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Highly selective glycosylated prodrugs of cytostatic CC-1065 analogues forantibody-directed enzyme tumor therapy
CHEMBIOCHEM
Novel anthracycline prodrugs
EXPERT OPINION ON THERAPEUTIC PATENTS
Purification and characterization of an enzyme from Mycobacterium sp Pyr-1, with nitroreductase activity and an N-terminal sequence similar to lipoamide dehydrogenase
ARCHIVES OF MICROBIOLOGY
A real-time trajectory modification algorithm
ROBOTICA
Prodrug strategies in cancer therapy
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Recent developments in the field of antitumour anthracyclines
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Adept focuses on acquisitions to secure new markets
INDUSTRIAL ROBOT
In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Potentiation of antitumor immunity by antibody-directed enzyme prodrug therapy
INTERNATIONAL JOURNAL OF CANCER
Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate
INTERNATIONAL JOURNAL OF CANCER
2-nitro and 4-nitro-quinone-methides are not irreversible inhibitors of bovine beta-glucuronidase
CARBOHYDRATE RESEARCH
PDEPT: polymer-directed enzyme prodrug therapy I. HPMA copolymer-cathepsinB and PK1 as a model combination
BRITISH JOURNAL OF CANCER
Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material
BRITISH JOURNAL OF CANCER
Oxidative activation of indole-3-acetic acids to cytotoxic species - a potential new role for plant auxins in cancer therapy
BIOCHEMICAL PHARMACOLOGY
Quantitative structure-activity relationships in two-electron reduction ofnitroaromatic compounds by Enterobacter cloacae NAD(P)H : nitroreductase
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
The potential use of carboxypeptidase G(2) in the treatment of cancer
EXPERT OPINION ON THERAPEUTIC PATENTS
Antibody-directed enzyme prodrug therapy: Efficacy and mechanism of actionin colorectal carcinoma
CLINICAL CANCER RESEARCH
5 '-[2-(2-nitrophenyl)-2-methylpropionyl]-2 '-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: Synthesis, stability andreductive activation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Recombinant anti-carcinoembryonic antigen antibodies for targeting cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamates
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Clinical applications of phage-derived sFvs and sFv fusion proteins
DISEASE MARKERS
Crystal structure of FMN-dependent nitroreductase from Escherichia coli B:A prodrug-activating enzyme
JOURNAL OF MEDICINAL CHEMISTRY
Cellular glutathione as a determinant of the sensitivity of colorectal tumour cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT)
BRITISH JOURNAL OF CANCER
Novel anthracycline-spacer-beta-glucuronide, -beta-glucoside, and -beta-galactoside prodrugs for application in selective chemotherapy
BIOORGANIC & MEDICINAL CHEMISTRY
A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2-dihydro-3H-benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Substituent effects on the kinetics of reductively-initiated fragmentationof nitrobenzyl carbamates designed as triggers for bioreductive prodrugs
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamate. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Intensely cytotoxic anthracycline prodrugs: galactosides
ANTI-CANCER DRUG DESIGN
Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT)
ANTI-CANCER DRUG DESIGN
Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy
ANTI-CANCER DRUG DESIGN
Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs
PHARMACOLOGY & THERAPEUTICS
Study of biscarbamates derived from 2-aminobenzylamines as models for alcohol prodrugs
TETRAHEDRON
Extending the beta-lactamase-dependent prodrug armory: S-aminosulfeniminocephalosporins as dual-release prodrugs
JOURNAL OF ORGANIC CHEMISTRY
Novel inhibitors of carboxypeptidase G(2) (CPG(2)): Potential use in antibody-directed enzyme prodrug therapy
JOURNAL OF MEDICINAL CHEMISTRY
Taking engineered anti-CEA antibodies to the clinic
JOURNAL OF IMMUNOLOGICAL METHODS
Characterization of an antineoplastic glucuronide prodrug
BIOCHEMICAL PHARMACOLOGY
Design of immuno-enzymosomes with maximum enzyme targeting capability: effect of the enzyme density on the enzyme targeting capability and cell binding properties
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
SYNTHESIS AND STUDY OF A DIPYRIDAMOLE PRODRUG - APPLICATION OF THE ADEPT STRATEGY TO THE MDR RESISTANCE IN CANCER-CHEMOTHERAPY
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
OVEREXPRESSION, ISOTOPIC LABELING, AND SPECTRAL CHARACTERIZATION OF ENEROBACTER-CLOACAE NITROREDUCTASE
Protein expression and purification
TOWARD TARGETED OXIDATION THERAPY OF CANCER - PEROXIDASE-CATALYZED CYTOTOXICITY OF INDOLE-3-ACETIC ACIDS
International journal of radiation oncology, biology, physics
CONSTRUCTION AND CHARACTERIZATION OF A FUSION PROTEIN OF SINGLE-CHAINANTI-CARCINOMA ANTIBODY 323 A3 AND HUMAN BETA-GLUCURONIDASE/
Cancer immunology and immunotherapy
Doxorubicin prodrugs with reduced cytotoxicity suited for tumour-specific activation
ANTI-CANCER DRUG DESIGN
Synthesis of self-immolative glucuronide-based prodrugs of a phenol mustard
ANTI-CANCER DRUG DESIGN
STEADY-STATE KINETIC MECHANISM, STEREOSPECIFICITY, SUBSTRATE AND INHIBITOR SPECIFICITY OF ENTEROBACTER-CLOACAE NITROREDUCTASE
Biochimica et biophysica acta. Protein structure and molecular enzymology
Catalytic antibodies
ADVANCES IN PHYSICAL ORGANIC CHEMISTRY, VOL 31
The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies
JOURNAL OF PHARMACY AND PHARMACOLOGY
THERAPEUTIC EFFECTS OF MONOCLONAL ANTIBODY-BETA-LACTAMASE CONJUGATES IN COMBINATION WITH A NITROGEN-MUSTARD ANTICANCER PRODRUG IN MODELS OFHUMAN RENAL-CELL CARCINOMA
Journal of medicinal chemistry
PRODRUGS OF ANTHRACYCLINES FOR USE IN ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY
Journal of medicinal chemistry
Self-immolative nitrogen mustard prodrugs for suicide gene therapy
JOURNAL OF MEDICINAL CHEMISTRY
ENZYME PRODRUG THERAPY OF CANCER
Expert opinion on therapeutic patents
SELECTIVE CELL ABLATION IN THE MAMMARY-GLAND OF TRANSGENIC MICE
Endocrine-related cancer
CONSTRUCTION, EXPRESSION, AND ACTIVITIES OF L49-SFV-BETA-LACTAMASE, ASINGLE-CHAIN ANTIBODY FUSION PROTEIN FOR ANTICANCER PRODRUG ACTIVATION
Bioconjugate chemistry
ANAEROBIC-BACTERIA AS A GENE DELIVERY SYSTEM THAT IS CONTROLLED BY THE TUMOR MICROENVIRONMENT
Gene therapy
THE EXPRESSION OF BACTERIAL NITROREDUCTASE IN TRANSGENIC MICE RESULTSIN SPECIFIC CELL-KILLING BY THE PRODRUG CB1954
Gene therapy
SELECTIVE CELL ABLATION IN TRANSGENIC MICE EXPRESSING ESCHERICHIA-COLI NITROREDUCTASE
Gene therapy
NITRO REDUCTION AS AN ELECTRONIC SWITCH FOR BIOREDUCTIVE DRUG ACTIVATION
Oncology research
SYNTHESIS OF AN AMINOPROPYL, ANALOG OF THE EXPERIMENTAL ANTICANCER DRUG TALLIMUSTINE, AND ACTIVATION OF ITS 4-NITROBENZYLCARBAMOYL PRODRUG BY NITROREDUCTASE AND NADH
Bioorganic & medicinal chemistry letters
SENSITIZATION OF COLORECTAL AND PANCREATIC-CANCER CELL-LINES TO THE PRODRUG 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE (CB1954) BY RETROVIRAL TRANSDUCTION AND EXPRESSION OF THE ESCHERICHIA-COLI NITROREDUCTASE GENE
Cancer gene therapy
BIODISTRIBUTION OF AN ANTIBODY-ENZYME CONJUGATE FOR ANTIBODY-DIRECTEDENZYME PRODRUG THERAPY IN NUDE-MICE BEARING A HUMAN COLON ADENOCARCINOMA XENOGRAFT
Cancer chemotherapy and pharmacology
ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY - PHARMACOKINETICS AND PLASMA-LEVELS OF PRODRUG AND DRUG IN A PHASE-I CLINICAL-TRIAL
Cancer chemotherapy and pharmacology
CONTROL OF ADEPT-ONE SCARA ROBOT USING NEURAL NETWORKS
IEEE transactions on industrial electronics
ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) - A REVIEW
Advanced drug delivery reviews
IMMUNOLIPOSOMES BEARING ENZYMES (IMMUNO-ENZYMOSOMES) FOR SITE-SPECIFIC ACTIVATION OF ANTICANCER PRODRUGS
Advanced drug delivery reviews
ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) - EVIDENCE FOR A BYSTANDER EFFECT IN-VITRO
International journal of oncology
INVESTIGATION OF ALTERNATIVE PRODRUGS FOR USE WITH ESCHERICHIA-COLI NITROREDUCTASE IN SUICIDE GENE APPROACHES TO CANCER-THERAPY
Gene therapy
A NOVEL NITROSUBSTITUTED SECO-CI - APPLICATION AS A REDUCTIVELY ACTIVATED ADEPT PRODRUG
Bioorganic & medicinal chemistry letters
IS THERE A FUTURE FOR CANCER-CHEMOTHERAPY - THE CLAVEL,MICHEL LECTURE
Annals of oncology
IMMUNOLIPOSOMES AS ENZYME-CARRIERS (IMMUNO-ENZYMOSOMES) FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) - OPTIMIZATION OF PRODRUG ACTIVATING CAPACITY
Pharmaceutical research
PRODRUGS OF THYMIDYLATE SYNTHASE INHIBITORS - POTENTIAL FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT)
Anti-cancer drug design
SYNTHESIS AND EVALUATION OF 4-SUBSTITUTED ANALOGS OF 5-[N,N-BIS(2-CHLOROETHYL)AMINO]2-NITROBENZAMIDE AS BIOREDUCTIVELY ACTIVATED PRODRUGS USING AN ESCHERICHIA-COLI NITROREDUCTASE
Anti-cancer drug design
ADVANCED DRUG-DELIVERY REVIEWS - ENZYME PRODRUG THERAPY
Advanced drug delivery reviews
PREPARATION AND PURIFICATION OF ANTIBODY-ENZYME CONJUGATES FOR THERAPEUTIC APPLICATIONS
Advanced drug delivery reviews
OPPORTUNITIES WITH PHAGE TECHNOLOGY AND ANTIBODY ENGINEERING OF FUSION PROTEINS
Advanced drug delivery reviews
ACCELERATED CLEARANCE SYSTEMS
Advanced drug delivery reviews
BIODISTRIBUTION STUDIES
Advanced drug delivery reviews
ALKYLATING AGENT PRODRUGS FOR ADEPT
Advanced drug delivery reviews
IMMUNE-RESPONSE IN ADEPT
Advanced drug delivery reviews
PRODRUGS AND TARGETED DRUG-DELIVERY
Advanced drug delivery reviews
PRODRUGS OF ANTICANCER AGENTS
Advanced drug delivery reviews
HISTOCHEMISTRY OF THERAPEUTICALLY RELEVANT ENZYMES IN HUMAN TUMORS TRANSPLANTED INTO SEVERE COMBINED IMMUNODEFICIENT (SCID) MICE - NITRIC-OXIDE SYNTHASE - ASSOCIATED DIAPHORASE, BETA-D-GLUCURONIDASE AND NONSPECIFIC ALKALINE-PHOSPHATASE
Acta histochemica
EFFECT OF CYCLOSPORINE ON IMMUNOGENICITY OF A BACTERIAL ENZYME CARBOXYPEPTIDASE G2 IN ADEPT
Transplantation proceedings
SYNTHESIS OF N-ALPHA-AMINOACYL DERIVATIVES OF MELPHALAN FOR POTENTIALUSE IN DRUG TARGETING
Tetrahedron letters
HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF ANOMERIC BETA-O-GLYCOPYRANOSYLCARBAMATES FROM ISOCYANATES
Synthesis
NEW MUSTARD PRODRUGS FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY - ALTERNATIVES TO THE AMIDE LINK
Journal of medicinal chemistry
ZD2767, AN IMPROVED SYSTEM FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY THAT RESULTS IN TUMOR REGRESSIONS IN COLORECTAL TUMOR XENOGRAFTS
Cancer research
RECENT DEVELOPMENTS IN THE DESIGN OF BIOREDUCTIVE DRUGS
British Journal of Cancer
CHARACTERIZATION OF NOVEL ANTHRACYCLINE PRODRUGS ACTIVATED BY HUMAN BETA-GLUCURONIDASE FOR USE IN ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY
Biochemical pharmacology
SYNTHESIS AND BETA-LACTAMASE-MEDIATED ACTIVATION OF A CEPHALOSPORIN-TAXOL PRODRUG
Chemistry & biology
PRODRUGS IN CANCER-CHEMOTHERAPY
Stem cells
GENETIC DELIVERY OF ENZYMES FOR CANCER-THERAPY
Gene therapy
THE CHOICE OF PRODRUGS FOR GENE DIRECTED ENZYME PRODRUG THERAPY OF CANCER
Gene therapy
ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) WITH MUSTARD PRODRUGS
Anti-cancer drug design
TARGETING SOLID TUMORS - CHALLENGES, DISAPPOINTMENTS, AND OPPORTUNITIES
Advanced drug delivery reviews
CHEMOTHERAPEUTIC TUMOR TARGETING USING CLOSTRIDIAL SPORES
FEMS microbiology reviews
PLASMA-CLEARANCE OF AN ANTIBODY-ENZYME CONJUGATE IN ADEPT BY MONOCLONAL ANTI-ENZYME - ITS EFFECT ON PRODRUG ACTIVATION IN-VIVO
British Journal of Cancer
ANTITUMOR EFFECTS OF AN ANTIBODY-CARBOXYPEPTIDASE G2 CONJUGATE IN COMBINATION WITH PHENOL MUSTARD PRODRUGS
British Journal of Cancer
BIOACTIVATION OF DINITROBENZAMIDE MUSTARDS BY AN ESCHERICHIA-COLI-B NITROREDUCTASE
Biochemical pharmacology
SYNTHESIS AND CHARACTERIZATION OF MONOCLONAL ANTIBODY-BETA-LACTAMASE CONJUGATES
Bioconjugate chemistry
ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) - REVIEW
Annals of oncology
PHYSICAL CHARACTERIZATION OF THE ESCHERICHIA-COLI-B GENE ENCODING NITROREDUCTASE AND ITS OVER-EXPRESSION IN ESCHERICHIA-COLI K12
FEMS microbiology letters