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La ricerca find articoli where soggetti phrase all words 'BRCA1' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1157 riferimenti
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    1. Xu, XL; Li, CL; Garrett-Beal, L; Larson, D; Wynshaw-Boris, A; Deng, CX
      Direct removal in the mouse of a flexed neo gene from a three-loxP conditional knockout allele by two novel approaches

      GENESIS
    2. Chandler, J; Hohenstein, P; Swing, DA; Tessarollo, L; Sharan, SK
      Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice

      GENESIS
    3. Orlow, I; Roy, P; Barz, A; Canchola, R; Song, Y; Berwick, M
      Validation of denaturing high performance liquid chromatography as a rapiddetection method for the identification of human INK4A gene mutations

      JOURNAL OF MOLECULAR DIAGNOSTICS
    4. Hurley, KE; Miller, SM; Costalas, JW; Gillespie, D; Daly, MB
      Anxiety/uncertainty reduction as a motivation for interest in prophylacticoophorectomy in women with a family history of ovarian cancer

      JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
    5. Potter, JD
      At the interfaces of epidemiology, genetics and genomics

      NATURE REVIEWS GENETICS
    6. Ostrer, H
      A genetic profile of contemporary Jewish populations

      NATURE REVIEWS GENETICS
    7. Fry, MJ
      Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?

      BREAST CANCER RESEARCH
    8. Koifman, S; Koifman, RJ
      Breast cancer mortality among Ashkenazi Jewish women in Sao Paulo and Porto Alegre, Brazil

      BREAST CANCER RESEARCH
    9. Gardner, K; Liu, ET
      BRCA1 function in T lymphocytes: a cellular specificity of a different kind

      BREAST CANCER RESEARCH
    10. Bernard-Gallon, DJ; Dechelotte, P; Vissac, C; Aunoble, B; Cravello, L; Malpuech, G; Bignon, YJ
      BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite

      BREAST CANCER RESEARCH
    11. Randall, J; Butow, P; Kirk, J; Tucker, K
      Psychological impact of genetic counselling and testing in women previously diagnosed with breast cancer

      INTERNAL MEDICINE JOURNAL
    12. Phillips, KA
      Current perspectives on BRCA1- and BRCA2-associated breast cancers

      INTERNAL MEDICINE JOURNAL
    13. Campos, B; Diez, O; Cortes, J; Domenech, M; Pericay, C; Alonso, C; Baiget, M
      Conditions for single-strand conformation polymorphism (SSCP) analysis of BRCA1 gene using an automated electrophoresis unit

      CLINICAL CHEMISTRY AND LABORATORY MEDICINE
    14. Schoumacher, F; Glaus, A; Mueller, H; Eppenberger, U; Bolliger, B; Senn, HJ
      BRCA1/2 mutations in Swiss patients with familial or early-onset breast and ovarian cancer

      SWISS MEDICAL WEEKLY
    15. Deng, CX
      Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    16. Ban, S; Shinohara, T; Hirai, Y; Moritaku, Y; Cologne, JB; MacPhee, DG
      Chromosomal instability in BRCA1-or BRCA2-defective human cancer cells detected by spontaneous micronucleus assay

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    17. Lakhani, SR
      Molecular genetics of solid tumours: translating research into clinical practice. What we could do now: breast cancer

      JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
    18. Vaziri, SAJ; Tubbs, RR; Darlington, G; Casey, G
      Absence of CCND 1 gene amplification in breast tumours of BRCA1 mutation carriers

      JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
    19. Kajiwara, K; O-Wang, JY; Sakurai, T; Yamashita, S; Tanaka, M; Sato, M; Tagawa, M; Sugaya, E; Nakamura, K; Nakao, K; Katsuki, M; Kimura, M
      Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis

      GENES TO CELLS
    20. Khanna, KK; Lavin, MF; Jackson, SP; Mulhern, TD
      ATM, a central controller of cellular responses to DNA damage

      CELL DEATH AND DIFFERENTIATION
    21. Kauff, ND; Scheuer, L; Robson, ME; Glogowski, E; Kelly, B; Barakat, R; Heerdt, A; Borgen, PI; Davis, JG; Offit, K
      Insurance reimbursement for risk-reducing mastectomy and oophorectomy in women with BRCA1 or BRCA2 mutations

      GENETICS IN MEDICINE
    22. Sandhaus, LM; Singer, ME; Dawson, NV; Wiesner, GL
      Reporting BRCA test results to primary care physicians

      GENETICS IN MEDICINE
    23. Takashima, H; Boerkoel, CF; Lupski, JR
      Screening for mutations in a genetically heterogeneous disorder: DHPLC versus DNA sequence for mutation detection in multiple genes causing Charcot-Marie-Tooth neuropathy

      GENETICS IN MEDICINE
    24. Velicer, CM; Taplin, S
      Genetic testing for breast cancer: Where are health care providers in the decision process?

      GENETICS IN MEDICINE
    25. Culver, JO; Hull, JL; Dunne, DFB; Burke, W
      Oncologists' opinions on genetic testing for breast and ovarian cancer

      GENETICS IN MEDICINE
    26. Gilbert, CS; Green, CM; Lowndes, NF
      Budding yeast Rad9 is an ATP-dependent Rad53 activating machine

      MOLECULAR CELL
    27. Hu, GK; Madore, SJ; Moldover, B; Jatkoe, T; Balaban, D; Thomas, J; Wang, YX
      Predicting splice variant from DNA chip expression data

      GENOME RESEARCH
    28. Premstaller, A; Xiao, WH; Oberacher, H; O'Keefe, M; Stern, D; Willis, T; Huber, CG; Oefner, PJ
      Temperature-modulated array high-performance liquid chromatography

      GENOME RESEARCH
    29. Mielnicki, LM; Asch, HL; Asch, BB
      Genes, chromatin, and breast cancer: An epigenetic tale

      JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
    30. Salisbury, JL
      The contribution of epigenetic changes to abnormal centrosomes and genomicinstability in breast cancer

      JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
    31. Brzovic, PS; Rajagopal, P; Hoyt, DW; King, MC; Klevit, RE
      Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

      NATURE STRUCTURAL BIOLOGY
    32. Newman, LA; Kuerer, HM; Hunt, KK; Vlastos, G; Ames, FC; Ross, MI; Singletary, SE
      Educational review: Role of the surgeon in hereditary breast cancer

      ANNALS OF SURGICAL ONCOLOGY
    33. Bucholtz, JD; Tranin, AS; Mancino, AT; Henry-Tillman, R; Westbrook, KC; McCarthy, MC
      Issues in bilateral prophylactic mastectomy

      CANCER PRACTICE
    34. Geisler, JR; Hatterman-Zogg, MA; Rathe, JA; Lallas, TA; Kirby, P; Buller, RE
      Ovarian cancer BRCA1 mutation detection: Protein truncation test (PTT) outperforms single strand conformation polymorphism analysis (SSCP)

      HUMAN MUTATION
    35. Jakubowska, A; Gorski, B; Byrski, T; Huzarski, T; Gronwald, J; Menkiszak, J; Cybulski, C; Debniak, T; Hadaczek, P; Scott, RJ; Lubinski, J
      Detection of germline mutations in the BRCA1 gene by RNA-based sequencing

      HUMAN MUTATION
    36. Lin, D; Goldstein, JA; Mhatre, AN; Lustig, LR; Pfister, M; Lalwani, AK
      Assessment of denaturing high-performance liquid chromatography (DHPLC) inscreening for mutations in connexin 26 (GJB2)

      HUMAN MUTATION
    37. Fry, A; Busby-Earle, C; Rush, R; Cull, A
      Prophylactic oophorectomy versus screening: Psychosocial outcomes in womenat increased risk of ovarian cancer

      PSYCHO-ONCOLOGY
    38. Elit, L; Jack, E; Kwan, E; Baigal, G; Narod, S
      A unique BRCA1 mutation identified in Mongolia

      INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
    39. Rhodes, N; Gilmer, TM; Lansing, TJ
      Expression and purification of active recombinant ATM protein from transiently transfected mammalian cells

      PROTEIN EXPRESSION AND PURIFICATION
    40. Hashemi, J; Bendahl, PO; Sandberg, T; Platz, A; Linder, S; Stierner, U; Olsson, H; Ingvar, C; Hansson, J; Borg, A
      Haplotype analysis and age estimation of the 113insR CDKN2A founder mutation in Swedish melanoma families

      GENES CHROMOSOMES & CANCER
    41. Hopper, JL
      Genetic epidemiology of female breast cancer

      SEMINARS IN CANCER BIOLOGY
    42. Borg, A
      Molecular and pathological characterization of inherited breast cancer

      SEMINARS IN CANCER BIOLOGY
    43. Vaessen, N; van Duijn, CM
      Opportunities for population-based studies of complex genetic disorders after the human genome project

      EPIDEMIOLOGY
    44. Surbone, A
      Ethical implications of genetic testing for breast cancer susceptibility

      CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
    45. Aunoble, B; Bernard-Gallon, D; Bignon, YJ
      Regulation of BRCA1 and BRCA2 transcript in response to cisplatin, adriamycin, taxol and ionising radiation is correlated to p53 functional status inovarian cancer cell lines

      ONCOLOGY REPORTS
    46. Choi, YH
      Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells

      INTERNATIONAL JOURNAL OF ONCOLOGY
    47. Sylvain, V; LaFarge, S; Bignon, YJ
      Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant

      INTERNATIONAL JOURNAL OF ONCOLOGY
    48. Van der Looij, M; Papp, J; Sztan, M; Pulay, T; Elfadil, I; Besznyak, I; Toth, J; Devilee, P; Olah, E
      Allelic imbalance and microsatellite instability in BRCA1 associated breast and ovarian tumors

      INTERNATIONAL JOURNAL OF ONCOLOGY
    49. Shinozaki, H; Okamoto, A; Shimizu, K; Saito, M; Yokota, J; Ochiai, K
      Absence of p51 alteration in human ovarian cancer

      INTERNATIONAL JOURNAL OF ONCOLOGY
    50. Bernard-Gallon, DJ; De Latour, MP; Sylvain, V; Vissac, C; Aunoble, B; Chassagne, J; Bignon, YJ
      Brca1 and Brca2 protein expression patterns in different tissues of murineorigin

      INTERNATIONAL JOURNAL OF ONCOLOGY
    51. Eisinger, F; Charafe-Jauffret, E; Jacquemier, J; Birnbaum, D; Julian-Reynier, C; Sobol, H
      Tamoxifen and breast cancer risk in women harboring a BRCA1 germline mutation: computed efficacy, effectiveness and impact

      INTERNATIONAL JOURNAL OF ONCOLOGY
    52. Lodder, L; Frets, PG; Trijsburg, RW; Tibben, A; Meijers-Heijboer, EJ; Duivenvoorden, HJ; Wagner, A; van der Meer, CA; Devilee, P; Cornelisse, CJ; Niermeijer, MF
      Men at risk of being a mutation carrier for hereditary breast/ovarian cancer: an exploration of attitudes and psychological functioning during genetic testing

      EUROPEAN JOURNAL OF HUMAN GENETICS
    53. Sarantaus, L; Vahteristo, P; Bloom, E; Tamminen, A; Unkila-Kallio, L; Butzow, R; Nevanlinna, H
      BRCA1 and BRCA2 mutations among 233 unselected Finnish ovarian carcinoma patients

      EUROPEAN JOURNAL OF HUMAN GENETICS
    54. Bergman, A; Einbeigi, Z; Olofsson, U; Taib, Z; Wallgren, A; Karlsson, P; Wahlstrom, J; Martinsson, T; Nordling, M
      The western Swedish BRCA1 founder mutation 3171ins5; a 3.7 cM conserved haplotype of today is a reminiscence of a 1500-year-old mutation

      EUROPEAN JOURNAL OF HUMAN GENETICS
    55. Datar, RH
      Nucleic acids in diagnosis (Part II): Genetic testing and screening

      NATIONAL MEDICAL JOURNAL OF INDIA
    56. Hull, SC; Prasad, K
      Reading between the lines: Direct-to-consumer advertising of genetic testing in the USA

      REPRODUCTIVE HEALTH MATTERS
    57. Balemans, W; Ebeling, M; Patel, N; Van Hul, E; Olson, P; Dioszegi, M; Lacza, C; Wuyts, W; Van den Ende, J; Willems, P; Paes-Alves, AF; Hill, S; Bueno, M; Ramos, FJ; Tacconi, P; Dikkers, FG; Stratakis, C; Lindpaintner, K; Vickery, B; Foernzler, D; Van Hul, W
      Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

      HUMAN MOLECULAR GENETICS
    58. Sekine, M; Nagata, H; Tsuji, S; Hirai, Y; Fujimoto, S; Hatae, M; Kobayashi, I; Fujii, T; Nagata, I; Ushijima, K; Obata, K; Suzuki, M; Yoshinaga, M; Umesaki, N; Satoh, S; Enomoto, T; Motoyama, S; Tanaka, K
      Localization of a novel susceptibility gene for familial ovarian cancer tochromosome 3p22-p25

      HUMAN MOLECULAR GENETICS
    59. Pierce, AJ; Stark, JM; Araujo, FD; Moynahan, ME; Berwick, M; Jasin, M
      Double-strand breaks and tumorigenesis

      TRENDS IN CELL BIOLOGY
    60. Zhu, J; Petersen, S; Tessarollo, L; Nussenzweig, A
      Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

      CURRENT BIOLOGY
    61. Walker, G; Hayward, N
      No evidence of a role for activating CDK2 mutations in melanoma

      MELANOMA RESEARCH
    62. Moller, P; Borg, A; Heimdal, K; Apold, J; Vallon-Christersson, J; Hovig, E; Maehle, L
      The BRCA1 syndrome and other inherited breast or breast-ovarian cancers ina Norwegian prospective series

      EUROPEAN JOURNAL OF CANCER
    63. Olsson, H
      A hypothesis about tumour development and the clinical features of hereditary breast cancers

      EUROPEAN JOURNAL OF CANCER
    64. Verhoog, LC; van den Ouweland, AMW; Berns, E; van Veghel-Plandsoen, MM; van Staveren, IL; Wagner, A; Bartels, CCM; Tilanus-Linthorst, MMA; Devilee, P; Seynaeve, C; Halley, DJJ; Niermeijer, MF; Klijn, JGM; Meijers-Heijboer, H
      Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families

      EUROPEAN JOURNAL OF CANCER
    65. Einbeigi, Z; Bergman, A; Kindblom, LG; Martinsson, T; Meis-Kindblom, JM; Nordling, M; Suurkula, M; Wahlstrom, J; Wallgren, A; Karlsson, P
      A founder mutation of the BRCA1 gene in Western Sweden associated with a high incidence of breast and ovarian cancer

      EUROPEAN JOURNAL OF CANCER
    66. Gui, GPH; Hogben, RKF; Walsh, G; A'Hern, R; Eles, R
      The incidence of breast cancer from screening women according to predictedfamily history risk: does annual clinical examination add to mammography?

      EUROPEAN JOURNAL OF CANCER
    67. Eerola, H; Pukkala, E; Pyrhonen, S; Blomqvist, C; Sankila, R; Nevanlinna, H
      Risk of cancer in BRCA1 and BRCA2 mutation-positive and -negative breast cancer families (Finland)

      CANCER CAUSES & CONTROL
    68. Hinkula, M; Pukkala, E; Kyyronen, P; Kauppila, A
      Grand multiparity and the risk of breast cancer: population-based study inFinland

      CANCER CAUSES & CONTROL
    69. Hirose, K; Tajima, K; Hamajima, N; Takezaki, T; Inoue, M; Kuroishi, T; Miura, S; Tokudome, S
      Association of family history and other risk factors with breast cancer risk among Japanese premenopausal and postmenopausal women

      CANCER CAUSES & CONTROL
    70. Bartek, J; Lukas, J
      Mammalian G1- and S-phase checkpoints in response to DNA damage

      CURRENT OPINION IN CELL BIOLOGY
    71. Fan, SJ; Yuan, RQ; Ma, YX; Meng, QH; Goldberg, ID; Rosen, EM
      Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1

      ONCOGENE
    72. Brodie, SG; Xu, XL; Qiao, WH; Li, WM; Cao, L; Deng, CX
      Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

      ONCOGENE
    73. Atlas, E; Stramwasser, M; Mueller, CR
      A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element

      ONCOGENE
    74. Lafarge, S; Sylvain, V; Ferrara, M; Bignon, YJ
      Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway

      ONCOGENE
    75. Mullan, PB; Quinn, JE; Gilmore, PM; McWilliams, S; Andrews, H; Gervin, C; McCabe, N; McKenna, S; White, P; Song, YH; Maheswaran, S; Liu, E; Haber, DA; Johnston, PG; Harkin, DP
      BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents

      ONCOGENE
    76. Suen, TC; Goss, PE
      Identification of a novel transcriptional repressor element located in thefirst intron of the human BRCA1 gene

      ONCOGENE
    77. DiNardo, DNM; Butcher, DT; Robinson, DP; Archer, TK; Rodenhiser, DI
      Functional analysis of CpG methylation in the BRCA1 promoter region

      ONCOGENE
    78. Fan, SJ; Yuan, RQ; Ma, YX; Xiong, JB; Meng, QH; Erdos, M; Zhao, JN; Goldberg, ID; Pestell, RG; Rosen, EM
      Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding

      ONCOGENE
    79. Wang, Q; Zhang, HT; Guerrette, S; Chen, JQ; Mazurek, A; Wilson, T; Slupianek, A; Skorski, T; Fishel, R; Greene, MI
      Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1

      ONCOGENE
    80. Signori, E; Bagni, C; Papa, S; Primerano, B; Rinaldi, M; Amaldi, F; Fazio, VM
      A somatic mutation in the 5 ' UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency

      ONCOGENE
    81. Orelli, BJ; Logsdon, JM; Bishop, DK
      Nine novel conserved motifs in BRCA1 identified by the chicken orthologue

      ONCOGENE
    82. Chen, F; Zhang, Z; Leonard, SS; Shi, XL
      Contrasting roles of NF-kappa B and JNK in arsenite-induced p53-independent expression of GADD45 alpha

      ONCOGENE
    83. Hohenstein, P; Kielman, MF; Breukel, C; Bennett, LM; Wiseman, R; Krimpenfort, P; Cornelisse, G; van Ommen, GJ; Devilee, P; Fodde, R
      A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

      ONCOGENE
    84. Chai, YL; Chipitsyna, G; Cui, JQ; Liao, BS; Liu, S; Aysola, K; Yezdani, M; Reddy, ESP; Rao, VN
      c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells

      ONCOGENE
    85. Fan, SJ; Ma, YX; Wang, CG; Yuan, RQ; Meng, QH; Wang, JA; Erdos, M; Goldberg, ID; Webb, P; Kushner, PJ; Pestell, RG; Rosen, EM
      Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

      ONCOGENE
    86. Pavelic, K; Gall-Troselj, K
      Recent advances in molecular genetics of breast cancer

      JOURNAL OF MOLECULAR MEDICINE-JMM
    87. Laes, JF; Quan, XJ; Ravoet, M; Stieber, D; Van Vooren, P; Van Reeth, T; Szpirer, J; Szpirer, C
      Analysis of candidate genes included in the mammary cancer susceptibility 1(Mcs1) region

      MAMMALIAN GENOME
    88. Randrianarison, V; Marot, D; Foray, N; Cabannes, J; Meret, V; Connault, E; Vitrat, N; Opolon, P; Perricaudet, M; Feunteun, J
      BRCA1 carries tumor suppressor activity distinct from that of p53 and p21

      CANCER GENE THERAPY
    89. Yamashita, T; Nakahata, T
      Current knowledge on the pathophysiology of Fanconi anemia: From genes to phenotypes

      INTERNATIONAL JOURNAL OF HEMATOLOGY
    90. Olopade, OI; Pichert, G
      Cancer genetics in oncology practice

      ANNALS OF ONCOLOGY
    91. Tsuchida, S; Ikemoto, S; Tagawa, M
      Microsatellite polymorphism in intron 14 of the canine BRCA1 gene

      JOURNAL OF VETERINARY MEDICAL SCIENCE
    92. Egawa, C; Miyoshi, Y; Taguchi, T; Tamaki, Y; Noguchi, S
      Quantitative analysis of BRCA1 and BRCA2 mRNA expression in sporadic breast carcinomas and its relationship with clinicopathological characteristics

      JAPANESE JOURNAL OF CANCER RESEARCH
    93. Kettenhofen, R; Hoppe, J; Eberhard, G; Seul, C; Ko, Y; Sachinidis, A
      Regulation of Gadd45a mRNa expression in vascular smooth muscle under growth and stress conditions

      CELLULAR SIGNALLING
    94. Boucher, KM; Kerber, RA
      The shape of the hazard function for cancer incidence

      MATHEMATICAL AND COMPUTER MODELLING
    95. Ludwig, T; Fisher, P; Ganesan, S; Efstratiadis, A
      Tumorigenesis in mice carrying a truncating Brca1 mutation

      GENES & DEVELOPMENT
    96. Srivastava, A; McKinnon, W; Wood, ME
      Msk of breast and ovarian cancer in women with strong family histories

      ONCOLOGY-NEW YORK
    97. Merajver, SD; Milliron, KJ
      Msk of breast and ovarian cancer in women with strong family histories - The Srivastava/McKinnon/Wood article reviewed

      ONCOLOGY-NEW YORK
    98. Godley, LA; Olopade, OI
      Msk of breast and ovarian cancer in women with strong family histories - The Srivastava/McKinnon/Wood article reviewed

      ONCOLOGY-NEW YORK
    99. Schwartz, PE
      Nongenetic screening of ovarian malignancies

      OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
    100. Meiser, B; Butow, P; Barratt, A; Gattas, M; Gaff, C; Haan, E; Gleeson, M; Dudding, T; Tucker, K
      Risk perceptions and knowledge of breast cancer genetics in women at increased risk of developing hereditary breast cancer

      PSYCHOLOGY & HEALTH


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Documento generato il 27/05/20 alle ore 09:38:53