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An introduction to hydrogen bond scalar couplings
CONCEPTS IN MAGNETIC RESONANCE
Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytictriad
PROTEIN SCIENCE
Influence of the temperature-dependent dielectric constant on the H/D isotope effects on the NMR chemical shifts and the hydrogen bond geometry of the collidine-HF complex in CDF3/CDClF2 solution
MAGNETIC RESONANCE IN CHEMISTRY
Strong hydrogen bonding in molecules and enzymatic complexes
MAGNETIC RESONANCE IN CHEMISTRY
Contributions of NMR spectroscopy to the study of hydrogen bonds in serineprotease active sites
MAGNETIC RESONANCE IN CHEMISTRY
Molecular characterization of a novel Staphylococcus aureus serine protease operon
INFECTION AND IMMUNITY
Structure-function relationships of hormone-sensitive lipase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Short, strong hydrogen bonds at the active site of human acetylcholinesterase: Proton NMR studies
BIOCHEMISTRY
Mechanism of phosphatidylinositol-specific phospholipase C: Origin of unusually high nonbridging thio effects
BIOCHEMISTRY
Structure of a serine protease proteinase K from Tritirachium album limberat 0.98 angstrom resolution
BIOCHEMISTRY
Cloning, expression, and characterization of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis
EXTREMOPHILES
The glutathione peroxidases
CELLULAR AND MOLECULAR LIFE SCIENCES
Rhamnogalacturonan acetylesterase elucidates the structure and function ofa new family of hydrolases
STRUCTURE WITH FOLDING & DESIGN
Atomic resolution structure of native porcine pancreatic elastase at 1.1 angstrom
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Homology modeling and identification of serine 160 as nucleophile of the active site in a thermostable carboxylesterase from the archaeon Archaeoglobus fulgidus
PROTEIN ENGINEERING
NMR studies of strong hydrogen bonds in enzymes and in a model compound
JOURNAL OF MOLECULAR STRUCTURE
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template
JOURNAL OF MEDICINAL CHEMISTRY
Nucleotide sequence and genome organization of Apple latent spherical virus: a new virus classified into the family Comoviridae
JOURNAL OF GENERAL VIROLOGY
Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate
JOURNAL OF BACTERIOLOGY
Identification of the histidine and aspartic acid residues essential for enzymatic activity of a family I.3 lipase by site-directed mutagenesis
FEBS LETTERS
Prediction of the tertiary structure of a caspase-9/inhibitor complex
FEBS LETTERS
Identification of active site serine and histidine residues in Escherichiacoli outer membrane protease OmpT
FEBS LETTERS
A novel extracellular esterase from Bacillus subtilis and its conversion to a monoacylglycerol hydrolase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: Characterization of the functional residues in Chromatium vinosum PHB synthase
BIOCHEMISTRY
The deuterium isotope effect on the NMR signal of the low-barrier hydrogenbond in a transition-state analog complex of chymotrypsin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The chemical nature of hydrogen bonding in proteins via NMR: J-couplings, chemical shifts, and AIM theory
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
PAF-acetylhydrolases
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Crystal structure and mechanism of a carbon-carbon bond hydrolase
STRUCTURE WITH FOLDING & DESIGN
Homology modeling and active-site residues probing of the thermophilic Alicyclobacillus acidocaldarius esterase 2
PROTEIN SCIENCE
A superfamily of archaeal, bacterial, and eukaryotic proteins homologous to animal transglutaminases
PROTEIN SCIENCE
Breaking the low barrier hydrogen bond in a serine protease
PROTEIN SCIENCE
Hydrogen bonding in complexes of carboxylic acids with 1-alkylimidazoles: steric and isotopic effects on low barrier hydrogen bonding
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
Knowledge-based modeling of the serine protease triad into non-proteases
PROTEIN ENGINEERING
Cloning and molecular characterization of a soluble epoxide hydrolase fromAspergillus niger that is related to mammalian microsomal epoxide hydrolase
BIOCHEMICAL JOURNAL
Crystal structure at 1.63 angstrom resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Study of the (S)-hydroxynitrile lyase from Hevea brasiliensis: mechanisticimplications
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
The prolyl aminopeptidase from Lactobacillus delbrueckii subsp. bulgaricusbelongs to the alpha/beta hydrolase fold family
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Nuclear magnetic resonance methods for the detection and study of low-barrier hydrogen bonds on enzymes
ENZYME KINETICS AND MECHANISM, PT E
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
The catalytic triad in Drosophila alcohol dehydrogenase: pH, temperature and molecular modelling studies
JOURNAL OF MOLECULAR BIOLOGY
Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases
JOURNAL OF MOLECULAR BIOLOGY
Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyltetrahydropterin synthase
JOURNAL OF MOLECULAR BIOLOGY
Proteolytic processing of tomato ringspot nepovirus 3C-like protease precursors: definition of the domains for the VPg, protease and putative RNA-dependent RNA polymerase
JOURNAL OF GENERAL VIROLOGY
Dengue virus NS3 serine protease - Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects
JOURNAL OF BIOLOGICAL CHEMISTRY
Functional linkage between the glutaminase and synthetase domains of carbamoyl-phosphate synthetase - Role of serine 44 in carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD)
JOURNAL OF BIOLOGICAL CHEMISTRY
Carboxypeptidase Y: Structural basis for protein sorting and catalytic triad
JOURNAL OF BIOCHEMISTRY
Identification of the catalytic triad in the haloalkane dehalogenase from Sphingomonas paucimobilis UT26
FEBS LETTERS
Some comments on the crystallography and the evolution of the catalytic structure in some serine hydrolases
CROATICA CHEMICA ACTA
Exploring zero-point energies and hydrogen bond geometries along proton transfer pathways by low-temperature NMR
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
Three-dimensional structure of Escherichia coli asparagine synthetase B: Ashort journey from substrate to product
BIOCHEMISTRY
The small subunit of carbamoyl phosphate synthetase: Snapshots along the reaction pathway
BIOCHEMISTRY
The roles of Glu-327 and His-446 in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by NMR spectroscopic and mutational analyses of the enzyme in the transient phosphohistidine intermediate complex
BIOCHEMISTRY
Formation and isolation of a covalent intermediate during the glutaminase reaction of a class II amidotransferase
BIOCHEMISTRY
Unusual properties of highly charged buffers: Large ionization volumes andlow barrier hydrogen bonds
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
SINGULAR POINTS OF PROTEIN BETA-SHEETS
Protein science
THE FUNCTION OF GLU(338) IN THE CATALYTIC TRIAD OF THE CARBAMOYL-PHOSPHATE SYNTHETASE AMIDOTRANSFERASE DOMAIN
Biochimica et biophysica acta. Protein structure and molecular enzymology
QUANTUM-CHEMICAL CALCULATIONS ON THE INTRAMOLECULAR HYDROGEN-BOND OF CIS-UROCANIC ACID
Journal of molecular structure. Theochem
Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes ofchymotrypsin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
COMPLETE PROTEIN LINKAGE MAP OF POLIOVIRUS P3 PROTEINS - INTERACTION OF POLYMERASE 3D(POL) WITH VPG AND WITH GENETIC-VARIANTS OF 3AB
Journal of virology
DETECTION OF PROTEIN 3-DIMENSIONAL SIDE-CHAIN PATTERNS - NEW EXAMPLESOF CONVERGENT EVOLUTION
Journal of Molecular Biology
IDENTIFICATION OF THE CATALYTIC TRIAD RESIDUES OF PORCINE LIVER ACYLAMINO ACID-RELEASING ENZYME
Journal of Biochemistry
AB-INITIO AND DENSITY-FUNCTIONAL THEORY STUDIES OF THE CATALYTIC MECHANISM FOR ESTER HYDROLYSIS IN SERINE HYDROLASES
International journal of quantum chemistry
ELUCIDATION OF THE CAUSE FOR REDUCED ACTIVITY OF ABNORMAL HUMAN PLASMIN CONTAINING AN ALA(55)-THR MUTATION - IMPORTANCE OF HIGHLY CONSERVEDALA(55) IN SERINE PROTEASES
FEBS letters
STAPHYLOCOCCAL LIPASES - MOLECULAR CHARACTERIZATION, SECRETION, AND PROCESSING
Chemistry and physics of lipids
THE 0.78 ANGSTROM STRUCTURE OF A SERINE-PROTEASE - BACILLUS-LENTUS SUBTILISIN
Biochemistry (Easton)
KINETIC MECHANISM OF ESCHERICHIA-COLI ASPARAGINE SYNTHETASE-B
Biochemistry
CORRELATIONS OF THE BASICITY OF HIS-57 WITH TRANSITION-STATE ANALOG BINDING, SUBSTRATE REACTIVITY, AND THE STRENGTH OF THE LOW-BARRIER HYDROGEN-BOND IN CHYMOTRYPSIN
Biochemistry
PROTONATION BEHAVIOR OF HISTIDINE-24 AND HISTIDINE-119 IN FORMING THEPH-4 FOLDING INTERMEDIATE OF APOMYOGLOBIN
Biochemistry
CHARACTERIZATION OF THE SHORT STRONG HYDROGEN-BOND IN BENZOYLACETONE BY AB-INITIO CALCULATIONS AND ACCURATE DIFFRACTION EXPERIMENTS - IMPLICATIONS FOR THE ELECTRONIC NATURE OF LOW-BARRIER HYDROGEN-BONDS IN ENZYMATIC-REACTIONS
Journal of the American Chemical Society
TOPOLOGICAL ANALYSIS OF THE CHARGE-DENSITY IN SHORT INTRAMOLECULAR O-H-CENTER-DOT-CENTER-DOT-CENTER-DOT-O HYDROGEN-BONDS - VERY-LOW TEMPERATURE X-RAY AND NEUTRON-DIFFRACTION STUDY OF BENZOYLACETONE
Journal of the American Chemical Society
ASSIGNMENT OF THE (NH)-H-EPSILON-2 AND (NH)-H-DELTA-1 RESONANCES AT THE ACTIVE-CENTER HISTIDINE IN CHYMOTRYPSIN AND SUBTILISIN COMPLEXED TOPEPTIDEBORONIC ACIDS WITHOUT SPECIFIC N-15 LABELING
Journal of the American Chemical Society
STRUCTURE AND REACTION-MECHANISM OF L-ARGININE-GLYCINE AMIDINOTRANSFERASE
Biological chemistry
THEORETICAL-STUDY OF THE INFLUENCE OF ELECTRIC-FIELDS ON HYDROGEN-BONDED ACID-BASE COMPLEXES
The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory
LINKERS OF SECONDARY STRUCTURES IN PROTEINS
Protein science
TESS - A GEOMETRIC HASHING ALGORITHM FOR DERIVING 3D COORDINATE TEMPLATES FOR SEARCHING STRUCTURAL DATABASES - APPLICATION TO ENZYME ACTIVE-SITES
Protein science
NONENZYMATIC ANTICOAGULANT ACTIVITY OF THE MUTANT SERINE-PROTEASE SER360ALA-ACTIVATED PROTEIN-C MEDIATED BY FACTOR VA
Protein science
MOLECULAR MODELING STUDIES OF SUBSTRATE-BINDING TO THE LIPASE FROM RHIZOMUCOR-MIEHEI
Journal of computer-aided molecular design
HYDROXYNITRILE LYASE FROM HEVEA-BRASILIENSIS - MOLECULAR CHARACTERIZATION AND MECHANISM OF ENZYME CATALYSIS
Proteins
NATURE OF H-BONDING IN CLUSTERS, LIQUIDS, AND ENZYMES - AN AB-INITIO,NATURAL BOND ORBITAL PERSPECTIVE
Journal of molecular structure. Theochem
HUMAN LYSOSOMAL ACID LIPASE CHOLESTERYL ESTER HYDROLASE AND HUMAN GASTRIC LIPASE - IDENTIFICATION OF THE CATALYTICALLY ACTIVE SERINE, ASPARTIC-ACID, AND HISTIDINE-RESIDUES
Journal of lipid research
VIRUS-ENCODED PROTEINASES OF THE PICORNAVIRUS SUPER-GROUP
Journal of General Virology
FUNCTIONS OF CHARACTERISTIC CYS-GLY-HIS-CYS (CGHC) AND GLN-GLU-ASP-LEU (QEDL) MOTIFS OF MICROSOMAL ER-60 PROTEASE
Journal of Biochemistry
DROSOPHILA ALCOHOL-DEHYDROGENASE - EVALUATION OF SER(139) SITE-DIRECTED MUTANTS
FEBS letters
IDENTIFICATION OF ESSENTIAL ASPARTIC-ACID AND HISTIDINE-RESIDUES OF HORMONE-SENSITIVE LIPASE - APPARENT RESIDUES OF THE CATALYTIC TRIAD
FEBS letters
GENETIC VARIANT SHOWING A POSITIVE INTERACTION WITH BETA-BLOCKING-AGENTS WITH A BENEFICIAL INFLUENCE ON LIPOPROTEIN-LIPASE ACTIVITY, HDL CHOLESTEROL, AND TRIGLYCERIDE LEVELS IN CORONARY-ARTERY DISEASE PATIENTS- THE SER(447)-STOP SUBSTITUTION IN THE LIPOPROTEIN-LIPASE GENE
Circulation
IDENTIFICATION OF CYSTEINE-523 IN THE ASPARTATE BINDING-SITE OF ESCHERICHIA-COLI ASPARAGINE SYNTHETASE-B
Biochemistry
RESIDUE ACCESSIBILITY, HYDROGEN-BONDING, AND MOLECULAR RECOGNITION - METAL-CHELATE PROBING OF ACTIVE-SITE HISTIDINES IN CHYMOTRYPSINS
Biochemistry
A THEORETICAL-STUDY OF THE ACTIVE-SITES OF PAPAIN AND S195C RAT TRYPSIN - IMPLICATIONS FOR THE LOW REACTIVITY OF MUTANT SERINE PROTEINASES
Protein science
COMPLEMENT FACTOR-D, A NOVEL SERINE-PROTEASE
Protein science
VIRAL CYSTEINE PROTEINASES
Perspectives in drug discovery and design
THE AGONISTIC BINDING-SITE AT THE HISTAMINE H-2-RECEPTOR .1. THEORETICAL INVESTIGATIONS OF HISTAMINE BINDING TO AN OLIGOPEPTIDE MIMICKING APART OF THE 5TH TRANSMEMBRANE ALPHA-HELIX
Journal of computer-aided molecular design
TAXONOMIC IDENTIFICATION OF STREPTOMYCES-EXFOLIATUS K10 AND CHARACTERIZATION OF ITS POLY(3-HYDROXYBUTYRATE) DEPOLYMERASE GENE
FEMS microbiology letters
DETERMINATION OF THE ACTIVE-SITES SERINE OF THE POLY(3-HYDROXYBUTYRATE) DEPOLYMERASES OF PSEUDOMONAS-LEMOIGNEI (PHAZ5) AND OF ALCALIGENES-FAECALIS
FEMS microbiology letters
CRYSTAL-STRUCTURE OF THE HUMAN ADENOVIRUS PROTEINASE WITH ITS 11-AMINO-ACID COFACTOR
EMBO journal
MUTATIONS IN THE POLIOVIRUS 3CD PROTEINASE S1-SPECIFICITY POCKET AFFECT SUBSTRATE RECOGNITION AND RNA-BINDING
Virology
THE ARTERIVIRUS NSP4 PROTEASE IS THE PROTOTYPE OF A NOVEL GROUP OF CHYMOTRYPSIN-LIKE ENZYMES, THE 3C-LIKE SERINE PROTEASES
The Journal of biological chemistry
THE CRYSTAL-STRUCTURE OF LIPASE-II FROM RHIZOPUS-NIVEUS AT 2.2 ANGSTROM RESOLUTION
Journal of Biochemistry
HIGHER TRIGLYCERIDES, LOWER HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL, ANDHIGHER SYSTOLIC BLOOD-PRESSURE IN LIPOPROTEIN LIPASE-DEFICIENT HETEROZYGOTES - A PRELIMINARY-REPORT
Circulation
A LOW-BARRIER HYDROGEN-BOND IN SUBTILISIN - H-1 AND N-15 NMR-STUDIES WITH PEPTIDYL TRIFLUOROMETHYL KETONES
Biochemistry