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La ricerca find articoli where soggetti phrase all words '5-aminosalicylic acid' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 462 riferimenti
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    1. Di Paolo, MC; Paoluzi, OA; Pica, R; Iacopini, F; Crispino, P; Rivera, M; Spera, G; Paoluzi, P
      Sulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerance and side-effects

      DIGESTIVE AND LIVER DISEASE
    2. Ishaq, S; Green, JRB
      Tolerability of aminosalicylates in inflammatory bowel disease

      BIODRUGS
    3. Vree, TB; Dammers, E; Exler, PS; Maes, RAA
      Multiple absorption patterns of mesalazine from two gastroresistant tablets in healthy male volunteers - Effects of food and formulation

      CLINICAL DRUG INVESTIGATION
    4. Vree, TB; Dammers, E; Exler, PS; Sorgel, F; Bondesen, S; Maes, RAA
      Upper and lower limits in the renal clearance of acetylmesalazine in humans - Indications for renal acetylation of mesalazine

      CLINICAL DRUG INVESTIGATION
    5. Farup, PG; Hinterleitner, TA; Lukas, M; Hebuterne, X; Rachmilewitz, D; Campieri, M; Meier, R; Keller, R; Rathbone, B; Oddsson, E
      Mesalazine 4 g daily given as prolonged-release granules twice daily and four times daily is at least as effective as prolonged-release tablets four times daily in patients with ulcerative colitis

      INFLAMMATORY BOWEL DISEASES
    6. Katz, JA; Pore, G
      Inflammatory bowel disease and pregnancy

      INFLAMMATORY BOWEL DISEASES
    7. Elvira, C; Gallardo, A; Lacroix, N; Schacht, E; San Roman, J
      Incorporation of salicylic acid derivatives to hydrophilic copolymer systems with biomedical applications

      JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
    8. Kumarathasan, P; Vincent, R; Goegan, P; Potvin, M; Guenette, J
      Hydroxyl radical adduct of 5-aminosalicylic acid: A potential marker of ozone-induced oxidative stress

      BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
    9. Nigovic, B; Mandic, Z; Simunic, B; Fistric, I
      Voltammetric studies of 2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid as a novel prodrug of 5-aminosalicylic acid

      JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
    10. Sinha, VR; Kumria, R
      Colonic drug delivery: Prodrug approach

      PHARMACEUTICAL RESEARCH
    11. Sinha, VR; Kumria, R
      Polysaccharides in colon-specific drug delivery

      INTERNATIONAL JOURNAL OF PHARMACEUTICS
    12. Gupta, VK; Assmus, MW; Beckert, TE; Price, JC
      A novel pH- and time-based multi-unit potential colonic drug delivery system. II. Optimization of multiple response variables

      INTERNATIONAL JOURNAL OF PHARMACEUTICS
    13. Kanski, J; Lauderback, C; Butterfield, DA
      5-aminosalicylic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro

      NEUROCHEMICAL RESEARCH
    14. Lee, JS; Jung, YJ; Doh, MJ; Kim, YM
      Synthesis and properties of dextran-nalidixic acid ester as a colon-specific prodrug of nalidixic acid

      DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
    15. Matasic, R; Dietz, AB; Vuk-Pavlovic, S
      Maturation of human dendritic cells as sulfasalazine target

      CROATIAN MEDICAL JOURNAL
    16. Schwab, M; Klotz, U
      Pharmacokinetic considerations in the treatment of inflammatory bowel disease

      CLINICAL PHARMACOKINETICS
    17. Rottembourg, D; Labarthe, F; Arsene, S; Jonville-Bera, AP; Maurage, C; Rolland, JC
      Headache during mesalamine therapy: A case report of mesalamine-induced pseudotumor cerebri

      JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
    18. Haas, M; Shetye, KR
      Acute renal failure in a 53-year-old woman with Crohn's disease treated with 5-aminosalicylic acid

      AMERICAN JOURNAL OF KIDNEY DISEASES
    19. Hong, JJ; Park, W; Ehrenpreis, ED
      Review article: current therapeutic options for radiation proctopathy

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    20. Fraser, JS; Muller, AF; Smith, DJ; Newman, DJ; Lamb, EJ
      Renal tubular injury is present in acute inflammatory bowel disease prior to the introduction of drug therapy

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    21. Oshima, T; Pavlick, K; Grisham, MB; Jordan, P; Manas, K; Joh, T; Itoh, M; Alexander, JS
      Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel diseasetherapy

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    22. Vecchi, M; Meucci, G; Gionchetti, P; Beltrami, M; Di Maurizio, P; Beretta, L; Ganio, E; Usai, P; Campieri, M; Fornaciari, G; De Franchis, R
      Oral versus combination mesalazine therapy in active ulcerative colitis: adouble-blind, double-dummy, randomized multicentre study

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    23. Rutgeerts, PJ
      Review article: the limitations of corticosteroid therapy in Crohn's disease

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    24. Hussain, FN; Ajjan, RA; Kapur, K; Moustafa, M; Riley, SA
      Once versus divided daily dosing with delayed-release mesalazine: a study of tissue drug concentrations and standard pharmacokinetic parameters

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    25. Trimarchi, HM; Iotti, A; Iotti, R; Freixas, EAR; Peters, R
      Immunoglobulin A nephropathy and ulcerative colitis - A focus on their pathogenesis

      AMERICAN JOURNAL OF NEPHROLOGY
    26. Valentine, JF
      Mesalamine induces manganese superoxide dismutase in rat intestinal epithelial cell lines and in vivo

      AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
    27. Margetts, PJ; Churchill, DN; Alexopoulou, I
      Interstitial nephritis in patients with inflammatory bowel disease treatedwith mesalamine

      JOURNAL OF CLINICAL GASTROENTEROLOGY
    28. Sakuma, S; Lu, ZR; Kopeckova, P; Kopecek, J
      Biorecognizable HPMA copolymer-drug conjugates for colon-specific deliveryof 9-aminocamptothecin

      JOURNAL OF CONTROLLED RELEASE
    29. Jorgensen, J; Mortensen, PB
      Hydrogen sulfide and colonic epithelial metabolism - Implications for ulcerative colitis

      DIGESTIVE DISEASES AND SCIENCES
    30. Stange, EF; Riemann, J; von Herbay, A; Lochs, H; Fleig, WE; Scholmerich, J; Kruis, W; Porschen, R; Bruch, HP; Zeitz, M; Schreiber, S; Moser, G; Matthes, H; Selbmann, HK; Goebell, H; Caspary, WF
      Diagnosis and therapy of ulcerative colitis - results of an evidence-basedConsensus conference of the German Society of Gastroenterology and Metabolic Diseases

      ZEITSCHRIFT FUR GASTROENTEROLOGIE
    31. Beckett, EL; Lawrence, NS; Evans, RG; Davis, J; Compton, RG
      Sonoelectrochemically enhanced determination of 5-aminosalicylic acid

      TALANTA
    32. Stein, RB; Lichtenstein, GR
      Medical therapy for Crohn's disease - The state of the art

      SURGICAL CLINICS OF NORTH AMERICA
    33. Ward, RM; Bates, BA; Benitz, WE; Burchfield, DJ; Ring, JC; Walls, RP; Walson, PD
      The transfer of drugs and other chemicals into human milk

      PEDIATRICS
    34. Haralambou, G; Teirstein, AS; Gil, J; Present, DH
      Bronchiolitis obliterans in a patient with ulcerative colitis receiving mesalamine

      MOUNT SINAI JOURNAL OF MEDICINE
    35. Sossai, P; Cappellato, MG; Stefani, S
      Can a drug-induced pulmonary hypersensitivity reaction be dose-dependent? A case with mesalamine

      MOUNT SINAI JOURNAL OF MEDICINE
    36. Sandborn, WJ
      The role of genetics (pharmacogenetics) in the treatment of inflammatory bowel disease in the future

      DRUGS OF TODAY
    37. Jung, YJ; Lee, JS; Kim, YM
      Colon-specific prodrugs of 5-aminosalicylic acid: Synthesis and in vitro/in vivo properties of acidic amino acid derivatives of 5-aminosalicylic acid

      JOURNAL OF PHARMACEUTICAL SCIENCES
    38. Lee, JS; Jung, YJ; Kim, YM
      Synthesis and evaluation of N-acyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil

      JOURNAL OF PHARMACEUTICAL SCIENCES
    39. Scholmerich, J; Stange, EF
      Chronic inflammatory bowel disease - Standards and outlook in pharmacotherapy

      INTERNIST
    40. Hasko, G; Szabo, C; Nemeth, ZH; Deitch, EA
      Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression

      IMMUNOLOGY
    41. Kruis, W; Schreiber, S; Theuer, D; Brandes, JW; Schutz, E; Howaldt, S; Krakamp, B; Hamling, J; Monnikes, H; Koop, I; Stolte, M; Pallant, D; Ewald, U
      Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three timesdaily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses

      GUT
    42. Lowry, PW; Franklin, CL; Weaver, AL; Pike, MG; Mays, DC; Tremaine, WJ; Lipsky, JJ; Sandborn, WJ
      Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease

      GUT
    43. Mahmud, N; Kamm, MA; Dupas, JL; Jewell, DP; O'Morain, CA; Weir, DG; Kelleher, D
      Olsalazine is not superior to placebo in maintaining remission of inactiveCrohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study

      GUT
    44. Nugent, SG; Kumar, D; Rampton, DS; Evans, DF
      Intestinal luminal pH in inflammatory bowel disease: possible determinantsand implications for therapy with aminosalicylates and other drugs

      GUT
    45. Oldenburg, B; van Kats-Renaud, H; Koningsberger, JC; Henegouwen, GPVB; van Asbeck, BS
      Chemiluminescence in inflammatory bowel disease patients: a parameter of inflammatory activity

      CLINICA CHIMICA ACTA
    46. Hayne, D; Vaizey, CJ; Boulos, PB
      Anorectal injury following pelvic radiotherapy

      BRITISH JOURNAL OF SURGERY
    47. Messori, A; Vaiani, M; Trippoli, S; Rigacci, L; Jerkeman, M; Longo, G
      Survival in patients with intermediate or high grade non-Hodgkin's lymphoma: meta-analysis of randomized studies comparing third generation regimens with CHOP

      BRITISH JOURNAL OF CANCER
    48. Kono, T; Nomura, M; Kasai, S; Kohgo, Y
      Effect of Ecabet sodium enema on mildly to moderately active ulcerative proctosigmoiditis: An open-label study

      AMERICAN JOURNAL OF GASTROENTEROLOGY
    49. Scholmerich, J
      Is there any step-wise treatment of chronic inflammatory intestinal disease?

      DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
    50. Cohen, RD
      The cost of Crohn's disease - Drugs or surgery?

      BIODRUGS
    51. Kitauchi, S; Nishi, S; Nishioka, S
      Intestinal Behcet's disease: Epidemiology, pathophysiology and potential of mesalazine

      BIODRUGS
    52. Messori, A; Trippoli, S; Vaiani, N; Cattel, F
      Survival meta-analysis of individual patient data and survival meta-analysis of published (aggregate) data - Is there an intermediate approach between these two opposite options?

      CLINICAL DRUG INVESTIGATION
    53. Vree, TB; Dammers, E; Exler, PS; Sorgel, F; Maes, RAA
      Saturable active tubular reabsorption in the renal clearance of mesalazinein human volunteers

      CLINICAL DRUG INVESTIGATION
    54. Yamamoto, A; Tozaki, H; Okada, N; Fujita, T
      Colon-specific delivery of peptide drugs and anti-inflammatory drugs usingchitosan capsules

      STP PHARMA SCIENCES
    55. Birketvedt, GS; Berg, KJ; Fausa, O; Florholmen, J
      Glomerular and tubular renal functions after long-term medication of sulphasalazine, olsalazine, and mesalazine in patients with ulcerative colitis

      INFLAMMATORY BOWEL DISEASES
    56. Sutherland, LR
      Prevention of relapse of Crohn's disease

      INFLAMMATORY BOWEL DISEASES
    57. Huang, HE; Helzlsouer, KJ; Appel, LJ
      The effects of vitamin C and vitamin E on oxidative DNA damage: Results from a randomized controlled trial

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    58. MacGregor, DJ; Kim, YS; Sleisenger, MH; Johnson, LK
      Chemoprevention of colon cancer carcinogenesis by balsalazide: Inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+mouse

      INTERNATIONAL JOURNAL OF ONCOLOGY
    59. Messori, A; Cattel, F; Trippoli, S; Vaiani, M
      Survival in patients with metastatic breast cancer: analysis of randomizedstudies comparing oral aromatase inhibitors versus megestrol

      ANTI-CANCER DRUGS
    60. Vree, TB; Dammers, E; Exler, PS; Sorgel, F; Bondesen, S; Maes, RAA
      Liver and gut mucosa acetylation of mesalazine in healthy volunteers

      INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
    61. Verzijl, JM; Kamphuis, TJ; Rensma, PL; van Roon, EN
      Clearance of an oral delayed-release mesalazine preparation (Salofalk (R))by haemodialysis - pharmacokinetic profile of mesalazine related to the effects of dialysis

      NEPHROLOGY DIALYSIS TRANSPLANTATION
    62. Parejo, C; Gallardo, A; San Roman, J
      HEMA-based methacrylic carriers incorporating ketoprofen: Chain flexibility and swelling behaviour

      JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
    63. Bystrowska, B; Nowak, J; Brandys, J
      Validation of a LC method for the determination of 5-aminosalicylic acid and its metabolite in plasma and urine

      JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
    64. Blau, S; Kohen, R; Bass, P; Rubinstein, A
      The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat

      PHARMACEUTICAL RESEARCH
    65. Liang, E; Proudfoot, J; Yazdanian, M
      Mechanisms of transport and structure-permeability relationship of sulfasalazine and its analogs in Caco-2 cell monolayers

      PHARMACEUTICAL RESEARCH
    66. Rolachon, A; Paillon, E; Fournet, J
      Is argon plasma coagulation an efficient treatment for digestive vascular malformation and radiation proctitis?

      GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
    67. Dekker-Saeys, BJ; Dijkmans, BAC; Tytgat, GNJ
      Treatment of spondyloarthropathy with 5-aminosalicylic acid (mesalazine): An open trial

      JOURNAL OF RHEUMATOLOGY
    68. De Vos, M
      Clinical pharmacokinetics of slow release mesalazine

      CLINICAL PHARMACOKINETICS
    69. Hussain, FN; Ajjan, RA; Riley, SA
      Dose loading with delayed-release mesalazine: a study of tissue drug concentrations and standard pharmacokinetic parameters

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    70. Tan, NCG; Borger, A; Slenders, P; Svitelskaya, A; Lettinga, G; Field, JA
      Degradation of azo dye Mordant Yellow 10 in a sequential anaerobic and bioaugmented aerobic bioreactor

      WATER SCIENCE AND TECHNOLOGY
    71. Rubinstein, A
      Natural polysaccharides as targeting tools of drugs to the human colon

      DRUG DEVELOPMENT RESEARCH
    72. Carty, E; Macey, M; Mccartney, SA; Rampton, DS
      Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    73. Corrigan, G; Stevens, PE
      Interstitial nephritis associated with the use of mesalazine in inflammatory bowel disease

      ALIMENTARY PHARMACOLOGY & THERAPEUTICS
    74. Bresci, G; Parisi, G; Bertoni, M; Masolino, P; Scatena, F; Capria, A
      Does the initial location of Crohn's disease have an influence on the time-to-relapse in patients under maintenance treatment with oral mesalamine?

      JOURNAL OF CLINICAL GASTROENTEROLOGY
    75. Ludwig, D; Stange, EF
      Treatment of ulcerative colitis

      HEPATO-GASTROENTEROLOGY
    76. Herrlinger, KR; Stange, EF
      The pancreas and inflammatory bowel diseases

      INTERNATIONAL JOURNAL OF PANCREATOLOGY
    77. Yamaoka, T; Makita, Y; Sasatani, H; Kim, SI; Kimura, Y
      Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: its properties, degradation behavior, and utilization for drug formulation

      JOURNAL OF CONTROLLED RELEASE
    78. Brown, WA; Farmer, KC; Skinner, SA; Malcontenti-Wilson, C; Misajon, A; O'Brien, PE
      5-aminosalicylic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer

      DIGESTIVE DISEASES AND SCIENCES
    79. Guslandi, M; Mezzi, G; Sorghi, M; Testoni, PA
      Saccharomyces boulardii in maintenance treatment of Crohn's disease

      DIGESTIVE DISEASES AND SCIENCES
    80. Peterson, TC; Cleary, CE; Shaw, AM; Malatjalian, DA; Van Zanten, SJOV
      Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat

      DIGESTIVE DISEASES AND SCIENCES
    81. Stein, RB; Hanauer, SB
      Comparative tolerability of treatments for inflammatory bowel disease

      DRUG SAFETY
    82. Rufle, W; Fruhmorgen, P; Huber, W; Kimmig, JM
      Budesonide foam as a new therapeutic concept in the therapy of distal ulcerative colitis in comparison to mesalazine enemas. An open, controlled, randomized and prospective multicenter pilot study

      ZEITSCHRIFT FUR GASTROENTEROLOGIE
    83. Klotz, U
      The role of aminosalicylates at the beginning of the new millennium in thetreatment of chronic inflammatory bowel disease

      EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
    84. Konishi, T
      Basic studies on the utility of ursodeoxycholic acid derivatives for clinical medicine

      YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
    85. Campieri, M; Gionchetti, P
      Medical treatment of ulcerative colitis

      DRUGS OF TODAY
    86. Vree, TB; Dammers, E; Exler, PS; Maes, RAA
      Mono- and biphasic plasma concentration-time curves of mesalazine from a 500 mg suppository in healthy male volunteers controlled by the time of defecation before dosing

      JOURNAL OF PHARMACY AND PHARMACOLOGY
    87. Jung, YJ; Lee, JS; Kim, YM
      Synthesis and in vitro/in vivo evaluation of 5-aminosalicyl-glycine as a colon-specific prodrug of 5-aminosalicylic acid

      JOURNAL OF PHARMACEUTICAL SCIENCES
    88. Frieri, G; Giacomelli, R; Pimpo, M; Palumbo, G; Passacantando, A; Pantaleoni, G; Caprilli, R
      Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis

      GUT
    89. Lochs, H; Mayer, M; Fleig, WE; Mortensen, PB; Bauer, P; Genser, D; Petritsch, W; Raithel, M; Hoffmann, R; Gross, V; Plauth, M; Staun, M; Nesje, LB
      Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's disease Study VI

      GASTROENTEROLOGY
    90. Clemett, D; Markham, A
      Prolonged-release mesalazine - A review of its therapeutic potential in ulcerative colitis and Crohn's disease

      DRUGS
    91. Martel, P; Betton, PO; Gallot, D; Sezeur, A; Malafosse, M
      Surgical treatment of Crohn's disease of the colon: impact of associated proctitis on the results of ileorectal anastomosis.

      ANNALES DE CHIRURGIE
    92. Hanauer, S; Good, LI; Goodman, MW; Pizinger, RJ; Strum, WB; Lyss, C; Haber, G; Williams, CN; Robinson, M
      Long-term use of mesalamine (Rowasa) suppositories in remission maintenance of ulcerative proctitis

      AMERICAN JOURNAL OF GASTROENTEROLOGY
    93. Cohen, RD; Woseth, DM; Thisted, RA; Hanauer, SB
      A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis

      AMERICAN JOURNAL OF GASTROENTEROLOGY
    94. Marteau, P; Florent, C
      Comparative, open, randomized trial of the efficacy and tolerance of slow-release 5-ASA suppositories once daily versus conventional 5-ASA suppositories twice daily in the treatment of active cryptogenic proctitis

      AMERICAN JOURNAL OF GASTROENTEROLOGY
    95. Leopold, CS
      Coated dosage forms for colon-specific drug delivery

      PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY
    96. Fish, NW; Bloor, JR
      Drug delivery to the colon

      EXPERT OPINION ON THERAPEUTIC PATENTS
    97. Ardizzone, S; Doldo, P; Ranzi, T; Sturniolo, GC; Giglio, LA; Annese, V; D'Arienzo, A; Gaia, E; Gullini, S; Riegler, G; Valentini, M; Massa, P; Del Piano, M; Rossini, F; Guidetti, CS; Pera, A; Greinwald, R; Porro, GB
      Mesalazine foam (Salofalk (R) foam) in the treatment of active distal ulcerative colitis. A comparative trial vs Salofalk (R) enema

      ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
    98. Scholmerich, J
      Treatment of distal ulcerative colitis: now the patients have the choice

      ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
    99. Prantera, C; Scribano, ML
      Current treatment for prevention of relapse and recurrence in Crohn's disease

      ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
    100. Van Boi, L; Al-Ebaisat, H
      Thiocarbamoylation of amine-containing compounds 3. 5-(N ',N '-dimethylthioureido)salicylic acid. Synthesis and reactions

      RUSSIAN CHEMICAL BULLETIN


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Documento generato il 04/08/20 alle ore 05:21:38