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    1. Fredriksson, A; Schroder, N; Eriksson, P; Izquierdo, I; Archer, T
      Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits

      PARKINSONISM & RELATED DISORDERS
    2. Vila, M; Jackson-Lewis, V; Guegan, C; Wu, DC; Teismann, P; Choi, DK; Tieu, K; Przedborski, S
      The role of glial cells in Parkinson's disease

      CURRENT OPINION IN NEUROLOGY
    3. Smeyne, M; Goloubeva, O; Smeyne, RJ
      Strain-dependent susceptibility to MPTP and MPP+-induced parkinsonism is determined by glia

      GLIA
    4. Petzinger, GM; Quik, M; Ivashina, E; Jakowec, MW; Jakubiak, M; Di Monte, D; Langston, JW
      Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate

      MOVEMENT DISORDERS
    5. Tariq, M; Khan, HA; Al Moutaery, K; Al Deeb, S
      Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents

      BRAIN RESEARCH BULLETIN
    6. Rothblat, DS; Schroeder, JA; Schneider, JS
      Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: Potential contributors to spontaneous recovery from experimental Parkinsonism

      JOURNAL OF NEUROSCIENCE RESEARCH
    7. Obata, T; Kubota, S; Yamanaka, Y
      Allopurinol suppresses para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum

      NEUROSCIENCE LETTERS
    8. Schmidt, N; Ferger, B
      Neurochemical findings in the MPTP model of Parkinson's disease

      JOURNAL OF NEURAL TRANSMISSION
    9. Zwart, R; Verhaagh, S; Buitelaar, M; Popp-Snijders, C; Barlow, DP
      Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice

      MOLECULAR AND CELLULAR BIOLOGY
    10. Kumagai, T; Ido, T; Araki, T; Matsubara, M; Imai, Y
      Riluzole protects against MPTP-induced dopamine and DOPAC depletion in mice

      BIOGENIC AMINES
    11. Sedelis, M; Schwarting, RKW; Huston, JP
      Behavioral phenotyping of the MPTP mouse model of Parkinson's disease

      BEHAVIOURAL BRAIN RESEARCH
    12. Mazzio, E; Huber, J; Darling, S; Harris, N; Soliman, KFA
      Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells

      NEUROTOXICOLOGY
    13. Lee, ESY; Charlton, CG
      1-Methyl-4-phenyl-pyridinium increases S-adenosyl-L-methionine dependent phospholipid methylation

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    14. Liou, HH; Chen, RC; Chen, THH; Tsai, YF; Tsai, MC
      Attenuation of paraquat-induced dopaminergic toxicity on the substantia nigra by (-)-deprenyl in vivo

      TOXICOLOGY AND APPLIED PHARMACOLOGY
    15. Boyce, S; Rupniak, NMJ; Steventon, MJ; Iversen, SD
      Differential effects of D-1 and D-2 agonists in MPTP,treated primates: Functional implications for Parkinson's disease

      NEUROLOGY
    16. Martel, F; Calhau, C; Soares-da-Silva, P; Azevedo, I
      Transport of [H-3]MPP+ in an immortalized rat brain microvessel endothelial cell line (RBE 4)

      NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
    17. Hofele, K; Sedelis, M; Auburger, GW; Morgan, S; Huston, JP; Schwarting, RKW
      Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility

      EXPERIMENTAL NEUROLOGY
    18. Bocquet, A; Lorent, G; Fuks, B; Grimee, R; Talaga, P; Daliers, J; Klitgaard, H
      Failure of GPI compounds to display neurotrophic activity in vitro and in vivo

      EUROPEAN JOURNAL OF PHARMACOLOGY
    19. Tahar, AH; Ekesbo, A; Gregoire, L; Bangassoro, E; Svensson, KA; Tedroff, J; Bedard, PJ
      Effects of acute and repeated treatment with a novel dopamine D-2 receptorligand on L-DOPA-induced dyskinesias in MPTP monkeys

      EUROPEAN JOURNAL OF PHARMACOLOGY
    20. Lipina, SJ; Colombo, JA
      Dissociated functional recovery in parkinsonian monkeys following transplantation of astroglial cells

      BRAIN RESEARCH
    21. Anderson, DW; Neavin, T; Smith, JA; Schneider, JS
      Neuroprotective effects of pramipexole in young and aged MPTP-treated mice

      BRAIN RESEARCH
    22. Wade, TV; Rothblat, DS; Schneider, JS
      Changes in striatal dopamine D3 receptor regulation during expression of and recovery from MPTP-induced parkinsonism

      BRAIN RESEARCH
    23. Ooms, F; Delvosal, S; Wouters, J; Durant, F; Dockendolf, G; Van't Land, C; Glass, T; Castagnoli, N; Van der Schyf, CJ
      Empirical and molecular modeling study of the pyridinium species RHPP+, anabundant and potentially neurotoxic metabolite of haloperidol

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
    24. Canudas, AM; Friguls, B; Planas, AM; Gabriel, C; Escubedo, E; Camarasa, J; Camins, A; Pallas, M
      MPP+ injection into rat substantia nigra causes secondary glial activationbut not cell death in the ipsilateral striatum

      NEUROBIOLOGY OF DISEASE
    25. Howell, LL; Byrd, LD; McDonough, AM; Iuvone, PM; Bakay, RAE
      Behavioral evaluation of hemiparkinsonian MPTP monkeys following dopamine pharmacological manipulation and adrenal co-graft transplantation

      CELL TRANSPLANTATION
    26. Fernandez-Gonzalez, A; Perez-Otano, I; Morgan, JI
      MPTP selectively induces haem oxygenase-1 expression in striatal astrocytes

      EUROPEAN JOURNAL OF NEUROSCIENCE
    27. Schneider, JS; Rothblat, DS
      Differences in release and clearance of extracellular dopamine in the striatum after spontaneous or GM1-ganglioside-stimulated recovery from experimental Parkinsonism

      RESTORATIVE NEUROLOGY AND NEUROSCIENCE
    28. Przedborski, S; Jackson-Lewis, V; Djaldetti, R; Liberatore, G; Vila, M; Vukosavic, S; Almer, G
      The parkinsonian toxin MPTP: action and mechanism

      RESTORATIVE NEUROLOGY AND NEUROSCIENCE
    29. Kilbourn, MR; Kuszpit, K; Sherman, P
      Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice

      SYNAPSE
    30. Di Monte, DA; McCormack, A; Petzinger, G; Janson, AM; Quik, M; Langston, WJ
      Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model

      MOVEMENT DISORDERS
    31. Albin, RL
      Basal ganglia neurotoxins

      NEUROLOGIC CLINICS
    32. Fahn, S
      The spectrum of levodopa-induced dyskinesias

      ANNALS OF NEUROLOGY
    33. Langston, JW; Quik, M; Petzinger, G; Jakowec, M; Di Monte, DA
      Investigating levodopa-induced dyskinesias in the Parkinsonian primate

      ANNALS OF NEUROLOGY
    34. Nutt, JG
      Clinical pharmacology of levodopa-induced dyskinesia

      ANNALS OF NEUROLOGY
    35. Marini, AM; Nowak, TS
      Metabolic effects of 1-methyl-4-phenylpyridinium (MPP+) in primary neuron cultures

      JOURNAL OF NEUROSCIENCE RESEARCH
    36. Cochiolo, JA; Ehsanian, R; Bruck, DK
      Acute ultrastructural effects of MPTP on the nigrostriatal pathway of the C57BL/6 adult mouse: Evidence of compensatory plasticity in nigrostriatal neurons

      JOURNAL OF NEUROSCIENCE RESEARCH
    37. Forsyth, JT; Grunewald, RA; Rostami-Hodjegan, A; Lennard, MS; Sagar, HJ; Tucker, GT
      Parkinson's disease and CYP1A2 activity

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    38. Elsworth, JD; Taylor, JR; Sladek, JR; Collier, TJ; Redmond, DE; Roth, RH
      Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in Old-World primates one year after MPTP treatment

      NEUROSCIENCE
    39. Mogi, M; Togari, A; Tanaka, K; Ogawa, N; Ichinose, H; Nagatsu, T
      Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506

      NEUROSCIENCE LETTERS
    40. Nicotra, A; Parvez, SH
      Cell death induced by MPTP, a substrate for monoamine oxidase B

      TOXICOLOGY
    41. Dorman, DC
      An integrative approach to neurotoxicology

      TOXICOLOGIC PATHOLOGY
    42. Nicotra, A; Parvez, SH
      MPTP neurotoxins inducing cell death and a substrate for B form of enzyme monoamine oxidase

      BIOGENIC AMINES
    43. Wu, WR; Zhu, ZT; Zhu, XZ
      Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens

      LIFE SCIENCES
    44. Snow, BJ; Vingerhoets, FJG; Langston, JW; Tetrud, JW; Sossi, V; Calne, DB
      Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism

      JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
    45. Lotharius, J; O'Malley, KL
      The Parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation - A novel mechanism of toxicity

      JOURNAL OF BIOLOGICAL CHEMISTRY
    46. Crossman, AR
      Functional anatomy of movement disorders

      JOURNAL OF ANATOMY
    47. Moussaoui, S; Obinu, MC; Daniel, N; Reibaud, M; Blanchard, V; Imperato, A
      The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease

      EXPERIMENTAL NEUROLOGY
    48. Lee, HS; Park, CW; Kim, YS
      MPP+ increases the vulnerability to oxidative stress rather than directly mediating oxidative damage in human neuroblastoma cells

      EXPERIMENTAL NEUROLOGY
    49. Jenner, P; Zeng, BY; Smith, LA; Pearce, RKB; Tel, B; Chancharme, L; Moachon, G
      Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset

      EXPERIMENTAL BRAIN RESEARCH
    50. Tahar, AH; Belanger, N; Bangassoro, E; Gregoire, L; Bedard, PJ
      Antidyskinetic effect of JL-18, a clozapine analog, in parkinsonian monkeys

      EUROPEAN JOURNAL OF PHARMACOLOGY
    51. Mandavilli, BS; Ali, SF; Van Houten, B
      DNA damage in brain mitochondria caused by aging and MPTP treatment

      BRAIN RESEARCH
    52. Wade, T; Rothblat, DS; Schneider, JS
      Changes in striatal dopamine D-2 receptors in relation to expression of and recovery from experimental parkinsonism

      BRAIN RESEARCH
    53. Storch, A; Kaftan, A; Burkhardt, K; Schwarz, J
      1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism

      BRAIN RESEARCH
    54. Sedelis, M; Hofele, K; Auburger, GW; Morgan, S; Huston, JP; Schwarting, RKW
      MPTP susceptibility in the mouse: Behavioral, neurochemical, and histological analysis of gender and strain differences

      BEHAVIOR GENETICS
    55. Przedborski, S
      Advances in our knowledge of MPTP action and mechanism

      NEUROTOXIC FACTORS IN PARKINSON'S DISEASE AND RELATED DISORDERS
    56. Nagatsu, T
      Isoquinoline neurotoxins

      NEUROTOXIC FACTORS IN PARKINSON'S DISEASE AND RELATED DISORDERS
    57. Collins, MA; Neafsey, EJ
      beta-carboline analogues of MPP+ as environmental neurotoxins

      NEUROTOXIC FACTORS IN PARKINSON'S DISEASE AND RELATED DISORDERS
    58. Kuhlmann, AC; Guilarte, TR
      Regional and temporal expression of the peripheral benzodiazepine receptorin MPTP neurotoxicity

      TOXICOLOGICAL SCIENCES
    59. Checkoway, H; Nelson, LM
      Epidemiologic approaches to the study of Parkinson's disease etiology

      EPIDEMIOLOGY
    60. Yu, JA; Castagnoli, N
      Synthesis and monoamine oxidase B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines

      BIOORGANIC & MEDICINAL CHEMISTRY
    61. Bahnmaier, AH; Woesle, B; Thomas, H
      Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver

      CHIRALITY
    62. Henry, B; Fox, SH; Peggs, D; Crossman, AR; Brotchie, JM
      The alpha(2)-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primatemodel of parkinson's disease

      MOVEMENT DISORDERS
    63. Wilms, H; Sievers, J; Deuschl, G
      Animal models of tremor

      MOVEMENT DISORDERS
    64. Grunblatt, E; Mandel, S; Berkuzki, T; Youdim, MBH
      Apomorphine protects against MPTP-induced neurotoxicity in mice

      MOVEMENT DISORDERS
    65. Le Couteur, DG; McLean, AJ; Taylor, MC; Woodham, BL; Board, PG
      Pesticides and Parkinson's disease

      BIOMEDICINE & PHARMACOTHERAPY
    66. Duan, WZ; Zhang, ZM; Gash, DM; Mattson, MP
      Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease

      ANNALS OF NEUROLOGY
    67. Kaku, K; Shikimi, T; Kamisaki, Y; Shinozuka, K; Ishino, H; Okunishi, H; Takaori, S
      Elevation of striatal interleukin-6 and serum corticosterone contents in MPTP-treated mice

      CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
    68. Mogi, M; Togari, A; Tanaka, K; Ogawa, N; Ichinose, H; Nagatsu, T
      Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction

      NEUROSCIENCE LETTERS
    69. Kaku, K; Shikimi, T; Inagaki, T; Ishino, H; Okunishi, H; Takaori, S
      Impairment of the correlation between urinary contents of alpha-1-microglobulin and ulinastatin is induced by intracerebroventricularly administered interleukin-6 in mice

      NEUROPSYCHOBIOLOGY
    70. Pearce, RKB; Costa, S; Jenner, P; Marsden, CD
      Chronic supranigral infusion of BDNF in normal and MPTP-treated common marmosets

      JOURNAL OF NEURAL TRANSMISSION
    71. Janetzky, B; Gille, G; Abdel-mohsen, M; God, R; Rausch, WD; Bringmann, G; Reichmann, H
      Effect of highly halogenated beta-carbolines on dopaminergic cells in culture and on mitochondrial respiration

      DRUG DEVELOPMENT RESEARCH
    72. Storch, A; Ludolph, AC; Schwarz, J
      HEK-293 cells expressing the human dopamine transporter are susceptible tolow concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism

      NEUROCHEMISTRY INTERNATIONAL
    73. Cummings, JL
      Understanding Parkinson disease

      JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
    74. Itzhak, Y; Martin, JL; Black, MD; Ali, SF
      Effect of the dopaminergic neurotoxin MPTP on cocaine-induced locomotor sensitization

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    75. Chekhonin, VP; Baklaushev, VP; Belopasov, VV; Dmitrieva, TB
      Transplantation of embrionic nervous tissue in therapy of parkinsonism: a current state of a problem

      ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA
    76. Tolwani, RJ; Jakowec, MW; Petzinger, GM; Green, S; Waggie, K
      Experimental models of Parkinson's disease: Insights from many models

      LABORATORY ANIMAL SCIENCE
    77. Han, JL; Cheng, FC; Yang, ZL; Dryhurst, G
      Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra, potential implications to Parkinson's disease

      JOURNAL OF NEUROCHEMISTRY
    78. Rothblat, DS; Schneider, JS
      Regional differences in striatal dopamine uptake and release associated with recovery from MPTP-induced parkinsonism: An in vivo electrochemical study

      JOURNAL OF NEUROCHEMISTRY
    79. Nimkar, SK; Mabic, S; Anderson, AH; Palmer, SL; Graham, TH; de Jonge, M; Hazelwood, L; Hislop, SJ; Castagnoli, N
      Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives

      JOURNAL OF MEDICINAL CHEMISTRY
    80. Shi, HL; Noguchi, N; Xu, YX; Niki, E
      1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium

      FEBS LETTERS
    81. Chen, Q; Andersen, AH; Zhang, ZM; Ovadia, A; Cass, WA; Gash, DM; Avison, MJ
      Functional MRI of basal ganglia responsiveness to levodopa in parkinsonianrhesus monkeys

      EXPERIMENTAL NEUROLOGY
    82. Bezard, E; Gross, CE; Fournier, MC; Dovero, S; Bloch, B; Jaber, M
      Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter

      EXPERIMENTAL NEUROLOGY
    83. Wichmann, T; Bergman, H; Starr, PA; Subramanian, T; Watts, RL; DeLong, MR
      Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates

      EXPERIMENTAL BRAIN RESEARCH
    84. Wu, WR; Zhu, XZ
      The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice

      EUROPEAN JOURNAL OF PHARMACOLOGY
    85. Wong, SS; Li, RHY; Stadlin, A
      Oxidative stress induced by MPTP and MPP+: selective vulnerability of cultured mouse astrocytes

      BRAIN RESEARCH
    86. Riedl, AG; Watts, PM; Edwards, RJ; Schulz-Utermoehl, T; Boobis, AR; Jenner, P; Marsden, CD
      Expression and localisation of CYP2D enzymes in rat basal ganglia

      BRAIN RESEARCH
    87. Fahn, S
      Parkinson disease, the effect of levodopa, and the ELLDOPA trial

      ARCHIVES OF NEUROLOGY
    88. Andringa, G; Stoof, JC; Cools, AR
      Sub-chronic administration of the dopamine D-1 antagonist SKF 83959 in bilaterally MPTP-treated rhesus monkeys: stable therapeutic effects and wearing-off dyskinesia

      PSYCHOPHARMACOLOGY
    89. WANG YX; MABIC S; CASTAGNOLI N
      1-METHYL-3-PYRROLINES AND 2-METHYLISOINDOLINES - NEW CLASSES OF CYCLIC TERTIARY AMINE MONOAMINE-OXIDASE-B SUBSTRATES

      Bioorganic & medicinal chemistry
    90. KRAMER PJ; CALDWELL J; HOFMANN A; TEMPEL P; WEISSE G
      NEUROTOXICITY RISK ASSESSMENT OF MPTP (N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE) AS A SYNTHETIC IMPURITY OF DRUGS

      Human & experimental toxicology
    91. DATE I; AOI M; TOMITA S; COLLINS F; OHMOTO T
      GDNF ADMINISTRATION INDUCES RECOVERY OF THE NIGROSTRIATAL DOPAMINERGIC SYSTEM BOTH IN YOUNG AND AGED PARKINSONIAN MICE

      NeuroReport
    92. MORISSETTE M; GOULET M; GRONDIN R; BLANCHET P; BEDARD PJ; DIPAOLO T; LEVESQUE D
      ASSOCIATIVE AND LIMBIC REGIONS OF MONKEY STRIATUM EXPRESS HIGH-LEVELSOF DOPAMINE D-3 RECEPTORS - EFFECTS OF MPTP AND DOPAMINE AGONIST REPLACEMENT THERAPIES

      European journal of neuroscience
    93. KNOLL J
      (-)DEPRENYL (SELEGILINE), A CATECHOLAMINERGIC ACTIVITY ENHANCER (CAE)SUBSTANCE ACTING IN THE BRAIN

      Pharmacology & toxicology
    94. TODD RD; PERLMUTTER JS
      MUTATIONAL AND BIOCHEMICAL-ANALYSIS OF DOPAMINE IN DYSTONIA - EVIDENCE FOR DECREASED DOPAMINE D-2 RECEPTOR INHIBITION

      Molecular neurobiology
    95. SELLEY ML
      (E)-4-HYDROXY-2-NONENAL MAY BE INVOLVED IN THE PATHOGENESIS OF PARKINSONS-DISEASE

      Free radical biology & medicine
    96. HUNG HC; LEE EHY
      MPTP PRODUCES DIFFERENTIAL OXIDATIVE STRESS AND ANTIOXIDATIVE RESPONSES IN THE NIGROSTRIATAL AND MESOLIMBIC DOPAMINERGIC PATHWAYS

      Free radical biology & medicine
    97. RYOO HL; PIERROTTI D; JOYCE JN
      DOPAMINE D-3 RECEPTOR IS DECREASED AND D-2 RECEPTOR IS ELEVATED IN THE STRIATUM OF PARKINSONS-DISEASE

      Movement disorders
    98. JENNER P
      OXIDATIVE MECHANISMS IN NIGRAL CELL-DEATH IN PARKINSONS-DISEASE

      Movement disorders
    99. SCHAPIRA AHV; GU M; TAANMAN JW; TABRIZI SJ; SEATON T; CLEETER M; COOPER JM
      MITOCHONDRIA IN THE ETIOLOGY AND PATHOGENESIS OF PARKINSONS-DISEASE

      Annals of neurology
    100. FAHN S
      WELCOME NEWS ABOUT LEVODOPA, BUT UNCERTAINTY REMAINS

      Annals of neurology


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Documento generato il 10/08/20 alle ore 09:15:53