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The complex clinical and genetic classification of inherited ataxias. II. Autosomal recessive ataxias
NEUROLOGICAL SCIENCES
DNA damage processing defects and disease
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
Chromosome instability syndromes
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Chromosomal stability and the DNA double-stranded break connection
NATURE REVIEWS GENETICS
Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex
NATURE CELL BIOLOGY
The evolution of diverse biological responses to DNA damage: insights fromyeast and p53
NATURE CELL BIOLOGY
Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?
BREAST CANCER RESEARCH
"Host factors" - evolution of concepts of individual sensitivity and susceptibility
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Homologous recombinational repair of DNA ensures mammalian chromosome stability
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
As to the clastogenic-, sister-chromatid exchange inducing- and cytotoxic activity of inosine triphosphate in cultures of human peripheral lymphocytes
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Genotoxicity of streptonigrin: a review
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Cell cycle dependent DNA break increase in ataxia telangiectasia lymphoblasts after radiation exposure
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice
CELL DEATH AND DIFFERENTIATION
ATM, a central controller of cellular responses to DNA damage
CELL DEATH AND DIFFERENTIATION
Ataxia telangiectasia with vascular abnormalities in the brain parenchyma:Report of an autopsy case and literature review
PATHOLOGY INTERNATIONAL
Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdfl/Hdf2 complexes
MOLECULAR CELL
Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
MOLECULAR CELL
A DNA damage response pathway controlled by Tel1 and the Mre11 complex
MOLECULAR CELL
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1
MOLECULAR CELL
Ophthalmic manifestations of immunodeficiency states
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
Breast cancer genetics: What we know and what we need
NATURE MEDICINE
Role of Nijmegen breakage syndrome protein in specific T-lymphocyte activation pathways
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele
NATURE GENETICS
DNA double-strand breaks: signaling, repair and the cancer connection
NATURE GENETICS
UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein
MOLECULAR BIOLOGY OF THE CELL
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p
MOLECULAR BIOLOGY OF THE CELL
ATM as a target for novel radiosensitizers
SEMINARS IN RADIATION ONCOLOGY
Expression and purification of active recombinant ATM protein from transiently transfected mammalian cells
PROTEIN EXPRESSION AND PURIFICATION
A complex pattern of recurrent chromosomal bosses and gains in T-cell prolymphocytic leukemia
GENES CHROMOSOMES & CANCER
TCL1 is activated by chromosomal rearrangement or by hypomethylation
GENES CHROMOSOMES & CANCER
Molecular and pathological characterization of inherited breast cancer
SEMINARS IN CANCER BIOLOGY
Knockout mouse models and mammary tumorigenesis
SEMINARS IN CANCER BIOLOGY
Involvement of DNA-dependent protein kinase in regulation of stress-induced JNK activation
DNA AND CELL BIOLOGY
Genomic instability in head and neck cancer patients
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
11q deletions in hematological malignancies
LEUKEMIA & LYMPHOMA
Unraveling DNA repair in human: Molecular mechanisms and consequences of repair defect
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Radiation-induced chromatid breaks and deficient DNA repair in cancer predisposition
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
The rad201 gene of Drosophila melanogaster controls mitotic delay in irradiated cells
RUSSIAN JOURNAL OF GENETICS
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-MbBAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region
EUROPEAN JOURNAL OF HUMAN GENETICS
DNA repair inhibition and cancer therapy
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Xeroderma pigmentosum: the first of the cellular caretakers
TRENDS IN BIOCHEMICAL SCIENCES
'Other' breast cancer susceptibility genes: searching for more holy grail
HUMAN MOLECULAR GENETICS
A deep intronic mutation in CDKN2A is associated with disease in a subset of melanoma pedigrees
HUMAN MOLECULAR GENETICS
hMRE11: Genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay
HUMAN MOLECULAR GENETICS
Integrating stress-response and cell-cycle checkpoint pathways
TRENDS IN CELL BIOLOGY
Altered spectra of hypermutation in DNA repair-deficient mice
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Synthetic lethality between mutation in Atm and DNA-PKcs during murine embryogenesis
CURRENT BIOLOGY
The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
CURRENT BIOLOGY
Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
CURRENT BIOLOGY
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
CURRENT BIOLOGY
Germ line mutations associated with breast cancer susceptibility
EUROPEAN JOURNAL OF CANCER
A hypothesis about tumour development and the clinical features of hereditary breast cancers
EUROPEAN JOURNAL OF CANCER
ATM and ATR: networking cellular responses to DNA damage
CURRENT OPINION IN GENETICS & DEVELOPMENT
Relationship between cellular radiosensitivity and DNA damage measured by comet assay in human normal, NBS and AT fibroblasts
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
The XRCC2 human repair gene influences recombinational rearrangements leading to chromatid breaks
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Investigation of G2-phase chromosomal radiosensitivity in hereditary non-polyposis colorectal cancer cells
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Evaluation of ionizing radiation sensitivity markers in a panel of lymphoid cell lines
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Telomeric sequences, radiation sensitivity and genomic instability
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Mammalian G1- and S-phase checkpoints in response to DNA damage
CURRENT OPINION IN CELL BIOLOGY
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
CURRENT OPINION IN CELL BIOLOGY
Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV
ONCOGENE
Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis
ONCOGENE
Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum groupE strains
ONCOGENE
Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas
ONCOGENE
The role of TCL1 in human T-cell leukemia
ONCOGENE
Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53
ONCOGENE
Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53
ONCOGENE
Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein
ONCOGENE
Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress
ONCOGENE
Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice
ONCOGENE
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
ONCOGENE
Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid
ONCOGENE
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group
ONCOGENE
Regulation of the G2/M transition by p53
ONCOGENE
Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors
ONCOGENE
Phenotype of FAECB (Facility for Automated Experiments in Cell Biology) Chinese hamster ovary mutants with minimal UV-sensitivity
MUTATION RESEARCH-DNA REPAIR
Complementation of chromosomal aberrations in AT/NBS hybrids: inadequacy of RDS as an endpoint in complementation studies with immortal NBS cells
MUTATION RESEARCH-DNA REPAIR
Regulatory mechanisms of female germ cell apoptosis during embryonic development
ENDOCRINE JOURNAL
X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts
JAPANESE JOURNAL OF CANCER RESEARCH
High frequency of deletions at the hypoxanthine-guanine phosphoribosyltransferase locus in an ataxia-telangiectasia lymphoblastoid cell line irradiated with gamma-rays
JAPANESE JOURNAL OF CANCER RESEARCH
Carcinogenicity of estrogens in human breast epithelial cells
APMIS
Carcinogenicity of estrogens in human breast epithelial cells
APMIS
Screening breast cancer patients for ATM mutations and polymorphisms by using denaturing high-performance liquid chromatography
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
C-elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint
GENES & DEVELOPMENT
Cell cycle checkpoint signaling through the ATM and ATR kinases
GENES & DEVELOPMENT
The yeast Xrs2 complex functions in S phase checkpoint regulation
GENES & DEVELOPMENT
Parotid and thyroid gland cancers in patients with ataxia-telangiectasia
PEDIATRIC HEMATOLOGY AND ONCOLOGY
Diagnostic value of alpha(1)-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood
PEDIATRIC HEMATOLOGY AND ONCOLOGY
Investigation on the role of the ATM gene in chronic myeloid leukaemia
LEUKEMIA
Identification of differentially expressed genes in human memory (CD45RO(+)) CD4(+) T lymphocytes
IMMUNOLOGICAL INVESTIGATIONS
Soft tissue sarcoma
PRESSE MEDICALE
Epstein-Barr virus in patients with immunodeficiency disorders
BIOMEDICINE & PHARMACOTHERAPY
Cancer-associated genodermatoses and familial cancer syndromes with cutaneous manifestations
CLINICS IN DERMATOLOGY
The role of genetic factors in the etiology of pancreatic adenocarcinoma: An update
CANCER INVESTIGATION
Postmastectomy radiotherapy: Clinical practice guidelines of the American Society of Clinical Oncology
JOURNAL OF CLINICAL ONCOLOGY