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Sensitivity to camptothecin in Aspergillus nidulans identifies a novel gene, scaA(+), related to the cellular DNA damage response
MOLECULAR GENETICS AND GENOMICS
Structural basis of Topotecan-DNA recognition probed by flow linear dichroism, circular dichroism, and Raman spectroscopy
JOURNAL OF PHYSICAL CHEMISTRY B
Novel clinical strategies for the treatment of pancreatic carcinoma
TRENDS IN MOLECULAR MEDICINE
The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis
ARTHRITIS RESEARCH
Analytical approaches for traditional Chinese medicines exhibiting antineoplastic activity
JOURNAL OF CHROMATOGRAPHY B
Antitumor drugs possessing topoisomerase I inhibition: applicable separation methods
JOURNAL OF CHROMATOGRAPHY B
Quantitation of camptothecin and related compounds
JOURNAL OF CHROMATOGRAPHY B
Separation methods for camptothecin and related compounds
JOURNAL OF CHROMATOGRAPHY B
High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma
JOURNAL OF CHROMATOGRAPHY B
Development of a simplified, sensitive high-performance liquid chromatographic method using fluorescence detection to determine the concentration of UCN-01 in human plasma
JOURNAL OF CHROMATOGRAPHY B
Development of a high-performance liquid chromatographic method to determine the concentration of karenitecin, a novel highly lipophilic camptothecinderivative, in human plasma and urine
JOURNAL OF CHROMATOGRAPHY B
Molecular characterisation of camptothecin-induced mutations at the hprt locus in Chinese hamster cells
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cellsbut does not interact with intrachromosomal recombination
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?
DRUG RESISTANCE UPDATES
Pathways for repair of topoisomerase I covalent complexes in Saccharomycescerevisiae
GENES TO CELLS
Inhibition of human DNA topoisomerase I by new DNA minor groove ligands: Derivatives of oligo-1,3-thiazolecarboxamides
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
Cellular and biophysical evidence for interactions between adenosine triphosphate and P-glycoprotein substrates: functional implications for adenosine triphosphate/drug cotransport in P-glycoprotein overexpressing tumor cells and in P-glycoprotein low-level expressing erythrocytes
BLOOD CELLS MOLECULES AND DISEASES
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
CLINICAL CANCER RESEARCH
P53-independent induction of apoptosis in human melanoma cells by a bcl-2/bcl-xL bispecific antisense oligonucleotide
CLINICAL CANCER RESEARCH
Why drugs fail: Of mice and men revisited
CLINICAL CANCER RESEARCH
A phase I study of irinotecan in pediatric patients: A Pediatric Oncology Group Study
CLINICAL CANCER RESEARCH
Weekly irinotecan and cisplatin in advanced non-small cell lung cancer: A multicenter phase II study
CLINICAL CANCER RESEARCH
Pharmacological determinants of 9-aminocamptothecin cytotoxicity
CLINICAL CANCER RESEARCH
Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression
CLINICAL CANCER RESEARCH
In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction
CLINICAL CANCER RESEARCH
Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I
CHEMISTRY & BIOLOGY
Effect of thidiazuron on adventitious shoot regeneration from seedling explants of Nothapodytes foetida
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug
BIOCONJUGATE CHEMISTRY
Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site
BIOCONJUGATE CHEMISTRY
Chemotherapy with irinotecan (CPT-11), a topoisomerase-I inhibitor, for refractory and relapsed non-Hodgkin's lymphoma
LEUKEMIA & LYMPHOMA
Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver
INTERNATIONAL JOURNAL OF ONCOLOGY
Unique action determinants of double acting topoisomerase inhibitor, TAS-103
INTERNATIONAL JOURNAL OF ONCOLOGY
The differentiation inducers phenylacetate and phenylbutyrate modulate camptothecin sensitivity in colon carcinoma cells in vitro by intracellular acidification
INTERNATIONAL JOURNAL OF ONCOLOGY
Stathmo-apoptosis: Arresting apoptosis by fluorochrome-labeled inhibitor of caspases
INTERNATIONAL JOURNAL OF ONCOLOGY
UCN-01 dose-dependent inhibition of normal hyperproliferative cells in mice
INTERNATIONAL JOURNAL OF ONCOLOGY
Effectiveness of water soluble poly(L-glutamic acid)camptothecin conjugateagainst resistant human lung cancer xenografted in nude mice
INTERNATIONAL JOURNAL OF ONCOLOGY
A series of enediynes as novel inhibitors of topoisomerase I
BIOORGANIC & MEDICINAL CHEMISTRY
Synthesis and properties of triple helix-forming oligodeoxyribonucleotidescontaining 7-chloro-7-deaza-2 '-deoxyguanosine
BIOORGANIC & MEDICINAL CHEMISTRY
Rebeccamycin analogues from indolo[2,3-c] carbazole
BIOORGANIC & MEDICINAL CHEMISTRY
Antagonistic effect of the combination gemcitabine/topotecan in ovarian cancer cells
ONCOLOGY RESEARCH
High sensitivity of human epidermal keratinocytes (HaCaT) to topoisomeraseinhibitors
CELL PROLIFERATION
Effects of a novel trinuclear platinum complex in cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines: interference with cellcycle progression and induction of apoptosis
EUROPEAN JOURNAL OF CANCER
Salivary and plasma pharmacokinetics of topotecan in patients with metastatic epithelial ovarian cancer
EUROPEAN JOURNAL OF CANCER
Biodistribution of NX211, liposomal lurtotecan, in tumor-bearing mice
ANTI-CANCER DRUGS
Modulation of camptothecin analogs in the treatment of cancer: a review
ANTI-CANCER DRUGS
The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison
ANTI-CANCER DRUGS
Combination therapy with irinotecan (CPT-11), mitoxantrone, and dexamethasone in relapsed or refractory non-Hodgkin's lymphoma: a pilot study
ANNALS OF HEMATOLOGY
Synthesis of heteroarenes via radical cyclisation onto nitriles
SYNLETT
Phase I trial of gemcitabine and CPT-11 given weekly for four weeks every six weeks
ANNALS OF ONCOLOGY
A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients
ANNALS OF ONCOLOGY
Phase I dose-finding and pharmacokinetic trial of irinotecan (CPT-11) administered every two weeks
ANNALS OF ONCOLOGY
Determination of topotecan by ELISA
BIOLOGICAL & PHARMACEUTICAL BULLETIN
High-performance liquid chromatographic analysis of lactone and hydroxy acid of new antitumor drug, DX-8951 (Exatecan), in mouse plasma
BIOLOGICAL & PHARMACEUTICAL BULLETIN
A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex
MOLECULAR CARCINOGENESIS
Camptothecin schedule and timing of administration with irradiation
ONCOLOGY-NEW YORK
Irinotecan in the treatment of colorectal cancer: Clinical overview
JOURNAL OF CLINICAL ONCOLOGY
Phase I study of topotecan plus cranial radiation for glioblastoma multiforme: Results of Radiation Therapy Oncology Group Trial 9507
JOURNAL OF CLINICAL ONCOLOGY
Sequence effect of irinotecan and fluorouracil treatment on pharmacokinetics and toxicity in chemotherapy-naive metastatic colorectal cancer patients
JOURNAL OF CLINICAL ONCOLOGY
Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents
PHARMACEUTICAL RESEARCH
Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila
PLANT CELL REPORTS
Copper(I) iodide-promoted hydroxylation onto the lithium or potassium enolate of lactones and lactams
HETEROCYCLES
Ground and excited-state ionization behavior of 9-aminocamptothecin: An absorption and fluorescence spectral study
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
Clinical effect of irinotecan in advanced and metastatic breast cancer patients previously treated with doxorubicin- and docetaxel-containing regimens
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Tumor cell death induced by topoisomerase-targeting drugs
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Assessment of the cytotoxic and clastogenic activities of the sesquiterpene lactone lychnopholide in mammalian cells in vitro and in vivo
CANCER DETECTION AND PREVENTION
Topotecan selectively enhances the radioresponse of human small-cell lung carcinoma and glioblastoma multiforme xenografts in nude mice
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Synergistic interaction between topotecan and microtubule-interfering agents
CANCER CHEMOTHERAPY AND PHARMACOLOGY
A phase I and pharmacologic study of 9-aminocamptothecin administered as a120-h infusion weekly to adult cancer patients
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Limited sampling models for CPT-11, SN-38, and SN-38 glucuronide
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Dose escalation study of irinotecan combined with carboplatin for advancednon-small-cell lung cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Sensitivity to topoisomerase I inhibitors and cisplatin is associated withepidermal growth factor receptor expression in human cervical squamous carcinoma ME180 sublines
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Improved respiratory delivery of the anticancer drugs, camptothecin and paclitaxel, with 5% CO2-enriched air: pharmacokinetic studies
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Bisimidazoacridones induce a potent cytostatic effect in colon tumor cellsthat sensitizes them to killing by UCN-01
CANCER CHEMOTHERAPY AND PHARMACOLOGY
A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro
NUCLEIC ACIDS RESEARCH
Effect of bile acids on the uptake of irinotecan and its active metabolite, SN-38, by intestinal cells
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma
CANCER LETTERS
Prospective phase II trial of irinotecan, 5-fluorouracil, and leucovorin in combination as salvage therapy for advanced colorectal cancer
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Genotoxic action of the sesquiterpene lactone centratherin on mammalian cells in vitro and in vivo
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
DNA topoisomerases as targets for anticancer drugs
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
High-performance liquid chromatographic assay for glucuronidation activityof 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan (CPT-11), in human liver microsomes
BIOMEDICAL CHROMATOGRAPHY
Validation study of assay method for DX-8951 and its metabolite in human plasma and urine by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry
BIOMEDICAL CHROMATOGRAPHY
Relationship between lactone ring forms of HCPT and their antitumor activities
ACTA PHARMACOLOGICA SINICA
9-nitrocamptothecin is an effective drug for the treatment of human lung tumors: Comparison of in vitro and in vivo studies
ANTICANCER RESEARCH
Immunohistochemical staining for DNA topoisomerase I, DNA topoisomerase II-alpha and p53 in gastric carcinomas
ANTICANCER RESEARCH
Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry
CYTOMETRY
Biorecognizable HPMA copolymer-drug conjugates for colon-specific deliveryof 9-aminocamptothecin
JOURNAL OF CONTROLLED RELEASE
Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic
JOURNAL OF CONTROLLED RELEASE
PEG drugs: an overview
JOURNAL OF CONTROLLED RELEASE
The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity
JOURNAL OF CONTROLLED RELEASE
Carrier and dose effects on the pharmacokinetics of T-0128, a camtothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats
JOURNAL OF CONTROLLED RELEASE
A phase II trial of 9-aminocaptothecin (9-AC) as a 120-h infusion in patients with non-small cell lung cancer
INVESTIGATIONAL NEW DRUGS
A theoretical study on camptothecin-AM1 treatment
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
Telomerase protects developing neurons against DNA damage-induced cell death
DEVELOPMENTAL BRAIN RESEARCH
9-Nitrocamptothecin inhibits HIV-1 replication in human peripheral blood lymphocytes: A potential alternative for HIV-Infection/AIDS therapy
JOURNAL OF MEDICAL VIROLOGY
A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4
DRUG METABOLISM AND DISPOSITION
DNA relaxation and cleavage assays to study topoisomerase I inhibitors
DRUG-NUCLEIC ACID INTERACTIONS
Partial synthesis of camptothecin analogs. Part 3: Easy approach to a quinoline-lactone system
TETRAHEDRON LETTERS
Synthesis of a model compound of mappicine ketone based on sulfur-directed5-exo selective aryl radical cyclization onto enamides
TETRAHEDRON LETTERS
Growth and production of camptothecin by cell suspension cultures of Nothapodytes foetida
PLANTA MEDICA