTERNATIONAL JOURNAL OF CANCER
    78. Wagner, M; Briza, P; Pierce, M; Winter, E
      Distinct steps in yeast spore morphogenesis require distinct SMK1 MAP kinase thresholds

      GENETICS
    79. Roger, PP; Demartin, S; Dumont, JE
      Nature of the critical labile event that controls RB phosphorylation in the cyclic AMP-dependent cell cycle of thyrocytes in primary culture

      EXPERIMENTAL CELL RESEARCH
    80. Terano, T; Tanaka, T; Tamura, Y; Kitagawa, M; Higashi, H; Saito, Y; Hirai, A
      Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2 cyclin E complex

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    81. Shoji, M; Dobashi, Y; Morinaga, S; Jiang, SX; Kameya, T
      Tumor extension and cell proliferation in adenocarcinomas of the lung

      AMERICAN JOURNAL OF PATHOLOGY
    82. Fussenegger, M; Bailey, JE
      Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: Implications for biotechnology

      BIOTECHNOLOGY PROGRESS
    83. Mendenhall, MD; Hodge, AE
      Regulation of cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae

      MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
    84. MORGAN DO; FISHER RP; ESPINOZA FH; FARRELL A; NOURSE J; CHAMBERLIN H; JIN P
      CONTROL OF EUKARYOTIC CELL-CYCLE PROGRESSION BY PHOSPHORYLATION OF CYCLIN-DEPENDENT KINASES

      The cancer journal from Scientific American
    85. FISHMAN DD; SEGAL S; LIVNEH E
      THE ROLE OF PROTEIN-KINASE-C IN G1 AND G2 M PHASES OF THE CELL-CYCLE (REVIEW)/

      International journal of oncology
    86. Yamaguchi, M; Umeda, M; Uchimiya, H
      A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent protein kinases and the carboxy-terminal domain of RNA polymerase II

      PLANT JOURNAL
    87. SCHNEIDER E; MONTENARH M; WAGNER P
      REGULATION OF CAK KINASE-ACTIVITY BY P53

      Oncogene
    88. MANDAL M; BANDYOPADHYAY D; GOEPFERT TM; KUMAR R
      INTERFERON-INDUCES EXPRESSION OF CYCLIN-DEPENDENT KINASE-INHIBITORS P21(WAF1) AND P27(KIP1) THAT PREVENT ACTIVATION OF CYCLIN-DEPENDENT KINASE BY CDK-ACTIVATING KINASE (CAK)

      Oncogene
    89. Garber, ME; Wei, P; KewalRamani, VN; Mayall, TP; Herrmann, CH; Rice, AP; Littman, DR; Jones, KA
      The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

      GENES & DEVELOPMENT
    90. THURIAUX P
      SUPPRESSION

      MS. Medecine sciences
    91. SOPORY SK; MUNSHI M
      PROTEIN-KINASES AND PHOSPHATASES AND THEIR ROLE IN CELLULAR SIGNALINGIN PLANTS

      Critical reviews in plant sciences
    92. KIM SO; KATZ S; PELECH SL
      EXPRESSION OF 2ND-MESSENGER-DEPENDENT AND CYCLIN-DEPENDENT PROTEIN-KINASES DURING POSTNATAL-DEVELOPMENT OF RAT-HEART

      Journal of cellular biochemistry
    93. PEREZ C; AURIOL J; SEROZ T; EGLY JM
      GENOMIC ORGANIZATION AND PROMOTER CHARACTERIZATION OF THE MOUSE AND HUMAN GENES ENCODING P62 SUBUNIT OF THE TRANSCRIPTION DNA-REPAIR FACTORTFIIH

      Gene
    94. EGAN EA; SOLOMON MJ
      CYCLIN-STIMULATED BINDING OF CKS PROTEINS TO CYCLIN-DEPENDENT KINASES

      Molecular and cellular biology
    95. LIU ZJ; UEDA T; MIYAZAKI T; TANAKA N; MINE S; TANAKA Y; TANIGUCHI T; YAMAMURA H; MINAMI Y
      A CRITICAL ROLE FOR CYCLIN-C IN PROMOTION OF THE HEMATOPOIETIC-CELL CYCLE BY COOPERATION WITH C-MYC

      Molecular and cellular biology
    96. JEOUNG DI; OEHLEN LJWM; CROSS FR
      CLN3-ASSOCIATED KINASE-ACTIVITY IN SACCHAROMYCES-CEREVISIAE IS REGULATED BY THE MATING FACTOR PATHWAY

      Molecular and cellular biology
    97. HAGTING A; KARLSSON C; CLUTE P; JACKMAN M; PINES J
      MPF LOCALIZATION IS CONTROLLED BY NUCLEAR EXPORT

      EMBO journal (Print)
    98. Wada, T; Takagi, T; Yamaguchi, Y; Watanabe, D; Handa, H
      Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro

      EMBO JOURNAL
    99. MOURIAUX F; CASAGRANDE F; PILLAIRE MJ; MANENTI S; MALECAZE F; DARBON JM
      DIFFERENTIAL EXPRESSION OF G1 CYCLINS AND CYCLIN-DEPENDENT KINASE INHIBITORS IN NORMAL AND TRANSFORMED MELANOCYTES

      Investigative ophthalmology & visual science
    100. Reinberg, D; Orphanides, G; Ebright, R; Akoulitchev, S; Carcamo, J; Cho, H; Cortes, P; Drapkin, R; Flores, O; Ha, I; Inostroza, JA; Kim, S; Kim, TK; Kumar, P; Lagrange, T; LeRoy, G; Lu, H; Ma, DM; Maldonado, E; Merino, A; Mermelstein, F; Olave, I; Sheldon, M; Shiekhattar, R; Stone, N; Sun, X; Weis, L; Yeung, K; Zawel, L
      The RNA polymerase II general transcription factors: Past, present, and future

      COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY


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Documento generato il 12/08/20 alle ore 15:12:56