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Drug-induced torsade de pointes: the perspectives of industry
EUROPEAN HEART JOURNAL SUPPLEMENTS
Screening lead compounds for QT interval prolongation
DRUG DISCOVERY TODAY
Acute canine model for drug-induced torsades de pointes in drug safety evaluation - Influences of anesthesia and validation with quinidine and astemizole
TOXICOLOGICAL SCIENCES
Development and evaluation of high throughput functional assay methods forhERG potassium channel
JOURNAL OF BIOMOLECULAR SCREENING
Controlled comparison of the efficacy and safety of cetirizine 10 mg od and fexofenadine 120 mg od in reducing symptoms of seasonal allergic rhinitis
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Determination of astemizole in pharmaceutical preparations using spectrophotometric methods
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Electropharmacologic effects of a new phosphodiesterase III inhibitor, toborinone (OPC-18790), assessed in an in vivo canine model
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Safety of antihistamines in children
DRUG SAFETY
Effects of 5-HT4 receptor agonist prokinetic agents on the action potential parameters of isolated rabbit myocardium
PHARMACOLOGY
Acute electropharmacological effects of intravenously administered amiodarone assessed in the in vivo canine model
JAPANESE JOURNAL OF PHARMACOLOGY
Triamcinolone acetonide aqueous nasal spray versus loratadine in seasonal allergic rhinitis: efficacy and quality of life
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Cetirizine for solar urticaria in the visible spectrum
DERMATOLOGY
Reversal of acquired resistance to doxorubicin in K562 human leukemia cells by astemizole
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Appropriate use of second generation antihistamines
CLEVELAND CLINIC JOURNAL OF MEDICINE
Prospective, long-term safety evaluation of the H-1-receptor antagonist cetirizine in very young children with atopic dermatitis
ALLERGOLOGIE
Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Cetirizine and loratadine: a comparison using the ED50 in skin reactions
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Comparative electrophysiological effects of the second generation antihistamines, astemizole and ebastine, in a canine myocardial infarction model
DRUG DEVELOPMENT RESEARCH
QT-prolonging effects of sparfloxacin, a fluoroquinolone antibiotic, assessed in the in vivo canine model with monophasic action potential monitoring
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years
CLINICAL THERAPEUTICS
Evaluation of the cardiac safety of second-generation antihistamines
ALLERGY
Onset of action of intranasal budesonide (Rhinocort Aqua) in seasonal allergic rhinitis studied in a controlled exposure model
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Effect of magnesium sulfate on the haloperidol-induced QT prolongation assessed in the canine in vivo model under the monitoring of monophasic actionpotential
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
The preclinical assessment of the risk for QT interval prolongation
THERAPIE
Pharmacological blockade of ERG K+ channels and Ca2+ influx through store-operated channels exerts opposite effects on intracellular Ca2+ oscillations in pituitary GH(3) cells
MOLECULAR PHARMACOLOGY
Epinastine: An update of its pharmacology, metabolism, clinical efficacy and tolerability in the treatment of allergic diseases
DRUGS OF TODAY
Loratadine blockade of K+ channels in human heart: Comparison with terfenadine under physiological conditions
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Effects of mexiletine on the canine cardiovascular system complicating cisapride overdose: Potential utility of mexiletine for the treatment of drug-induced long QT syndrome
JAPANESE JOURNAL OF PHARMACOLOGY
Electrophysiological and cardiohemodynamic effects of AH-1058, a new type calcium channel blocker, assessed by the in vivo canine model
JAPANESE JOURNAL OF PHARMACOLOGY
Predictors of Torsades de Pointes in rabbit ventricles perfused with sedating and nonsedating histamine H-1-receptor antagonists
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Inhibition of HERG1 K+ channels by the novel second-generation antihistamine mizolastine
BRITISH JOURNAL OF PHARMACOLOGY
Mechanism of terfenadine block of ATP-sensitive K+ channels
BRITISH JOURNAL OF PHARMACOLOGY
Cardiotoxic potential and CNS effects of first-generation antihistamines
TRENDS IN PHARMACOLOGICAL SCIENCES
H-1-receptor antagonists: safety issues
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Therapeutic index of H-1-antihistamines: example of cetirizine
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Comparison of the efficacy, safety, and onset of action of mizolastine, cetirizine, and placebo in the management of seasonal allergic rhinoconjunctivitis
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Cardiovascular safety of second-generation antihistamines
AMERICAN JOURNAL OF RHINOLOGY
Mechanism of action of the nonlipophilic antiallergic drug eclazolast (REV2871) in the inhibition of mediator release in a mast cell model
INFLAMMATION RESEARCH
Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity
CLINICAL AND EXPERIMENTAL ALLERGY
Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome
CLINICAL AND EXPERIMENTAL ALLERGY
Cardiovascular profile of loratadine
CLINICAL AND EXPERIMENTAL ALLERGY
Efficacy and safety of mizolastine 10 mg in a placebo-controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILOR study
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
A 3-month evaluation of electrocardiographic effects of loratadine in healthy individuals
ADVANCES IN THERAPY
Delayed toxidromes
JOURNAL OF EMERGENCY MEDICINE
Determination of astemizole, terfenadine and flunarizine hydrochloride by ternary complex formation with eosin and lead(II)
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmentalexposure unit
ALLERGOLOGIE
Effects of acrivastine, loratadine and cetirizine on histamine-induced wheal and flare responses
CLINICAL AND EXPERIMENTAL DERMATOLOGY
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Indole amide derivatives: synthesis, structure-activity relationships and molecular modelling studies of a new series of histamine H-1-receptor antagonists
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Novel antipsychotics: Comparison of weight gain liabilities
JOURNAL OF CLINICAL PSYCHIATRY
Electrophysiologic, cardiohemodynamic and beta-blocking actions of a new ultra-short-acting beta-blocker, ONO-1101, assessed by the in vivo canine model in comparison with esmolol
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Second-generation antihistamines: The risk of ventricular arrhythmias
CLINICAL THERAPEUTICS
Blockade of cardiac potassium and other channels by antihistamines
DRUG SAFETY
Effects of H-1 antihistamines on animal models of QTc prolongation
DRUG SAFETY
Comparative tolerability of second generation antihistamines
DRUG SAFETY
A double-blind, single-dose, crossover comparison of cetirizine, ebastine,epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in
ALLERGY
Prospective, long-term safety evaluation of the H-1-receptor antagonist cetirizine in very young children with atopic dermatitis
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Comparison between nasal provocation tests and skin tests in patients treated with loratadine and cetirizine
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine
JOURNAL OF CLINICAL PHARMACOLOGY
Antihistamines H1 drugs: past and present
THERAPIE
A new sensitive spectrophotometric method for the analysis of some antihistamines
SPECTROSCOPY LETTERS
Consistency and efficacy of cetirizine (10 mg) versus ebastine (20 mg) at 4 h on skin reactivity
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramine
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Effects of a class III antiarrhythmic drug, dofetilide, on the in situ canine heart assessed by the simultaneous monitoring of hemodynamic and electrophysiological parameters
JAPANESE JOURNAL OF PHARMACOLOGY
Effects of terfenadine, astemizole and epinastine on electrocardiogram in conscious cynomolgus monkeys
EUROPEAN JOURNAL OF PHARMACOLOGY
Epinastine, a nonsedating histamine H-1 receptor antagonist, has a negligible effect on HERG channel
EUROPEAN JOURNAL OF PHARMACOLOGY
Rate-dependent blockade of a potassium current in human atrium by the antihistamine loratadine
BRITISH JOURNAL OF PHARMACOLOGY
Colorimetric and fluorimetric methods for the determination of some antihistaminics using acid dyes and charge transfer techniques
ANALYTICAL LETTERS
Innovar treatment for Meniere's disease
ACTA OTO-LARYNGOLOGICA
TREATMENT OF ALLERGIC RHINITIS - AN EVIDENCE-BASED EVALUATION OF NASAL CORTICOSTEROIDS VERSUS NONSEDATING ANTIHISTAMINES
American journal of managed care
STUDY OF HPLC RETENTION BEHAVIOR OF 1-HYDROXY-IMIDAZOLE-3-N-OXIDES, SUBSTITUTED IMIDAZOLES, AND IMIDAZOLE DERIVATIVES USING MOLECULAR AND ADSORPTION PARAMETERS
Journal of liquid chromatography & related technologies
COMPARISON OF EFFICACY AND SAFETY OF CETIRIZINE AND EBASTINE IN PATIENTS WITH PERENNIAL ALLERGIC RHINITIS
Annals of allergy, asthma, & immunology
CONSISTENCY OF THE EFFICACY OF CETIRIZINE AND EBASTINE ON SKIN REACTIVITY
Annals of allergy, asthma, & immunology
The pre-clinical assessment of QT interval prolongation: a comparison of in vitro and in vivo methods
HUMAN & EXPERIMENTAL TOXICOLOGY
Antihistamines in severe/chronic rhinitis
CLINICAL AND EXPERIMENTAL ALLERGY
PHARMACOKINETIC OVERVIEW OF ORAL 2ND-GENERATION H-1 ANTIHISTAMINES
International journal of clinical pharmacology and therapeutics
PHARMACOLOGICAL CHARACTERIZATION OF A NOVEL LONG-ACTING HISTAMINE H-1RECEPTOR ANTAGONIST, KAA-276
Biological & pharmaceutical bulletin
Effects of antiarrhythmic drugs on the monophasic action potential of the canine isolated, blood-perfused ventricular septum preparation
HEART AND VESSELS
ANTIHISTAMINES
The journal of head trauma rehabilitation
SPARFLOXACIN BUT NOT LEVOFLOXACIN OR OFLOXACIN PROLONGS CARDIAC REPOLARIZATION IN RABBIT PURKINJE-FIBERS
Fundamental and clinical pharmacology
Histaminergic ligands attenuate barrel rotation in rats following unilateral labyrinthectomy
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
Cardiac adverse effects of H-1-antihistamines
REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE
DOUBLE-BLIND, PARALLEL, RANDOMIZED PILOT-STUDY COMPARING THE EFFICACYAND TOLERANCE OF CETIRIZINE 10 MG, MEQUITAZINE 2X5 MG AND PLACEBO IN THE TREATMENT OF PATIENTS SUFFERING FROM CHRONIC URTICARIA - COMPARISON OF SUPPRESSIVE EFFECTS ON HISTAMINE-INDUCED WEALS AND FLARES
Drug development research
CONVENTIONAL ANTIHISTAMINES SLOW CARDIAC REPOLARIZATION IN ISOLATED-PERFUSED (LANGENDORFF) FELINE HEARTS
Journal of cardiovascular pharmacology
EFFECTS OF ASTEMIZOLE ON VENTRICULAR ACTIVATION, EFFECTIVE REFRACTORYPERIODS, RT INTERVALS, AND PROGRAMMED STIMULATION-INDUCED VENTRICULARARRHYTHMIAS IN DOG HEARTS WITH MYOCARDIAL-INFARCTION
Journal of cardiovascular pharmacology
EFFICACY AND SAFETY RELATIVE TO PLACEBO OF AN ORAL FORMULATION OF CETIRIZINE AND SUSTAINED-RELEASE PSEUDOEPHEDRINE IN THE MANAGEMENT OF NASAL CONGESTION
Allergy
CHANGES IN SKIN-TEST REACTIVITY DO NOT CORRELATE WITH CLINICAL EFFICACY OF H-1-BLOCKERS IN SEASONAL ALLERGIC RHINITIS
Allergy
A COMPARISON OF THE EFFICACY OF FLUTICASONE PROPIONATE AQUEOUS NASAL SPRAY AND LORATADINE, ALONE AND IN COMBINATION, FOR THE TREATMENT OF SEASONAL ALLERGIC RHINITIS
Journal of family practice
CETIRIZINE, IORATADINE, OR PLACEBO IN SUBJECTS WITH SEASONAL ALLERGICRHINITIS - EFFECTS AFTER CONTROLLED RAGWEED POLLEN CHALLENGE IN AN ENVIRONMENTAL EXPOSURE UNIT
Journal of allergy and clinical immunology
BROMPHENIRAMINE, LORATADINE, AND PLACEBO IN ALLERGIC RHINITIS - A PLACEBO-CONTROLLED COMPARATIVE CLINICAL-TRIAL
Journal of clinical pharmacology
ASTEMIZOLE-INDUCED TORSADES-DE-POINTES IN A PATIENT WITH VASOSPASTIC ANGINA
Japanese Circulation Journal
SPECTROPHOTOMETRIC DETERMINATION OF ASTEMIZOLE
Talanta
MOLECULAR-BASIS FOR THE LACK OF HERG K-RELATED CARDIOTOXICITY BY THE H-1 RECEPTOR BLOCKER CETIRIZINE COMPARED WITH OTHER 2ND-GENERATION ANTIHISTAMINES( CHANNEL BLOCK)
Molecular pharmacology
INHIBITION OF NEURONAL DOPAMINE UPTAKE BY SOME ANTIALLERGIC DRUGS
European journal of pharmacology
STRUCTURE-ACTIVITY-RELATIONSHIPS OF ASTEMIZOLE DERIVATIVES FOR INHIBITION OF STORE OPERATED CA2+ CHANNELS AND EXOCYTOSIS
European journal of pharmacology
PROPHYLACTIC TREATMENT WITH LORATADINE VERSUS CROMOLYN SODIUM IN CHILDREN WITH MILD-TO-MODERATE PERENNIAL ALLERGIC-ASTHMA
Current therapeutic research
DUAL EFFECT OF THE ANTIALLERGIC ASTEMIZOLE ON CA2-2H3) CELLS - RELEASE OF CA2+ FROM INTRACELLULAR STORES AND INHIBITION OF CA2+ RELEASE-ACTIVATED CA2+ INFLUX( FLUXES IN RAT BASOPHILIC LEUKEMIA (RBL)
Biochemical pharmacology
EFFECTS OF INHALED KAA-276, A SELECTIVE HISTAMINE H-1 RECEPTOR ANTAGONIST, ON ANTIGEN-INDUCED AND HISTAMINE-INDUCED BRONCHOCONSTRICTION IN ANIMALS
Arzneimittel-Forschung
COMPARISON OF INTRANASAL TRIAMCINOLONE ACETONIDE WITH ORAL LORATADINEIN THE TREATMENT OF SEASONAL RAGWEED-INDUCED ALLERGIC RHINITIS
American journal of managed care