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    1. Noble, D; Rudy, Y
      Models of cardiac ventricular action potentials: iterative interaction between experiment and simulation

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
    2. Kohl, P; Sachs, F
      Mechanoelectric feedback in cardiac cells

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
    3. Weeks, BS; Alston, NI; Cadet, P; Zhu, W; Rialas, C; Stefano, GB
      Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    4. Eliyahu, E; Kaplan-Kraicer, R; Shalgi, R
      PKC in eggs and embryos

      FRONTIERS IN BIOSCIENCE
    5. Combes, A; McTiernan, C; Brooks, SS; Feldman, AM
      UV light synergistically enhances the cardiotoxic effects of interleukin 1beta through peroxynitrite formation

      JOURNAL OF CARDIAC FAILURE
    6. Zarse, M; Stellbrink, C; Athanatou, E; Robert, J; Schotten, U; Hanrath, P
      Verapamil prevents stretch-induced shortening of atrial effective refractory period in Langendorff-perfused rabbit heart

      JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
    7. Lohr, C; Beck, A; Deitmer, JW
      Activity-dependent accumulation of Ca2+ in axon and dendrites of them leech Leydig neuron

      NEUROREPORT
    8. Martinez-Galan, JR; Lopez-Bendito, G; Lujan, R; Shigemoto, R; Fairen, A; Valdeolmillos, M
      Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors

      EUROPEAN JOURNAL OF NEUROSCIENCE
    9. Pellegrini, M; Menconi, MC; Pellegrino, M
      Stretch-activated cation channels of leech neurons exhibit two activity modes

      EUROPEAN JOURNAL OF NEUROSCIENCE
    10. Pletjushkina, OJ; Rajfur, Z; Pomorski, P; Oliver, TN; Vasiliev, JM; Jacobson, KA
      Induction of cortical oscillations in spreading cells by depolymerization of microtubules

      CELL MOTILITY AND THE CYTOSKELETON
    11. Chen, GP; Carroll, S; Racay, P; Dick, J; Pette, D; Traub, I; Vrbova, G; Eggli, P; Celio, M; Schwaller, B
      Deficiency in parvalbumin increases fatigue resistance in fast-twitch muscle and upregulates mitochondria

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    12. Ungvari, Z; Sun, D; Huang, A; Kaley, G; Koller, A
      Role of endothelial [Ca2+](i) in activation of eNOS in pressurized arterioles by agonists and wall shear stress

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    13. Arutunyan, A; Webster, DR; Swift, LM; Sarvazyan, N
      Localized injury in cardiomyocyte network: a new experimental model of ischemia-reperfusion arrhythmias

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    14. Boknik, P; Khorchidi, S; Bodor, GS; Huke, S; Knapp, J; Linck, B; Luss, H; Muller, FU; Schmitz, W; Neumann, J
      Role of protein phosphatases in regulation of cardiac inotropy and relaxation

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    15. Kang, HS; Kerstan, D; Dai, LJ; Ritchie, G; Quamme, GA
      Adenosine modulates Mg2+ uptake in distal convoluted tubule cells via A(1)and A(2) purinoceptors

      AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
    16. Dai, LJ; Kang, HS; Kerstan, D; Ritchie, G; Quamme, GA
      ATP inhibits Mg2+ uptake in MDCT cells via P2X purinoceptors

      AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
    17. Kapur, A; Yeckel, M; Johnston, D
      Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway

      NEUROSCIENCE
    18. Empson, RM; Jefferys, JGR
      Ca2+ entry through L-type Ca2+ channels helps terminate epileptiform activity by activation of a Ca2+ dependent afterhyperpolarisation in hippocampalCA3

      NEUROSCIENCE
    19. Varju, P; Katarova, Z; Madarasz, E; Szabo, G
      GABA signalling during development: new data and old questions

      CELL AND TISSUE RESEARCH
    20. Bernengo, JC; Collet, C; Jacquemond, V
      Intracellular Mg2+ diffusion within isolated rat skeletal muscle fibers

      BIOPHYSICAL CHEMISTRY
    21. Voigt, T; Opitz, T; de Lima, AD
      Synchronous oscillatory activity in immature cortical network is driven byGABAergic preplate neurons

      JOURNAL OF NEUROSCIENCE
    22. Yazawa, H; Yanagida, K; Sato, A
      Oocyte activation and Ca2+ oscillation-inducing abilities of mouse round/elongated spermatids and the developmental capacities of embryos from spermatid injection

      HUMAN REPRODUCTION
    23. Robert, V; Gurlini, P; Tosello, V; Nagai, T; Miyawaki, A; Di Lisa, F; Pozzan, T
      Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells

      EMBO JOURNAL
    24. Stefano, GB; Fricchione, GL; Slingsby, BT; Benson, H
      The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide

      BRAIN RESEARCH REVIEWS
    25. Cordeiro, JM; Bridge, JHB; Spitzer, KW
      Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy

      CELL CALCIUM
    26. Mohri, T; Shirakawa, H; Oda, S; Sato, MS; Mikoshiba, K; Miyazaki, S
      Analysis of Mn2+/Ca2+ influx and release during Ca2+ oscillations in mouseeggs injected with sperm extract

      CELL CALCIUM
    27. Torrecilla, I; Leganes, F; Bonilla, I; Fernandez-Pinas, E
      Calcium transients in response to salinity and osmotic stress in the nitrogen-fixing cyanobacterium Anabaena sp PCC7120, expressing cytosolic apoaequorin

      PLANT CELL AND ENVIRONMENT
    28. Honda, H; Naya, T; Koiwa, Y
      Cardiac twitch properties simulated by three states model

      TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
    29. Beck, A; Lohr, C; Nett, W; Deitmer, JW
      Bursting activity in leech Retzius neurons induced by low external chloride

      PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
    30. Hartell, NA
      Receptors, second messengers and protein kinases required for heterosynaptic cerebellar long-term depression

      NEUROPHARMACOLOGY
    31. Hanse, E; Gustafsson, B
      Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus

      JOURNAL OF PHYSIOLOGY-LONDON
    32. Wang, YF; Gao, XB; Van den Pol, AN
      Membrane properties underlying patterns of GABA-dependent action potentials in developing mouse hypothalamic neurons

      JOURNAL OF NEUROPHYSIOLOGY
    33. Frick, A; Zieglgansberger, W; Dodt, HU
      Glutamate receptors form hot spots on apical dendrites of neocortical pyramidal neurons

      JOURNAL OF NEUROPHYSIOLOGY
    34. Oakley, JC; Schwindt, PC; Crill, WE
      Initiation and propagation of regenerative Ca2+-dependent potentials in dendrites of layer 5 pyramidal neurons

      JOURNAL OF NEUROPHYSIOLOGY
    35. Jeremic, A; Jeftinija, K; Stevanovic, J; Glavaski, A; Jeftinija, S
      ATP stimulates calcium-dependent glutamate release from cultured astrocytes

      JOURNAL OF NEUROCHEMISTRY
    36. Allansson, L; Khatibi, S; Olsson, T; Hansson, E
      Acute ethanol exposure induces [Ca2+](i) transients, cell swelling and transformation of actin cytoskeleton in astroglial primary cultures

      JOURNAL OF NEUROCHEMISTRY
    37. Ferraz, SA; Bassani, JWM; Bassani, RA
      Rest-dependence of twitch amplitude and sarcoplasmic reticulum calcium content in the developing rat myocardium

      JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
    38. Milnes, JT; MacLeod, KT
      Reduced ryanodine receptor to dihydropyridine receptor ratio may underlie slowed contraction in a rabbit model of left ventricular cardiac hypertrophy

      JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
    39. Petering, H; Kluthe, C; Dulkys, Y; Kiehl, P; Ponath, PD; Kapp, A; Elsner, J
      Characterization of the CC chemokine receptor 3 on human keratinocytes

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    40. Hardie, RC
      Phototransduction in Drosophila melanogaster

      JOURNAL OF EXPERIMENTAL BIOLOGY
    41. Liu, YW; Cseresnyes, Z; Randall, WR; Schneider, MF
      Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers

      JOURNAL OF CELL BIOLOGY
    42. Min, JY; Ding, B; Wang, JF; Sullivan, MF; Morgan, JP
      Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts

      EUROPEAN JOURNAL OF PHARMACOLOGY
    43. Mehlmann, LM; Chattopadhyay, A; Carpenter, G; Jaffe, LA
      Evidence that phospholipase c from the sperm is not responsible for initiating Ca2+ release at fertilization in mouse eggs

      DEVELOPMENTAL BIOLOGY
    44. Ito, K; Yan, XH; Feng, X; Manning, WJ; Dillmann, WH; Lorell, BH
      Transgenic expression of sarcoplasmic reticulum Ca2+ ATPase modifies the transition from hypertrophy to early heart failure

      CIRCULATION RESEARCH
    45. Ohata, H; Ikeuchi, T; Kamada, A; Yamamoto, M; Momose, K
      Lysophosphatidic acid positively regulates the fluid flow-induced local Ca2+ influx in bovine aortic endothelial cells

      CIRCULATION RESEARCH
    46. O'Donnell, JM; Sumbilla, CM; Ma, H; Farrance, IKG; Cavagna, M; Klein, MG; Inesi, G
      Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes

      CIRCULATION RESEARCH
    47. McPherson, BC; Yao, ZH
      Morphine mimics preconditioning via free radical signals and mitochondrialK-ATP channels in myocytes

      CIRCULATION
    48. Miura, M; Wakayama, Y; Sugai, Y; Kagaya, Y; Watanabe, J; ter Keurs, HEDJ; Shirato, K
      Effect of transient stretch on intracellular Ca2+ during triggered propagated contractions in intact trabeculae

      CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
    49. Sorrentino, V; Rizzuto, R
      Molecular genetics of Ca2+ stores and intracellular Ca2+ signalling

      TRENDS IN PHARMACOLOGICAL SCIENCES
    50. Massaeli, H; Austria, JA; Pierce, GN
      Lesions in ryanodine channels in smooth muscle cells exposed to oxidized low density lipoprotein

      ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    51. Behar, TN; Schaffner, AE; Scott, CA; Greene, CL; Barker, JL
      GABA receptor antagonists modulate postmitotic cell migration in slice cultures of embryonic rat cortex

      CEREBRAL CORTEX
    52. Takahashi, T; Saito, H; Hiroi, M; Doi, K; Takahashi, E
      Effects of aging on inositol 1,4,5-triphosphate-induced Ca2+ release in unfertilized mouse oocytes

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    53. Isaev, D; Gerber, G; Park, SK; Chung, JM; Randic, M
      Facilitation of NMDA-induced currents and Ca2+ transients in the rat substantia gelatinosa neurons after ligation of L5-L6 spinal nerves

      NEUROREPORT
    54. Tapia, JC; Cardenas, AM; Nualart, F; Mentis, GZ; Navarrete, R; Aguayo, LG
      Neurite outgrowth in developing mouse spinal cord neurons is modulated by glycine receptors

      NEUROREPORT
    55. Marchenko, SM; Sage, SO
      Effects of shear stress on [Ca2+](i) and membrane potential of vascular endothelium of intact rat blood vessels

      EXPERIMENTAL PHYSIOLOGY
    56. Glitsch, M; Parra, P; Llano, I
      The retrograde inhibition of IPSCs in rat cerebellar Purkinje cells is highly sensitive to intracellular Ca2+

      EUROPEAN JOURNAL OF NEUROSCIENCE
    57. Peng, YY; Wang, KS
      A four-compartment model for Ca2+ dynamics: An interpretation of Ca2+ decay after repetitive firing of intact nerve terminals

      JOURNAL OF COMPUTATIONAL NEUROSCIENCE
    58. Vautrin, J; Maric, D; Sukhareva, M; Schaffner, AE; Barker, JL
      Surface-accessible GABA supports tonic and quantal synaptic transmission

      SYNAPSE
    59. Pei, JM; Zhou, JJ; Bian, JS; Yu, XC; Fung, ML; Wong, TM
      Impaired [Ca2+](i) and pH(i) responses to kappa-opioid receptor stimulation in the heart of chronically hypoxic rats

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    60. Bayguinov, O; Hagen, B; Bonev, AD; Nelson, MT; Sanders, KM
      Intracellular calcium events activated by ATP in murine colonic myocytes

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    61. Jaimovich, E; Reyes, R; Liberona, JL; Powell, JA
      IP3 receptors, IP3 transients, and nucleus-associated Ca2+ signals in cultured skeletal muscle

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    62. Ren, J; Sowers, JR; Walsh, MF; Brown, RA
      Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    63. Trouve, P; Carre, F; Belikova, I; Leclercq, C; Dakhli, T; Soufir, L; Coquard, I; Ramirez-Gil, J; Charlemagne, D
      Na+-K+-ATPase alpha 2-isoform expression in guinea pig hearts during transition from compensation to decompensation

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    64. Ren, J; Bode, AM
      Altered cardiac excitation-contraction coupling in ventricular myocytes from spontaneously diabetic BB rats

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    65. Ferrier, GR; Redondo, IM; Mason, CA; Mapplebeck, C; Howlett, SE
      Regulation of contraction and relaxation by membrane potential in cardiac ventricular myocytes

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    66. Coughlan, CM; McManus, CM; Sharron, M; Gao, ZY; Murphy, D; Jaffer, S; Choe, W; Chen, W; Hesselgesser, J; Gaylord, H; Kalyuzhny, A; Lee, VMY; Wolf, B; Doms, RW; Kolson, DL
      Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons

      NEUROSCIENCE
    67. Massaeli, H; Austria, JA; Pierce, GN
      Overexpression of SERCA2 ATPaase in vascular smooth muscle cells treated with oxidized low density lipoprotein

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    68. Kulik, A; Nishimaru, H; Ballanyi, K
      Role of bicarbonate and chloride in GABA- and glycine-induced depolarization and [Ca2+](i) rise in fetal rat motoneurons in situ

      JOURNAL OF NEUROSCIENCE
    69. Lautermilch, NJ; Spitzer, NC
      Regulation of calcineurin by growth cone calcium waves controls neurite extension

      JOURNAL OF NEUROSCIENCE
    70. Cheung, A; Swann, K; Carroll, J
      The ability to generate normal Ca2+ transients in response to spermatozoa develops during the final stages of oocyte growth and maturation

      HUMAN REPRODUCTION
    71. Nixon, VL; McDougall, A; Jones, KT
      Ca2+ oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs

      BIOLOGY OF THE CELL
    72. Parrington, J; Lai, FA; Swann, K
      The soluble mammalian sperm factor protein that triggers Ca2+ oscillationsin eggs: Evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells

      BIOLOGY OF THE CELL
    73. Takagi, H
      Roles of ion channels in EPSP integration at neuronal dendrites

      NEUROSCIENCE RESEARCH
    74. Blackman, BR; Thibault, LE; Barbee, KA
      Selective modulation ef endothelial cell[Ca2+]i response to flow by the onset rate of shear stress

      JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
    75. Day, ML; McGuinness, OM; Berridge, MJ; Johnson, MH
      Regulation of fertilisation-induced Ca2+ spiking in the mouse zygote (vol 28, pg 47, 2000)

      CELL CALCIUM
    76. Day, ML; McGuinness, OM; Berridge, MJ; Johnson, MH
      Regulation of fertilization-induced Ca2+ spiking in the mouse zygote

      CELL CALCIUM
    77. Decostre, V; Gillis, JM; Gailly, P
      Effect of adrenaline on the post-tetanic potentiation in mouse skeletal muscle

      JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
    78. Levitan, I; Helmke, BP; Davies, PF
      A chamber to permit invasive manipulation of adherent cells in laminar flow with minimal disturbance of the flow field

      ANNALS OF BIOMEDICAL ENGINEERING
    79. Kline, D
      Attributes and dynamics of the endoplasmic reticulum in mammalian eggs

      CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 50
    80. Ju, YK; Allen, DG
      The distribution of calcium in toad cardiac pacemaker cells during spontaneous firing

      PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
    81. Cox, CL; Denk, W; Tank, DW; Svoboda, K
      Action potentials reliably invade axonal arbors of rat neocortical neurons

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    82. Kortvely, A; Szigeti, G; Gesztelyi, R; Zsuga, J; Banyasz, T; Magyar, J; Szigligeti, P; Kovacs, L; Jednakovits, A; Szentmiklosi, AJ; Nanasi, PP
      Cardiovascular effects of BRX-005 comparison to bimoclomol

      LIFE SCIENCES
    83. Cavagna, M; O'Donnell, JM; Sumbilla, C; Inesi, G; Klein, MG
      Exogenous Ca2+-ATPase isoform effects on Ca2+ transients of embryonic chicken and neonatal rat cardiac myocytes

      JOURNAL OF PHYSIOLOGY-LONDON
    84. Reynolds, T; Hartell, NA
      An evaluation of the synapse specificity of long-term depression induced in rat cerebellar slices

      JOURNAL OF PHYSIOLOGY-LONDON
    85. Raymackers, JM; Gailly, P; Colson-Van Schoor, M; Pette, D; Schwaller, B; Hunziker, W; Celio, MR; Gillis, JM
      Tetanus relaxation of fast skeletal muscles of the mouse made parvalbumin deficient by gene inactivation

      JOURNAL OF PHYSIOLOGY-LONDON
    86. Korngreen, A; Sakmann, B
      Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients

      JOURNAL OF PHYSIOLOGY-LONDON
    87. Wegener, C; Nassel, DR
      Peptide-induced Ca2+ movements in a tonic insect muscle: effects of proctolin and periviscerokinin-2

      JOURNAL OF NEUROPHYSIOLOGY
    88. Nettleton, JS; Spain, WJ
      Linear to supralinear summation of AMPA-mediated EPSPs in neocortical pyramidal neurons

      JOURNAL OF NEUROPHYSIOLOGY
    89. Kalil, K; Szebenyi, G; Dent, EW
      Common mechanisms underlying growth cone guidance and axon branching

      JOURNAL OF NEUROBIOLOGY
    90. Colegrove, SL; Albrecht, MA; Friel, DD
      Dissection of mitochondrial Ca2+ uptake and release fluxes in situ after depolarization-evoked [Ca2+](i) elevations in sympathetic neurons

      JOURNAL OF GENERAL PHYSIOLOGY
    91. Salzet, M; Breton, C; Bisogno, T; Di Marzo, V
      Comparative biology of the endocannabinoid system - Possible role in the immune response

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    92. Jones, KT; Nixon, VL
      Sperm-induced Ca2+ oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: Evidence to support a continuous low level production of inositol 1,4,5-trisphosphate during mammalian fertilization

      DEVELOPMENTAL BIOLOGY
    93. Brind, S; Swann, K; Carroll, J
      Inositol 1,4,5-trisphosphate receptors are downregulated in mouse oocytes in response to sperm or adenophostin a but not to increases in intracellular Ca2+ or egg activation

      DEVELOPMENTAL BIOLOGY
    94. Boyden, PA; Pu, JL; Pinto, J; ter Keurs, HEDJ
      Ca2+ transients and Ca2+ waves in Purkinje cells - Role in action potential initiation

      CIRCULATION RESEARCH
    95. McIntosh, MA; Cobbe, SM; Smith, GL
      Heterogeneous changes in action potential and intracellular Ca2+ in left ventricular myocyte sub-types from rabbits with heart failure

      CARDIOVASCULAR RESEARCH
    96. Dixon, CJ
      Evidence that 2-methylthioATP and 2-methylthioADP are both agonists at therat hepatocyte P2Y(1) receptor

      BRITISH JOURNAL OF PHARMACOLOGY
    97. Dixon, CJ; Woods, NM; Webb, TE; Green, AK
      Evidence that rat hepatocytes co-express functional P2Y(1) and P2Y(2) receptors

      BRITISH JOURNAL OF PHARMACOLOGY
    98. Sonn, J; Mayevsky, A
      Effects of brain oxygenation on metabolic, hemodynamic, ionic and electrical responses to spreading depression in the rat

      BRAIN RESEARCH
    99. Carey, MB; Matsumoto, SG
      Calcium transient activity in cultured murine neural crest cells is regulated at the IP3 receptor

      BRAIN RESEARCH
    100. Zoghbi, ME; Bolanos, P; Villalba-Galea, C; Marcano, A; Hernandez, E; Fill, M; Escobar, AL
      Spatial Ca2+ distribution in contracting skeletal and cardiac muscle cells

      BIOPHYSICAL JOURNAL


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Documento generato il 22/01/21 alle ore 11:56:38