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Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2Cl2 cells
BONE
The effect of bone morphogenetic protein-2 expression on the early fate ofskeletal muscle-derived cells
BONE
Cooperativity of binding epitopes and receptor chains in the BMP/TGF beta superfamily
BIOLOGICAL CHEMISTRY
Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy
JOURNAL OF GENE MEDICINE
Conotruncal myocardium arises from a secondary heart field
DEVELOPMENT
Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes
MECHANISMS OF DEVELOPMENT
Focal adhesion kinase activity is required for bone morphogenetic protein - Smad1 signaling and osteoblastic differentiation in murine MC3T3-E1 cells
JOURNAL OF BONE AND MINERAL RESEARCH
BMP-2 induction and TGF-beta 1 modulation of rat periosteal cell chondrogenesis
JOURNAL OF CELLULAR BIOCHEMISTRY
An optimized method for the chemiluminescent detection of alkaline phosphatase levels during osteodifferentiation by bone morphogenetic protein 2
JOURNAL OF CELLULAR BIOCHEMISTRY
Biomedical applications of collagen
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart
CELL AND TISSUE RESEARCH
Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2
DIFFERENTIATION
Experimental osteoinduction by recombinant human bone morphogenetic protein 2 in tissue with low blood flow: a study in rats
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Effect of hyperbaric oxygenation on bone induced by recombinant human bonemorphogenetic protein-2
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Maxillary sinus floor augmentation in rabbits: A comparative histologic-histomorphometric study between rhBMP-2 and autogenous bone
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
Perspectives in the biological function, the technical and therapeutic application of bone morphogenetic proteins
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene
CALCIFIED TISSUE INTERNATIONAL
A bone replaceable artificial bone substitute: Osteoinduction by combiningwith bone inducing agent
ARTIFICIAL ORGANS
Comparative effects of nacre water-soluble matrix and dexamethasone on thealkaline phosphatase activity of MRC-5 fibroblasts
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
Altered expression of growth factors and cytokines in keratoconus, bullouskeratopathy and diabetic human corneas
EXPERIMENTAL EYE RESEARCH
Regulation of growth plate chondrogenesis by bone morphogenetic protein-2
ENDOCRINOLOGY
Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Cell differentiation under the influence of rh-BMP-2
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts
BONE
The chondrocyte: from cell aging to osteoarthritis
JOINT BONE SPINE
Practical illustrations in tissue engineering: Surgical considerations relevant to the implantation of osteoinductive devices
TISSUE ENGINEERING
The use of bone morphogenetic protein gene therapy in craniofacial bone repair
JOURNAL OF CRANIOFACIAL SURGERY
The efficiency of muscle-derived cell-mediated bone formation
CELL TRANSPLANTATION
Constructive antagonism in limb development
CURRENT OPINION IN GENETICS & DEVELOPMENT
Osteoinduction by recombinant human bone morphogenetic protein-2 at intramuscular, intermuscular, subcutaneous and intrafatty sites
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
Heterotopic ossification of degenerating rat skeletal muscle induced by adenovirus-mediated transfer of bone morphogenetic protein-2 gene
JOURNAL OF BONE AND MINERAL RESEARCH
Phenotypic stability of articular chondrocytes in vitro: The effects of culture models, bone morphogenetic protein 2, and serum supplementation
JOURNAL OF BONE AND MINERAL RESEARCH
Transfection of cultured mesenchyme cells isolated from embryonic chick limb buds and facial primordia
BIOTECHNIQUES
Regulation of the promoters for the human bone morphogenetic protein 2 and4 genes
GENE
Merging the old skeletal biology with the new. II. Molecular aspects of bone formation and bone growth
JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY
Potential applications and delivery strategies for bone morphogenetic proteins
ADVANCED DRUG DELIVERY REVIEWS
Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
The effect of blood supply in muscle and an elevated muscle flap on endogenous tissue-engineered bone by rhBMP-2 in the rat
ANNALS OF PLASTIC SURGERY
Bone regeneration at rabbit skull defects treated with transforming growthfactor-beta 1 incorporated into hydrogels with different levels of biodegradability
JOURNAL OF NEUROSURGERY
Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing
JOURNAL OF CELL BIOLOGY
MFH-1 is required for bone morphogenetic protein-2-induced osteoblastic differentiation of C2C12 myoblasts
FEBS LETTERS
Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Osteoinduction by bone morphogenetic protein-2 via adenoviral vector undertransient immunosuppression
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Evidence for the involvement of bone morphogenetic protein-2 in phenytoin-stimulated osteocalcin secretion in human bone cells
ARCHIVES OF ORAL BIOLOGY
Differential expression of cSmad1 and cSmad5 in the primitive streak during chick embryo gastrulation
ANATOMICAL RECORD
Comparative study of intramuscular and intraskeletal osteogenesis by recombinant human bone morphogenetic protein-2
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
SF/HGF is a mediator between limb patterning and muscle development
DEVELOPMENT
Distinct signaling molecules control Hoxa-11 and Hoxa-13 expression in themuscle precursor and mesenchyme of the chick limb bud
DEVELOPMENT
Blood cell induction in Xenopus animal cap explants: Effects of fibroblastgrowth factor, bone morphogenetic proteins, and activin
DEVELOPMENT GENES AND EVOLUTION
Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae
MECHANISMS OF DEVELOPMENT
1,25-dihydroxyvitamin D-3, recombinant human transforming growth factor-beta(1), and recombinant human bone morphogenetic protein-2 induce in vitro differentiation of canine osteosarcoma cells
JOURNAL OF VETERINARY MEDICAL SCIENCE
Effects of apatite, transforming growth factor beta-1, bone morphogenetic protein-2 and interleukin-7 on ameloblast differentiation in vitro
EUROPEAN JOURNAL OF ORAL SCIENCES
EFFECTS OF BONE MORPHOGENETIC PROTEIN-2 ON HUMAN NEONATAL CALVARIA CELL-DIFFERENTIATION
Journal of cellular biochemistry
Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion
SPINE
Mechanism of BMP-2 stimulated adhesion of osteoblastic cells to titanium alloy
BIOLOGY OF THE CELL
Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia
CALCIFIED TISSUE INTERNATIONAL
The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity
NATURE
Mandibular reconstruction using bone morphogenetic protein 2: Long-term follow-up in a canine model
LARYNGOSCOPE
Crystal structure of human bone morphogenetic protein-2 at 2.7 angstrom resolution
JOURNAL OF MOLECULAR BIOLOGY
p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells
EXPERIMENTAL CELL RESEARCH
Lack of regulation in the heart forming region of avian embryos
DEVELOPMENTAL BIOLOGY
Sonic hedgehog signaling during digit pattern duplication after application of recombinant protein and expressing cells
DEVELOPMENT GROWTH & DIFFERENTIATION
Expression of bone morphogenetic protein-2 via adenoviral vector in C2C12 myoblasts induces differentiation into the osteoblast lineage
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1 alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Treatment of resting zone chondrocytes with bone morphogenetic protein-2 induces maturation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25(OH)(2)D-3 and upregulating responsiveness to 1,25-(OH)(2)D-3
ENDOCRINE
DIFFERENTIAL-EFFECTS OF LOCAL APPLICATION OF BMP-2 OR TGF-BETA-1 ON BOTH ARTICULAR-CARTILAGE COMPOSITION AND OSTEOPHYTE FORMATION
Osteoarthritis and cartilage
IDENTIFICATION OF AN ENHANCER SEQUENCE IN 5'-FLANKING REGION OF 1A EXON OF MOUSE LIVER BONE/KIDNEY-TYPE ALKALINE-PHOSPHATASE GENE/
Biochemistry and molecular biology international
In vivo bone formation by human bone marrow cells: effect of osteogenic culture supplements and cell densities
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
BMP-2 -4 AND WNT-8 COOPERATIVELY PATTERN THE XENOPUS MESODERM/
Mechanisms of development
BMP-2 INDUCES ECTOPIC EXPRESSION OF CARDIAC LINEAGE MARKERS AND INTERFERES WITH SOMITE FORMATION IN CHICKEN EMBRYOS
Mechanisms of development
COMPARISON OF BONE REGENERATION IN A RABBIT SKULL DEFECT BY RECOMBINANT HUMAN BMP-2 INCORPORATED IN BIODEGRADABLE HYDROGEL AND IN SOLUTION
Journal of biomaterials science. Polymer ed.
ECTOPIC BONE-FORMATION INDUCED BY BIODEGRADABLE HYDROGELS INCORPORATING BONE MORPHOGENETIC PROTEIN
Journal of biomaterials science. Polymer ed.
INDUCTIVE PROPERTIES OF RECOMBINANT HUMAN BMP-2 PRODUCED IN A BACTERIAL EXPRESSION SYSTEM
International journal of oral and maxillofacial surgery
SMAD2 TRANSDUCES COMMON SIGNALS FROM RECEPTOR SERINE-THREONINE AND TYROSINE KINASES
Genes & development
BONE MORPHOGENETIC PROTEINS AND BFGF EXERT OPPOSING REGULATORY EFFECTS ON PTHRP EXPRESSION AND INORGANIC PYROPHOSPHATE ELABORATION IN IMMORTALIZED MURINE ENDOCHONDRAL HYPERTROPHIC CHONDROCYTES (MCT CELLS)
Journal of bone and mineral research
BONE MORPHOGENETIC PROTEIN-2 AND TRANSFORMING GROWTH FACTOR-BETA(2) INTERACT TO MODULATE HUMAN BONE-MARROW STROMAL CELL-PROLIFERATION AND DIFFERENTIATION
Journal of cellular biochemistry
IMMUNOHISTOCHEMICAL LOCALIZATION OF BONE MORPHOGENETIC PROTEINS AND THE RECEPTORS IN EPIPHYSEAL GROWTH-PLATE
Anticancer research
BONE MORPHOGENETIC PROTEIN-2 AND RETINOIC ACID INDUCE NEUROTROPHIN-3 RESPONSIVENESS IN DEVELOPING RAT SYMPATHETIC NEURONS
Molecular brain research
BONE MORPHOGENETIC PROTEIN SIGNALING IS REQUIRED FOR MAINTENANCE OF DIFFERENTIATED PHENOTYPE, CONTROL OF PROLIFERATION, AND HYPERTROPHY IN CHONDROCYTES
The Journal of cell biology
Regulation of avian cardiac myogenesis by activin/TGF beta and bone morphogenetic proteins
DEVELOPMENTAL BIOLOGY
FUNCTIONAL-ANALYSIS OF AN ASCIDIAN HOMOLOG OF VERTEBRATE BMP-2 BMP-4 SUGGESTS ITS ROLE IN THE INHIBITION OF NEURAL FATE SPECIFICATION/
Development
ECTOPIC APPLICATION OF RECOMBINANT BMP-2 AND BMP-4 CAN CHANGE PATTERNING OF DEVELOPING CHICK FACIAL PRIMORDIA
Development
REGULATION OF BONE-MATRIX PROTEIN EXPRESSION AND INDUCTION OF DIFFERENTIATION OF HUMAN OSTEOBLASTS AND HUMAN BONE-MARROW STROMAL CELLS BY BONE MORPHOGENETIC PROTEIN-2
Journal of cellular biochemistry
CLONING OF MOUSE DIASTROPHIC DYSPLASIA SULFATE TRANSPORTER GENE INDUCED DURING OSTEOBLAST DIFFERENTIATION BY BONE MORPHOGENETIC PROTEIN-2
Gene
BONE MORPHOGENETIC PROTEIN-2 (BMP-2) ENHANCES BMP-3, BMP-4, AND BONE CELL-DIFFERENTIATION MARKER GENE-EXPRESSION DURING THE INDUCTION OF MINERALIZED BONE-MATRIX FORMATION IN CULTURES OF FETAL-RAT CALVARIAL OSTEOBLASTS
Calcified tissue international
BONE MORPHOGENETIC PROTEIN-2 TRANSCRIPTS IN RAPIDLY DEVELOPING DEER ANTLER TISSUE CONTAIN AN EXTENDED 5'-NONCODING REGION ARISING FROM A DISTAL PROMOTER
Biochimica et biophysica acta, N. Gene structure and expression
UTILIZATION OF TYPE-I COLLAGEN GEL, DEMINERALIZED BONE-MATRIX, AND BONE MORPHOGENETIC PROTEIN-2 TO ENHANCE AUTOLOGOUS BONE LUMBAR SPINAL-FUSION
Journal of neurosurgery
CLONING OF RAT TYPE-I RECEPTOR CDNA FOR BONE MORPHOGENETIC PROTEIN-2 AND BONE MORPHOGENETIC PROTEIN-4, AND THE LOCALIZATION COMPARED WITH THAT OF THE LIGANDS
Developmental dynamics
BMP-2 -4 MEDIATE PROGRAMMED CELL-DEATH IN CHICKEN LIMB BUDS/
Development
THE ECTODERMAL CONTROL IN CHICK LIMB DEVELOPMENT - WNT-7A, SHH, BMP-2AND BMP-4 EXPRESSION AND THE EFFECT OF FGF-4 ON GENE-EXPRESSION
Mechanisms of development
OVEREXPRESSION OF BMP-2 AND BMP-4 ALTERS THE SIZE AND SHAPE OF DEVELOPING SKELETAL ELEMENTS IN THE CHICK LIMB
Mechanisms of development
SYNERGISTIC EFFECT OF BMP-2 AND ASCORBATE ON THE PHENOTYPIC-EXPRESSION OF OSTEOBLASTIC MC3T3-E1 CELLS
Molecular and cellular biochemistry
MOLECULAR METHODS OF ENHANCING LUMBAR SPINE FUSION
Neurosurgery
GENE-EXPRESSION, POLARIZING ACTIVITY AND SKELETAL PATTERNING IN REAGGREGATED HIND-LIMB MESENCHYME
Development
EXPRESSION PATTERNS OF THE BONE MORPHOGENETIC PROTEIN GENES BMP-4 ANDBMP-2 IN THE DEVELOPING CHICK FACE SUGGEST A ROLE IN OUTGROWTH OF THEPRIMORDIA
Developmental dynamics
TRANSFORMING GROWTH-FACTOR-BETA AND BONE MORPHOGENETIC PROTEIN-2 ACT BY DISTINCT MECHANISMS TO PROMOTE CHICK LIMB CARTILAGE DIFFERENTIATIONIN-VITRO
Developmental dynamics
BONE MORPHOGENETIC PROTEINS AND A SIGNALING PATHWAY THAT CONTROLS PATTERNING IN THE DEVELOPING CHICK LIMB
Development
EXPRESSION OF BONE MORPHOGENETIC PROTEIN MESSENGER-RNAS BY NORMAL RATAND HUMAN PROSTATE AND PROSTATE-CANCER CELLS
The Prostate