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Considerations in the evaluation of inverse agonism and protean agonism atG protein-coupled receptors
G PROTEIN PATHWAYS, PT A, RECEPTORS
Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors
G PROTEIN PATHWAYS, PT A, RECEPTORS
Use of fluorescence spectroscopy to study conformational changes in the beta(2)-adrenoceptor
G PROTEIN PATHWAYS, PT A, RECEPTORS
Identification of adrenergic receptor polymorphisms
G PROTEIN PATHWAYS, PT A, RECEPTORS
Measurement of receptor desensitization and internalization in intact cells
G PROTEIN PATHWAYS, PT A, RECEPTORS
Characterization of arrestin expression and function
G PROTEIN PATHWAYS, PT A, RECEPTORS
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms
AMERICAN JOURNAL OF HUMAN GENETICS
Pharmacogenomics: The inherited basis for interindividual differences in drug response
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors
NATURE REVIEWS NEUROSCIENCE
Constitutively active mutants of 5-HT4 receptors are they in unique activestates?
EMBO REPORTS
Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma
RESPIRATORY RESEARCH
Possible association of beta(2)- and beta(3)-adrenergic receptor gene polymorphisms with susceptibility to breast cancer
BREAST CANCER RESEARCH
Bradykinin signalling to MAP kinase: Cell-specific connections versus principle mitogenic pathways
BIOLOGICAL CHEMISTRY
Pharmacogenetics
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
Endocytosis and downregulation of G protein-coupled receptors
PARKINSONISM & RELATED DISORDERS
Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Quantification of receptor interactions using binding methods (Reprinted from Receptor-Based Drug Design, vol 89, pg 49-77, 1998)
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
Long-acting inhaled beta(2)-agonist therapy in asthma
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Cardiac receptor physiology and its application to clinical imaging: Present and future
JOURNAL OF NUCLEAR CARDIOLOGY
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
MOLECULAR BIOLOGY OF THE CELL
Analytical pharmacology of G protein-coupled receptors by stoichiometric expression of the receptor and G alpha protein subunits
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Multiple ligand and cell-dependent states of lateral mobility of plasmalemmal G protein-coupled cholecystokinin receptors
JOURNAL OF FLUORESCENCE
Immunoaffinity purification and reconstitution of human alpha(2)-adrenergic receptor subtype C2 into phospholipid vesicles
PROTEIN EXPRESSION AND PURIFICATION
How to optimize in vivo gene transfer to cardiac myocytes: Mechanical or pharmacological procedures?
HUMAN GENE THERAPY
Nuclear factor-kappa B augments beta(2)-adrenergic receptor expression in human airway epithelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Crystal structure of beta-arrestin at 1.9 angstrom: Possible mechanism of receptor binding and membrane translocation
STRUCTURE
Signaling at zero G: G-protein-independent functions for 7-TM receptors
TRENDS IN BIOCHEMICAL SCIENCES
Physiological significance of beta-adrenergic receptor polymorphisms: in-vivo or in-vitro veritas?
PHARMACOGENETICS
Genetic polymorphisms of adrenergic receptors
CLINICAL AUTONOMIC RESEARCH
Desensitisation of the oxytocin receptor and other G-protein coupled receptors in the human myometrium
EXPERIMENTAL PHYSIOLOGY
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking
CURRENT OPINION IN CELL BIOLOGY
Agonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves beta-arrestin and clathrin coated vesicles
JOURNAL OF NEUROENDOCRINOLOGY
Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation
ONCOGENE
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
ONCOGENE
G protein coupled receptor dimerization: implications in modulating receptor function
JOURNAL OF MOLECULAR MEDICINE-JMM
Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
The mechanism of angiotensin Ii-induced extracellular signal-regulated kinase-1/2 activation is independent of angiotensin AT(1A) receptor internalisation
CELLULAR SIGNALLING
beta Arrestins: New roles in regulating heptahelical receptors' functions
CELLULAR SIGNALLING
Inverse, protean, and ligand-selective agonism: matters of receptor conformation
FASEB JOURNAL
Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta(1)-adrenergic receptor
FASEB JOURNAL
Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis
MOLECULAR ENDOCRINOLOGY
Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat LH receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway
MOLECULAR ENDOCRINOLOGY
Association of beta-arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus correlates with receptor internalization
MOLECULAR ENDOCRINOLOGY
Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTH-related protein receptors and regulation of cyclic adenosine 3 ',5 '-monophosphate signaling by beta-arrestin2
MOLECULAR ENDOCRINOLOGY
Genetic variance and lipolysis regulation: implications for obesity
ANNALS OF MEDICINE
Diversity of signalling by G protein-coupled receptors
M S-MEDECINE SCIENCES
Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Protein kinase C-mediated desensitization of the neurokinin 1 receptor
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Differential renal distribution of NHERF isoforms and their colocalizationwith NHE3, ezrin, and ROMK
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
NHERF: targeting and trafficking membrane proteins
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Pharmacogenomics: Unlocking the human genome for better drug therapy
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Genetic variations and polymorphisms of G protein-coupled receptors: Functional and therapeutic implications
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Molecular basis of ethnic differences in drug disposition and response
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
The E27 beta(2)-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males
THROMBOSIS AND HAEMOSTASIS
The importance of beta-adrenergic receptors in immune regulation: a link between neuroendocrine and immune system
MEDICAL HYPOTHESES
Candidate gene case-control association studies: advantages and potential pitfalls
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
A novel glucocorticoid regulatory unit mediates the hormone responsivenessof the beta 1-adrenergic receptor gene
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Characterization of the molecular motions of constitutively active G protein-coupled receptors for parathyroid hormone
BIOPHYSICAL CHEMISTRY
Role of endocytosis in signalling and regulation of G-protein-coupled receptors
BIOCHEMICAL SOCIETY TRANSACTIONS
Multiple pathways for the dynamin-regulated internalization of muscarinic acetylcholine receptors
BIOCHEMICAL SOCIETY TRANSACTIONS
Sensitization of adenylate cyclase induced by a dopamine D2 receptor mutant: Inverse agonism by D2 receptor antagonists
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Pharmacological characterization of the rat brain P2Y(1) receptor expressed in HEK293 cells: Ca2+ signaling and receptor regulation
DRUG DEVELOPMENT RESEARCH
Ezrin-radixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epithelia
HEPATOLOGY
Cross talk between beta-adrenergic and bradykinin B-2 receptors results incooperative regulation of cyclic AMP accumulation and mitogen-activated protein kinase activity
MOLECULAR AND CELLULAR BIOLOGY
Cyclic AMP-mediated inhibition of cell growth requires the small G proteinRap1
MOLECULAR AND CELLULAR BIOLOGY
Cloning, expression, and regulation of a glucocorticoid-induced receptor in rat brain: Effect of repetitive amphetamine
JOURNAL OF NEUROSCIENCE
Nociceptor sensitization by extracellular signal-regulated kinases
JOURNAL OF NEUROSCIENCE
The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association
BIOCHEMICAL JOURNAL
Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B-2 receptor and bradykinin in HEK293 cells
BIOCHEMICAL JOURNAL
New methods for the isolation of skeletal muscle sarcolemma and sarcoplasmic reticulum allowing a comparison between the mammalian and amphibian beta(2)-adrenergic receptors and calcium pumps
CELL BIOCHEMISTRY AND FUNCTION
Characterization of sarcolemma and sarcoplasmic reticulum isolated from skeletal muscle of the freeze tolerant wood frog, Rana sylvatica: the beta(2)-adrenergic receptor and calcium transport systems in control, frozen and thawed states
CELL BIOCHEMISTRY AND FUNCTION
beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2
EMBO JOURNAL
Chemokine receptor homo- or heterodimerization activates distinct signaling pathways
EMBO JOURNAL
beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
HYPERTENSION
Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Re-evaluation of the cytokinin receptor role of the Arabidopsis gene GCR1
JOURNAL OF PLANT PHYSIOLOGY
Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop
MOLECULAR BRAIN RESEARCH
Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors
PHARMACOLOGY & THERAPEUTICS
Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Ligand-induced endocytosis and nuclear localization of angiotensin II receptors expressed in CHO cells
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Prospects for cardiovascular research
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Molecular genetics of salt-sensitivity and hypertension
DRUG METABOLISM AND DISPOSITION
Genetic variation in beta-adrenergic receptors and their relationship to susceptibility for asthma and therapeutic response
DRUG METABOLISM AND DISPOSITION
Interethnic variability in human drug responses
DRUG METABOLISM AND DISPOSITION
Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex
KIDNEY INTERNATIONAL
Immunofluorescent imaging of beta(1)- and beta(2)-adrenergic receptors in rat kidney
KIDNEY INTERNATIONAL
beta-2 adrenergic receptor gene variations and blood pressure under stressin normal twins
PSYCHOPHYSIOLOGY
Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
PHARMACOLOGICAL REVIEWS
The effect of common polymorphisms of the beta(2)-adrenergic receptor on agonist-mediated vascular desensitization
NEW ENGLAND JOURNAL OF MEDICINE
G-protein-coupled receptor kinase 3-and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells
NEUROPHARMACOLOGY
Modulation of 5-HT1A receptor activation by its interaction with wild-typeand mutant G(alpha i3) proteins
NEUROPHARMACOLOGY
beta-arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Agonist-induced conformational changes in the G-protein-coupling domain ofthe beta(2) adrenergic receptor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA