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Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors:Novel agents targeting beta-tubulin?
JOURNAL OF ENZYME INHIBITION
Synthetic studies toward diazonamide A. A novel approach for polyoxazole synthesis
ORGANIC LETTERS
Synthesis of the diazonamide A macrocyclic core via a Dieckmann-type cyclization
ORGANIC LETTERS
Synthesis of the C1-C12 fragment of fostriecin
ORGANIC LETTERS
Synthetic seco forms of (-)-diazonamide A
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins
BIOLOGICAL CHEMISTRY
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
HUMAN MOLECULAR GENETICS
Titanium(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of the anticancer drug titanocene dichloride
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Multiple hepatic infarction after transcatheter arterial infusion with SMANCS
JOURNAL OF GASTROENTEROLOGY
Comparative molecular field analysis (CoMFA) study of epothilones-tubulin depolymerization inhibitors: Pharmacophore development using 3D QSAR methods
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
Serotonergic neurotoxicity of 3,4-(+/-) -methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase
CHEMICAL RESEARCH IN TOXICOLOGY
Pharmacokinetic evaluation of N-[2(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography
JOURNAL OF CLINICAL ONCOLOGY
Stability-indicating HPLC assay and solution stability of a new diaziridinyl benzoquinone
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Usefulness of magnetic resonance imaging for surgical management of extravasation of an antitumor agent: a case report
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Development of a lyophilized parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent kahalalide F
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates
JOURNAL OF CONTROLLED RELEASE
Compatibility and stability of the investigational polypeptide marine anticancer agent kahalalide F in infusion devices
INVESTIGATIONAL NEW DRUGS
Apoptosis and epithelial phagocytosis in mitomycin C-treated human pulmonary adenocarcinoma A549 cells
TISSUE & CELL
Photo-Fries rearrangement for the synthesis of the diazonamide macrocycle
TETRAHEDRON LETTERS
Synthesis of chlorooxazoles related to natural products
SYNTHESIS-STUTTGART
Synthesis of (S)-4-methyl-3,6-dihydro-2H-pyran-2-carbaldehyde by two-directional ring closing metathesis: Application to the C27-C15-fragment of laulimalide
SYNTHESIS-STUTTGART
Recent progress in the synthesis of bis-triazenes
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
The tight linkage between DNA replication and double-strand break repair in bacteriophage T4
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H : Quinone oxidoreductase 1
MOLECULAR PHARMACOLOGY
Regulation of metamorphosis in ascidians involves NO/cGMP signaling and HSP90
JOURNAL OF EXPERIMENTAL ZOOLOGY
Repair of topoisomerase-mediated DNA damage in bacteriophage T4
GENETICS
Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugates
CHEMICO-BIOLOGICAL INTERACTIONS
Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA
BIOCHEMISTRY
Natural-product hybrids: Design, synthesis, and biological evaluation of quinone-annonaceous acetogenins
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Non-camptothecin topoisomerase I active compounds as potential anticancer agents
EXPERT OPINION ON THERAPEUTIC PATENTS
Design of poly(ethylene glycol) immobilizing platinum complex through chelate-type coordination bond
POLYMERS FOR ADVANCED TECHNOLOGIES
A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Synthesis and antitumor activity of cyclotriphosphazene-(diamine)platinum(II) conjugates
ANTI-CANCER DRUGS
Cinnamamide, an antitumor agent with low cytotoxicity acting on matrix metalloproteinase
ANTI-CANCER DRUGS
A convergent total synthesis of (-)-mucocin: An acetogenin from Annonaceae
CHEMISTRY-A EUROPEAN JOURNAL
Hepatic vascular side effects of styrene maleic acid neocarzinostatin in the treatment of hepatocellular carcinoma
JOURNAL OF GASTROENTEROLOGY
Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A
CELL BIOLOGY AND TOXICOLOGY
Examination of 8-Cl-cAMP genotoxicity by two in vivo test in BALB/c strainmice
ACTA VETERINARIA-BEOGRAD
A convenient method for the synthesis of C-10 alkylated docetaxel analogs using tris-(trimethylsilyl)silane as a radical mediator
HETEROCYCLES
The temporal organization of life: the impact of multi-frequency non-linear biologic time structure upon the host-cancer balance
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Synthesis of the taxane analogue PNU-105298 labelled with deuterium and with carbon-14
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Induced apoptosis and necrosis by 2-methylfuranonaphthoquinone in human cervical cancer HeLa cells
CANCER DETECTION AND PREVENTION
Amaryllidaceae, muscarine, imidazole, oxazole, thiazole and peptide alkaloids, and other miscellaneous alkaloids
NATURAL PRODUCT REPORTS
Requirement of heat shock protein 90 in mesangial cell mitogenesis
KIDNEY INTERNATIONAL
Establishment of an isogenic human colon tumor model for NQO1 gene expression: Application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo
MOLECULAR PHARMACOLOGY
Synthesis and preliminary biological evaluations of CC-1065 analogues: Effects of different linkers and terminal amides on biological activity
JOURNAL OF MEDICINAL CHEMISTRY
Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases
JOURNAL OF IMMUNOLOGY
Post-translational disruption of the Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes Delta F508 CFTR in the rabbit reticulocyte lysate
JOURNAL OF BIOLOGICAL CHEMISTRY
Spectroscopic characterization of titanocene complexes with thionucleobases
INORGANICA CHIMICA ACTA
Design, synthesis, conformational analysis and biological activities of purine-based 1,2-di-substituted carbocyclic nucleosides
CHEMICAL & PHARMACEUTICAL BULLETIN
Synthesis and properties of novel bifunctional nitrosamines with omega-chloroalkyl groups
CHEMICAL & PHARMACEUTICAL BULLETIN
Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts
CANCER RESEARCH
An investigation into the formation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells
BIOCHEMICAL PHARMACOLOGY
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells
BIOCHEMICAL PHARMACOLOGY
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice
BIOCHEMICAL PHARMACOLOGY
Bleomycin: Synthetic and mechanistic studies
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Lipid A mutant Salmonella with suppressed virulence and TNF alpha induction retain tumor-targeting in vivo
NATURE BIOTECHNOLOGY
Pharmacokinetics of PK1 and doxorubicin in experimental colon tumor modelswith differing responses to PK1
CLINICAL CANCER RESEARCH
Glaucarubolone and simalikalactone D, respectively, preferentially inhibitauxin-induced and constitutive components of plant cell enlargement and the plasma membrane NADH oxidase
INTERNATIONAL JOURNAL OF PLANT SCIENCES
Ligand docking and scoring in DNA oligonucleotides. Binding of doxorubicinand modeled analogs to optimize sequence specificity
MEDICINAL CHEMISTRY RESEARCH
Hsp90 & Co. - a holding for folding
TRENDS IN BIOCHEMICAL SCIENCES
Plasma pharmacokinetics of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in a phase I trial
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Metabolism of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in cancer patients undergoing a phase I clinical trial
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Pharmacokinetic analysis and antitumor efficacy of MKT-077, a novel antitumor agent
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Yoshixol(TR) inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death
GENERAL PHARMACOLOGY
In vitro and in vivo antiturnor activity of Yoshixol(TR) against murine L1210 leukemic cells
GENERAL PHARMACOLOGY
Inhibition of initiation of simian virus 40 DNA replication in vitro by the ursodeoxycholic acid and its derivatives
CANCER LETTERS
A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress
MOLECULAR AND CELLULAR BIOLOGY
Synthesis of sesquiterpene derivatives as potential antitumor agents; Elemane derivatives
ARCHIVES OF PHARMACAL RESEARCH
N-acetylation of the heterocyclic amine batracylin by human liver
DRUG METABOLISM AND DISPOSITION
Development of large-scale synthetic process for antitumor agent EO9
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Topoisomerase poisoning activity of novel disaccharide anthracyclines
MOLECULAR PHARMACOLOGY
Synthesis and antitumor activities of water-soluble benzoylphenylureas
CHEMICAL & PHARMACEUTICAL BULLETIN
Phase I and pharmacokinetic study of DACA (XR5000): a novel inhibitor of topoisomerase I and II
BRITISH JOURNAL OF CANCER
Relationship between hexamerization and ssDNA binding affinity in the uvsYrecombination protein of bacteriophage T4
BIOCHEMISTRY
DT-diaphorase expression and tumor cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
JOURNAL OF THE NATIONAL CANCER INSTITUTE
APOPTIN(R) SPECIFICALLY CAUSES APOPTOSIS IN TUMOR-CELLS AND AFTER UV-TREATMENT IN UNTRANSFORMED CELLS FROM CANCER-PRONE INDIVIDUALS - A REVIEW
Mutation research. Fundamental and molecular mechanisms of mutagenesis
MODULATION OF O-6-ALKYLATING AGENT INDUCED CLASTOGENICITY BY ENHANCEDDNA-REPAIR CAPACITY OF BONE-MARROW CELLS
Mutation research. Genetic toxicology and environmental mutagenesis
BACTERIOPHAGE-T4 INITIATES BIDIRECTIONAL DNA-REPLICATION THROUGH A 2-STEP PROCESS
MOLECULAR CELL
EFFECT OF PYRAZOLOACRIDINE (NSC-366140) ON DNA TOPOISOMERASE-I AND TOPOISOMERASE-II
Clinical cancer research
EFFECT OF PYRAZOLOACRIDINE (NSC-366140) ON DNA TOPOISOMERASE-I AND TOPOISOMERASE-II
Clinical cancer research
5-FLUOROURACIL DERIVATIVES - XXIII - SYNTHESIS AND ANTITUMOR ACTIVITIES OF 1-CARBAMOYL-5-FLUOROURACILS HAVING AROMATIC RING
Chinese journal of chemistry
FIRST TOTAL SYNTHESIS OF PANAXYTRIOL, A POTENT ANTITUMOR AGENT ISOLATED FROM PANAX-GINSENG
Synlett
ANTIPROLIFERATIVE AND CYTOTOXIC EFFECTS OF GELDANAMYCIN, CYTOCHALASIN-E, SURAMIN AND THIACETAZONE IN HUMAN PROSTATE XENOGRAFT TUMOR HISTOCULTURES
Pharmaceutical research
THE BENZOQUINONE ANSAMYCIN 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN BINDS TO HSP90 AND SHARES IMPORTANT BIOLOGIC ACTIVITIES WITH GELDANAMYCIN
Cancer chemotherapy and pharmacology
GELDANAMYCIN-INDUCED CYTOTOXICITY IN HUMAN COLON-CANCER CELL-LINES - EVIDENCE AGAINST THE INVOLVEMENT OF C-SRC OR DT-DIAPHORASE
Cancer chemotherapy and pharmacology
CONVENIENT METHODS FOR REGIO-SELECTIVE AND OR CHEMO-SELECTIVE O-DEACYLATION OF TAXININE, A NATURALLY-OCCURRING TAXANE DITERPENOID/
Journal of the Chemical Society. Perkin transactions. I
DISCOVERY OF PODOPHYLLOTOXINS
Biochimie
SYNTHESIS OF ANTINEOPLASTON A10 ANALOGS AS POTENTIAL ANTITUMOR AGENTS
Archives of pharmacal research
EFFECTS OF SASA HEALTH(R), EXTRACT OF BAMBOO GRASS LEAVES, ON SPONTANEOUS MAMMARY TUMORIGENESIS IN SHN MICE
Anticancer research
BACTERIOPHAGE-T4, A MODEL SYSTEM FOR UNDERSTANDING THE MECHANISM OF TYPE-II TOPOISOMERASE INHIBITORS
Biochimica et biophysica acta, N. Gene structure and expression
THE SBCCD NUCLEASE OF ESCHERICHIA-COLI IS A STRUCTURAL MAINTENANCE OFCHROMOSOMES (SMC) FAMILY PROTEIN THAT CLEAVES HAIRPIN DNA
Proceedings of the National Academy of Sciences of the United Statesof America
PROTEIN-LINKED DNA STRAND BREAKS INDUCED BY NSC-314622, A NOVEL NONCAMPTOTHECIN TOPOISOMERASE-I POISON
Molecular pharmacology
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
JOURNAL OF EXPERIMENTAL MEDICINE
MERBARONE INHIBITS THE CATALYTIC ACTIVITY OF HUMAN TOPOISOMERASE II-ALPHA BY BLOCKING DNA CLEAVAGE
The Journal of biological chemistry
THE SPECTRUM OF ACRIDINE RESISTANT MUTANTS OF BACTERIOPHAGE-T4 REVEALS CRYPTIC EFFECTS OF THE TSL141 DNA-POLYMERASE ALLELE ON SPONTANEOUS MUTAGENESIS
Genetics
PERSISTENT INDUCTION OF NITRIC-OXIDE SYNTHASE IN TUMORS FROM MICE TREATED WITH THE ANTITUMOR AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID
British Journal of Cancer
THE HSP90 COMPLEX - A SUPER-CHAPERONE MACHINE AS A NOVEL DRUG TARGET
Biochemical pharmacology