Le informazioni sugli articoli di fonte ISI sono coperte da copyright

Per ulteriori informazioni selezionare i riferimenti di interesse.

1. Kato-Emori, S; Higashi, K; Hosoya, K; Kobayashi, T; Ezura, H
   Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in melon (Cucumis melo L. reticulatus)
   MOLECULAR GENETICS AND GENOMICS
   
   S. Kato-Emori et al., "Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in melon (Cucumis melo L. reticulatus)", MOL GENET G, 265(1), 2001, pp. 135-142
2. Avorn, J
   Unhealthy ageing: functional and socioeconomic impact
   EUROPEAN HEART JOURNAL SUPPLEMENTS
   
   J. Avorn, "Unhealthy ageing: functional and socioeconomic impact", EUR H J SUP, 3(N), 2001, pp. N3-N5
3. Buckley, BM
   Healthy ageing: ageing safely
   EUROPEAN HEART JOURNAL SUPPLEMENTS
   
   B.M. Buckley, "Healthy ageing: ageing safely", EUR H J SUP, 3(N), 2001, pp. N6-N10
4. Gaw, A
   Healthy ageing: addressing acute coronary syndrome?
   EUROPEAN HEART JOURNAL SUPPLEMENTS
   
   A. Gaw, "Healthy ageing: addressing acute coronary syndrome?", EUR H J SUP, 3(N), 2001, pp. N11-N15
5. Blauw, GJ; Bollen, ELEM; van Buchem, MA; Westendorp, RGJ
   Dementia at old age: a clinical end-point of atherosclerotic disease
   EUROPEAN HEART JOURNAL SUPPLEMENTS
   
   G.J. Blauw et al., "Dementia at old age: a clinical end-point of atherosclerotic disease", EUR H J SUP, 3(N), 2001, pp. N16-N19
6. Martinez-Botas, J; Ferruelo, AJ; Suarez, Y; Fernandez, C; Gomez-Coronado, D; Lasuncion, MA
   Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives
   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
   
   J. Martinez-Botas et al., "Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives", BBA-MOL C B, 1532(3), 2001, pp. 185-194
7. Park, EJ; Lee, D; Shin, YG; Lantvit, DD; van Breemen, RB; Kinghorn, AD; Pezzuto, JM
   Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry
   JOURNAL OF CHROMATOGRAPHY B
   
   E.J. Park et al., "Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry", J CHROMAT B, 754(2), 2001, pp. 327-332
8. Garrett, IR; Gutierrez, G; Mundy, GR
   Statins and bone formation
   CURRENT PHARMACEUTICAL DESIGN
   
   I.R. Garrett et al., "Statins and bone formation", CUR PHARM D, 7(8), 2001, pp. 715-736
9. Metz, CA; Lucas, KH
   Alternate-day dosing of HMG-CoA reductase inhibitors for cholesterol reduction
   ANNALS OF PHARMACOTHERAPY
   
   C.A. Metz e K.H. Lucas, "Alternate-day dosing of HMG-CoA reductase inhibitors for cholesterol reduction", ANN PHARMAC, 35(4), 2001, pp. 496-500
10. Menendez, R; Mas, R; Amor, AM; Rodeiros, I; Gonzalez, RM; Alfonso, JL
    Inhibition of cholesterol biosynthesis in cultured fibroblasts by D003, a mixture of very long chain saturated fatty acids
    PHARMACOLOGICAL RESEARCH
    
    R. Menendez et al., "Inhibition of cholesterol biosynthesis in cultured fibroblasts by D003, a mixture of very long chain saturated fatty acids", PHARMAC RES, 44(4), 2001, pp. 299-304
11. Ha, SH; Lee, SW; Kim, YM; Hwang, YS
    Molecular characterization of Hmg2 gene encoding a 3-hydroxy-methylglutaryl-CoA reductase in rice
    MOLECULES AND CELLS
    
    S.H. Ha et al., "Molecular characterization of Hmg2 gene encoding a 3-hydroxy-methylglutaryl-CoA reductase in rice", MOL CELLS, 11(3), 2001, pp. 295-302
12. Gil-Nunez, AC; Villanueva, JA
    Advantages of lipid-lowering therapy in cerebral ischemia: Role of HMG-CoAreductase inhibitors
    CEREBROVASCULAR DISEASES
    
    A.C. Gil-Nunez e J.A. Villanueva, "Advantages of lipid-lowering therapy in cerebral ischemia: Role of HMG-CoAreductase inhibitors", CEREB DIS, 11, 2001, pp. 85-95
13. Qureshi, AA; Sami, SA; Salser, WA; Khan, FA
    Synergistic effect of tocotrienol-rich fraction (TRF25) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY
    
    A.A. Qureshi et al., "Synergistic effect of tocotrienol-rich fraction (TRF25) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans", J NUTR BIOC, 12(6), 2001, pp. 318-329
14. Obata, T; Ebihara, A; Yamanaka, Y
    Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzymeA reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
    
    T. Obata et al., "Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzymeA reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart", BBA-MOL BAS, 1536(1), 2001, pp. 55-63
15. Aoki, S; Ikeda, K; Yamamura, M; Kojo, S
    Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma
    BIOLOGICAL & PHARMACEUTICAL BULLETIN
    
    S. Aoki et al., "Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma", BIOL PHAR B, 24(2), 2001, pp. 123-126
16. Johnston, TP; Nguyen, LB; Chu, WA; Shefer, S
    Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis
    INTERNATIONAL JOURNAL OF PHARMACEUTICS
    
    T.P. Johnston et al., "Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis", INT J PHARM, 229(1-2), 2001, pp. 75-86
17. Rosa-Putra, S; Hemmerlin, A; Epperson, J; Bach, TJ; Guerra, LH; Rohmer, M
    Zeaxanthin and menaquinone-7 biosynthesis in Sphingobacterium multivorum via the methylerythritol phosphate pathway
    FEMS MICROBIOLOGY LETTERS
    
    S. Rosa-Putra et al., "Zeaxanthin and menaquinone-7 biosynthesis in Sphingobacterium multivorum via the methylerythritol phosphate pathway", FEMS MICROB, 204(2), 2001, pp. 347-353
18. Scripture, CD; Pieper, JA
    Clinical pharmacokinetics of fluvastatin
    CLINICAL PHARMACOKINETICS
    
    C.D. Scripture e J.A. Pieper, "Clinical pharmacokinetics of fluvastatin", CLIN PHARMA, 40(4), 2001, pp. 263-281
19. McCarty, MF
    Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation
    MEDICAL HYPOTHESES
    
    M.F. McCarty, "Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation", MED HYPOTH, 56(1), 2001, pp. 12-16
20. Yeo, KR; Yeo, WW
    Inhibitory effects of verapamil and diltiazem on simvastatin metabolism inhuman liver microsomes
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    
    K.R. Yeo e W.W. Yeo, "Inhibitory effects of verapamil and diltiazem on simvastatin metabolism inhuman liver microsomes", BR J CL PH, 51(5), 2001, pp. 461-470
21. Kurata, T; Kurata, M; Okada, T
    Cerivastatin induces carotid artery plaque stabilization independently of cholesterol lowering in patients with hypercholesterolaemia
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
    
    T. Kurata et al., "Cerivastatin induces carotid artery plaque stabilization independently of cholesterol lowering in patients with hypercholesterolaemia", J INT MED R, 29(4), 2001, pp. 329-334
22. Hardie, DG; Hawley, SA
    AMP-activated protein kinase: the energy charge hypothesis revisited
    BIOESSAYS
    
    D.G. Hardie e S.A. Hawley, "AMP-activated protein kinase: the energy charge hypothesis revisited", BIOESSAYS, 23(12), 2001, pp. 1112-1119
23. Shimano, H
    Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
    PROGRESS IN LIPID RESEARCH
    
    H. Shimano, "Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes", PROG LIPID, 40(6), 2001, pp. 439-452
24. Caldwell, SH; Hespenheide, ER; Von Borstel, RW
    Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simavastatin
    DIGESTIVE DISEASES AND SCIENCES
    
    S.H. Caldwell et al., "Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simavastatin", DIG DIS SCI, 46(2), 2001, pp. 376-378
25. Davidson, MH; Toth, P; Weiss, S; McKenney, J; Hunninghake, D; Isaacsohn, J; Donovan, JM; Burke, SK
    Low-dose combination therapy with colesevelam hydrochloride and lovastatineffectively decreases low-density lipoprotein cholesterol in patients withprimary hypercholesterolemia
    CLINICAL CARDIOLOGY
    
    M.H. Davidson et al., "Low-dose combination therapy with colesevelam hydrochloride and lovastatineffectively decreases low-density lipoprotein cholesterol in patients withprimary hypercholesterolemia", CLIN CARD, 24(6), 2001, pp. 467-474
26. Auer, J; Berent, R; Eber, B
    Lessons learned from statin trials
    CLINICAL CARDIOLOGY
    
    J. Auer et al., "Lessons learned from statin trials", CLIN CARD, 24(4), 2001, pp. 277-280
27. Istvan, ES; Deisenhofer, J
    Structural mechanism for statin inhibition of HMG-CoA reductase
    SCIENCE
    
    E.S. Istvan e J. Deisenhofer, "Structural mechanism for statin inhibition of HMG-CoA reductase", SCIENCE, 292(5519), 2001, pp. 1160-1164
28. Cowan, AK; Cripps, RF; Richings, EW; Taylor, NJ
    Fruit size: Towards an understanding of the metabolic control of fruit growth using avocado as a model system
    PHYSIOLOGIA PLANTARUM
    
    A.K. Cowan et al., "Fruit size: Towards an understanding of the metabolic control of fruit growth using avocado as a model system", PHYSL PLANT, 111(2), 2001, pp. 127-136
29. Cenedella, RJ
    Specific labeling of lens aldehyde dehydrogenase class 1 from H-3-cholesterol or its derivatives
    OPHTHALMIC RESEARCH
    
    R.J. Cenedella, "Specific labeling of lens aldehyde dehydrogenase class 1 from H-3-cholesterol or its derivatives", OPHTHAL RES, 33(4), 2001, pp. 210-216
30. Buemi, M; Senatore, M; Corica, F; Aloisi, C; Romeo, A; Cavallaro, E; Frisina, N
    Are there potential non-lipid-lowering uses of statins in the kidney?
    NEPHRON
    
    M. Buemi et al., "Are there potential non-lipid-lowering uses of statins in the kidney?", NEPHRON, 89(4), 2001, pp. 363-368
31. Dubrac, S; Parquet, M; Gripois, D; Blouquit, MF; Serougne, C; Loison, C; Lutton, C
    Diet-dependent effects of insulin infusion on the hepatic lipoprotein receptors and the key enzymes of bile acid synthesis in the hamster
    LIFE SCIENCES
    
    S. Dubrac et al., "Diet-dependent effects of insulin infusion on the hepatic lipoprotein receptors and the key enzymes of bile acid synthesis in the hamster", LIFE SCI, 69(21), 2001, pp. 2517-2532
32. Zhang, Z; Li, DS; Blanchard, DE; Lear, SR; Erickson, SK; Spencer, TA
    Key regulatory oxysterols in liver: analysis as Delta(4)-3-ketone derivatives by HPLC and response to physiological perturbations
    JOURNAL OF LIPID RESEARCH
    
    Z. Zhang et al., "Key regulatory oxysterols in liver: analysis as Delta(4)-3-ketone derivatives by HPLC and response to physiological perturbations", J LIPID RES, 42(4), 2001, pp. 649-658
33. Patel, DD; Knight, BL; Wiggins, D; Humphreys, SM; Gibbons, GF
    Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice
    JOURNAL OF LIPID RESEARCH
    
    D.D. Patel et al., "Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice", J LIPID RES, 42(3), 2001, pp. 328-337
34. Field, FJ; Born, E; Murthy, S; Mathur, SN
    Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells
    JOURNAL OF LIPID RESEARCH
    
    F.J. Field et al., "Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells", J LIPID RES, 42(10), 2001, pp. 1687-1698
35. Fitzky, BU; Moebius, FF; Asaoka, H; Waage-Baudet, H; Xu, LW; Xu, GR; Maeda, N; Kluckman, K; Hiller, S; Yu, HW; Batta, AK; Shefer, S; Chen, T; Salen, G; Sulik, K; Simoni, RD; Ness, GC; Glossmann, H; Patel, SB; Tint, GS
    7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppressessterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome
    JOURNAL OF CLINICAL INVESTIGATION
    
    B.U. Fitzky et al., "7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppressessterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome", J CLIN INV, 108(6), 2001, pp. 905-915
36. Ubels, FL; Muntinga, JHJ; van Doormaal, JJ; Reitsma, WD; Smit, AJ
    Effects of initial and long-term lipid-lowering therapy on vascular wall characteristics
    ATHEROSCLEROSIS
    
    F.L. Ubels et al., "Effects of initial and long-term lipid-lowering therapy on vascular wall characteristics", ATHEROSCLER, 154(1), 2001, pp. 155-161
37. Hirano, N; Kohno, J; Tsunoda, S; Nishio, M; Kishi, N; Okuda, T; Kawano, K; Komatsubara, S; Nakanishi, N
    TMC-69, a new antitumor antibiotic with Cdc25A inhibitory activity, produced by Chrysosporium sp TC1068 - Taxonomy, fermentation and biological activities
    JOURNAL OF ANTIBIOTICS
    
    N. Hirano et al., "TMC-69, a new antitumor antibiotic with Cdc25A inhibitory activity, produced by Chrysosporium sp TC1068 - Taxonomy, fermentation and biological activities", J ANTIBIOT, 54(5), 2001, pp. 421-427
38. Imai, K; Kudo, N; Koyama, M; Shirahata, A; Kawashima, Y
    Effects of dehydroepiandrosterone on oleic acid formation in the liver of rats, mice and guinea pigs
    JAPANESE JOURNAL OF PHARMACOLOGY
    
    K. Imai et al., "Effects of dehydroepiandrosterone on oleic acid formation in the liver of rats, mice and guinea pigs", JPN J PHARM, 86(4), 2001, pp. 437-447
39. Ozaki, K; Yamamato, T; Ishibashi, T; Matsubara, T; Nishio, M; Aizawa, Y
    Regulation of endothelial nitric oxide synthase and endothelin-1 expression by fluvastatin in human vascular endothelial cells
    JAPANESE JOURNAL OF PHARMACOLOGY
    
    K. Ozaki et al., "Regulation of endothelial nitric oxide synthase and endothelin-1 expression by fluvastatin in human vascular endothelial cells", JPN J PHARM, 85(2), 2001, pp. 147-154
40. Sawada, M; Matsuo, M; Hagihara, H; Tenda, N; Nagayoshi, A; Okumura, H; Washizuka, K; Seki, J; Goto, T
    Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells
    EUROPEAN JOURNAL OF PHARMACOLOGY
    
    M. Sawada et al., "Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells", EUR J PHARM, 431(1), 2001, pp. 11-16
41. Shea-Eaton, WK; Trinidad, MJ; Lopez, D; Nackley, A; McLean, MP
    Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene
    ENDOCRINOLOGY
    
    W.K. Shea-Eaton et al., "Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene", ENDOCRINOL, 142(4), 2001, pp. 1525-1533
42. Takemoto, M; Kitahara, M; Yokote, K; Asaumi, S; Take, A; Saito, Y; Mori, S
    NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells
    BRITISH JOURNAL OF PHARMACOLOGY
    
    M. Takemoto et al., "NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells", BR J PHARM, 133(1), 2001, pp. 83-88
43. Bogman, K; Peyer, AK; Torok, M; Kusters, E; Drewe, J
    HMG-CoA reductase inhibitors and P-glycoprotein modulation
    BRITISH JOURNAL OF PHARMACOLOGY
    
    K. Bogman et al., "HMG-CoA reductase inhibitors and P-glycoprotein modulation", BR J PHARM, 132(6), 2001, pp. 1183-1192
44. Istvan, ES; Deisenhofer, J
    The structure of the catalytic portion of human HMG-CoA reductase
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    
    E.S. Istvan e J. Deisenhofer, "The structure of the catalytic portion of human HMG-CoA reductase", BBA-MOL C B, 1529(1-3), 2000, pp. 9-18
45. Olivier, LM; Krisans, SK
    Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    
    L.M. Olivier e S.K. Krisans, "Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes", BBA-MOL C B, 1529(1-3), 2000, pp. 89-102
46. Edwards, PA; Tabor, D; Kast, HR; Venkateswaran, A
    Regulation of gene expression by SREBP and SCAP
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    
    P.A. Edwards et al., "Regulation of gene expression by SREBP and SCAP", BBA-MOL C B, 1529(1-3), 2000, pp. 103-113
47. Peng, YL; Demain, AL
    Bioconversion of compactin to pravastatin by Actinomadura sp ATCC 55678
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
    
    Y.L. Peng e A.L. Demain, "Bioconversion of compactin to pravastatin by Actinomadura sp ATCC 55678", J MOL CAT B, 10(1-3), 2000, pp. 151-156
48. Kumar, MS; Jana, SK; Senthil, V; Shashanka, V; Kumar, SV; Sadhukhan, AK
    Repeated fed-batch process for improving lovastatin production
    PROCESS BIOCHEMISTRY
    
    M.S. Kumar et al., "Repeated fed-batch process for improving lovastatin production", PROCESS BIO, 36(4), 2000, pp. 363-368
49. Duportets, L; Belles, X; Rossignol, F; Couillaud, F
    Molecular cloning and structural analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the moth Agrotis ipsilon
    INSECT MOLECULAR BIOLOGY
    
    L. Duportets et al., "Molecular cloning and structural analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the moth Agrotis ipsilon", INSEC MOL B, 9(4), 2000, pp. 385-392
50. Kim, DY; Stauffacher, CV; Rodwell, VW
    Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase
    PROTEIN SCIENCE
    
    D.Y. Kim et al., "Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase", PROTEIN SCI, 9(6), 2000, pp. 1226-1234
51. Dansette, PM; Jaoen, M; Pons, C
    HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins
    EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
    
    P.M. Dansette et al., "HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins", EXP TOX PAT, 52(2), 2000, pp. 145-148
52. Heise, N; Opperdoes, FR
    Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics
    ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
    
    N. Heise e F.R. Opperdoes, "Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics", Z NATURFO C, 55(5-6), 2000, pp. 473-477
53. Siefken, W; Hoppner, H; Harris, IR
    Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes
    EXPERIMENTAL DERMATOLOGY
    
    W. Siefken et al., "Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes", EXP DERMATO, 9(2), 2000, pp. 138-145
54. Gesquiere, L; Loreau, N; Blache, D
    Role of the cyclic AMP-dependent pathway in free radical-induced cholesterol accumulation in vascular smooth muscle cells
    FREE RADICAL BIOLOGY AND MEDICINE
    
    L. Gesquiere et al., "Role of the cyclic AMP-dependent pathway in free radical-induced cholesterol accumulation in vascular smooth muscle cells", FREE RAD B, 29(2), 2000, pp. 181-190
55. Smith, JL; Roach, PD; Wittenberg, LN; Riottot, M; Pillay, SP; Nestel, PJ; Nathanson, LK
    Effects of simvastatin on hepatic cholesterol metabolism, bile lithogenicity and bile acid hydrophobicity in patients with gallstones
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
    
    J.L. Smith et al., "Effects of simvastatin on hepatic cholesterol metabolism, bile lithogenicity and bile acid hydrophobicity in patients with gallstones", J GASTR HEP, 15(8), 2000, pp. 871-879
56. Bellosta, S; Ferri, N; Bernini, F; Paoletti, R; Corsini, A
    Non-lipid-related effects of statins
    ANNALS OF MEDICINE
    
    S. Bellosta et al., "Non-lipid-related effects of statins", ANN MED, 32(3), 2000, pp. 164-176
57. Profant, DA; Roberts, CJ; Wright, RL
    Mutational analysis of the karmellae-inducing signal in Hmg1p, a yeast HMG-CoA reductase isozyme
    YEAST
    
    D.A. Profant et al., "Mutational analysis of the karmellae-inducing signal in Hmg1p, a yeast HMG-CoA reductase isozyme", YEAST, 16(9), 2000, pp. 811-827
58. Hanaka, S; Abe, T; Itakura, H; Matsumoto, A
    Gene expression related to cholesterol metabolism in mouse brain during development
    BRAIN & DEVELOPMENT
    
    S. Hanaka et al., "Gene expression related to cholesterol metabolism in mouse brain during development", BRAIN DEVEL, 22(5), 2000, pp. 321-326
59. Suzumura, K; Kasahara, E; Ohnishi, Y; Chien, KC; Inoue, M
    Fluvastatin normalizes the decreased turnovers of glutathione and ascorbicacid in watanabe heritable hyperlipidaemic rabbits
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
    
    K. Suzumura et al., "Fluvastatin normalizes the decreased turnovers of glutathione and ascorbicacid in watanabe heritable hyperlipidaemic rabbits", CLIN EXP PH, 27(9), 2000, pp. 709-714
60. Mo, H; Tatman, D; Jung, M; Elson, CE
    Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas
    CANCER LETTERS
    
    H. Mo et al., "Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas", CANCER LETT, 157(2), 2000, pp. 145-153
61. Istvan, ES; Palnitkar, M; Buchanan, SK; Deisenhofer, J
    Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
    EMBO JOURNAL
    
    E.S. Istvan et al., "Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis", EMBO J, 19(5), 2000, pp. 819-830
62. Schulte, AE; Duran, EML; van der Heijden, R; Verpoorte, R
    Mevalonate kinase activity in Catharanthus roseus plants and suspension cultured cells
    PLANT SCIENCE
    
    A.E. Schulte et al., "Mevalonate kinase activity in Catharanthus roseus plants and suspension cultured cells", PLANT SCI, 150(1), 2000, pp. 59-69
63. Recto, CS; Acosta, S; Dobs, A
    Comparison of the efficacy and tolerability of simvastatin and atorvastatin in the treatment of hypercholesterolemia
    CLINICAL CARDIOLOGY
    
    C.S. Recto et al., "Comparison of the efficacy and tolerability of simvastatin and atorvastatin in the treatment of hypercholesterolemia", CLIN CARD, 23(9), 2000, pp. 682-688
64. Pedersen, TR; Jahnsen, KE; Vatn, S; Semb, AG; Kontny, F; Zalmai, A; Nerdrum, T
    Benefits of early lipid-lowering intervention in high-risk patients: The lipid intervention strategies for coronary patients study
    CLINICAL THERAPEUTICS
    
    T.R. Pedersen et al., "Benefits of early lipid-lowering intervention in high-risk patients: The lipid intervention strategies for coronary patients study", CLIN THER, 22(8), 2000, pp. 949-960
65. Honda, M; Tint, GS; Honda, A; Salen, G; Shefer, S; Batta, AK; Matsuzaki, Y; Tanaka, N
    Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome
    JOURNAL OF INHERITED METABOLIC DISEASE
    
    M. Honda et al., "Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome", J INH MET D, 23(5), 2000, pp. 464-474
66. Inoue, I; Goto, S; Mizotani, K; Awata, T; Mastunaga, T; Kawai, S; Nakajima, T; Hokari, S; Komoda, T; Katayama, S
    Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect - Reduction of MRNA levels for interleukin-1 beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary endothelial cells
    LIFE SCIENCES
    
    I. Inoue et al., "Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect - Reduction of MRNA levels for interleukin-1 beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary endothelial cells", LIFE SCI, 67(8), 2000, pp. 863-876
67. Nagasawa, K; Muraki, Y; Matsuda, T; Ohnishi, N; Yokoyama, T
    Inhibitory effect of statins on fetal bovine serum-induced proliferation of rat cultured mesangial cells and correlation between their inhibitory effect and transport characteristics
    JOURNAL OF PHARMACEUTICAL SCIENCES
    
    K. Nagasawa et al., "Inhibitory effect of statins on fetal bovine serum-induced proliferation of rat cultured mesangial cells and correlation between their inhibitory effect and transport characteristics", J PHARM SCI, 89(12), 2000, pp. 1594-1604
68. Olivier, LM; Kovacs, W; Masuda, K; Keller, GA; Krisans, SK
    Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes: AA-CoA thiolase, HMG-CoA synthase, MPPD, and FPP synthase
    JOURNAL OF LIPID RESEARCH
    
    L.M. Olivier et al., "Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes: AA-CoA thiolase, HMG-CoA synthase, MPPD, and FPP synthase", J LIPID RES, 41(12), 2000, pp. 1921-1935
69. Levy, E; Beaulieu, JF; Delvin, E; Seidman, E; Yotov, W; Basque, JR; Menard, D
    Human crypt intestinal epithelial cells are capable of lipid production, apolipoprotein synthesis, and lipoprotein assembly
    JOURNAL OF LIPID RESEARCH
    
    E. Levy et al., "Human crypt intestinal epithelial cells are capable of lipid production, apolipoprotein synthesis, and lipoprotein assembly", J LIPID RES, 41(1), 2000, pp. 12-22
70. Harris, IR; Hoppner, H; Siefken, W; Farrell, AM; Wittern, KP
    Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth factor in HaCaT keratinocytes
    JOURNAL OF INVESTIGATIVE DERMATOLOGY
    
    I.R. Harris et al., "Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth factor in HaCaT keratinocytes", J INVES DER, 114(1), 2000, pp. 83-87
71. Scharnagl, H; Schliack, M; Loser, R; Nauck, M; Gierens, H; Jeck, N; Wieland, H; Gross, W; Marz, W
    The effects of lifibrol (K12.148) on the cholesterol metabolism of cultured cells: evidence for sterol independent stimulation of the LDL receptor pathway
    ATHEROSCLEROSIS
    
    H. Scharnagl et al., "The effects of lifibrol (K12.148) on the cholesterol metabolism of cultured cells: evidence for sterol independent stimulation of the LDL receptor pathway", ATHEROSCLER, 153(1), 2000, pp. 69-80
72. Sindermann, JR; Fan, L; Weigel, KA; Troyer, D; Muller, JG; Schmidt, A; March, KL; Breithardt, G
    Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture
    ATHEROSCLEROSIS
    
    J.R. Sindermann et al., "Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture", ATHEROSCLER, 150(2), 2000, pp. 331-341
73. Ma, JY; Li, YG; Ye, Q; Li, J; Hua, YJ; Ju, DJ; Zhang, DC; Cooper, R; Chang, M
    Constituents of red yeast rice, a traditional Chinese food and medicine
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
    
    J.Y. Ma et al., "Constituents of red yeast rice, a traditional Chinese food and medicine", J AGR FOOD, 48(11), 2000, pp. 5220-5225
74. Leppimaki, P; Mattinen, J; Slotte, JP
    Sterol-induced upregulation of phosphatidylcholine synthesis in cultured fibroblasts is affected by the double-bond position in the sterol tetracyclic ring structure
    EUROPEAN JOURNAL OF BIOCHEMISTRY
    
    P. Leppimaki et al., "Sterol-induced upregulation of phosphatidylcholine synthesis in cultured fibroblasts is affected by the double-bond position in the sterol tetracyclic ring structure", EUR J BIOCH, 267(21), 2000, pp. 6385-6394
75. Nakamura, T; Nishi, H; Kokusenya, Y; Hirota, K; Miura, Y
    Mechanism of antioxidative activity of fluvastatin-determination of the active position
    CHEMICAL & PHARMACEUTICAL BULLETIN
    
    T. Nakamura et al., "Mechanism of antioxidative activity of fluvastatin-determination of the active position", CHEM PHARM, 48(2), 2000, pp. 235-237
76. de Sotomayor, MA; Herrera, MD; Marhuenda, E; Andriantsitohaina, R
    Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat
    BRITISH JOURNAL OF PHARMACOLOGY
    
    M.A. de Sotomayor et al., "Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat", BR J PHARM, 131(6), 2000, pp. 1179-1187
77. Hrboticky, N; Draude, G; Hapfelmeier, G; Lorenz, R; Weber, PC
    Lovastatin decreases the receptor-mediated degradation of acetylated and oxidized LDLs in human blood monocytes during the early stage of differentiation into macrophages
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    
    N. Hrboticky et al., "Lovastatin decreases the receptor-mediated degradation of acetylated and oxidized LDLs in human blood monocytes during the early stage of differentiation into macrophages", ART THROM V, 19(5), 1999, pp. 1267-1275
78. Ranganathan, A; Timoney, M; Bycroft, M; Cortes, J; Thomas, IP; Wilkinson, B; Kellenberger, L; Hanefeld, U; Galloway, IS; Staunton, J; Leadlay, PF
    Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues
    CHEMISTRY & BIOLOGY
    
    A. Ranganathan et al., "Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues", CHEM BIOL, 6(10), 1999, pp. 731-741
79. Profant, DA; Roberts, CJ; Koning, AJ; Wright, RL
    The role of the 3-hydroxy 3-methylglutaryl coenzyme A reductase cytosolic domain in karmellae biogenesis
    MOLECULAR BIOLOGY OF THE CELL
    
    D.A. Profant et al., "The role of the 3-hydroxy 3-methylglutaryl coenzyme A reductase cytosolic domain in karmellae biogenesis", MOL BIOL CE, 10(10), 1999, pp. 3409-3423
80. Kim, DY; Bochar, DA; Stauffacher, CV; Rodwell, VW
    Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus
    PROTEIN EXPRESSION AND PURIFICATION
    
    D.Y. Kim et al., "Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus", PROT EX PUR, 17(3), 1999, pp. 435-442
81. Randall, SK; Crowell, DN
    Protein isoprenylation in plants
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
    
    S.K. Randall e D.N. Crowell, "Protein isoprenylation in plants", CR R BIOCHE, 34(5), 1999, pp. 325-338
82. Newman, JD; Chappell, J
    Isoprenoid biosynthesis in plants: Carbon partitioning within the cytoplasmic pathway
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
    
    J.D. Newman e J. Chappell, "Isoprenoid biosynthesis in plants: Carbon partitioning within the cytoplasmic pathway", CR R BIOCHE, 34(2), 1999, pp. 95-106
83. Bach, TJ; Boronat, A; Campos, N; Ferrer, A; Vollack, KU
    Mevalonate biosynthesis in plants
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
    
    T.J. Bach et al., "Mevalonate biosynthesis in plants", CR R BIOCHE, 34(2), 1999, pp. 107-122
84. Frye, LL; Leonard, DA
    Lanosterol analogs: Dual-action inhibitors of cholesterol biosynthesis
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
    
    L.L. Frye e D.A. Leonard, "Lanosterol analogs: Dual-action inhibitors of cholesterol biosynthesis", CR R BIOCHE, 34(2), 1999, pp. 123-140
85. Kemp, BE; Mitchelhill, KI; Stapleton, D; Michell, BJ; Chen, ZP; Witters, LA
    Dealing with energy demand: the AMP activated protein kinase
    TRENDS IN BIOCHEMICAL SCIENCES
    
    B.E. Kemp et al., "Dealing with energy demand: the AMP activated protein kinase", TRENDS BIOC, 24(1), 1999, pp. 22-25
86. Suzuki, M; Yanagawa, Y; Iwasaki, H; Kanda, H; Yanagihara, K; Matsumoto, H; Ohara, Y; Yazaki, Y; Sakoda, R
    First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    M. Suzuki et al., "First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104", BIOORG MED, 9(20), 1999, pp. 2977-2982
87. Thompson, GR; Barter, PJ
    Clinical lipidology at the end of the millennium
    CURRENT OPINION IN LIPIDOLOGY
    
    G.R. Thompson e P.J. Barter, "Clinical lipidology at the end of the millennium", CURR OP LIP, 10(6), 1999, pp. 521-526
88. Thompson, GR
    The proving of the lipid hypothesis
    CURRENT OPINION IN LIPIDOLOGY
    
    G.R. Thompson, "The proving of the lipid hypothesis", CURR OP LIP, 10(3), 1999, pp. 201-205
89. Tahvanainen, E; Molin, M; Laakso, J; Sundvall, J; Jauhiainen, M; Vaskonen, T; Karppanen, H
    Interrelationships between tow density lipoprotein receptor defect, serum fatty acid composition, and serum cholesterol concentration
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY
    
    E. Tahvanainen et al., "Interrelationships between tow density lipoprotein receptor defect, serum fatty acid composition, and serum cholesterol concentration", J NUTR BIOC, 10(6), 1999, pp. 360-366
90. Oda, H; Suzuki, Y; Shibata, T; Yoshida, A
    Glucocorticoid-dependent induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY
    
    H. Oda et al., "Glucocorticoid-dependent induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes", J NUTR BIOC, 10(11), 1999, pp. 644-653
91. Nakamoto, M; Takahashi, N; Iwahori, A; Sato, H; Fukui, T
    Effects of development on acetoacetyl-CoA synthetase biosynthesis in rat liver
    BIOLOGICAL & PHARMACEUTICAL BULLETIN
    
    M. Nakamoto et al., "Effects of development on acetoacetyl-CoA synthetase biosynthesis in rat liver", BIOL PHAR B, 22(9), 1999, pp. 981-983
92. Yalcinkaya, C; Dincer, A; Gunduz, E; Ficicioglu, C; Kocer, N; Aydin, A
    MRI and MRS in HMG-CoA lyase deficiency
    PEDIATRIC NEUROLOGY
    
    C. Yalcinkaya et al., "MRI and MRS in HMG-CoA lyase deficiency", PED NEUROL, 20(5), 1999, pp. 375-380
93. Petrovic, U; Gunde-Cimerman, N; Plemenitas, A
    Salt stress affects sterol biosynthesis in the halophilic black yeast Hortaea werneckii
    FEMS MICROBIOLOGY LETTERS
    
    U. Petrovic et al., "Salt stress affects sterol biosynthesis in the halophilic black yeast Hortaea werneckii", FEMS MICROB, 180(2), 1999, pp. 325-330
94. Osada, K; Inoue, T; Nakamura, S; Sugano, M
    Dietary soybean protein moderates the deleterious disturbance of lipid metabolism caused by exogenous oxidized cholesterol in rats
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
    
    K. Osada et al., "Dietary soybean protein moderates the deleterious disturbance of lipid metabolism caused by exogenous oxidized cholesterol in rats", BBA-GEN SUB, 1427(3), 1999, pp. 337-350
95. Bates, RW; Fernandez-Megia, E; Ley, SV; Ruck-Braun, K; Tilbrook, DMG
    Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    
    R.W. Bates et al., "Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex", J CHEM S P1, (14), 1999, pp. 1917-1925
96. Brunet, S; Thibault, L; Delvin, E; Yotov, W; Bendayan, M; Levy, E
    Dietary iron overload and induced lipid peroxidation are associated with impaired plasma lipid transport and hepatic sterol metabolism in rats
    HEPATOLOGY
    
    S. Brunet et al., "Dietary iron overload and induced lipid peroxidation are associated with impaired plasma lipid transport and hepatic sterol metabolism in rats", HEPATOLOGY, 29(6), 1999, pp. 1809-1817
97. de Sotomayor, MA; Perez-Guerrero, C; Herrera, MD; Marhuenda, E
    Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats
    JOURNAL OF HYPERTENSION
    
    M.A. de Sotomayor et al., "Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats", J HYPERTENS, 17(6), 1999, pp. 769-776
98. Lee, SH; Park, YB; Bae, KH; Bok, SH; Kwon, YK; Lee, ES; Choi, MS
    Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A : cholesterol acyltransferase in rats
    ANNALS OF NUTRITION AND METABOLISM
    
    S.H. Lee et al., "Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A : cholesterol acyltransferase in rats", ANN NUTR M, 43(3), 1999, pp. 173-180
99. Wang, DQH; Lammert, F; Cohen, DE; Paigen, B; Carey, MC
    Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
    
    D.Q.H. Wang et al., "Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis", AM J P-GAST, 39(3), 1999, pp. G751-G760
100. del Villar-Martinez, AA; Ma, R; Paredes-Lopez, O
     Molecular characterization of cDNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in marigold (Tagetes erecta)
     JOURNAL OF PLANT PHYSIOLOGY
     
     A.A. del Villar-Martinez et al., "Molecular characterization of cDNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in marigold (Tagetes erecta)", J PLANT PHY, 155(2), 1999, pp. 205-211