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La ricerca find articoli where soggetti phrase all words 'AMYLOID PRECURSOR PROTEIN' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 2281 riferimenti
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    1. Aliev, G; Smith, MA; Seyidova, D; Neal, ML; Lamb, BT; Nunomura, A; Gasimov, EK; Vinters, HV; Perry, G; LaManna, JC; Friedland, RP
      The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease

      BRAIN PATHOLOGY
    2. Hass, S; Weidemann, A; Utermann, G; Baier, G
      Intracellular apolipoprotein E affects amyloid precursor protein processing and amyloid A beta production in COS-1 cells

      MOLECULAR GENETICS AND GENOMICS
    3. Nalivaeva, NN; Turner, AJ
      Post-translational modifications of proteins: Acetylcholinesterase as a model system

      PROTEOMICS
    4. Travins, JM; Bursavich, MG; Veber, DF; Rich, DH
      Aspartic protease inhibitors: Expedient synthesis of 2-substituted statines

      ORGANIC LETTERS
    5. Golde, TE; Younkin, SG
      Presenilins as therapeutic targets for the treatment of Alzheimer's disease

      TRENDS IN MOLECULAR MEDICINE
    6. Yong, VW; Power, C; Forsyth, P; Edwards, DR
      Metalloproteinases in biology and pathology of the nervous system

      NATURE REVIEWS NEUROSCIENCE
    7. Chen, FS; Yu, G; Arawaka, S; Nishimura, M; Kawarai, T; Yu, H; Tandon, A; Supala, A; Song, YQ; Rogaeva, E; Milman, P; Sato, C; Yu, C; Janus, C; Lee, J; Song, LX; Zhang, LL; Fraser, PE; St George-Hyslop, PH
      Nicastrin binds to membrane tethered Notch

      NATURE CELL BIOLOGY
    8. Petit, A; Bihel, F; da Costa, CA; Pourquie, O; Checler, F; Kraus, JL
      New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage

      NATURE CELL BIOLOGY
    9. De Strooper, B; Annaert, W
      Presenilins and the intramembrane proteolysis of proteins: facts and fiction

      NATURE CELL BIOLOGY
    10. Rohlff, C
      Proteomics in neuropsychiatric disorders

      INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
    11. Shastry, BS
      Molecular and cell biological aspects of Alzheimer disease

      JOURNAL OF HUMAN GENETICS
    12. Toepert, F; Pires, JR; Landgraf, C; Oschkinat, H; Schneider-Mergener, J
      Synthesis of an array comprising 837 variants of the hYAP WW protein domain

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    13. Bogdanovic, N; Zilmer, M; Zilmer, K; Rehema, A; Karelson, E
      The Swedish APP670/671 Alzheimer's disease mutation: The first evidence for strikingly increased oxidative injury in the temporal inferior cortex

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    14. Davidsson, P; Bogdanovic, N; Lannfelt, L; Blennow, K
      Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    15. Sjogren, M; Davidsson, P; Gottfries, J; Vanderstichele, H; Edman, A; Vanmechelen, E; Wallin, A; Blennow, K
      The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    16. Huse, JT; Doms, RW
      Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease

      TRAFFIC
    17. Daugherty, BL; Green, SA
      Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing

      TRAFFIC
    18. Jankowsky, JL; Slunt, HH; Ratovitski, T; Jenkins, NA; Copeland, NG; Borchelt, DR
      Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

      BIOMOLECULAR ENGINEERING
    19. Parisi, V; Restuccia, R; Fattapposta, F; Mina, C; Bucci, MG; Pierelli, F
      Morphological and functional retinal impairment in Alzheimer's disease patients

      CLINICAL NEUROPHYSIOLOGY
    20. Moss, ML; White, JM; Lambert, MH; Andrews, RC
      TACE and other ADAM proteases as targets for drug discovery

      DRUG DISCOVERY TODAY
    21. Golde, TE; Eckman, CB
      Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease

      DRUG DISCOVERY TODAY
    22. Racchi, M; Sironi, M; Caprera, A; Konig, G; Govoni, S
      Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein

      MOLECULAR PSYCHIATRY
    23. Zubenko, GS; Hughes, HB; Stiffler, JS
      D10S1423 identifies a susceptibility locus for Alzheimer's disease in a prospective, longitudinal, double-blind study of asymptomatic individuals

      MOLECULAR PSYCHIATRY
    24. Emre, M; Qizilbash, N
      Experimental approaches and drugs in development for the treatment of dementia

      EXPERT OPINION ON INVESTIGATIONAL DRUGS

    25. Statine-derived tetrapeptide inhibitors of beta-secretase - Elan Pharm., Inc.: WO0077030

      EXPERT OPINION ON THERAPEUTIC PATENTS
    26. Stoessl, AJ
      Antisense strategies for the treatment of neurological disease

      EXPERT OPINION ON THERAPEUTIC PATENTS
    27. Myers, AJ; Goate, AM
      The genetics of late-onset Alzheimer's disease

      CURRENT OPINION IN NEUROLOGY
    28. Duff, K; Rao, MV
      Progress in the modeling of neurodegenerative diseases in transgenic mice

      CURRENT OPINION IN NEUROLOGY
    29. Heo, HJ; Cho, HY; Hong, BS; Kim, HK; Kim, EK; Kim, BG; Shin, DH
      Protective effect of 4 ',5-dihydroxy-3 ',6,7-trimethoxyflavone from Artemisia asiatica against A beta-indueed oxidative stress in PC12 cells

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    30. Dominguez, DI; De Strooper, B; Annaert, W
      Secretases as therapeutic targets for the treatment of Alzheimer's disease

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    31. Giacobini, E
      Do cholinesterase inhibitors have disease-modifying effects in Alzheimer'sdisease?

      CNS DRUGS
    32. Martin, LJ
      Neuronal cell death in nervous system development, disease, and injury (Review)

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    33. Nilsberth, C; Westlind-Danielsson, A; Eckman, CB; Condron, MM; Axelman, K; Forsell, C; Stenh, C; Luthman, J; Teplow, DB; Younkin, SG; Naslund, J; Lannfelt, L
      The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

      NATURE NEUROSCIENCE
    34. Cai, HB; Wang, YS; McCarthy, D; Wen, HJ; Borchelt, DR; Price, DL; Wong, PC
      BACE1 is the major beta-secretase for generation of A beta peptides by neurons

      NATURE NEUROSCIENCE
    35. Chen, M; Fernandez, HL
      Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency

      FRONTIERS IN BIOSCIENCE
    36. Chen, M; Fernandez, HL
      Alzheimer movement re-examined 25 years later: Is it a "disease" or a senile condition in medical nature?

      FRONTIERS IN BIOSCIENCE
    37. Argraves, WS
      Members of the low density lipoprotein receptor family control diverse physiological processes

      FRONTIERS IN BIOSCIENCE
    38. Hussain, MM
      Structural, biochemical and signaling properties of the low-density lipoprotein receptor gene family

      FRONTIERS IN BIOSCIENCE
    39. Swertfeger, DK; Hui, DY
      Apolipoprotein E: A cholesterol transport protein with lipid transport-independent cell signaling properties

      FRONTIERS IN BIOSCIENCE
    40. Reynish, W; Andrieu, S; Nourhashemi, F; Vellas, B
      Nutritional factors and Alzheimer's disease

      JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
    41. Balaspiri, L; Langel, U
      Synthesis of of beta-amyloid precursor peptide and presenilin segments

      JOURNAL OF PEPTIDE SCIENCE
    42. Snow, DM; Mullins, N; Hynds, DL
      Nervous system-derived chondroitin sulfate proteoglycans regulate growth cone morphology and inhibit neurite outgrowth: A light, epifluorescence, andelectron microscopy study

      MICROSCOPY RESEARCH AND TECHNIQUE
    43. Patrie, KM; Drescher, AJ; Goyal, M; Wiggins, RC; Margolis, B
      The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes

      JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
    44. Moceri, VM; Kukull, WA; Emanual, I; van Belle, G; Starr, JR; Schellenberg, GD; McCormick, WC; Bowen, JD; Teri, L
      Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimers disease

      EPIDEMIOLOGY
    45. Battaini, F
      Protein kinase c isoforms as therapeutic targets in nervous system diseasestates

      PHARMACOLOGICAL RESEARCH
    46. Head, E; Garzon-Rodriguez, W; Johnson, JK; Lott, IT; Cotman, CW; Glabe, C
      Oxidation of a beta and plaque biogenesis in Alzheimer's disease and Down syndrome

      NEUROBIOLOGY OF DISEASE
    47. Poduslo, JF; Curran, GL; Wengenack, TM; Malester, B; Duff, K
      Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease

      NEUROBIOLOGY OF DISEASE
    48. Harkany, T; O'Mahony, S; Keijser, J; Kelly, JP; Konya, C; Borostyankoi, ZA; Gorcs, TJ; Zarandi, M; Penke, B; Leonard, BE; Luiten, PGM
      beta-amyloid((1-42))-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex

      NEUROBIOLOGY OF DISEASE
    49. Steiner, H; Winkler, E; Shearman, MS; Prywes, R; Haass, C
      Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins

      NEUROBIOLOGY OF DISEASE
    50. Ditaranto, K; Tekirian, TL; Yang, AJ
      Lysosomal membrane damage in soluble A beta-mediated cell death in Alzheimer's disease

      NEUROBIOLOGY OF DISEASE
    51. Van den Haute, C; Spittaels, K; Van Dorpe, J; Lasrado, R; Vandezande, K; Laenen, I; Geerts, H; Van Leuven, F
      Coexpression of human cdk5 and its activator p35 with human protein tau inneurons in brain of triple transgenic mice

      NEUROBIOLOGY OF DISEASE
    52. Chung, CW; Song, YH; Kim, IK; Yoon, WJ; Ryu, BR; Jo, DG; Woo, HN; Kwon, YK; Kim, HH; Gwag, BJ; Mook-Jung, IH; Jung, YK
      Proapoptotic effects of Tau cleavage product generated by caspase-3

      NEUROBIOLOGY OF DISEASE
    53. De Jonghe, C; Esselens, C; Kumar-Singh, S; Craessaerts, K; Serneels, S; Checler, F; Annaert, W; Van Broeckhoven, C; De Strooper, B
      Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability

      HUMAN MOLECULAR GENETICS
    54. Roberds, SL; Anderson, J; Basi, G; Bienkowski, MJ; Branstetter, DG; Chen, KS; Freedman, SB; Frigon, NL; Games, D; Hu, K; Johnson-Wood, K; Kappenman, KE; Kawabe, TT; Kola, I; Kuehn, R; Lee, M; Liu, WQ; Motter, R; Nichols, NF; Power, M; Robertson, DW; Schenk, D; Schoor, M; Shopp, GM; Shuck, ME; Sinha, S; Svensson, KA; Tatsuno, G; Tintrup, H; Wijsman, J; Wright, S; McConlogue, L
      BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

      HUMAN MOLECULAR GENETICS
    55. Giraldo, P; Montoliu, L
      Size matters: Use of YACs, BACs and PACs in transgenic animals

      TRANSGENIC RESEARCH
    56. Morris, RGM
      Episodic-like memory in animals: psychological criteria, neural mechanismsand the value of episodic-like tasks to investigate animal models of neurodegenerative disease

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    57. Goedert, M; Spillantini, MG; Serpell, LC; Berriman, J; Smith, MJ; Jakes, R; Crowther, RA
      From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    58. Riddell, DR; Christie, G; Hussain, I; Dingwall, C
      Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

      CURRENT BIOLOGY
    59. Lyons, D; McLoughlin, DM
      Recent advances - Psychiatry

      BRITISH MEDICAL JOURNAL
    60. Nowotny, P; Kwon, JM; Chakraverty, S; Nowotny, V; Morris, JC; Goate, AM
      Association studies using novel polymorphisms in BACE1 and BACE2

      NEUROREPORT
    61. Naidu, A; Catalano, R; Bales, K; Wu, S; Paul, SM; Cordell, B
      Conversion of brain apolipoprotein E to an insoluble form in a mouse modelof Alzheimer disease

      NEUROREPORT
    62. Eckert, GP; Kirsch, C; Mueller, WE
      Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice

      NEUROREPORT
    63. Murphy, T; Yip, A; Brayne, C; Easton, D; Evans, JG; Xuereb, J; Cairns, N; Esiri, MM; Rubinsztein, DC
      The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease

      NEUROREPORT
    64. Gonzalez-Lima, F; Berndt, JD; Valla, JE; Games, D; Reiman, EM
      Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease

      NEUROREPORT
    65. Lukiw, WJ; Gordon, WC; Rogaev, EI; Thompson, H; Bazan, NG
      Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis

      NEUROREPORT
    66. Walter, J; Kaether, C; Steiner, H; Haass, C
      The cell biology of Alzheimer's disease: uncovering the secrets of secretases

      CURRENT OPINION IN NEUROBIOLOGY
    67. Shepherd, J
      Issues surrounding age: vascular disease in the elderly

      CURRENT OPINION IN LIPIDOLOGY
    68. Dietschy, JM; Turley, SD
      Cholesterol metabolism in the brain

      CURRENT OPINION IN LIPIDOLOGY
    69. Fortini, ME
      Notch and Presenilin: a proteolytic mechanism emerges

      CURRENT OPINION IN CELL BIOLOGY
    70. Rossner, S; Mendla, K; Schliebs, R; Bigl, V
      Protein kinase C alpha and beta 1 isoforms are regulators of alpha-secretory proteolytic processing of amyloid precursor protein in vivo

      EUROPEAN JOURNAL OF NEUROSCIENCE
    71. Rossner, S; Mehlhorn, G; Schliebs, R; Bigl, V
      Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology

      EUROPEAN JOURNAL OF NEUROSCIENCE
    72. Koizumi, K; Nakajima, M; Yuasa, S; Saga, Y; Sakai, T; Kuriyama, T; Shirasawa, T; Koseki, H
      The role of presenilin 1 during somite segmentation

      DEVELOPMENT
    73. Hartmann, U; Maurer, P
      Proteoglycans in the nervous system - the quest for functional roles in vivo

      MATRIX BIOLOGY
    74. Sayre, LM; Smith, MA; Perry, G
      Chemistry and biochemistry of oxidative stress in neurodegenerative disease

      CURRENT MEDICINAL CHEMISTRY
    75. Imaizumi, K; Miyoshi, K; Katayama, T; Yoneda, T; Taniguchi, M; Kudo, T; Tohyama, M
      The unfolded protein response and Alzheimer's disease

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
    76. Singleton, RH; Stone, JR; Okonkwo, DO; Pellicane, AJ; Povlishock, JT
      The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury

      JOURNAL OF NEUROTRAUMA
    77. Kupina, NC; Nath, R; Bernath, EE; Inoue, J; Mitsuyoshi, A; Yuen, PW; Wang, KKW; Hall, ED
      The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury

      JOURNAL OF NEUROTRAUMA
    78. Leclercq, PD; McKenzie, JE; Graham, DI; Gentleman, SM
      Axonal injury is accentuated in the caudal corpus callosum of head-injuredpatients

      JOURNAL OF NEUROTRAUMA
    79. Yu, HK; Saura, CA; Choi, SY; Sun, LD; Yang, XD; Handler, M; Kawarabayashi, T; Younkin, L; Fedeles, B; Wilson, MA; Younkin, S; Kandel, ER; Kirkwood, A; Shen, J
      APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

      NEURON
    80. Herz, J
      The LDL receptor gene family: (Un)expected signal transducers in the brain

      NEURON
    81. Morris, JC; Price, JL
      Pathologic correlates of nondemented aging, mild cognitive impairment, andearly-stage Alzheimer's disease

      JOURNAL OF MOLECULAR NEUROSCIENCE
    82. Galasko, D
      Biological markers and the treatment of Alzheimer's disease

      JOURNAL OF MOLECULAR NEUROSCIENCE
    83. Vassar, R
      The beta-secretase, BACE - A prime drug target for Alzheimer's disease

      JOURNAL OF MOLECULAR NEUROSCIENCE
    84. Hartmann, D; Tournoy, J; Saftig, P; Annaert, W; De Strooper, B
      Implication of APP secretases in notch signaling

      JOURNAL OF MOLECULAR NEUROSCIENCE
    85. Thinakaran, G
      Metabolism of presenilins

      JOURNAL OF MOLECULAR NEUROSCIENCE
    86. Steiner, H; Haass, C
      Nuclear signaling - A common function of presenilin substrates?

      JOURNAL OF MOLECULAR NEUROSCIENCE
    87. Wolfe, MS
      gamma-secretase inhibitors as molecular probes of presenilin function

      JOURNAL OF MOLECULAR NEUROSCIENCE
    88. Wong, PC; Cai, HB; Borchelt, DR; Price, DL
      Genetically engineered models relevant to neurodegenerative disorders - Their value for understanding disease mechanisms and designing/testing experimental therapeutics

      JOURNAL OF MOLECULAR NEUROSCIENCE
    89. Schenk, D; Games, D; Seubert, P
      Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization

      JOURNAL OF MOLECULAR NEUROSCIENCE
    90. Mautes, AEM; Thome, D; Steudel, WI; Nacimiento, AC; Yang, Y; Shohami, E
      Changes in regional energy metabolism after closed head injury in the rat

      JOURNAL OF MOLECULAR NEUROSCIENCE
    91. Aisen, PS; Marin, DB; Brickman, AM; Santoro, J; Fusco, M
      Pilot tolerability studies of hydroxychloroquine and colchicine in Alzheimer disease

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    92. Anders, A; Gilbert, S; Garten, W; Postina, R; Fahrenholz, F
      Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases

      FASEB JOURNAL
    93. Choi, SH; Park, CH; Koo, JW; Seo, JH; Kim, HS; Jeong, SJ; Lee, JH; Kim, SS; Suh, YH
      Memory impairment and cholinergic dysfunction by centrally administered A beta and carboxyl-terminal fragment of Alzheimer's APP in mice

      FASEB JOURNAL
    94. Pinnix, I; Council, JE; Roseberry, B; Onstead, L; Mallender, W; Sucic, J; Sambamurti, K
      Convertases other than furin cleave beta-secretase to its mature form

      FASEB JOURNAL
    95. Vaucher, E; Aumont, N; Pearson, D; Rowe, W; Poirier, J; Kar, S
      Amyloid beta peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats

      JOURNAL OF CHEMICAL NEUROANATOMY
    96. Clarke, NA; Soininen, H; Gustafson, L; Minthon, L; Alhainen, K; Francis, PT
      Tacrine may alter APP-like protein levels in the lumbar CSF of Alzheimer patients

      INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
    97. Ripova, D; Strunecka, A
      An ideal biological marker of Alzheimer's disease: Dream or reality?

      PHYSIOLOGICAL RESEARCH
    98. Bani-Yaghoub, M; Felker, JM; Ozog, MA; Bechberger, JF; Naus, CCG
      Array analysis of the genes regulated during neuronal differentiation of human embryonal cells

      BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
    99. Kumar, VB; Vyas, K; Franko, M; Choudhary, V; Buddhiraju, C; Alvarez, J; Morley, JE
      Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8)

      BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
    100. Schneider, LS
      Treatment of Alzheimer's disease with cholinesterase inhibitors

      CLINICS IN GERIATRIC MEDICINE


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 14:58:08