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Early development of cyclin dependent kinase modulators
CURRENT PHARMACEUTICAL DESIGN
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway
CELL DEATH AND DIFFERENTIATION
A20 zinc finger protein inhibits TNF-induced apoptosis and stress responseearly in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins
CELL DEATH AND DIFFERENTIATION
Histone acetylation and the cell-cycle in cancer
FRONTIERS IN BIOSCIENCE
It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes
BLOOD CELLS MOLECULES AND DISEASES
Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotidereductase M2 subunit
CLINICAL CANCER RESEARCH
A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer
CLINICAL CANCER RESEARCH
Overexpressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy
CRITICAL REVIEWS IN IMMUNOLOGY
Cell cycle arrest mediated by a pyridopyrimidine is not abrogated by over-expression of Bcl-2 and cyclin D1
INTERNATIONAL JOURNAL OF ONCOLOGY
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies
LEUKEMIA
Galectins as modulators of cell adhesion
BIOCHIMIE
The integrin, alpha 6 beta 1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells
HEPATOLOGY
Aminoterminal propeptide of the alpha 1-homotrimer variant of human type Iprocollagen (hotPINP) in malignant pleural effusion
ANTICANCER RESEARCH
Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells
CYTOMETRY
Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells
INVESTIGATIONAL NEW DRUGS
The CRK3 protein kinase is essential for cell cycle progression of Leishmania Mexicana
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
The toxic responses induced by okadaic acid involve processing of multiplecaspase isoforms
TOXICON
Extracellular signaling through the microenvironment: A hypothesis relating carcinogenesis, bystander effects, and genomic instability
RADIATION RESEARCH
The differential inhibitory effects of genistein on the growth of cervicalcancer cells in vitro
NEOPLASMA
Glutamine and cancer
JOURNAL OF NUTRITION
Disruption of transforming growth factor beta-regulated laminin receptor function by expression of antisense laminin, a chain RNA in human colon cancer cells
JOURNAL OF CELLULAR PHYSIOLOGY
Suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix-induced apoptosis
JOURNAL OF CELL BIOLOGY
Retinoic acid-mediated growth arrest requires ubiquitylation and degradation of the F-box protein Skp2
JOURNAL OF BIOLOGICAL CHEMISTRY
Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit
JOURNAL OF BIOLOGICAL CHEMISTRY
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
JOURNAL OF BIOLOGICAL CHEMISTRY
Inhibitory effect of selenite on invasion of HT1080 tumor cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY
Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by ravopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity
CANCER RESEARCH
Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1
BIOCHEMICAL PHARMACOLOGY
Cyclin-dependent kinase and protein kinase C inhibitors: A novel class of antineoplastic agents in clinical development
CANCER JOURNAL
Galectins: A new family of regulators of inflammation
CLINICAL IMMUNOLOGY
The biology of cell locomotion within three-dimensional extracellular matrix
CELLULAR AND MOLECULAR LIFE SCIENCES
Cyclin-dependent kinase inhibitors: novel anticancer agents
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappa B, activation protein-1, and c-Jun N-terminal kinase
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Flavopiridol metabolism in cancer patients is associated with the occurrence of diarrhea
CLINICAL CANCER RESEARCH
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
CLINICAL CANCER RESEARCH
Antisense oligonucleotides: An evolving technology for the modulation of gene expression in human disease
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
Integrins as receptors for laminins
MICROSCOPY RESEARCH AND TECHNIQUE
Staurosporine analogues - pharmacological toys or useful antitumour agents?
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol
INTERNATIONAL JOURNAL OF ONCOLOGY
Fas and Fas ligand interactions in malignant disease (Review)
INTERNATIONAL JOURNAL OF ONCOLOGY
Lipids: A key role in multidrug resistance? (Review)
INTERNATIONAL JOURNAL OF ONCOLOGY
Small molecule modulators of cyclin-dependent kinases for cancer therapy
ONCOGENE
pRb and Cdk regulation by N-(4-hydroxyphenyl)retinamide
ONCOGENE
Molecular mechanisms of anticancer activity of natural dietetic products
JOURNAL OF MOLECULAR MEDICINE-JMM
Interrelationships between cellular nucleotide excision repair, cisplatin cytotoxicity, HER-2/neu gene expression, and epidermal growth factor receptor level in non-small cell lung cancer cells
JAPANESE JOURNAL OF CANCER RESEARCH
Monomethyl selenium-specific inhibition of MMP-2 and VEGF expression: Implications for angiogenic switch regulation
MOLECULAR CARCINOGENESIS
Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A University of Chicago phase II consortium study
JOURNAL OF CLINICAL ONCOLOGY
Chemical inhibitors of cyclin-dependent kinases: preclinical and clinical studies.
PATHOLOGIE BIOLOGIE
Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Growth factor-dependent induction of p21(CIP1) by the green tea by polyphenol, epigallocatechin gallate
CANCER LETTERS
Vesicle-associated urokinase plasminogen activator promotes invasion in prostate cancer cell lines
CLINICAL & EXPERIMENTAL METASTASIS
Regulation of VEGF in the reproductive tract by sex-steroid hormones
HISTOLOGY AND HISTOPATHOLOGY
Ionizing radiation alters Fas antigen ligand at the cell surface and on exfoliated plasma membrane-derived vesicles: Implications for apoptosis and intercellular signaling
RADIATION RESEARCH
Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27(KIP1)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Huanglian, a Chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells
MOLECULAR PHARMACOLOGY
Cyclin-dependent kinase inhibitors: Useful targets in cell cycle regulation
JOURNAL OF MEDICINAL CHEMISTRY
Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells
JOURNAL OF CELLULAR PHYSIOLOGY
Phosphorylation of geranyl and farnesyl pyrophosphates by Nm23 proteins/nucleoside diphosphate kinases
JOURNAL OF BIOLOGICAL CHEMISTRY
Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
JOURNAL OF BIOLOGICAL CHEMISTRY
Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Mechanism of action of aragusterol A (YTA0040), a potent anti-tumor marinesteroid targeting the G(1) phase of the cell cycle
INTERNATIONAL JOURNAL OF CANCER
Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane
EUROPEAN JOURNAL OF BIOCHEMISTRY
Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents
DRUGS
Regulatory effect of interleukin-4 and interleukin-13 on colon cancer celladhesion
BRITISH JOURNAL OF CANCER
Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin: Inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Preclinical and clinical development of cyclin-dependent kinase modulators
JOURNAL OF THE NATIONAL CANCER INSTITUTE
HLA class II expression in human tumor lines
MICROBES AND INFECTION
Metallothionein-induced suppression of cytotoxic T lymphocyte function: Animportant immunoregulatory control
TOXICOLOGICAL SCIENCES
JNK and p53 stress signaling cascades are altered in MCF-7 cells resistantto tumor necrosis factor-mediated apoptosis
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Stable transfection of dihydrodiol dehydrogenase in MCF-7 breast carcinomacells promotes polycyclic aromatic hydrocarbon-o-quinone formation which leads to cell death
POLYCYCLIC AROMATIC COMPOUNDS
Identification of c-myc promoter-binding protein and X-box binding proteinI as interleukin-6 target genes in human multiple myeloma cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
Comparison of flow cytometry and RT-PCR for the detection of ovarian cancer cells in peripheral blood
ONCOLOGY RESEARCH
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts
ONCOGENE
Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene
ONCOGENE
Adenovirus-mediated transfer of wild-type p53 gene sensitizes TNF resistant MCF7 derivatives to the cytotoxic effect of this cytokine: relationship with c-myc and Rb
ONCOGENE
PRB is required for interferon-gamma-induction of the MHC class II A beta gene
ONCOGENE
beta 1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts
ONCOGENE
Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake
MOLECULAR CARCINOGENESIS
Multiple biological responses activated by nuclear protein kinase C
JOURNAL OF CELLULAR BIOCHEMISTRY
In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY
The RAR gamma selective agonist CD437 inhibits gastric cell growth throughthe mechanism of apoptosis
CANCER LETTERS
Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status
CANCER LETTERS
Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development
JOURNAL OF NEUROSCIENCE
Cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin)
PROSTATE
Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro
CLINICAL & EXPERIMENTAL METASTASIS
Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells
ANTICANCER RESEARCH
Membrane vesicles in ovarian cancer fluids: A new potential marker
ANTICANCER RESEARCH
Tamoxifen and genistein synergistically down-regulate signal transduction and proliferation in estrogen receptor-negative human breast carcinoma MDA-MB-435 cells
ANTICANCER RESEARCH
Reduction of transglutaminase 2 expression is associated with an inductionof drug sensitivity in the PC-14 human lung cancer cell line
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
IGF-I and retinoic acid regulate the distribution pattern of IGFBPs synthesized by the canine mammary tumor cell line CMT-U335
BREAST CANCER RESEARCH AND TREATMENT
Wild-type NM23-H1, but not its S120 mutants, suppresses desensitization ofmuscarinic potassium current
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target
PHARMACOLOGY & THERAPEUTICS
Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line
ENVIRONMENTAL HEALTH PERSPECTIVES
In vivo properties of three human HER2/neu-expressing murine cell lines inimmunocompetent mice
LABORATORY ANIMAL SCIENCE
Anticancer drug targets: cell cycle and checkpoint control
JOURNAL OF CLINICAL INVESTIGATION
Laminin and beta 1 integrins are crucial for normal mammary gland development in the mouse
DEVELOPMENTAL BIOLOGY
S100A4 involvement in metastasis: Deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme
CANCER RESEARCH