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    1. Camalli, M; Pifferi, A; Costi, R; Di Santo, R; Massa, S; Artico, M
      1-{[4-(4-chlorophenyl)-1H-pyrrol-3-yl](2,4-dichloro-phenyl)methyl}-1H-imidazole (RDS 416)

      ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
    2. Arvidsson, PI; Frackenpohl, J; Ryder, NS; Liechty, B; Petersen, F; Zimmermann, H; Camenisch, GP; Woessner, R; Seebach, D
      On the antimicrobial and hemolytic activities of amphiphilic beta-peptides

      CHEMBIOCHEM
    3. Staib, P; Wirsching, S; Strauss, A; Morschhauser, J
      Gene regulation and host adaptation mechanisms in Candida albicans

      INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
    4. Dehoux, C; Gorrichon, L; Baltas, M
      Stereoselective preparation of protected thymine polyoxin C and approachestowards synthesis of its C2 '-modified analogues

      EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    5. van 't Hof, W; Veerman, ECI; Helmerhorst, EJ; Amerongen, AVN
      Antimicrobial peptides: Properties and applicability

      BIOLOGICAL CHEMISTRY
    6. Ueta, E; Tanida, T; Osaki, T
      A novel bovine lactoferrin peptide, FKCRRWQWRM, suppresses Candida cell growth and activates neutrophils

      JOURNAL OF PEPTIDE RESEARCH
    7. Katiyar, SK; Edlind, TD
      Identification and expression of multidrug resistance-related ABC transporter genes in Candida krusei

      MEDICAL MYCOLOGY
    8. Fachin, AL; Contel, EPB; Martinez-Rossi, NM
      Effect of sub-MICs of antimycotics on expression of intracellular esteraseof Trichophyton rubrum

      MEDICAL MYCOLOGY
    9. White, DJ; Habib, AR; Vanthuyne, A; Langford, S; Symonds, M
      Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections

      SEXUALLY TRANSMITTED INFECTIONS
    10. Ellepola, ANB; Samaranayake, LP
      Adjunctive use of chlorhexidine in oval candidoses: a review

      ORAL DISEASES
    11. Hossain, MA; Ghannoum, MA
      New developments in chemotherapy for non-invasive fungal infections

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    12. Groll, AH; Walsh, TJ
      Caspofungin: pharmacology, safety and therapeutic potential in superficialand invasive fungal infections

      EXPERT OPINION ON INVESTIGATIONAL DRUGS

    13. Bissulfonamides as inhibitors of the dehydroquinate synthetase enzyme AroBand of the type II dehydroquinase enzyme AroQ

      EXPERT OPINION ON THERAPEUTIC PATENTS
    14. Manavathu, EK; Abraham, OC; Chandrasekar, PH
      Isolation and in vitro susceptibility to amphotericin B, itraconazole and posaconazole of voriconazole-resistant laboratory isolates of Aspergillus fumigatus

      CLINICAL MICROBIOLOGY AND INFECTION
    15. Moore, CB; Oakley, KL; Denning, DW
      In vitro activity of a new echinocandin, LY303366, and comparison with fluconazole, flucytosine and amphotericin B against Candida species

      CLINICAL MICROBIOLOGY AND INFECTION
    16. Jansen, R; Redekop, WK; Rutten, FFH
      Cost effectiveness of continuous terbinafine compared with intermittent itraconazole in the treatment of dermatophyte toenail onychomycosis - An analysis based on results from the LION study

      PHARMACOECONOMICS
    17. Giammanco, GM; Pecorella, S; Distefano, S; Pecoraro, V; Milici, ME; Pizzo, G
      Fluconazole susceptibility of Italian Candida dabliniensis clinical isolates determined by reference and simplified tests

      MICROBIOLOGICA
    18. Yucesoy, M; Guldas, NS; Yulug, N
      Disk diffusion method for fluconazole susceptibility testing of Candida albicans strains

      JOURNAL OF CHEMOTHERAPY
    19. Ally, R; Schurmann, D; Kreisel, W; Carosi, G; Aguirrebengoa, K; Dupont, B; Hodges, M; Troke, P; Romero, AJ
      A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients

      CLINICAL INFECTIOUS DISEASES
    20. Villanueva, A; Arathoon, EG; Gotuzzo, E; Berman, RS; DiNubile, MJ; Sable, CA
      A randomized double-blind study of caspofungin versus amphotericin for thetreatment of candidal esophagitis

      CLINICAL INFECTIOUS DISEASES
    21. Miller, DJ; Mejicano, GC
      Vertebral osteomyelitis due to Candida species: Case report and literaturereview

      CLINICAL INFECTIOUS DISEASES
    22. Gupta, AK; Gregurek-Novak, T
      Efficacy of itraconazole, terbinafine, fluconazole, griseofulvin and ketoconazole in the treatment of Scopulariopsis brevicaulis causing onychomycosis of the toes

      DERMATOLOGY
    23. Sun, XC; Zhang, YZ; Zeckner, D; Current, W; Chen, SH
      Synthesis and evaluation of novel pseudomycin side-chain analogues. Part 3

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    24. Bader, O; Schaller, M; Klein, S; Kukula, J; Haack, K; Muhlschlegel, F; Korting, HC; Schafer, W; Hube, B
      The KEX2 gene of Candida glabrata is required for cell surface integrity

      MOLECULAR MICROBIOLOGY
    25. Breierova, E; Sajbidor, J; Lamacka, M
      The influence of newly synthesised fenpropimorph derivatives on some pathogen yeasts

      ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
    26. Wolfger, H; Mamnun, YM; Kuchler, K
      Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification

      RESEARCH IN MICROBIOLOGY
    27. Anil, S; Ellepola, ANB; Samaranayake, LP
      Post-antifungal effect of polyene, azole and DNA-analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV disease

      JOURNAL OF ORAL PATHOLOGY & MEDICINE
    28. Jokinen, MJ; Ahonen, J; Neuvonen, PJ; Olkkola, KT
      Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine

      PHARMACOLOGY & TOXICOLOGY
    29. Germaud, P; Renaudin, K; Danner, I; Morin, O; De Lajartre, AY
      Bronchopulmonary aspergillosis: new developments

      REVUE DES MALADIES RESPIRATOIRES
    30. Panwar, SL; Krishnamurthy, S; Gupta, V; Alarco, AM; Raymond, M; Sanglard, D; Prasad, R
      CaALK8, an alkane assimilating cytochrome P450, confers multidrug resistance when expressed in a hypersensitive strain of Candida albicans

      YEAST
    31. Emami, S; Shafiee, A
      Stereoselective syntheses of (E)- and (Z)-2,3-dihydro-3-(1,2,4-triazolyl)-4H-1-benzopyran-4-one oxime ethers

      HETEROCYCLES
    32. Ellabib, MS; ElJariny, IA
      In vitro activity of 6 antifungal agents on candida species isolated as causative agents from vaginal and other clinical specimens

      SAUDI MEDICAL JOURNAL
    33. Palacin, C; Tarrago, C; Agut, J; Guglietta, A
      In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates

      METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
    34. Sharma, S; Kaur, H; Khuller, GK
      Cell cycle effects of the phenothiazines: trifluoperazine and chlorpromazine in Candida albicans

      FEMS MICROBIOLOGY LETTERS
    35. Koks, CHW; Crommentuyn, KML; Hoetelmans, RMW; Burger, DM; Koopmans, PP; Mathot, RAA; Mulder, JW; Meenhorst, PL; Beijnen, JH
      The effect of fluconazole on ritonavir and saquinavir pharmacokinetics in HIV-1-infected individuals

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    36. Rambali, B; Fernandez, JA; Van Nuffel, L; Woestenborghs, F; Baert, L; Massart, DL; Odds, FC
      Susceptibility testing of pathogenic fungi with itraconazole: a process analysis of test variables

      Journal of antimicrobial chemotherapy
    37. Shadkchan, Y; Segal, E
      Treatment of experimental candidosis with amphotericin B-Intralipid admixtures in immunocompromised mice

      Journal of antimicrobial chemotherapy
    38. Maebashi, K; Niimi, M; Kudoh, M; Fischer, FJ; Makimura, K; Niimi, K; Piper, RJ; Uchida, K; Arisawa, M; Cannon, RD; Yamaguchi, H
      Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients

      Journal of antimicrobial chemotherapy
    39. Kontoyiannis, DP
      A clinical perspective for the management of invasive fungal infections: Focus on IDSA guidelines

      PHARMACOTHERAPY
    40. D'Auria, FD; Tecca, M; Strippoli, R; Simonetti, N
      In vitro activity of propyl gallate-azole drug combination against fluconazole- and itraconazole-resistant Candida albicans strains

      LETTERS IN APPLIED MICROBIOLOGY
    41. Kohli, A; Gupta, V; Krishnamurthy, S; Hasnain, SE; Prasad, R
      Specificity of drug transport mediated by CaMDR1: a major facilitator of Candida albicans

      JOURNAL OF BIOSCIENCES
    42. Garcia-Martos, P; Dominguez, I; Marin, P; Garcia-Agudo, R; Mira, SAYJ
      Antifungal susceptibility of emerging yeast pathogens

      ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
    43. Gupta, AK; Lynde, CW; Konnikov, N
      Single-blind, randomized, prospective study of sequential itraconazole andterbinafine pulse compared with terbinafine pulse for the treatment of toenail onychomycosis

      JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
    44. Lundmark, J; Reis, M; Bengtsson, F
      Serum concentrations of fluoxetine in the clinical treatment setting

      THERAPEUTIC DRUG MONITORING
    45. Ramage, G; Vande Walle, K; Wickes, BL; Lopez-Ribot, JL
      Biofilm formation by Candida dubliniensis

      JOURNAL OF CLINICAL MICROBIOLOGY
    46. Gupta, AK; Kohli, Y; Summerbell, RC
      Variation in restriction fragment length polymorphisms among serial isolates from patients with Trichophyton rubrum infection

      JOURNAL OF CLINICAL MICROBIOLOGY
    47. Liao, RS; Rennie, RP; Talbot, JA
      Novel fluorescent broth microdilution method for fluconazole susceptibility testing of Candida albicans

      JOURNAL OF CLINICAL MICROBIOLOGY
    48. Espinel-Ingroff, A
      In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi

      JOURNAL OF CLINICAL MICROBIOLOGY
    49. Meletiadis, J; Meis, JFGM; Mouton, JW; Verweij, PE
      Analysis of growth characteristics of filamentous fungi in different nutrient media

      JOURNAL OF CLINICAL MICROBIOLOGY
    50. Pfaller, MA; Messer, SA; Mills, K; Bolmstrom, A; Jones, RN
      Evaluation of etest method for determining caspofungin (MK-0991) susceptibilities of 726 clinical isolates of Candida species

      JOURNAL OF CLINICAL MICROBIOLOGY
    51. Pfaller, MA; Messer, SA; Mills, K; Bolmstrom, A; Jones, RN
      Evaluation of Etest method for determining posaconazole MICs for 314 clinical isolates of Candida species

      JOURNAL OF CLINICAL MICROBIOLOGY
    52. Venkatakrishnan, K; Schmider, J; Harmatz, JS; Ehrenberg, BL; von Moltke, LL; Graf, JA; Mertzanis, P; Corbett, KE; Rodriguez, MC; Shader, RI; Greenblatt, DJ
      Relative contribution of CYP3A to amitriptyline clearance in humans: In vitro and in vivo studies

      JOURNAL OF CLINICAL PHARMACOLOGY
    53. Ekins, S; De Groot, MJ; Jones, JP
      Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome P450 active sites

      DRUG METABOLISM AND DISPOSITION
    54. Espinel-Ingroff, A; Bartlett, M; Chaturvedi, V; Ghannoum, M; Hazen, KC; Pfaller, MA; Rinaldi, M; Walsh, TJ
      Optimal susceptibility testing conditions for detection of azole resistance in Aspergillus spp.: NCCLS collaborative evaluation

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    55. Andes, D; Stamsted, T; Conklin, R
      Pharmacodynamics of amphotericin B in a neutropenic-mouse disseminated-candidiasis model

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    56. Larabi, M; Legrand, P; Appel, M; Gil, S; Lepoivre, M; Devissaguet, JP; Puisieux, F; Barratt, G
      Reduction of NO synthase expression and tumor necrosis factor alpha production in macrophages by amphotericin B lipid carriers

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    57. Nakamura, K; Niimi, M; Niimi, K; Holmes, AR; Yates, JE; Decottignies, A; Monk, BC; Goffeau, A; Cannon, RD
      Functional expression of candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    58. Wirsching, S; Moran, GP; Sullivan, DJ; Coleman, DC; Morschhauser, J
      MDR1-mediated drug resistance in Candida dubliniensis

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    59. Woyke, T; Pettit, GR; Winkelmann, G; Pettit, RK
      In vitro activities and postantifungal effects of the potent dolastatin 10derivative auristatin PHE

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    60. Nakayama, H; Nakayama, N; Arisawa, M; Aoki, Y
      In vitro and in vivo effects of 14 alpha-demethylase (ERG11) depletion in Candida glabrata

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    61. Pfaller, MA; Messer, SA; Hollis, RJ; Jones, RN
      In vitro activities of posaconazole (Sch 56592) compared with those of itraconazole and fluconazole against 3,685 clinical isolates of Candida spp. and Cryptococcus neoformans

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    62. Krohn, K; Florke, U; John, M; Root, N; Steingrover, K; Aust, HJ; Draeger, S; Schulz, B; Antus, S; Simonyi, M; Zsila, F
      Biologically active metabolites from fungi. Part 16: New preussomerins J, K and L from an endophytic fungus: structure elucidation, crystal structureanalysis and determination of absolute configuration by CD calculations

      TETRAHEDRON
    63. Hwang, EI; Ahn, BT; Lee, HB; Kim, YK; Lee, KS; Bok, SH; Kim, YT; Kim, SU
      Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds

      PLANTA MEDICA
    64. Schnabel, G; Jones, AL
      The 14 alpha-demethylase (CYP51A1) gene is overexpressed in Venturia inaequalis strains resistant to myclobutanil

      PHYTOPATHOLOGY
    65. Mariotta, S; Giuffreda, E; Tramontano, F; Treggiari, S; Ricci, A; Schmid, G
      Therapeutic approach in pulmonary mycetoma - Analysis of 27 patients

      PANMINERVA MEDICA
    66. Podust, LM; Poulos, TL; Waterman, MR
      Crystal structure of cytochrome P450 14 alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    67. Chandrasekar, PH; Manavathu, E
      Voriconazole: A second-generation triazole

      DRUGS OF TODAY
    68. Cupp-Vickery, JR; Garcia, C; Hofacre, A; McGee-Estrada, K
      Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF

      JOURNAL OF MOLECULAR BIOLOGY
    69. Pina-Vaz, C; Sansonetty, F; Rodrigues, AG; Costa-De-Oliveira, S; Martinez-De-Oliveira, J; Fonseca, AF
      Susceptibility to fluconazole of Candida clinical isolates determined by FUN-1 staining with flow cytometry and epifluorescence microscopy

      JOURNAL OF MEDICAL MICROBIOLOGY
    70. Nitahara, Y; Kishimoto, K; Yabusaki, Y; Gotoh, O; Yoshida, Y; Horiuchi, T; Aoyama, Y
      The amino acid residues affecting the activity and azole susceptibility ofrat CYP51 (Sterol 14-demethylase p450)

      JOURNAL OF BIOCHEMISTRY
    71. Chandra, J; Kuhn, DM; Mukherjee, PK; Hoyer, LL; McCormick, T; Ghannoum, MA
      Biofilm formation by the fungal pathogen Candida albicans: Development, architecture, and drug resistance

      JOURNAL OF BACTERIOLOGY
    72. Milani, G; Schereiber, AZ; Vercesi, AE
      Ca2+ transport into an intracellular acidic compartment of Candida parapsilosis

      FEBS LETTERS
    73. Abbasoglu, OE; Hosal, BM; Sener, B; Erdemoglu, N; Gursel, E
      Penetration of topical fluconazole into human aqueous humor

      EXPERIMENTAL EYE RESEARCH
    74. Aboul-Enein, HY; Ali, I
      Enantiomeric resolution of some imidazole antifungal agents on Chiralpak WH chiral stationary phase using HPLC

      CHROMATOGRAPHIA
    75. Samaranayake, YH; Samaranayake, LP; Yeung, KWS
      Evaluation of polyene-azole antagonism in liquid cultures of Candida albicans using an automated turbidometric method

      CHEMOTHERAPY
    76. Lamb, DC; Cannieux, M; Warrilow, AGS; Bak, S; Kahn, RA; Manning, NJ; Kelly, DE; Kelly, SL
      Plant sterol 14 alpha-demethylase affinity for azole fungicides

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    77. Gupta, AK; Joseph, WS
      Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States

      JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
    78. Gupta, AK; Malkin, KF
      Ciclopirox nail lacquer and podiatric practice

      JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
    79. Ellis, M; Richardson, M
      Management

      HOSPITAL MEDICINE
    80. Bu, HZ; Poglod, M; Micetich, RG; Khan, JK
      Novel sample preparation method facilitating identification of urinary drug metabolites by liquid chromatography-tandem mass spectrometry

      JOURNAL OF CHROMATOGRAPHY B
    81. Sugar, AM; Liu, XP
      Effect of grapefruit juice on serum voriconazole concentrations in the mouse

      MEDICAL MYCOLOGY
    82. Ponton, J; Ruchel, R; Clemons, KV; Coleman, DC; Grillot, R; Guarro, J; Aldebert, D; Ambroise-Thomas, P; Cano, J; Carrillo-Munoz, AJ; Gene, J; Pinel, C; Stevens, DA; Sullivan, DJ
      Emerging pathogens

      MEDICAL MYCOLOGY
    83. Calabrese, D; Bille, J; Sanglard, D
      A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole

      MICROBIOLOGY-UK
    84. Gupta, AK
      Onychomycosis in the elderly

      DRUGS & AGING
    85. Amrouni, B; Pereiro, M; Florez, A; Pontes, C; Izquierdo, I; Toribio, J
      A phase-III comparative study of the efficacies of flutrimazole versus clotrimazole for the treatment of vulvovaginal candidiasis

      JOURNAL DE MYCOLOGIE MEDICALE
    86. Michel-Nguyen, A; Favel, A; Azan, P; Regli, P; Penaud, A
      Candida (Torulopsis) glabrata: a 19-year epidemiological study in a university hospital; susceptibility

      JOURNAL DE MYCOLOGIE MEDICALE
    87. Fanos, V; Cataldi, L
      Amphotericin B-induced nephrotoxicity: A review

      JOURNAL OF CHEMOTHERAPY
    88. Cross, EW; Park, S; Perlin, DS
      Cross-resistance of clinical isolates of Candida albicans and Candida glabrata to over-the-counter azoles used in the treatment of vaginitis

      MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE
    89. Donlan, RM
      Role of biofilms in antimicrobial resistance

      ASAIO JOURNAL
    90. Ellepola, ANB; Samaranayake, LP
      Oral candidal infections and antimycotics

      CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
    91. Ragno, R; Marshall, GR; Di Santo, R; Costi, R; Massa, S; Rompei, R; Artico, M
      Antimycobacterial pyrroles: Synthesis, anti-Mycobacterium tuberculosis activity and QSAR studies

      BIOORGANIC & MEDICINAL CHEMISTRY
    92. Mangla, AT; Nes, WD
      Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition

      BIOORGANIC & MEDICINAL CHEMISTRY
    93. Cotter, G; Kavanagh, K
      Adherence mechanisms of Candida albicans

      BRITISH JOURNAL OF BIOMEDICAL SCIENCE
    94. Geraghty, M; Cronin, JF; Devereux, M; McCann, M
      Synthesis and antimicrobial activity of copper(II) and manganese(II) alpha,omega-dicarboxylate complexes

      BIOMETALS
    95. Morschhauser, J; Kohler, G; Ziebuhr, W; Blum-Oehler, G; Dobrindt, U; Hacker, J
      Evolution of microbial pathogens

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    96. Wirsching, S; Michel, S; Morschhauser, J
      Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates

      MOLECULAR MICROBIOLOGY
    97. Alvarez-Fernandez, JG; Castano-Suarez, E; Comejo-Navarro, P; de la Fuente, EG; de Frutos, FJO; Iglesias-Diez, L
      Photosensitivity induced by oral itraconazole

      JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
    98. Lee, JK; Peters, D; Obias, AA; Noskin, GA; Peterson, LR
      Activity of voriconazole against Candida albicans and Candida krusei isolated since 1984

      INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
    99. Ascioglu, S; de Pauw, BE; Meis, JFGM
      Prophylaxis and treatment of fungal infections associated with haematological malignancies

      INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
    100. Chalumeau, M; Adamsbaum, C; Raymond, J; Iniguez, JL; Gendrel, D
      Mediastinal aspergilloma ten years after thoracic surgery

      PEDIATRIC INFECTIOUS DISEASE JOURNAL


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Documento generato il 28/01/21 alle ore 01:15:35