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La ricerca find articoli where soggetti phrase all words '3,4-METHYLENEDIOXYMETHAMPHETAMINE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 399 riferimenti
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    1. Chung, YL; Liu, JT; Lin, CH
      On-line identification of 3,4-methylenedioxymethamphetamine in human urineby non-aqueous capillary electrophoresis-fluorescence spectroscopy at 77 K

      JOURNAL OF CHROMATOGRAPHY B
    2. Brunnenberg, M; Kovar, KA
      Stereospecific analysis of ecstasy-like N-ethyl-3,4-ethylenedioxyamphetamine and its metabolites in humans

      JOURNAL OF CHROMATOGRAPHY B
    3. Kavanagh, P; Dunne, J; Feely, J; Maguire, R; Corrigan, D; Keating, JJ; Meegan, MJ; Clancy, JM; Burdett, J
      Phenylalkylamine abuse among opiate addicts attending a methadone treatment programme in the Republic of Ireland

      ADDICTION BIOLOGY
    4. Frei, E; Gamma, A; Pascual-Marqui, R; Lehmann, D; Hell, D; Vollenweider, FX
      Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)

      HUMAN BRAIN MAPPING
    5. Maldonado, E; Navarro, JF
      MDMA ('ecstasy') exhibits an anxiogenic-like activity in social encountersbetween male mice

      PHARMACOLOGICAL RESEARCH
    6. Winstock, AR; Wolff, K; Ramsey, J
      Ecstasy pill testing: harm minimization gone too far?

      ADDICTION
    7. Obergriesser, T; Ende, G; Braus, DF; Henn, FA
      Hippocampal H-1-MRSI in ecstasy users

      EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
    8. Zemishlany, Z; Aizenberg, D; Weizman, A
      Subjective effects of MDMA ('ecstasy') on human sexual function

      EUROPEAN PSYCHIATRY
    9. Wrona, MZ; Dryhurst, G
      A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: Possible relevance to the serotonergic neurotoxicity of methamphetamine

      CHEMICAL RESEARCH IN TOXICOLOGY
    10. Bai, FJ; Jones, DC; Lau, SS; Monks, TJ
      Serotonergic neurotoxicity of 3,4-(+/-) -methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase

      CHEMICAL RESEARCH IN TOXICOLOGY
    11. Fletcher, PJ; Robinson, SR; Slippoy, DL
      Pre-exposure to (+/-)3,4-methylenedioxy-methamphetamine (MDMA) facilitatesacquisition of intravenous cocaine self-administration in rats

      NEUROPSYCHOPHARMACOLOGY
    12. Vollenweider, FX; Jones, RT; Baggott, MJ
      Response: Caveat emptor: Editors beware

      NEUROPSYCHOPHARMACOLOGY
    13. Taffe, MA; Weed, MR; Davis, S; Huitron-Resendiz, S; Schroeder, R; Parsons, LH; Henriksen, SJ; Gold, LH
      Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine(MDMA) treatment in rhesus monkeys

      NEUROPSYCHOPHARMACOLOGY
    14. Liechti, ME; Geyer, MA; Hell, D; Vollenweider, FX
      Effects of MDMA (ecstasy) on prepulse inhibition and habituation of startle in humans after pretreatment with citalopram, haloperidol, or ketanserin

      NEUROPSYCHOPHARMACOLOGY
    15. Callahan, BT; Cord, BJ; Ricaurte, GA
      Long-term impairment of anterograde axonal transport along fiber projection originating in the rostral raphe nuclei after treatment with fenfluramineor methylenedioxymethamphetamine

      SYNAPSE
    16. Rothman, RB; Baumann, MH; Dersch, CM; Romero, DV; Rice, KC; Carroll, FI; Partilla, JS
      Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

      SYNAPSE
    17. Heffernan, TM; Ling, J; Scholey, AB
      Subjective ratings of prospective memory deficits in MDMA ('ecstasy') users

      HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
    18. Kalant, H
      The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs

      CANADIAN MEDICAL ASSOCIATION JOURNAL
    19. Tancer, ME; Johanson, CE
      The subjective effects of MDMA and mCPP in moderate MDMA users

      DRUG AND ALCOHOL DEPENDENCE
    20. Winstock, AR; Griffiths, P; Stewart, D
      Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK

      DRUG AND ALCOHOL DEPENDENCE
    21. Lawler, LP; Abraham, S; Fishman, EK
      3,4-methylenedioxymethamphetamine (Ecstasy)-induced hepatotoxicity: Multidetector CT and pathology findings

      JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
    22. Verdone, F
      Rhabdomyolysis and 3,4 methylenedioxymethamphetamine in rheumatological practice

      JOURNAL OF RHEUMATOLOGY
    23. Mayerhofer, A; Kovar, KA; Schmidt, WJ
      Changes in serotonin, dopamine and noradrenaline levels in striatum and nucleus accumbens after repeated administration of the abused drug MDMA in rats

      NEUROSCIENCE LETTERS
    24. Fernandez, F; Aguerre, S; Mormede, P; Chaouloff, F
      Differential sensitivities to the lethal, but not the neurotoxic, effects of p-chloroamphetamine in inbred rat strains

      NEUROSCIENCE LETTERS
    25. Granoff, MI; Ashby, CR
      Effect of the repeated administration of (+/-)-3,4-methylenedioxymethamphetamine on the behavioral response of rats to the 5-HT1A receptor agonist (+/-)-8-hydroxy-(di-n-propylamino)Tetralin

      NEUROPSYCHOBIOLOGY
    26. Abekawa, T; Ohmori, T; Honda, M; Ito, K; Koyama, T
      Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum

      JOURNAL OF NEURAL TRANSMISSION
    27. Yu, L; Kuo, YM; Cherng, CFG
      Opioid peptides alleviated while naloxone potentiated methamphetamine-induced striatal dopamine depiction in mice

      JOURNAL OF NEURAL TRANSMISSION
    28. Pentney, AR
      An exploration of the history and controversies surrounding MDMA and MDA

      JOURNAL OF PSYCHOACTIVE DRUGS
    29. Teter, CJ; Guthrie, SK
      A comprehensive review of MDMA and GHB: Two common club drugs

      PHARMACOTHERAPY
    30. Pham, JV; Puzantian, T
      Ecstasy: Dangers and controversies

      PHARMACOTHERAPY
    31. Gamma, A; Buck, A; Berthold, T; Vollenweider, FX
      No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine)users and control subjects: A [(H2O)-O-15]-positron emission tomography study

      JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
    32. Broening, HW; Morford, LL; Inman-Wood, SL; Fukumura, M; Vorhees, CV
      3,4-Methylenedioxymethamphetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development

      JOURNAL OF NEUROSCIENCE
    33. Sandoval, V; Riddle, EL; Ugarte, YV; Hanson, GR; Fleckenstein, AE
      Methamphetamine-induced rapid and reversible changes in dopamine transporter function: An in vitro model

      JOURNAL OF NEUROSCIENCE
    34. MacInnes, N; Handley, SL; Harding, GFA
      Former chronic methylenedioxymethamphetamine (MDMA or ecstasy) users report mild depressive symptoms

      JOURNAL OF PSYCHOPHARMACOLOGY
    35. Connor, TJ; Connelly, DB; Kelly, JP
      Methylenedioxymethamphetamine (MDMA; 'Ecstasy') suppresses antigen specific IgG(2a) and IFN-gamma production

      IMMUNOLOGY LETTERS
    36. Kraner, JC; McCoy, DJ; Evans, MA; Evans, LE; Sweeney, BJ
      Fatalities caused by the MDMA-related drug paramethoxyamphetamine (PMA)

      JOURNAL OF ANALYTICAL TOXICOLOGY
    37. Zhao, HR; Brenneisen, R; Scholer, A; McNally, AJ; ElSohly, MA; Murphy, TP; Salamone, SJ
      Profiles of urine samples taken from ecstasy users at rave parties: Analysis by immunoassays, HPLC, and GC-MS

      JOURNAL OF ANALYTICAL TOXICOLOGY
    38. Garbino, J; Henry, JA; Mentha, G; Romand, JA
      Ecstasy ingestion and fulminant hepatic failure: Liver transplantation to be considered as a last therapeutic option

      VETERINARY AND HUMAN TOXICOLOGY
    39. Buchert, R; Obrocki, J; Thomasius, R; Vaterlein, O; Petersen, K; Jenicke, L; Bohuslavizki, KH; Clausen, M
      Long-term effects of 'ecstasy' abuse on the human brain studied by FDG PET

      NUCLEAR MEDICINE COMMUNICATIONS
    40. Gold, MS; Tabrah, H; Frost-Pineda, K
      Psychopharmacology of MDMA (Ecstasy)

      PSYCHIATRIC ANNALS
    41. Reneman, L; Majoie, CBLM; Habraken, JBA; den Heeten, GJ
      Effects of ecstasy (MDMA) on the brain in abstinent users: Initial observations with diffusion and perfusion MR imaging

      RADIOLOGY
    42. Ratzenboeck, E; Saria, A; Kriechbaum, N; Zernig, G
      Reinforcing effects of MDMA ('ecstasy') in drug-naive and cocaine-trained rats

      PHARMACOLOGY
    43. Spitzer, M; Franke, B; Walter, H; Buechler, J; Wunderlich, AP; Schwab, M; Kovar, KA; Hermle, L; Gron, G
      Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans

      NEUROPHARMACOLOGY
    44. O'Shea, E; Esteban, B; Camarero, J; Green, AR; Colado, MI
      Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

      NEUROPHARMACOLOGY
    45. Ling, LH; Marchant, C; Buckley, NA; Prior, M; Irvine, RJ
      Poisoning with the recreational drug paramethoxyamphetamine ("death")

      MEDICAL JOURNAL OF AUSTRALIA
    46. Pacifici, R; Zuccaro, P; Farre, M; Pichini, S; Di Carlo, S; Roset, PN; Ortuno, J; Pujadas, M; Bacosi, A; Menoyo, E; Segura, J; de la Torre, R
      Effects of repeated doses of MDMA ("ecstasy") on cell-mediated immune response in humans

      LIFE SCIENCES
    47. Harkin, A; Connor, TJ; Mulrooney, J; Kelly, JP; Leonard, BE
      Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats

      LIFE SCIENCES
    48. Nixdorf, WL; Burrows, KB; Gudelsky, GA; Yamamoto, BK
      Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate

      JOURNAL OF NEUROCHEMISTRY
    49. Sharma, A
      A case of sensorineural deafness following ingestion of Ecstasy

      JOURNAL OF LARYNGOLOGY AND OTOLOGY
    50. Sugimoto, Y; Ohkura, M; Inoue, K; Yamada, J
      Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice

      EUROPEAN JOURNAL OF PHARMACOLOGY
    51. Al-Sahli, W; Ahmad, H; Kheradmand, F; Connolly, C; Docherty, JR
      Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of rat right ventricle and small mesenteric artery

      EUROPEAN JOURNAL OF PHARMACOLOGY
    52. Acquas, E; Marrocu, P; Pisanu, A; Cadoni, C; Zernig, G; Saria, A; Di Chiara, G
      Intravenous administration of ecstasy (3,4-methylendioxymethamphetamine) enhances cortical and striatal acetylcholine release in vivo

      EUROPEAN JOURNAL OF PHARMACOLOGY
    53. Connor, TJ; Dennedy, MC; Harkin, A; Kelly, JP
      Methylenedioxymethamphetamine-induced suppression of interleukin-1 beta and tumour necrosis factor-alpha is not mediated by serotonin

      EUROPEAN JOURNAL OF PHARMACOLOGY
    54. Cannon, DM; Keenan, AK; Guiry, PJ; Buon, C; Baird, AW; McBean, GJ
      In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA

      BRITISH JOURNAL OF PHARMACOLOGY
    55. Sanchez, V; Camarero, J; Esteban, B; Peter, MJ; Green, AR; Colado, MI
      The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain

      BRITISH JOURNAL OF PHARMACOLOGY
    56. McDaid, J; Docherty, JR
      Vascular actions of MDMA involve alpha(1) and alpha(2)-adrenoceptors in the anaesthetized rat

      BRITISH JOURNAL OF PHARMACOLOGY
    57. Yamada, J; Sugimoto, Y; Ohkura, M; Inoue, K; Shinozuka, K; Kunitomo, M
      Role of 5-HT2 receptor subtypes in depletion of 5-HT induced by p-chloroamphetamine in the mouse frontal cortex

      BRAIN RESEARCH
    58. McCann, UD; Ricaurte, GA; Molliver, ME
      "Ecstasy" and serotonin neurotoxicity - New findings raise more questions

      ARCHIVES OF GENERAL PSYCHIATRY
    59. Cadet, JL; Thiriet, N; Jayanthi, S
      Involvement of free radicals in MDMA-induced neurotoxicity in mice

      ANNALES DE MEDECINE INTERNE
    60. Lin, CH; Chung, YL; Chen, YH
      Development of a capillary electrophoresis-77 K luminescence detection system for online spectral identification

      ANALYST
    61. Croft, RJ; Klugman, A; Baldeweg, T; Gruzelier, JH
      Electrophysiological evidence of serotonergic impairment in long-term MDMA("ecstasy") users

      AMERICAN JOURNAL OF PSYCHIATRY
    62. Colado, MI; O'Shea, E; Esteban, B; Green, AR
      Studies on the neuroprotective effect of the enantiomers of AR-A008055, a compound structurally related to clomethiazole, on MDMA ("ecstasy")-inducedneurodegeneration in rat brain

      PSYCHOPHARMACOLOGY
    63. Mechan, AO; O'Shea, E; Elliott, JM; Colado, MI; Green, AR
      A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation

      PSYCHOPHARMACOLOGY
    64. Esteban, B; O'Shea, E; Camarero, J; Sanchez, V; Green, AR; Colado, MI
      3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected nenrotoxic dose

      PSYCHOPHARMACOLOGY
    65. Liechti, ME; Gamma, A; Vollenweider, FX
      Gender differences in the subjective effects of MDMA

      PSYCHOPHARMACOLOGY
    66. Croft, RJ; Mackay, AJ; Mills, ATD; Gruzelier, JGH
      The relative contributions of ecstasy and cannabis to cognitive impairment

      PSYCHOPHARMACOLOGY
    67. Verkes, RJ; Gijsman, HJ; Pieters, MSM; Schoemaker, RC; de Visser, S; Kuijpers, M; Pennings, EJM; de Bruin, D; Van de Wijngaart, G; Van Gerven, JMA; Cohen, AF
      Cognitive performance and serotonergic function in users of ecstasy

      PSYCHOPHARMACOLOGY
    68. Crowe, AV; Howse, M; Bell, GM; Henry, JA
      Substance abuse and the kidney

      QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
    69. Chinaka, S; Tanaka, S; Takayama, N; Komai, K; Ohshima, T; Ueda, K
      Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis

      JOURNAL OF CHROMATOGRAPHY B
    70. Van Aerts, LAGJM; Mallaret, M; Rigter, H
      N-methyl-1-(1,3-benzodioxol-5-yl)-2-buta (MBDB): its properties and possible risks

      ADDICTION BIOLOGY
    71. Neiman, J; Haapaniemi, HM; Hillbom, M
      Neurological complications of drug abuse: pathophysiological mechanisms

      EUROPEAN JOURNAL OF NEUROLOGY
    72. Grob, CS
      Deconstructing ecstasy: The politics of MDMA research

      ADDICTION RESEARCH
    73. Gamma, A; Frei, E; Lehmann, D; Pascual-Marqui, RD; Hell, D; Vollenweider, FX
      Mood state and brain electric activity in Ecstasy users

      NEUROREPORT
    74. Fischer, HS; Zernig, G; Schatz, DS; Humpel, C; Saria, A
      MDMA ('ecstasy') enhances basal acetylcholine release in brain slices of the rat striatum

      EUROPEAN JOURNAL OF NEUROSCIENCE
    75. McCann, UD; Ricaurte, GA
      Drug abuse and dependence: hazards and consequences of heroin, cocaine andamphetamines

      CURRENT OPINION IN PSYCHIATRY
    76. De Letter, EA; De Paepe, P; Clauwaert, KM; Belpaire, FM; Lambert, WE; Van Bocxlaer, JF; Piette, MHA
      Is vitreous humour useful for the interpretation of 3,4-methylenedioxymethamphetamine (MDMA) blood levels? Experimental approach with rabbits

      INTERNATIONAL JOURNAL OF LEGAL MEDICINE
    77. Carter, N; Rutty, GN; Milroy, CM; Forrest, ARW
      Deaths associated with MBDB misuse

      INTERNATIONAL JOURNAL OF LEGAL MEDICINE
    78. Buchler, J; Maichle-Mossmer, C; Kovar, KA
      Enantioselective production and crystal structure of the ecstasy analogue N-ethyl-3,4-methylenedioxyamphetamine-HCl (MDE) and its major metabolites MDA and HME

      ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
    79. Liechti, ME; Vollenweider, FX
      Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans

      EUROPEAN NEUROPSYCHOPHARMACOLOGY
    80. Burgess, C; O'Donohoe, A; Gill, M
      Agony and ecstasy: a review of MDMA effects and toxicity

      EUROPEAN PSYCHIATRY
    81. Liechti, ME; Saur, MR; Gamma, A; Hell, D; Vollenweider, FX
      Psychological and physiological effects of MDMA ("ecstasy") after pretreatment with the 5-HT2 antagonist ketanserin in healthy humans

      NEUROPSYCHOPHARMACOLOGY
    82. Tuchtenhagen, F; Daumann, J; Norra, C; Gobbele, R; Becker, S; Pelz, S; Sass, H; Buchner, H; Gouzoulis-Mayfrank, E
      High intensity dependence of auditory evoked dipole source activity indicates decreased serotonergic activity in abstinent ecstasy (MDMA) users

      NEUROPSYCHOPHARMACOLOGY
    83. Dulawa, SC; Gross, C; Stark, KL; Hen, R; Geyer, MA
      Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition

      NEUROPSYCHOPHARMACOLOGY
    84. Liechti, ME; Baumann, C; Gamma, A; Vollenweider, FX
      Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram

      NEUROPSYCHOPHARMACOLOGY
    85. Schatz, DS; Kaufmann, WA; Schuligoi, R; Humpel, C; Saria, A
      3,4-methylenedioxymetamphetamine (ecstasy) induces c-fos-like protein and mRNA in rat organotypic dorsal striatal slices

      SYNAPSE
    86. Shannon, M
      Methylenedioxymethamphetamine (MDMA, "Ecstasy")

      PEDIATRIC EMERGENCY CARE
    87. Graeme, KA
      New drugs of abuse

      EMERGENCY MEDICINE CLINICS OF NORTH AMERICA
    88. Ricaurte, GA; McCann, UD; Szabo, Z; Scheffel, U
      Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

      TOXICOLOGY LETTERS
    89. Morland, J
      Toxicity of drug abuse - amphetamine designer drugs (ecstasy): mental effects and consequences of single dose use

      TOXICOLOGY LETTERS
    90. Parrott, AC; Sisk, E; Turner, JJD
      Psychobiological problems in heavy 'ecstasy' (MDMA) polydrug users

      DRUG AND ALCOHOL DEPENDENCE
    91. Ricaurte, GA; Yuan, J; McCann, UD
      (+/-)3,4-methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Studies in animals

      NEUROPSYCHOBIOLOGY
    92. McCann, UD; Eligulashvili, V; Ricaurte, GA
      (+/-)3,4-methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Clinical studies

      NEUROPSYCHOBIOLOGY
    93. Parrott, AC
      Human research on MDMA (3,4-methylenedioxymethamphetamine) neurotoxicity: Cognitive and behavioural indices of change

      NEUROPSYCHOBIOLOGY
    94. Schifano, F
      Potential human neurotoxicity of MDMA ('ecstasy'): Subjective self-reports, evidence from an Italian Drug Addiction Centre and clinical case studies

      NEUROPSYCHOBIOLOGY
    95. Curran, HV
      Is MDMA ('ecstasy') neurotoxic in humans? An overview of evidence and of methodological problems in research

      NEUROPSYCHOBIOLOGY
    96. Daws, LC; Irivne, RJ; Callaghan, PD; Toop, NP; White, JM; Bochner, F
      Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat

      PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
    97. Maldonado, E; Navarro, JF
      Effects of 3,4-methylenedioxy-methamphetamine (MDMA) on anxiety in mice tested in the light-dark box

      PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
    98. Xie, T; McCann, UD; Kim, S; Yuan, J; Ricaurte, GA
      Effect of temperature on dopamine transporter function and intracellular accumulation of methamphetamine: Implications for methamphetamine-induced dopaminergic neurotoxicity

      JOURNAL OF NEUROSCIENCE
    99. Liechti, ME; Vollenweider, FX
      The serotonin uptake inhibitor citalopram reduces acute cardiovascular andvegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers

      JOURNAL OF PSYCHOPHARMACOLOGY
    100. Duflou, J; Mark, A
      Aortic dissection after ingestion of "ecstasy" (MDMA)

      AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY


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Documento generato il 22/02/20 alle ore 18:01:33