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    1. Martello, LA; LaMarche, MJ; He, LF; Beauchamp, TJ; Smith, AB; Horwitz, SB
      The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies

      CHEMISTRY & BIOLOGY
    2. Lim, SK; Li, SZ; Lee, CH; Yoon, CJ; Baik, JH; Lee, W
      Minimization of MC1R selectivity by modification of the core structure of alpha-MSH-ND

      CHEMISTRY & BIOLOGY
    3. Scaldaferro, S; Tinelli, S; Borgnetto, ME; Azzini, A; Capranico, G
      Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I

      CHEMISTRY & BIOLOGY
    4. Wang, L; Schultz, PG
      A general approach for the generation of orthogonal tRNAs

      CHEMISTRY & BIOLOGY
    5. Raillard, S; Krebber, A; Chen, YC; Ness, JE; Bermudez, E; Trinidad, R; Fullem, R; Davis, C; Welch, M; Seffernick, J; Wackett, LP; Stemmer, WPC; Minshull, J
      Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes

      CHEMISTRY & BIOLOGY
    6. Chen, HW; O'Connor, S; Cane, DE; Walsh, CT
      Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit

      CHEMISTRY & BIOLOGY
    7. Kessler, BM; Tortorella, D; Altun, M; Kisselev, AF; Fiebiger, E; Hekking, BG; Ploegh, HL; Overkleeft, HS
      Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

      CHEMISTRY & BIOLOGY
    8. Kisselev, AF; Goldberg, AL
      Proteasome inhibitors: from research tools to drug candidates

      CHEMISTRY & BIOLOGY
    9. Kwok, BHB; Koh, B; Ndubuisi, MI; Elofsson, M; Crews, CM
      The anti-inflammatory natural product parthenolide from the medicinal herbFeverfew directly binds to and inhibits I kappa B kinase

      CHEMISTRY & BIOLOGY
    10. Blanco-Molina, M; Tron, GC; Macho, A; Lucena, C; Calzado, MA; Munoz, E; Appendino, G
      Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappa B independent pathway

      CHEMISTRY & BIOLOGY
    11. Walther, M; Ivanov, I; Myagkova, G; Kuhn, H
      Alterations of lipoxygenase specificity by targeted substrate modificationand site-directed mutagenesis

      CHEMISTRY & BIOLOGY
    12. Boehr, DD; Lane, WS; Wright, GD
      Active site labeling of the gentamicin resistance enzyme AAQ6 ')-APH(2 '')by the lipid kinase inhibitor wortmannin

      CHEMISTRY & BIOLOGY
    13. Scott, CP; Abel-Santos, E; Jones, AD; Benkovic, SJ
      Structural requirements for the biosynthesis of backbone cyclic peptide libraries

      CHEMISTRY & BIOLOGY
    14. Cerdeno, AM; Bibb, MJ; Challis, GL
      Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes

      CHEMISTRY & BIOLOGY
    15. Lejeune, A; Vanhove, M; Lamotte-Brasseur, J; Pain, RH; Frere, JM; Matagne, A
      Quantitative analysis of the stabilization by substrate of Staphylococcus aureus PC1 beta-lactamase

      CHEMISTRY & BIOLOGY
    16. Venkatraman, J; Aggarwal, K; Balaram, P
      Helical peptide models for protein glycation: proximity effects in catalysis of the Amadori rearrangement

      CHEMISTRY & BIOLOGY
    17. Blanchard, JE; Withers, SG
      Rapid screening of the aglycone specificity of glycosidases: applications to enzymatic synthesis of oligosaccharides

      CHEMISTRY & BIOLOGY
    18. Mendes, MV; Recio, E; Fouces, R; Luiten, R; Martin, JF; Aparicio, JF
      Engineered biosynthesis of novel polyenes: a pimaricin derivative producedby targeted gene disruption in Streptomyces natalensis

      CHEMISTRY & BIOLOGY
    19. Razinkov, V; Gazumyan, A; Nikitenko, A; Ellestad, G; Krishnamurthy, G
      RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein

      CHEMISTRY & BIOLOGY
    20. Olofsson, L; Ankarloo, J; Andersson, PO; Nicholls, IA
      Filamentous bacteriophage stability in non-aqueous media

      CHEMISTRY & BIOLOGY
    21. Villain, M; Vizzavona, J; Rose, K
      Covalent capture: a new tool for the purification of synthetic and recombinant polypeptides

      CHEMISTRY & BIOLOGY
    22. Wohlert, SE; Lomovskaya, N; Kulowski, K; Fonstein, L; Occi, JL; Gewain, KM; MacNeil, DJ; Hutchinson, CR
      Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

      CHEMISTRY & BIOLOGY
    23. Liu, JJ; Shikhman, AR; Lotz, MK; Wong, CH
      Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis

      CHEMISTRY & BIOLOGY
    24. Caffrey, P; Lynch, S; Flood, E; Finnan, S; Oliynyk, M
      Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes

      CHEMISTRY & BIOLOGY
    25. Sanchez, C; Du, LC; Edwards, DJ; Toney, MD; Shen, B
      Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin

      CHEMISTRY & BIOLOGY
    26. Tantillo, DJ; Houk, KN
      Canonical binding arrays as molecular recognition elements in the immune system: tetrahedral anions and the ester hydrolysis transition state

      CHEMISTRY & BIOLOGY
    27. Tang, L; McDaniel, R
      Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

      CHEMISTRY & BIOLOGY
    28. Hoffmeister, D; Ichinose, K; Bechthold, A
      Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity

      CHEMISTRY & BIOLOGY
    29. Weitnauer, G; Muhlenweg, A; Trefzer, A; Hoffmeister, D; Sussmuth, RD; Jung, G; Welzel, K; Vente, A; Girreser, U; Bechthold, A
      Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomycesviridochromogenes Tu57 and production of new antibiotics

      CHEMISTRY & BIOLOGY
    30. Ansari, AZ; Mapp, AK; Nguyen, DH; Dervan, PB; Ptashne, M
      Towards a minimal motif for artificial transcriptional activators

      CHEMISTRY & BIOLOGY
    31. Tondi, D; Powers, RA; Caselli, E; Negri, MC; Blazquez, J; Costi, MP; Shoichet, BK
      Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase

      CHEMISTRY & BIOLOGY
    32. Leland, PA; Raines, RT
      Cancer chemotherapy - ribonucleases to the rescue

      CHEMISTRY & BIOLOGY
    33. Guelev, V; Lee, J; Ward, J; Sorey, S; Hoffman, DW; Iverson, BL
      Peptide bis-intercalator binds DNA via threading mode with sequence specific contacts in the major groove

      CHEMISTRY & BIOLOGY
    34. Weatherman, RV; Clegg, NJ; Scanlon, TS
      Differential SERM activation of the estrogen receptors (ER alpha and ER beta) at AP-1 sites

      CHEMISTRY & BIOLOGY
    35. Mayer, C; Jakeman, DL; Mah, M; Karjala, G; Gal, L; Warren, RAJ; Withers, SG
      Directed evolution of new glycosynthases from Agrobacterium beta-glucosidase: a general screen to detect enzymes for oligosaccharide synthesis

      CHEMISTRY & BIOLOGY
    36. Anderson, AC; O'Neil, RH; Surti, TS; Stroud, RM
      Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking

      CHEMISTRY & BIOLOGY
    37. Sengle, G; Eisenfuhr, A; Arora, PS; Nowick, JS; Famulok, M
      Novel RNA catalysts for the Michael reaction

      CHEMISTRY & BIOLOGY
    38. Rowe, CJ; Bohm, IU; Thomas, IP; Wilkinson, B; Rudd, BAM; Foster, G; Blackaby, AP; Sidebottom, PJ; Roddis, Y; Buss, AD; Staunton, J; Leadlay, PF
      Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

      CHEMISTRY & BIOLOGY
    39. Waldron, C; Matsushima, P; Rosteck, PR; Broughton, MC; Turner, J; Madduri, K; Crawford, KP; Merlo, DJ; Baltz, RH
      Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

      CHEMISTRY & BIOLOGY
    40. Shi, YH; Koh, JT
      Selective regulation of gene expression by an orthogonal estrogen receptor-ligand pair created by polar-group exchange

      CHEMISTRY & BIOLOGY
    41. Zhang, Q; Harada, K; Cho, HS; Frankel, AD; Wemmer, DE
      Structural characterization of the complex of the Rev response element RNAwith a selected peptide

      CHEMISTRY & BIOLOGY
    42. Peelle, B; Lorens, J; Li, WQ; Bogenberger, J; Payan, DG; Anderson, DC
      Intracellular protein scaffold-mediated display of random peptide libraries for phenotypic screens in mammalian cells

      CHEMISTRY & BIOLOGY
    43. Chen, HW; Walsh, CT
      Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI

      CHEMISTRY & BIOLOGY
    44. Schaschke, N; Matschiner, G; Zettl, F; Marquardt, U; Bergner, A; Bode, W; Sommerhoff, CP; Moroder, L
      Bivalent inhibition of human beta-tryptase

      CHEMISTRY & BIOLOGY
    45. Holzbaur, IE; Ranganathan, A; Thomas, IP; Kearney, DJA; Reather, JA; Rudd, BAM; Staunton, J; Leadlay, PF
      Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates

      CHEMISTRY & BIOLOGY
    46. Endo, Y; Iijima, T; Yamakoshi, Y; Fukasawa, H; Miyaura, C; Inada, M; Kubo, A; Itai, A
      Potent estrogen agonists based on carborane as a hydrophobic skeletal structure - A new medicinal application of boron clusters

      CHEMISTRY & BIOLOGY
    47. Rotonda, J; Garcia-Calvo, M; Bull, HG; Geissler, WM; McKeever, BM; Willoughby, CA; Thornberry, NA; Becker, JW
      The three-dimensional structure of human granzyme B compared to caspase-3,key mediators of cell death with cleavage specificity for aspartic acid inP1

      CHEMISTRY & BIOLOGY
    48. Kino, K; Sugiyama, H
      Possible cause of G center dot C -> C center dot G transversion mutation by guanine oxidation product, imidazolone

      CHEMISTRY & BIOLOGY
    49. Zheng, WP; Scheibner, KA; Ho, AK; Cole, PA
      Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase

      CHEMISTRY & BIOLOGY
    50. Zhang, ZW; Ly, T; Kodadek, T
      An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme

      CHEMISTRY & BIOLOGY
    51. Sche, PP; McKenzie, KM; White, JD; Austin, DJ
      Display cloning: functional identification of natural product receptors using cDNA-phage display (vol 6, pg 707, 1999)

      CHEMISTRY & BIOLOGY
    52. Arthanari, H; Bolton, PH
      Functional and dysfunctional roles of quadruplex DNA in cells

      CHEMISTRY & BIOLOGY
    53. Kasanov, J; Pirozzi, G; Uveges, AJ; Kay, BK
      Characterizing Class IWW domains defines key specificity determinants and generates mutant domains with novel specificities

      CHEMISTRY & BIOLOGY
    54. Becker, CFW; Hunter, CL; Seidel, RP; Kent, SBH; Goody, RS; Engelhard, M
      A sensitive fluorescence monitor for the detection of activated Ras: totalchemical synthesis of site-specifically labeled Ras binding domain of c-Raf1 immobilized on a surface

      CHEMISTRY & BIOLOGY
    55. Blanco, G; Patallo, EP; Brana, AF; Trefzer, A; Bechthold, A; Rohr, J; Mendez, C; Salas, JA
      Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin

      CHEMISTRY & BIOLOGY
    56. Lemieux, GA; Bertozzi, CR
      Modulating cell surface immunoreactivity by metabolic induction of unnatural carbohydrate antigens

      CHEMISTRY & BIOLOGY
    57. Tedesco, R; Thomas, JA; Katzenellenbogen, BS; Katzenellenbogen, JA
      The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations

      CHEMISTRY & BIOLOGY
    58. Chiosis, G; Timaul, MN; Lucas, B; Munster, PN; Zheng, FF; Sepp-Lorenzino, L; Rosen, N
      A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

      CHEMISTRY & BIOLOGY
    59. Kodadek, T
      Protein microarrays: prospects and problems

      CHEMISTRY & BIOLOGY
    60. Ramster, B
      Finding people on the Web

      CHEMISTRY & BIOLOGY
    61. Haidekker, MA; Ling, TT; Anglo, M; Stevens, HY; Frangos, JA; Theodorakis, EA
      New fluorescent probes for the measurement of cell membrane viscosity

      CHEMISTRY & BIOLOGY
    62. Macmillan, D; Bill, RM; Sage, KA; Fern, D; Flitsch, SL
      Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin

      CHEMISTRY & BIOLOGY
    63. Kasher, R; Balass, M; Scherf, T; Fridkin, M; Fuchs, S; Katchalski-Katzir, E
      Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity

      CHEMISTRY & BIOLOGY
    64. Nicholson, TP; Rudd, BAM; Dawson, M; Lazarus, CM; Simpson, TJ; Cox, RJ
      Design and utility of oligonucleotide gene probes for fungal polyketide synthases

      CHEMISTRY & BIOLOGY
    65. Houbaviy, HB; Burley, SK
      Thermodynamic analysis of the interaction between YY1 and the AAV P5 promoter initiator element

      CHEMISTRY & BIOLOGY
    66. Fujii, I; Watanabe, A; Sankawa, U; Ebizuka, Y
      Identification of Claisen cyclase domain in fungal polyketide synthase WA,a naphthopyrone synthase of Aspergillus nidulans

      CHEMISTRY & BIOLOGY
    67. Bergstrom, RC; Mayfield, LD; Corey, DR
      A bridge between the RNA and protein worlds? Accelerating delivery of chemical reactivity to RNA and DNA by a specific short peptide (AAKK)(4)

      CHEMISTRY & BIOLOGY
    68. Heathcole, ML; Staunton, J; Leadlay, PF
      Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

      CHEMISTRY & BIOLOGY
    69. Famulok, M; Blind, M; Mayer, G
      Intramers as promising new tools in functional proteomics

      CHEMISTRY & BIOLOGY
    70. Russell, SJ; Gonzalez, F; Joshua-Tor, L; Johnston, SA
      Selective chemical inactivation of AAA proteins reveals distinct functionsof proteasomal ATPases

      CHEMISTRY & BIOLOGY
    71. Speight, RE; Hart, DJ; Sutherland, JD; Blackburn, JM
      A new plasmid display technology for the in vitro selection of functional phenotype-genotype linked proteins

      CHEMISTRY & BIOLOGY
    72. Hardwidge, PR; Lee, DK; Prakash, TP; Iglesias, B; Den, RB; Switzer, C; Maher, LJ
      DNA bending by asymmetrically tethered cations: influence of tether flexibility

      CHEMISTRY & BIOLOGY
    73. Fritz, TA; Tondi, D; Finer-Moore, JS; Costi, MP; Stroud, RM
      Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase

      CHEMISTRY & BIOLOGY
    74. Schwarzer, D; Mootz, HD; Marahiel, MA
      Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases

      CHEMISTRY & BIOLOGY
    75. Braasch, DA; Corey, DR
      Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

      CHEMISTRY & BIOLOGY
    76. Inoue, T; Kikuchi, K; Hirose, K; Iino, M; Nagano, T
      Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor

      CHEMISTRY & BIOLOGY
    77. Caselli, E; Powers, RA; Blasczcak, LC; Wu, CYE; Prati, F; Shoichet, BK
      Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases

      CHEMISTRY & BIOLOGY
    78. Tsang, SK; Cheh, J; Isaacs, L; Joseph-McCarthy, D; Choi, SK; Pevear, DC; Whitesides, GM; Hogle, JM
      A structurally biased combinatorial approach for discovering new anti-picornaviral compounds

      CHEMISTRY & BIOLOGY
    79. Li, LT; Zhong, WG; Zacharias, N; Gibbs, C; Lester, HA; Dougherty, DA
      The tethered agonist approach to mapping ion channel proteins toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor

      CHEMISTRY & BIOLOGY
    80. Silakowski, B; Nordsiek, G; Kunze, B; Blocker, H; Muller, R
      Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15

      CHEMISTRY & BIOLOGY
    81. Salomon, AR; Voehringer, DW; Herzenberg, LA; Khosla, C
      Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase

      CHEMISTRY & BIOLOGY
    82. Adam, GC; Cravatt, BF; Sorensen, EJ
      Profiling the specific reactivity of the proteome with non-directed activity-based probes

      CHEMISTRY & BIOLOGY
    83. Okeley, NM; van der Donk, WA
      Novel cofactors via post-translational modifications of enzyme active sites (vol 7, pg R159, 2000)

      CHEMISTRY & BIOLOGY
    84. Uiterdijk, G
      Chemistry and Biology; a fruitful future

      CHEMISTRY & BIOLOGY
    85. Brooks, N; McHugh, PJ; Lee, M; Hartley, JA
      Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove

      CHEMISTRY & BIOLOGY
    86. Hamy, F; Gelus, N; Zeller, M; Lazdins, JL; Bailly, C; Klimkait, T
      Blocking HIV replication by targeting Tat protein

      CHEMISTRY & BIOLOGY
    87. Rath, VL; Ammirati, M; Danley, DE; Ekstrom, JL; Gibbs, EM; Hynes, TR; Mathiowetz, AM; McPherson, RK; Olson, TV; Treadway, JL; Hoover, DJ
      Human liver glycogen phosphorylase inhibitors bind at a new allosteric site

      CHEMISTRY & BIOLOGY
    88. Cochran, JR; Stern, LJ
      A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions

      CHEMISTRY & BIOLOGY
    89. Fancy, DA; Denison, C; Kim, K; Xie, YQ; Holdeman, T; Amini, F; Kodadek, T
      Scope, limitations and mechanistic aspects of the photo-induced cross-linking of proteins by water-soluble metal complexes

      CHEMISTRY & BIOLOGY
    90. Liebeton, K; Zonta, A; Schimossek, K; Nardini, M; Lang, D; Dijkstra, BW; Reetz, MT; Jaeger, KE
      Directed evolution of an enantioselective lipase

      CHEMISTRY & BIOLOGY
    91. Lescrinier, E; Esnouf, R; Schraml, J; Busson, R; Heus, HA; Hilbers, CW; Herdewijn, P
      Solution structure of a HNA-RNA hybrid

      CHEMISTRY & BIOLOGY
    92. Du, XH; Hansell, E; Engel, JC; Caffrey, CR; Cohen, FE; McKerrow, JH
      Aryl ureas represent a new class of anti-trypanosomal agents

      CHEMISTRY & BIOLOGY
    93. Sha, RJ; Liu, FR; Millar, DP; Seeman, NC
      Atomic force microscopy of parallel DNA branched junction arrays

      CHEMISTRY & BIOLOGY
    94. Schiller, J; Benard, S; Reichl, S; Arnhold, J; Arnold, K
      Cartilage degradation by stimulated human neutrophils: reactive oxygen species decrease markedly the activity of proteolytic enzymes

      CHEMISTRY & BIOLOGY
    95. Greenbaum, D; Medzihradszky, KF; Burlingame, A; Bogyo, M
      Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

      CHEMISTRY & BIOLOGY
    96. Gestwicki, JE; Strong, LE; Kiessling, LL
      Tuning chemotactic responses with synthetic multivalent ligands

      CHEMISTRY & BIOLOGY
    97. Nicolaou, KC; Scarpelli, R; Bollbuck, B; Werschkun, B; Pereira, MMA; Wartmann, M; Altmann, KH; Zaharevitz, D; Gussio, R; Giannakakou, P
      Chemical synthesis and biological properties of pyridine epothilones

      CHEMISTRY & BIOLOGY
    98. Kays, AR; Schepartz, A
      Virtually unidirectional binding of TBP to the AdMLP TATA box within the quaternary complex with TFIIA and TFIIB

      CHEMISTRY & BIOLOGY
    99. Zhang, J; Boone, L; Kocz, R; Zhang, CH; Binns, AN; Lynn, DG
      At the maize/Agrobacterium interface: natural factors limiting host transformation

      CHEMISTRY & BIOLOGY
    100. Du, LC; Sanchez, C; Chen, M; Edwards, DJ; Shen, B
      The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

      CHEMISTRY & BIOLOGY


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Documento generato il 31/10/20 alle ore 22:36:43