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Substrate specificity and regioselectivity of tryptophan 7-halogenase fromPseudomonas fluorescens BL915
ADVANCED SYNTHESIS & CATALYSIS
Nature's carbohydrate chemists: The enzymatic glycosylation of bioactive bacterial metabolites
CURRENT ORGANIC CHEMISTRY
Tailoring enzymes that modify nonribosomal peptides during and after chainelongation on NRPS assembly lines
CURRENT OPINION IN CHEMICAL BIOLOGY
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Influence of dimethylsulfoxide on tylosin production in Streptomyces fradiae
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Epothilones and their analogues - a new class of promising microtubule inhibitors
EXPERT OPINION ON THERAPEUTIC PATENTS
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
CHEMISTRY & BIOLOGY
Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates
CHEMISTRY & BIOLOGY
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin
CHEMISTRY & BIOLOGY
Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15
CHEMISTRY & BIOLOGY
The role of ABC transporters in antibiotic-producing organisms: drug secretion and resistance mechanisms
RESEARCH IN MICROBIOLOGY
Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase
GENE
The development of mechanistic enzymology in the 20th century
NATURAL PRODUCT REPORTS
Altering the glycosylation pattern of bioactive compounds
TRENDS IN BIOTECHNOLOGY
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies
JOURNAL OF NATURAL PRODUCTS
Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Role of alginate and its O acetylation in formation of Pseudomonas aeruginosa microcolonies and biofilms
JOURNAL OF BACTERIOLOGY
Role of alginate O acetylation in resistance of mucoid Pseudomonas aeruginosa to opsonic phagocytosis
INFECTION AND IMMUNITY
Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics
BIOCHEMISTRY
In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptidesynthesis of pyochelin: Characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities
BIOCHEMISTRY
The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates
BIOCHEMISTRY
C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Insights into long-range structural effects on the stereochemistry of aldol condensations: A practical total synthesis of desoxyepothilone F
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Purification and partial characterization of tryptophan 7-halogenase (PrnA) from Pseudomonas fluorescens
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Understanding and exploiting nature's chemical arsenal: The past, present and future of calicheamicin research
CURRENT PHARMACEUTICAL DESIGN
Recent developments in the area of macrolide antibiotics
EXPERT OPINION ON THERAPEUTIC PATENTS
Artificial chromosomes for antibiotic-producing actinomycetes
NATURE BIOTECHNOLOGY
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
CHEMISTRY & BIOLOGY
Mechanisms of molecular recognition in the pikromycin polyketide synthase
CHEMISTRY & BIOLOGY
Biocontrol ability of fluorescent pseudomonads genetically dissected: importance of positive feedback regulation
CURRENT OPINION IN BIOTECHNOLOGY
Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-I
BIOCHEMICAL SOCIETY TRANSACTIONS
Identification of a methyltransferase from Mycobacterium smegmatis involved in glycopeptidolipid synthesis
JOURNAL OF BIOLOGICAL CHEMISTRY
Characterization of alginate lyase from Pseudomonas syringae pv. syringae
JOURNAL OF BACTERIOLOGY
Inversion of the anomeric configuration of the transferred sugar during inactivation of the macrolide antibiotic oleandomycin catalyzed by a macrolide glycosyltransferase
FEBS LETTERS
Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Novel enzymatic mechanisms in carbohydrate metabolism
CHEMICAL REVIEWS
Posttranslationally modified bacteriocins - The lantibiotics
BIOPOLYMERS
Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growthof competing Saccharomyces cerevisiae and Cryptococcus neoformans
MICROBIOLOGY-UK
A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D
CHEMISTRY & BIOLOGY
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues
CHEMISTRY & BIOLOGY
Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Involvement of the exopolysaccharide alginate in the virulence and epiphytic fitness of Pseudomonas syringae pv. syringae
MOLECULAR MICROBIOLOGY
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis
FEMS MICROBIOLOGY LETTERS
Tolerance and specificity of polyketide synthases
ANNUAL REVIEW OF BIOCHEMISTRY
A multiplasmid approach to preparing large libraries of polyketides
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Novel organization and sequences of five genes encoding all six enzymes for de novo pyrimidine biosynthesis in Trypanosoma cruzi
JOURNAL OF MOLECULAR BIOLOGY
A1gT (sigma(22)) controls alginate production and tolerance to environmental stress in Pseudomonas syringae
JOURNAL OF BACTERIOLOGY
Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine
BIOCHEMISTRY
Learning nature's strategies for making deoxy sugars: Pathways, mechanisms, and combinatorial applications
ACCOUNTS OF CHEMICAL RESEARCH
Transformation of Saccharopolyspora erythraea by electroporation of germinating spores: construction of propionyl Co-A carboxylase mutants
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ENGINEERING OF A MINIMAL MODULAR POLYKETIDE SYNTHASE, AND TARGETED ALTERATION OF THE STEREOSPECIFICITY OF POLYKETIDE CHAIN EXTENSION
Chemistry & biology
HYDROXYLATION OF MACROLACTONES YC-17 AND NARBOMYCIN IS MEDIATED BY THE PIKC-ENCODED CYTOCHROME-P450 IN STREPTOMYCES-VENEZUELAE
Chemistry & biology
Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis
MOLECULAR MICROBIOLOGY
CONSTRUCTION OF NEW VECTORS FOR HIGH-LEVEL EXPRESSION IN ACTINOMYCETES
Gene
ENGINEERING BROADER SPECIFICITY INTO AN ANTIBIOTIC-PRODUCING POLYKETIDE SYNTHASE
Science
DELETION OF ALGK IN MUCOID PSEUDOMONAS-AERUGINOSA BLOCKS ALGINATE POLYMER FORMATION AND RESULTS IN URONIC-ACID SECRETION
Journal of bacteriology
THE MYSTERY OF THE TRICHOTHECENE 3-O-ACETYLTRANSFERASE GENE - ANALYSIS OF THE REGION AROUND TRI101 AND CHARACTERIZATION OF ITS HOMOLOG FROMFUSARIUM-SPOROTRICHIOIDES
FEBS letters
EXPRESSION OF THE STREPTOMYCES-ALBONIGER PUR CLUSTER IN STREPTOMYCES-LIVIDANS IS DEPENDENT ON THE BLDA-ENCODED TRNA(LEU)
FEBS letters
THE IN-VITRO CONVERSION OF NORSOLORINIC ACID TO AFLATOXIN B-1 - AN IMPROVED METHOD OF CELL-FREE ENZYME PREPARATION AND STABILIZATION
Journal of the American Chemical Society
ALCOHOL STEREOCHEMISTRY IN POLYKETIDE BACKBONES IS CONTROLLED BY THE BETA-KETOREDUCTASE DOMAINS OF MODULAR POLYKETIDE SYNTHASES
Journal of the American Chemical Society
PREFERENTIAL PRODUCTION OF RAPAMYCIN VS PROLYLRAPAMYCIN BY STREPTOMYCES-HYGROSCOPICUS
Journal of industrial microbiology & biotechnology
5-HYDROXYALOESAPONARIN-II, A MINOR BLUE PIGMENT IN AN ACTINORHODIN-NEGATIVE MUTANT OF STREPTOMYCES-COELICOLOR A3(2)
Biotechnology and applied biochemistry
NATURAL-PRODUCTS DERIVED FROM UNUSUAL VARIANTS OF THE SHIKIMATE PATHWAY
Natural product reports
ACYLTRANSFERASE DOMAIN SUBSTITUTIONS IN ERYTHROMYCIN POLYKETIDE SYNTHASE YIELD NOVEL ERYTHROMYCIN DERIVATIVES
Journal of bacteriology
POSTTRANSLATIONAL CONTROL OF THE ALGT (ALGU)-ENCODED SIGMA(22) FOR EXPRESSION OF THE ALGINATE REGULON IN PSEUDOMONAS-AERUGINOSA AND LOCALIZATION OF ITS ANTAGONIST PROTEINS MUCA AND MUCB (ALGN)
Journal of bacteriology
CONSTITUTION OF THE METABOLIC TYPE OF STREPTOMYCETES DURING THE FIRSTHOURS OF CULTIVATION
Folia microbiologica
MANIPULATION OF MODULAR POLYKETIDE SYNTHESES
Chemical reviews
MODULAR PEPTIDE SYNTHETASES INVOLVED IN NONRIBOSOMAL PEPTIDE-SYNTHESIS
Chemical reviews
THE MOLECULAR-BASIS OF CELMERS RULES - THE STEREOCHEMISTRY OF THE CONDENSATION STEP IN CHAIN EXTENSION ON THE ERYTHROMYCIN POLYKETIDE SYNTHASE
Biochemistry
ENGINEERING ANTIBIOTIC PRODUCERS TO OVERCOME THE LIMITATIONS OF CLASSICAL STRAIN IMPROVEMENT PROGRAMS
Critical reviews in microbiology
MICROBIAL PATHOGENESIS IN CYSTIC-FIBROSIS - MUCOID PSEUDOMONAS-AERUGINOSA AND BURKHOLDERIA-CEPACIA
Microbiological reviews
DECIPHERING THE MECHANISM FOR THE ASSEMBLY OF AROMATIC POLYKETIDES BYA BACTERIAL POLYKETIDE SYNTHASE
Proceedings of the National Academy of Sciences of the United Statesof America
ALGINATE SYNTHESIS IN PSEUDOMONAS-AERUGINOSA - THE ROLE OF ALGL (ALGINATE LYASE) AND ALGX
Journal of bacteriology
PSEUDOMONAS-AERUGINOSA BIOFILMS - ROLE OF THE ALGINATE EXOPOLYSACCHARIDE
Journal of industrial microbiology
POLYSACCHARIDE LYASES
FEMS microbiology reviews
FUNCTIONAL-ANALYSIS OF PUTATIVE BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE AND ACYLTRANSFERASE ACTIVE-SITE MOTIFS IN A TYPE-II POLYKETIDE SYNTHASE OF STREPTOMYCES-GLAUCESCENS
Journal of bacteriology
NUCLEOTIDE-SEQUENCE OF THE LANTIBIOTIC PEP5 BIOSYNTHETIC GENE-CLUSTERAND FUNCTIONAL-ANALYSIS OF PEPP AND PEPC - EVIDENCE FOR A ROLE OF PEPC IN THIOETHER FORMATION
European journal of biochemistry
DAUNORUBICIN TYPE-II POLYKETIDE SYNTHASE ENZYMES DPSA AND DPSB DETERMINE NEITHER THE CHOICE OF STARTER UNIT NOR THE CYCLIZATION PATTERN OF AROMATIC POLYKETIDES
Journal of the American Chemical Society
MUCOID-TO-NONMUCOID CONVERSION IN ALGINATE-PRODUCING PSEUDOMONAS-AERUGINOSA OFTEN RESULTS FROM SPONTANEOUS MUTATIONS IN ALGT, ENCODING A PUTATIVE ALTERNATE SIGMA-FACTOR, AND SHOWS EVIDENCE FOR AUTOREGULATION
Journal of bacteriology
MUCOID-TO-NONMUCOID CONVERSION IN ALGINATE-PRODUCING PSEUDOMONAS-AERUGINOSA OFTEN RESULTS FROM SPONTANEOUS MUTATIONS IN ALGT, ENCODING A PUTATIVE ALTERNATE SIGMA-FACTOR, AND SHOWS EVIDENCE FOR AUTOREGULATION
Journal of bacteriology