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La ricerca find articoli where soggetti phrase all words 'BETA-SECRETASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 90 riferimenti
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    1. Brewer, M; Rich, DH
      Synthesis of a tripeptide derivative containing the Phe-Arg hydroxyethylene dipeptide isostere

      ORGANIC LETTERS
    2. Golde, TE; Younkin, SG
      Presenilins as therapeutic targets for the treatment of Alzheimer's disease

      TRENDS IN MOLECULAR MEDICINE
    3. Petit, A; Bihel, F; da Costa, CA; Pourquie, O; Checler, F; Kraus, JL
      New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage

      NATURE CELL BIOLOGY
    4. Huse, JT; Doms, RW
      Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease

      TRAFFIC
    5. Daugherty, BL; Green, SA
      Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing

      TRAFFIC
    6. Studer, R; Baysang, G; Brack, C
      N-acetyl-L-cystein downregulates ss-amyloid precursor protein gene transcription in human neuroblastoma cells

      BIOGERONTOLOGY
    7. Moss, ML; White, JM; Lambert, MH; Andrews, RC
      TACE and other ADAM proteases as targets for drug discovery

      DRUG DISCOVERY TODAY
    8. Southan, C
      A genomic perspective on human proteases as drug targets

      DRUG DISCOVERY TODAY

    9. Statine-derived tetrapeptide inhibitors of beta-secretase - Elan Pharm., Inc.: WO0077030

      EXPERT OPINION ON THERAPEUTIC PATENTS
    10. Chen, M; Fernandez, HL
      Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency

      FRONTIERS IN BIOSCIENCE
    11. Lyons, D; McLoughlin, DM
      Recent advances - Psychiatry

      BRITISH MEDICAL JOURNAL
    12. Nowotny, P; Kwon, JM; Chakraverty, S; Nowotny, V; Morris, JC; Goate, AM
      Association studies using novel polymorphisms in BACE1 and BACE2

      NEUROREPORT
    13. Murphy, T; Yip, A; Brayne, C; Easton, D; Evans, JG; Xuereb, J; Cairns, N; Esiri, MM; Rubinsztein, DC
      The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease

      NEUROREPORT
    14. Walter, J; Kaether, C; Steiner, H; Haass, C
      The cell biology of Alzheimer's disease: uncovering the secrets of secretases

      CURRENT OPINION IN NEUROBIOLOGY
    15. Rossner, S; Mehlhorn, G; Schliebs, R; Bigl, V
      Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology

      EUROPEAN JOURNAL OF NEUROSCIENCE
    16. Vassar, R
      The beta-secretase, BACE - A prime drug target for Alzheimer's disease

      JOURNAL OF MOLECULAR NEUROSCIENCE
    17. Schenk, D; Games, D; Seubert, P
      Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization

      JOURNAL OF MOLECULAR NEUROSCIENCE
    18. Anders, A; Gilbert, S; Garten, W; Postina, R; Fahrenholz, F
      Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases

      FASEB JOURNAL
    19. Cataldo, A; Rebeck, GW; Ghetti, B; Hulette, C; Lippa, C; Van Broeckhovan, C; van Duijn, C; Cras, P; Bogdanovic, N; Bird, T; Peterhoff, C; Nixon, R
      Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders

      ANNALS OF NEUROLOGY
    20. Rossner, S; Apelt, J; Schliebs, R; Perez-Polo, JR; Bigl, V
      Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

      JOURNAL OF NEUROSCIENCE RESEARCH
    21. Dierssen, M; Marti, E; Pucharcos, C; Fotaki, V; Altafaj, X; Casas, K; Solans, A; Arbones, ML; Fillat, C; Estivill, X
      Functional genomics of Down syndrome: a multidisciplinary approach

      JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
    22. Seidl, R; Cairns, N; Lubec, G
      The brain in Down syndrome

      JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
    23. Mudher, A; Chapman, S; Richardson, J; Asuni, A; Gibb, G; Pollard, C; Killick, R; Iqbal, T; Raymond, L; Varndell, I; Sheppard, P; Makoff, A; Gower, E; Soden, PE; Lewis, P; Murphy, M; Golde, TE; Rupniak, HT; Anderton, BH; Lovestone, S
      Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase

      JOURNAL OF NEUROSCIENCE
    24. Slack, BE; Ma, LK; Seah, CC
      Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

      BIOCHEMICAL JOURNAL
    25. Chen, CD; Huff, ME; Matteson, J; Page, L; Phillips, R; Kelly, JW; Balch, WE
      Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization

      EMBO JOURNAL
    26. Vieira, M; Pissarra, J; Verissimo, P; Castanheira, P; Costa, Y; Pires, E; Faro, C
      Molecular cloning and characterization of cDNA encoding cardosin B, an aspartic proteinase accumulating extracellularly in the transmitting tissue ofCynara cardunculus L.

      PLANT MOLECULAR BIOLOGY
    27. Vattemi, G; Engel, WK; McFerrin, J; Buxbaum, JD; Pastorino, L; Askanas, V
      Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis

      LANCET
    28. Wong, PC; Price, DL; Cai, HB
      The brain's susceptibility to amyloid plaques

      SCIENCE
    29. Puglielli, L; Kovacs, DM
      Alzheimer disease: 100 years later

      REVISTA MEDICA DE CHILE
    30. Levitan, D; Lee, J; Song, LX; Manning, R; Wong, G; Parker, E; Zhang, LL
      PS1N-and C-terminal fragments form a complex that functions in APP processing and Notch signaling

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    31. Mizutani, T; Taniguchi, Y; Aoki, T; Hashimoto, N; Honjo, T
      Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    32. Kojro, E; Gimpl, G; Lammich, S; Marz, W; Fahrenholz, F
      Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    33. Small, DH
      The role of presenilins in gamma-secretase activity: catalyst or cofactor?

      JOURNAL OF NEUROCHEMISTRY
    34. Checler, F
      The multiple paradoxes of presenilins

      JOURNAL OF NEUROCHEMISTRY
    35. Skovronsky, DM; Fath, S; Lee, VMY; Milla, ME
      Neuronal localization of the TNF alpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

      JOURNAL OF NEUROBIOLOGY
    36. Dingwall, C
      Spotlight on BACE: The secretases as targets for treatment in Alzheimer disease

      JOURNAL OF CLINICAL INVESTIGATION
    37. Beher, D; Wrigley, JDJ; Nadin, A; Evin, G; Masters, CL; Harrison, T; Castro, JL; Shearman, MS
      Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma-secretase inhibitor - Implications for presenilin biology

      JOURNAL OF BIOLOGICAL CHEMISTRY
    38. Yan, RQ; Munzner, JB; Shuck, ME; Bienkowski, MJ
      BACE2 functions as an alternative alpha-secretase in cells

      JOURNAL OF BIOLOGICAL CHEMISTRY
    39. Hussain, I; Christie, G; Schneider, K; Moore, S; Dingwall, C
      Prodomain processing of Asp1 (BACE2) is autocatalytic

      JOURNAL OF BIOLOGICAL CHEMISTRY
    40. Southan, C
      A genomic perspective on human proteases

      FEBS LETTERS
    41. Nunan, J; Shearman, MS; Checler, F; Cappai, R; Evin, G; Beyreuther, K; Masters, CL; Small, DH
      The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    42. Lefterov, IM; Koldamova, RP; Lefterova, MI; Schwartz, DR; Lazo, JS
      Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    43. Borroni, B; Colciaghi, F; Pastorino, L; Pettenati, C; Cottini, E; Rozzini, L; Monastero, R; Lenzi, GL; Cattabeni, F; Di Luca, M; Padovani, A
      Amyloid precursor protein in platelets of patients with Alzheimer disease - Effect of acetylcholinesterase inhibitor treatment

      ARCHIVES OF NEUROLOGY
    44. Esler, WP; Kimberly, WT; Ostaszewski, BL; Xia, WM; Selkoe, DJ; Wolfe, MS
      Toward the identification of gamma-secretase: Using transition state analog inhibitors

      ALZHEIMER'S DISEASE
    45. Smith, RG
      The aging process: where are the drug opportunities?

      CURRENT OPINION IN CHEMICAL BIOLOGY
    46. Papassotiropoulos, A; Bagli, M; Jessen, F; Frahnert, C; Rao, ML; Maier, W; Heun, R
      Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease

      MOLECULAR PSYCHIATRY
    47. Citron, M
      Secretases as targets for the treatment of Alzheimer's disease

      MOLECULAR MEDICINE TODAY
    48. Struhl, G; Adachi, A
      Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins

      MOLECULAR CELL
    49. Pastorino, L; Colciaghi, F; Marcon, G; Borroni, B; Cottini, E; Cattabeni, F; Padovani, A; Di Luca, M
      Presenilin 2 mutation does not influence expression and concentration of APP forms in human platelets

      MOLECULAR MEDICINE
    50. Lau, KF; McLoughlin, DM; Standen, C; Miller, CCJ
      X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains

      MOLECULAR AND CELLULAR NEUROSCIENCE
    51. Blasko, I; Veerhuis, R; Stampfer-Kountchev, M; Saurwein-Teissl, M; Eikelenboom, P; Grubeck-Loebenstein, B
      Costimulatory effects of interferon-gamma and interleukin-1 beta or tumor necrosis factor alpha on the synthesis of a beta 1-40 and a beta 1-42 by human astrocytes

      NEUROBIOLOGY OF DISEASE
    52. Evin, G; Le Brocque, D; Culvenor, JG; Galatis, D; Weidemann, A; Beyreuther, K; Masters, CL; Cappai, R
      Presenilin I expression in yeast lowers secretion of the amyloid precursorprotein

      NEUROREPORT
    53. Blobel, CP
      Remarkable roles of proteolysis on and beyond the cell surface

      CURRENT OPINION IN CELL BIOLOGY
    54. Koike, H; Kouchi, Z; Kinouchi, T; Maeda, T; Sorimachi, H; Saido, TC; Maruyama, K; Okuyama, A; Suzuki, K; Ishiura, S
      Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate

      CYTOTECHNOLOGY
    55. Kopan, R; Goate, A
      A common enzyme connects Notch signaling and Alzheimer's disease

      GENES & DEVELOPMENT
    56. Kienlen-Campard, P; Tasiaux, B; Octave, JN
      The processing and biological function of the human amyloid precursor protein (APP): lessons from different cellular models

      EXPERIMENTAL GERONTOLOGY
    57. Levey, AI
      Immunization for Alzheimer's disease: a shot in the arm or a whiff?

      ANNALS OF NEUROLOGY
    58. Bigl, M; Apelt, J; Luschekina, EA; Lange-Dohna, C; Rossner, S; Schliebs, R
      Expression of beta-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology

      NEUROSCIENCE LETTERS
    59. Crawford, FC; Freeman, MJ; Schinka, J; Abdullah, LI; Richards, D; Sevush, S; Duara, R; Mullan, MJ
      The genetic association between cathepsin D and Alzheimer's disease

      NEUROSCIENCE LETTERS
    60. Van Gassen, G; Van Broeckhoven, C
      Molecular genetics of Alzheimer's disease: what have we learned?

      ACTA NEUROLOGICA BELGICA
    61. Hooper, NM; Turner, AJ
      Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease

      BIOCHEMICAL SOCIETY TRANSACTIONS
    62. Niwa, K; Carlson, GA; Iadecola, C
      Exogenous A beta 1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice

      JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
    63. Rosenberg, RN
      The molecular and genetic basis of AD: The end of the beginning - The 2000Wartenberg lecture

      NEUROLOGY
    64. Aldhous, P; Abbott, A
      Neurodegeneration - Battling the killer proteins

      NATURE
    65. De Strooper, B
      Alzheimer's disease - Closing in on gamma-secretase

      NATURE
    66. Cescato, R; Dumermuth, E; Spiess, M; Paganetti, PA
      Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis

      JOURNAL OF NEUROCHEMISTRY
    67. Moore, CL; Leatherwood, DD; Diehl, TS; Selkoe, DJ; Wolfe, MS
      Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: Implications for inhibitor design

      JOURNAL OF MEDICINAL CHEMISTRY
    68. Seiffert, D; Bradley, JD; Rominger, CM; Rominger, DH; Yang, FD; Meredith, JE; Tang, Q; Roach, AH; Thompson, LA; Spitz, SM; Higaki, JN; Prakash, SR; Combs, AP; Copeland, RA; Arneric, SP; Hartig, PR; Robertson, DW; Cordell, B; Stern, AM; Olson, RE; Zaczek, R
      Presenilin-1 and-2 are molecular targets for gamma-secretase inhibitors

      JOURNAL OF BIOLOGICAL CHEMISTRY
    69. Bennett, BD; Babu-Khan, S; Loeloff, R; Louis, JC; Curran, E; Citron, M; Vassar, R
      Expression analysis of BACE2 in brain and peripheral tissues

      JOURNAL OF BIOLOGICAL CHEMISTRY
    70. Sudoh, S; Hua, G; Kawamura, Y; Maruyama, K; Komano, H; Yanagisawa, K
      Intracellular site of gamma-secretase cleavage for A beta 42 generation inNeuro 2a cells harbouring a presenilin 1 mutation

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    71. Thakur, MK
      Alzheimer's disease - A challenge in the new millennium

      CURRENT SCIENCE
    72. Gurwitz, D
      Mutated presenilins and Alzheimer's disease: the culprit could be calcium signaling

      CLINICAL GENETICS
    73. Koike, H; Ishiura, S
      Alzheimer disease and amyloid-secretase

      NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY
    74. Buchet, R; Pikula, S
      Alzheimer's disease: Its origin at the membrane, evidence and questions

      ACTA BIOCHIMICA POLONICA
    75. Frears, ER; Stephens, DJ; Walters, CE; Davies, H; Austen, BM
      The role of cholesterol in the biosynthesis of beta-amyloid.

      NEUROREPORT
    76. Papassotiropoulos, A; Bagli, M; Feder, O; Jessen, F; Maier, G; Rao, ML; Ludwig, M; Schwab, SG; Heun, R
      Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease

      NEUROSCIENCE LETTERS
    77. Petanceska, SS; Gandy, S
      The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein

      JOURNAL OF NEUROCHEMISTRY
    78. Huber, G; Thompson, A; Gruninger, F; Mechler, H; Hochstrasser, R; Hauri, HP; Malherbe, P
      cDNA cloning and molecular characterization of human brain metalloproteaseMP100: A beta-secretase candidate?

      JOURNAL OF NEUROCHEMISTRY
    79. Koike, H; Seki, H; Kouchi, Z; Ito, M; Kinouchi, T; Tomioka, S; Sorimachi, H; Saido, TC; Maruyama, K; Suzuki, K; Ishiura, S
      Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells

      JOURNAL OF BIOCHEMISTRY
    80. RAPALAKOZIK M; KOZIK A; TRAVIS J
      EFFECT OF OXIDATION OF BETA-AMYLOID PRECURSOR PROTEIN ON ITS BETA-SECRETASE CLEAVAGE - A MODEL STUDY WITH SYNTHETIC PEPTIDES AND CANDIDATE BETA-SECRETASES

      The journal of peptide research
    81. Urmoneit, B; Turner, J; Dyrks, T
      Pulse-chase experiments revealed beta-secretase cleavage from immature full-length amyloid precursor protein harboring the Swedish mutation - Implications for distinct pathways

      JOURNAL OF MOLECULAR NEUROSCIENCE
    82. THOMPSON A; GRUENINGERLEITCH F; HUBER G; MALHERBE P
      EXPRESSION AND CHARACTERIZATION OF HUMAN BETA-SECRETASE CANDIDATES METALLOENDOPEPTIDASE MP78 AND CATHEPSIN-D IN BETA-APP-OVEREXPRESSING CELLS

      Molecular brain research
    83. CHEVALLIER N; JIRACEK J; VINCENT B; BAUR CP; SPILLANTINI MG; GOEDERT M; DIVE V; CHECLER F
      EXAMINATION OF THE ROLE OF ENDOPEPTIDASE-3.4.24.15 IN A-BETA SECRETION BY HUMAN TRANSFECTED CELLS

      British Journal of Pharmacology
    84. CHEVALLIER N; VIZZAVONA J; MARAMBAUD P; BAUR CP; SPILLANTINI M; FULCRAND P; MARTINEZ J; GOEDERT M; VINCENT JP; CHECLER F
      CATHEPSIN-D DISPLAYS IN-VITRO BETA-SECRETASE-LIKE SPECIFICITY

      Brain research
    85. CAPELL A; TEPLOW DB; CITRON M; SELKOE DJ; HAASS C
      SUBSTITUTION OF PHENYLALANINE BY PROLINE AT POSITION-19 OF AMYLOID-BETA PEPTIDE RESULTS IN AN INCREASED PRODUCTION OF AMYLOID-BETA PEPTIDESWITH ALTERNATIVE N-TERMINI AFTER PROTEIN-KINASE-C STIMULATION

      AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION
    86. STEPHENS DJ; AUSTEN BM
      METABOLITES OF THE BETA-AMYLOID PRECURSOR PROTEIN GENERATED BY BETA-SECRETASE LOCALIZE TO THE TRANS-GOLGI NETWORK AND LATE ENDOSOME IN 293 CELLS

      Journal of neuroscience research
    87. MATSUMOTO A; MATSUMOTO R; ENOMOTO T; BABA H
      HUMAN BRAIN BETA-SECRETASE CONTAINS HEPARAN-SULFATE GLYCOCONJUGATES

      Neuroscience letters
    88. BROWN AM; TUMMOLO DM; SPRUYT MA; JACOBSEN JS; SONNENBERGREINES J
      EVALUATION OF CATHEPSIN-D AND CATHEPSIN-G AND EC.3.4.24.15 AS CANDIDATE BETA-SECRETASE PROTEASES USING PEPTIDE AND AMYLOID PRECURSOR PROTEIN SUBSTRATES

      Journal of neurochemistry
    89. HAASS C; HUNG AY; CITRON M; TEPLOW DB; SELKOE DJ
      BETA-AMYLOID, PROTEIN PROCESSING AND ALZHEIMERS-DISEASE

      Arzneimittel-Forschung
    90. STRATMANN GC; WEBSTER MT; FRANCIS PT; PROCTER AW; BOWEN DM
      BRAIN MEMBRANE SERINE-PROTEASE ACTIVITY IN HUMAN CORTEX COMPARED WITHRAT - IMPLICATION FOR ALZHEIMERS-DISEASE

      Dementia


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Documento generato il 19/02/20 alle ore 17:58:28