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Inhibitors of human and rat testes microsomal 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) as potential agents for prostatic cancer
JOURNAL OF ENZYME INHIBITION
Genetic susceptibility and environmental estrogen-like compounds
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
SDR: Structure, mechanism of action, and substrate recognition
CURRENT ORGANIC CHEMISTRY
Inhibitors of steroidogenesis as agents for the treatment of hormone-dependent cancers
EXPERT OPINION ON THERAPEUTIC PATENTS
Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer
CLINICAL CANCER RESEARCH
Importance of focal aromatase activity in hormone-dependent breast cancer:a review
BREAST
Paradoxical effect of estradiol: it can block its own bioformation in human breast cancer cells
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
The selective estrogen enzyme modulator (SEEM) in breast cancer
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Analysis and characteristics of multiple types of human 17 beta-hydroxysteroid dehydrogenase
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Regulation of steroidogenic enzymes and a novel testicular RNA helicase
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Multiple signal transduction pathways mediate interleukin-4-induced 3 beta-hydroxysteroid dehydrogenase/Delta 5-Delta 4 isomerase in normal and tumoral target tissues
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Seasonal variation in androgen-metabolizing enzymes in the diencephalon and telencephalon of the male European starling (Sturnus vulgaris)
JOURNAL OF NEUROENDOCRINOLOGY
Crystallization and preliminary X-ray studies of meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae IAM1063
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Effect of human chorionic gonadotrophin coadministration on the activitiesof ovarian Delta(5)-3 beta-hydroxysteroid dehydrogenase, and 17 beta-hydroxysteroid dehydrogenase, and ovarian and uterine histology in lithium chloride-treated albino rats
REPRODUCTIVE TOXICOLOGY
Estrogen and antiestrogen actions on transforming growth factor beta (Tgf beta) in normal human breast epithelial (HBE) cells
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Cytokine regulation of the expression of estrogenic biosynthetic enzymes in cultured rat granulosa cells
MOLECULAR AND CELLULAR ENDOCRINOLOGY
A guide to 17 beta-hydroxysteroid dehydrogenases
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Crucial role of cytokines in sex steroid formation in normal and tumoral tissues
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Estrogen metabolism and malignancy: analysis of the expression and function of 17 beta-hydroxysteroid dehydrogenases in colonic cancer
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Molecular basis of D-bifunctional protein deficiency
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Type 5 17 beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Arrested testis development in the cpk mouse may be the result of abnormalsteroid metabolism
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Pan1b (17 beta HSD11)-enzymatic activity and distribution in the lung
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Structure-function aspects and inhibitor design of type 5 17 beta-hydroxysteroid dehydrogenase (AKR1C3)
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Distribution of 17 beta-hydroxysteroid dehydrogenases in human osteoblast-like cells
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Expression of the 17 beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Expression and regulation of 17 beta-hydroxysteroid dehydrogenase 7 in therabbit
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Mechanisms of estradiol inactivation in primate endometrium
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Expression of the estradiol-synthesizing 17 beta-hydroxysteroid dehydrogenases type 1 and type 7 in the nonhuman primate Callithrix jacchus
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Searching for the physiological function of 17 beta-hydroxysteroid dehydrogenase from the fungus Cochliobulus lunatus: studies of substrate specificity and expression analysis
MOLECULAR AND CELLULAR ENDOCRINOLOGY
17 beta-hydroxysteroid dehydrogenase type 7 - an ancient 3-ketosteroid reductase of cholesterogenesis
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Evolution of 17 beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Aromatase regulation and breast cancer
CLINICAL ENDOCRINOLOGY
Molecular epidemiology of hormone-metabolic loci in prostate cancer
EPIDEMIOLOGIC REVIEWS
Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
BREAST CANCER RESEARCH AND TREATMENT
17 beta-hydroxysteroid dehydrogenase type 2 expression and enzyme activityin the human gastrointestinal tract
CLINICAL SCIENCE
DHEA and its transformation into androgens and estrogens in peripheral target tissues: Intracrinology
FRONTIERS IN NEUROENDOCRINOLOGY
Metabolism of estradiol, ethynylestradiol, and moxestrol in rat uterus, vagina, and aorta: Influence of sex steroid treatment
DRUG METABOLISM AND DISPOSITION
Chemical synthesis of 16 beta-propylaminoacyl derivatives of estradiol andtheir inhibitory potency on type 1 17 beta-hydroxy steroid dehydrogenase and binding affinity on steroid receptors
STEROIDS
Expression of 17 beta-hydroxysteroid dehydrogenases in mesophilic and extremophilic yeast
STEROIDS
Chalcones are potent inhibitors of aromatase and 17 beta-hydroxysteroid dehydrogenase activities
LIFE SCIENCES
Etiological studies of severe or familial hypospadias
JOURNAL OF UROLOGY
Sebocytes are the key regulators of androgen homeostasis in human skin
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Genotype versus phenotype in families with androgen insensitivity syndrome
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
The role of the liver in the acute effect of alcohol on androgens in women
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
5 alpha-Reductases in human breast carcinoma: Possible modulator of in situ androgenic actions
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Characterization of the 5 alpha-reductase-3 alpha-hydroxysteroid dehydrogenase complex in the human brain
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Structure of the human 3 alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution
JOURNAL OF BIOLOGICAL CHEMISTRY
The crystallographic structure of the mannitol 2-dehydrogenase NADP(+) binary complex from Agaricus bisporus
JOURNAL OF BIOLOGICAL CHEMISTRY
Porcine carbonyl reductase - Structural basis for a functional monomer in short chain dehydrogenases/reductases
JOURNAL OF BIOLOGICAL CHEMISTRY
Crystal structure of glucose dehydrogenase from Bacillus megaterium IWG3 at 1.7 angstrom resolution
JOURNAL OF BIOCHEMISTRY
Androgens, androgen receptors, and male gender role behavior
HORMONES AND BEHAVIOR
Characterization and localization of human type10 17 beta-hydroxysteroid dehydrogenase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Minireview: Sex differentiation
ENDOCRINOLOGY
Divergent immune responses in male and female mice after trauma-hemorrhage: Dimorphic alterations in T lymphocyte steroidogenic enzyme activities
ENDOCRINOLOGY
Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo
ENDOCRINOLOGY
Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes
ENDOCRINOLOGY
Molecular mechanisms of estrogen recognition and 17-keto reduction by human 17 beta-hydroxysteroid dehydrogenase
CHEMICO-BIOLOGICAL INTERACTIONS
17 beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus:structural and functional aspects
CHEMICO-BIOLOGICAL INTERACTIONS
Cloning and expression of cDNA encoding hamster liver 3-hydroxyhexobarbita/17 beta(3 alpha)-hydroxysteroid dehydrogenase 1
CHEMICO-BIOLOGICAL INTERACTIONS
Prostate short-chain dehydrogenase reductase 1 (PSDR1): A new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium
CANCER RESEARCH
Oxidations of 17 beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavone
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
3 alpha-hydroxysteroid dehydrogenase in animal and human tissues
BIOCHEMISTRY-MOSCOW
Solid-phase synthesis of phenolic steroids: From optimization studies to aconvenient procedure for combinatorial synthesis of biologically relevant estradiol derivatives
JOURNAL OF COMBINATORIAL CHEMISTRY
Interaction of cytotoxic bicyclic peptides, theonellamides A and F, with glutamate dehydrogenase and 17 beta-hydroxysteroid dehydrogenase IV
MARINE BIOTECHNOLOGY
Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression
CELLULAR AND MOLECULAR LIFE SCIENCES
Testosterone dehydrogenase activity in koala liver: characterisation of cofactor and steroid substrate differences
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY
Biology of aromatase in the mammary gland
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Estrogen metabolism as a regulator of estrogen action in the mammary gland
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Expression of 17 beta-hydroxysteroid dehydrogenase type 5 in human ovary: A pilot study
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
Unique features of the basal cells of human prostate epithelium
MICROSCOPY RESEARCH AND TECHNIQUE
The role of local estrogen biosynthesis in males and females
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Sex steroids and parasitism: Taenia crassiceps cisticercus metabolizes exogenous androstenedione to testosterone in vitro
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Activin-A, but not inhibin, regulates 17 beta-hydroxysteroid dehydrogenasetype 1 activity and expression in cultured rat granulosa cells
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Progesterone effect on cell growth, ultrastructural aspect and estradiol receptors of normal human breast epithelial (HBE) cells in culture
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
A novel HPLC-RIA method for the simultaneous detection of estrone, estradiol and estrone sulphate levels in breast cancer tissue
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Role of aromatase in sex steroid action
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Characterization of a human 20 alpha-hydroxysteroid dehydrogenase
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Expression of mRNAs encoding for 17 beta-hydroxisteroid dehydrogenase isozymes 1, 2, 3 and 4 in epileptic human hippocampus
EPILEPSY RESEARCH
17 beta-hydroxysteroid dehydrogenase type 2 and dehydroepiandrosterone sulfotransferase in the human liver
ENDOCRINE JOURNAL
The molecular basis of male sexual differentiation
EUROPEAN JOURNAL OF ENDOCRINOLOGY
Radiolabeled estradiol derivatives to predict response to hormonal treatment in breast cancer: a review
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
Characterization of fungal 17 beta-hydroxysteroid dehydrogenases
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
Clinical, endocrine, and molecular genetic findings in patients with 17 beta-hydroxysteroid dehydrogenase deficiency
HORMONE RESEARCH
The testosterone : androstenedione ratio in male undermasculinization
CLINICAL ENDOCRINOLOGY
Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis
ACTA PHARMACOLOGICA SINICA
17 beta-hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinomain situ and intraductal proliferative lesions of the human breast
ANTICANCER RESEARCH
Genistein: Does it prevent or promote breast cancer?
ENVIRONMENTAL HEALTH PERSPECTIVES
Steroid dehydrogenase structures, mechanism of action, and disease
VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 58
Pluripotency of 17 beta-hydroxysteroid dehydrogenase from the filamentous fungus Cochliobolus lunatus
STEROIDS
17-Beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma - A new development in intracrinology
ONCOLOGY
Effects of phytoestrogens on aromatase, 3 beta and 17 beta-hydroxysteroid dehydrogenase activities and human breast cancer cells
LIFE SCIENCES
Olive oil phenols inhibit human hepatic microsomal activity
JOURNAL OF NUTRITION
Structure-activity relationships of 17 alpha-derivatives of estradiol as inhibitors of steroid sulfatase
JOURNAL OF MEDICINAL CHEMISTRY
Effect of transforming growth factor beta(2) on oestrogen metabolism in the MCF-7 breast cancer cell line
JOURNAL OF CLINICAL PATHOLOGY
Tissue- and site-specific gene expression of type 2 17 ss-hydroxysteroid dehydrogenase: In situ hybridization and specific enzymatic activity studiesin human placental endothelial cells of the arterial system
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Human peroxisomal multifunctional enzyme type 2 - Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity
JOURNAL OF BIOLOGICAL CHEMISTRY
Molecular characterization of a first human 3(alpha ->beta)-hydroxysteroidepimerase
JOURNAL OF BIOLOGICAL CHEMISTRY
The effect of epitestosterone on estrogen biosynthesis in vitro
HORMONE AND METABOLIC RESEARCH