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Agouti signaling protein stimulates islet amyloid polypeptide (amylin) secretion in pancreatic beta-cells
EXPERIMENTAL BIOLOGY AND MEDICINE
Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: A physiological approach toward improvedmetabolic control
CURRENT PHARMACEUTICAL DESIGN
Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Quantitation in receptor pharmacology
RECEPTORS & CHANNELS
Cloning, characterization and distribution of receptor activity central nervous system modifying proteins in the rat
EUROPEAN JOURNAL OF NEUROSCIENCE
Progressive histopathological changes in pancreatic islets of Zucker Diabetic Fatty rats
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Distribution of amylin-immunoreactive neurons in the monkey hypothalamus and their relationships with the histaminergic system
ARCHIVES OF HISTOLOGY AND CYTOLOGY
Receptor activity modifying proteins
CELLULAR SIGNALLING
Amylin and bone metabolism in streptozotocin-induced diabetic rats
JOURNAL OF BONE AND MINERAL RESEARCH
Pramlintide acetate - Antidiabetic
DRUGS OF THE FUTURE
The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema nucleus of the solitary tract (AP/NTS) lesioned rats
INTERNATIONAL JOURNAL OF OBESITY
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells
MOLECULAR AND CELLULAR BIOCHEMISTRY
Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat
PEPTIDES
Direct inhibitory effect of adrenomedullin, calcitonin gene-related peptide, calcitonin, and amylin on cholecystokinin-induced contraction of guinea-pig isolated caecal circular smooth muscle cells
PEPTIDES
Does neuropeptide Y contribute to the anorectic action of amylin?
PEPTIDES
Glucose and forskolin regulate IAPP gene expression through different signal transduction pathways
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Evidence that amylin stimulates lipolysis in vivo: a possible mediator of induced insulin resistance
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Expression of receptor-activity modifying protein (RAMP) mRNAs in the mouse brain
MOLECULAR BRAIN RESEARCH
Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Effect of calcitonin gene related peptide on the adenylate cyclase activity in abalone gill membranes
REGULATORY PEPTIDES
Gastric neuropeptides and gastric motor abnormality in streptozotocin-induced diabetic rats - Observation for four weeks after streptozotocin
DIGESTIVE DISEASES AND SCIENCES
Familial early-onset type 2 diabetes in Chinese patients - Obesity and genetics have more significant roles than autoimmunity
DIABETES CARE
Relationships of upper gastrointestinal motor and sensory function with glycemic control
DIABETES CARE
Insulin resistance and type 2 diabetes: time for a new hypothesis
NEW ZEALAND MEDICAL JOURNAL
Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Islet amyloid polypeptide: Identification of long-range contacts and localorder on the fibrillogenesis pathway
JOURNAL OF MOLECULAR BIOLOGY
Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis
JOURNAL OF MOLECULAR BIOLOGY
Systemic administration of adrenomedullin(27-52) increases bone volume andstrength in male mice
JOURNAL OF ENDOCRINOLOGY
Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide - An experimental support for the key role of the phenylalanine residue in amyloid formation
JOURNAL OF BIOLOGICAL CHEMISTRY
Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins
JOURNAL OF BIOLOGICAL CHEMISTRY
Adrenomedullin and the blood-brain barrier
HORMONE AND METABOLIC RESEARCH
Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation
FEBS LETTERS
Characterization of CGRP(1) receptors in the guinea pig basilar artery
EUROPEAN JOURNAL OF PHARMACOLOGY
A potential role for adrenomedullin as a local regulator of bone growth
ENDOCRINOLOGY
Diabetes mellitus and the stomach
DIABETOLOGIA
Islet amyloid polypeptide promotes beta-cell proliferation in neonatal ratpancreatic islets
DIABETOLOGIA
A novel mutation in islet amyloid polypeptide (IAPP) gene promoter is associated with Type II diabetes mellitus
DIABETOLOGIA
S20G mutation of the amylin gene is associated with Type II diabetes in Japanese
DIABETOLOGIA
Alteration in phosphorylation of P20 is associated with insulin resistance
DIABETES
The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site
DIABETES
beta-cell dysfunction and failure in type 2 diabetes - Potential mechanisms
DIABETES
Plasma islet amyloid polypeptide is not an effective tumor marker for pancreatic cancer even when protease inhibitors and rapid freezing of specimensare utilized
CLINICAL CHEMISTRY
CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (W098/11128), a non-peptide antagonist
BRITISH JOURNAL OF PHARMACOLOGY
Turn structures in CGRP C-terminal analogues promote stable arrangements of key residue side chains
BIOCHEMISTRY
Synthesis and purification of amyloidogenic peptides
ANALYTICAL BIOCHEMISTRY
Pharmacological characterization of the CGRP receptor in the lateral line organ of Xenopus laevis
JARO
Novel anti-obesity drugs
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block)
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION
Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP
MOLECULAR MEDICINE
Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP)
CHEMISTRY & BIOLOGY
Monitoring biomolecular interactions by time-lapse atomic force microscopy
JOURNAL OF STRUCTURAL BIOLOGY
Review: Amyloidogenesis-unquestioned answers and unanswered questions
JOURNAL OF STRUCTURAL BIOLOGY
Amyloid fibril formation from full-length and fragments of amylin
JOURNAL OF STRUCTURAL BIOLOGY
Human amylin stimulates inflammatory cytokine secretion from human glioma cells
NEUROIMMUNOMODULATION
Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry
PROTEIN SCIENCE
Calcitonin and calcitonin receptors: bone and beyond
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
Adiposity signals and the control of energy homeostasis
NUTRITION
A novel receptor for calcitonin gene-related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis
FASEB JOURNAL
Islet amyloid polypeptide regulates multiple steps in stimulus-secretion coupling of beta cells in rat pancreatic islets
PANCREAS
Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: Channel formation and disruption of calcium homeostasis
BRAIN RESEARCH BULLETIN
Islet amyloid polypeptide (amylin) modulates chylomicron metabolism in rats
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Genomic structure and chromosome mapping of human and mouse RAMP genes
CYTOGENETICS AND CELL GENETICS
Circulating amylin in human essential hypertension: heritability and earlyincrease in individuals at genetic risk
JOURNAL OF HYPERTENSION
Amylin receptors mediate the anorectic action of salmon calcitonin (sCT)
PEPTIDES
The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat
PEPTIDES
Systemic administration of a novel octapeptide, amylin-(1-8), increases bone volume in male mice
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Islet amyloid polypeptide (amylin)-deficient mice develop a more severe form of alloxan-induced diabetes
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
High-frequency oscillations in circulating amylin concentrations in healthy humans
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance
DIABETES RESEARCH AND CLINICAL PRACTICE
S20G mutation of the amylin gene in Japanese patients with type 2 diabetes
DIABETES RESEARCH AND CLINICAL PRACTICE
Aggregation of an amyloidogenic fragment of human islet amyloid polypeptide
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Calcitonin gene-related peptide (CGRP) inhibits contractions of the prostatic stroma of the rat but not the guinea-pig
REGULATORY PEPTIDES
A drug on the market?
LANCET
Immunohistochemical and statistical studies on the islets of Langerhans pancreas in autopsied patients after gastrectomy
HUMAN PATHOLOGY
Attenuation of the anorectic effects of cholecystokinin and bombesin by the specific amylin antagonist AC 253
PHYSIOLOGY & BEHAVIOR
Islet amyloid and type 2 diabetes mellitus
NEW ENGLAND JOURNAL OF MEDICINE
Agouti-related protein (83-132) aggregates and crosses the blood-brain barrier slowly
METABOLISM-CLINICAL AND EXPERIMENTAL
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia
JOURNAL OF NEUROCHEMISTRY
Isolation, structure, synthesis, and activity of a new member of the calcitonin gene-related peptide family from frog skin and molecular cloning of its precursor
JOURNAL OF BIOLOGICAL CHEMISTRY
Glucose regulates islet amyloid polypeptide gene transcription in a PDX1-and calcium-dependent manner
JOURNAL OF BIOLOGICAL CHEMISTRY
Effects of early protein restriction and adult obesity on rat pancreatic hormone content and glucose tolerance
HORMONE AND METABOLIC RESEARCH
Hormonal and metabolic counterregulation during and after high-dose insulin-induced hypoglycemia in diabetes mellitus type 2
HORMONE AND METABOLIC RESEARCH
Glycosylation of the calcitonin receptor-like receptor at Asn(60) or Asn(112) is important for cell surface expression
FEBS LETTERS
Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils
FEBS LETTERS
Effects of calcitonin gene-related peptide and amylin on human osteoblast-like cells proliferation
EUROPEAN JOURNAL OF PHARMACOLOGY
Positive inotropy mediated via CGRP receptors in isolated human myocardialtrabeculae
EUROPEAN JOURNAL OF PHARMACOLOGY
A rational approach to drug therapy of type 2 diabetes mellitus
DRUGS
Islet amyloid polypeptide in the islets of Langerhans: friend or foe?
DIABETOLOGIA
Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes
DIABETOLOGIA
The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells
DIABETES
Non-competitive antagonism of amylin on CGRP(1)-receptors in rat coronary small arteries
BRITISH JOURNAL OF PHARMACOLOGY
CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification
BRITISH JOURNAL OF PHARMACOLOGY
CGRP and adrenomedullin binding correlates with transcript levels for Calcitonin Receptor-Like Receptor (CRLR) and Receptor Activity Modifying Proteins (RAMPs) in rat tissues
BRITISH JOURNAL OF PHARMACOLOGY
Bioactive beta-bend structures for the antagonist h alpha CGRP(8-37) at the CGRP(1) receptor of the rat pulmonary artery
BRITISH JOURNAL OF PHARMACOLOGY
Effects of long-term infusion of anorexic concentrations of islet amyloid polypeptide on neurotransmitters and neuropeptides in rat brain
BRAIN RESEARCH
Amylin compared with calcitonin: competitive binding studies in rat brain and antinociceptive activity
BRAIN RESEARCH
Synthesis of biologically active tritiated amylin and salmon calcitonin analogues
ANALYTICAL BIOCHEMISTRY
A feline model of experimentally induced islet amyloidosis
AMERICAN JOURNAL OF PATHOLOGY
The molecular pharmacology of CGRP and related peptide receptor subtypes
TRENDS IN PHARMACOLOGICAL SCIENCES