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La ricerca find articoli where authors phrase all words 'Lake, BG' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 77 riferimenti
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    1. Lake, BG; Edwards, AJ; Price, RJ; Phillips, BJ; Renwick, AB; Beamand, JA; Adams, TB
      Lack of effect of furfural on unscheduled DNA synthesis in the in vivo ratand mouse hepatocyte DNA repair assays and in precision-cut human liver slices

      FOOD AND CHEMICAL TOXICOLOGY
    2. Murray, S; Lake, BG; Gray, S; Edwards, AJ; Springall, C; Bowey, EA; Williamson, G; Boobis, AR; Gooderham, NJ
      Effect of cruciferous vegetable consumption on heterocyclic aromatic aminemetabolism in man

      CARCINOGENESIS
    3. Subrahmanyam, V; Renwick, AB; Walters, DG; Young, PJ; Price, RJ; Tonelli, AP; Lake, BG
      Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

      DRUG METABOLISM AND DISPOSITION
    4. Andersson, TB; Sjoberg, H; Hoffmann, KJ; Boobis, AR; Watts, P; Edwards, RJ; Lake, BG; Price, RJ; Renwick, AB; Gomez-Lechon, MJ; Castell, JV; Ingelman-Sundberg, M; Hidestrand, M; Goldfarb, PS; Lewis, DFV; Corcos, L; Guillouzo, A; Taavitsainen, P; Pelkonen, O
      An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant

      DRUG METABOLISM AND DISPOSITION
    5. Pelkonen, O; Myllynen, P; Taavitsainen, P; Boobis, AR; Watts, P; Lake, BG; Price, RJ; Renwick, AB; Gomez-Lechon, MJ; Castell, JV; Ingelman-Sundberg, M; Hidestrand, M; Guillouzo, A; Corcos, L; Goldfarb, PS; Lewis, DFV
      Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

      XENOBIOTICA
    6. Renwick, AB; Lewis, DFV; Fulford, S; Surry, D; Williams, B; Worboys, PD; Cai, X; Wang, RW; Price, RJ; Lake, BG; Evans, DC
      Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4

      XENOBIOTICA
    7. Lake, BG; Rumsby, PC; Price, RJ; Cunninghame, ME
      Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta 1 gene expression in the rat, Syrian hamster and guinea pig

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    8. Edwards, AJ; Price, RJ; Benwick, AB; Lake, BG
      Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rathepatocyte DNA repair assay

      FOOD AND CHEMICAL TOXICOLOGY
    9. Renwick, AB; Watts, PS; Edwards, RJ; Barton, PT; Guyonnet, I; Price, RJ; Tredger, JM; Pelkonen, O; Boobis, AR; Lake, BG
      Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

      DRUG METABOLISM AND DISPOSITION
    10. Price, RJ; Surry, D; Renwick, AB; Meneses-Lorente, G; Lake, BG; Evans, DC
      CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes

      XENOBIOTICA
    11. Renwick, AB; Surry, D; Price, RJ; Lake, BG; Evans, DC
      Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms

      XENOBIOTICA
    12. Lewis, DFV; Bird, MG; Dickins, M; Lake, BG; Eddershaw, PJ; Tarbit, MH; Goldfarb, PS
      Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform

      XENOBIOTICA
    13. Lake, BG; Beamand, JA; Tredger, JM; Barton, PT; Renwick, AB; Price, RJ
      Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    14. Lovell, DP; van Iersel, M; Walters, DG; Price, RJ; Lake, BG
      Genetic variation in the metabolism of coumarin in mouse liver

      PHARMACOGENETICS
    15. Lewis, DFV; Lake, BG; George, SG; Dickins, M; Eddershaw, PJ; Tarbit, MH; Beresford, AP; Goldfarb, PS; Guengerich, FP
      Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102

      TOXICOLOGY
    16. Lewis, DFV; Dickens, M; Lake, BG; Eddershaw, PJ; Tarbit, MH; Goldfarb, PS
      Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

      TOXICOLOGY
    17. Renwick, AB; Mistry, H; Barton, PT; Mallet, F; Price, RJ; Beamand, JA; Lake, BG
      Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices

      FOOD AND CHEMICAL TOXICOLOGY
    18. Lake, BG
      Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment

      FOOD AND CHEMICAL TOXICOLOGY
    19. Doull, J; Cattley, R; Elcombe, C; Lake, BG; Swenberg, J; Wilkinson, C; Williams, G; van Gemert, M
      A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new US EPA risk assessment guidelines

      REGULATORY TOXICOLOGY AND PHARMACOLOGY
    20. Phillips, JC; Davies, S; Lake, BG
      Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: The use of immunoslot blotting for adduct quantitation

      TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
    21. Lewis, DFV; Lake, BG
      Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102

      XENOBIOTICA
    22. Sauer, MJ; Dave, M; Lake, BG; Manchee, GR; Howells, LC; Coldham, NG
      beta(2)-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance

      XENOBIOTICA
    23. Lewis, DFV; Lake, BG; Dickins, M; Eddershaw, PJ; Tarbit, MH; Goldfarb, PS
      Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substratecharacteristics, the cytochrome b(5) binding site and comparisons with CYP2B1 and CYP2B4

      XENOBIOTICA
    24. Murphy, AT; Lake, BG; Bernstein, JR; Franklin, RB; Gillespie, TA
      Characterization of olanzapine (LY170053) in human liver slices by liquid chromatography tandem mass spectrometry

      JOURNAL OF MASS SPECTROMETRY
    25. Lewis, DFV; Lake, BG
      Molecular modelling of the rat peroxisome proliferator-activated receptor-alpha (rPPAR alpha) by homology with the human retinoic acid X receptor alpha (hRXR alpha) and investigation of ligand binding interactions I: QSARs

      TOXICOLOGY IN VITRO
    26. LEWIS DFV; LAKE BG
      MOLECULAR MODELING AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON THE INTERACTION OF OMEPRAZOLE WITH CYTOCHROME-P450 ISOZYMES

      Toxicology
    27. Lake, BG; Renwick, AB; Cunninghame, ME; Price, RJ; Surry, D; Evans, DC
      Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

      TOXICOLOGY
    28. BEAMAND JA; BARTON PT; PRICE RJ; LAKE BG
      LACK OF EFFECT OF COUMARIN ON UNSCHEDULED DNA-SYNTHESIS IN PRECISION-CUT HUMAN LIVER SLICES

      Food and chemical toxicology
    29. BEAMAND JA; BARTON PT; TREDGER JM; PRICE RJ; LAKE BG
      EFFECT OF SOME COOKED FOOD MUTAGENS ON UNSCHEDULED DNA-SYNTHESIS IN CULTURED PRECISION-CUT RAT, MOUSE AND HUMAN LIVER SLICES

      Food and chemical toxicology
    30. CATTLEY RC; DELUCA J; ELCOMBE C; FENNERCRISP P; LAKE BG; MARSMAN DS; PASTOOR TA; POPP JA; ROBINSON DE; SCHWETZ B; TUGWOOD J; WAHLI W
      DO PEROXISOME PROLIFERATING COMPOUNDS POSE A HEPATOCARCINOGENIC HAZARD TO HUMANS

      Regulatory toxicology and pharmacology
    31. PRICE RJ; RENWICK AB; BARTON PT; HOUSTON JB; LAKE BG
      INFLUENCE OF SLICE THICKNESS AND CULTURE CONDITIONS ON THE METABOLISMOF 7-ETHOXYCOUMARIN IN PRECISION-CUT RAT-LIVER SLICES

      ATLA. Alternatives to laboratory animals
    32. LAKE BG; TREDGER JM; RENWICK AB; BARTON PT; PRICE RJ
      3,3'-DIINDOLYLMETHANE INDUCES CYP1A2 IN CULTURED PRECISION-CUT HUMAN LIVER SLICES

      Xenobiotica
    33. RENWICK AB; MISTRY H; BALL SE; WALTERS DG; KAO J; LAKE BG
      METABOLISM OF ZALEPLON BY HUMAN HEPATIC-MICROSOMAL CYTOCHROME-P450 ISOFORMS

      Xenobiotica
    34. PRICE RJ; BALL SE; RENWICK AB; BARTON PT; BEAMAND JA; LAKE BG
      USE OF PRECISION-CUT RAT-LIVER SLICES FOR STUDIES OF XENOBIOTIC METABOLISM AND TOXICITY - COMPARISON OF THE KRUMDIECK AND BRENDEL TISSUE SLICERS

      Xenobiotica
    35. LEWIS DFV; WATSON E; LAKE BG
      EVOLUTION OF THE CYTOCHROME-P450 SUPERFAMILY - SEQUENCE ALIGNMENTS AND PHARMACOGENETICS

      Mutation research-reviews in mutation research
    36. LEWIS DFV; LAKE BG
      QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) ANALYSIS FOR A SERIES OF RODENT PEROXISOME PROLIFERATORS - INTERACTION WITH THE MOUSE-LIVER PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-ALPHA (MPPAR-ALPHA)

      Toxicology in vitro
    37. LAKE BG; PRICE RJ; CUNNINGHAME ME; WALTERS DG
      COMPARISON OF THE EFFECTS OF DI-(2-ETHYLHEXYL)ADIPATE ON HEPATIC PEROXISOME PROLIFERATION AND CELL REPLICATION IN THE RAT AND MOUSE

      Toxicology
    38. LAKE BG; PRICE RJ; CUNNINGHAME ME; WALTERS DG
      COMPARISON OF THE EFFECTS OF CINNAMYL ANTHRANILATE ON HEPATIC PEROXISOME PROLIFERATION AND CELL REPLICATION IN THE RAT AND MOUSE

      Fundamental and applied toxicology
    39. LAKE BG; CUNNINGHAME ME; PRICE RJ
      COMPARISON OF THE HEPATIC AND RENAL EFFECTS OF 1,4-DICHLOROBENZENE INTHE RAT AND MOUSE

      Fundamental and applied toxicology
    40. PHILLIPS JC; PRICE RJ; CUNNINGHAME ME; OSIMITZ TG; COCKBURN A; GABRIEL KL; PREISS FJ; BUTLER WH; LAKE BG
      EFFECT OF PIPERONYL BUTOXIDE ON CELL REPLICATION AND XENOBIOTIC METABOLISM IN THE LIVERS OF CD-1 MICE AND F344 RATS

      Fundamental and applied toxicology
    41. LEWIS DFV; LAKE BG
      MOLECULAR MODELING OF MAMMALIAN CYP2B ISOFORMS AND THEIR INTERACTION WITH SUBSTRATES, INHIBITORS AND REDOX PARTNERS

      Xenobiotica
    42. LAKE BG; BALL SE; RENWICK AB; TREDGER JM; KAO J; BEAMAND JA; PRICE RJ
      INDUCTION OF CYP3A ISOFORMS IN CULTURED PRECISION-CUT HUMAN LIVER SLICES

      Xenobiotica
    43. PRICE RJ; MISTRY H; WIELD PT; RENWICK AB; BEAMAND JA; LAKE BG
      COMPARISON OF THE TOXICITY OF ALLYL ALCOHOL, COUMARIN AND MENADIONE IN PRECISION CUT RAT, GUINEA-PIG, CYNOMOLGUS MONKEY AND HUMAN LIVER SLICES

      Archives of toxicology
    44. PRICE RJ; WALTERS DG; HOFF C; MISTRY H; RENWICK AB; WIELD PT; BEAMAND JA; LAKE BG
      METABOLISM OF [RING-U-C-14] AGARITINE BY PRECISION-CUT RAT, MOUSE ANDHUMAN LIVER AND LUNG SLICES

      Food and chemical toxicology
    45. COTTRELL S; OLIVER K; LAKE BG; POWELL CJ
      STRAIN-SPECIFIC ENHANCEMENT OR INHIBITION OF COUMARIN HEPATOTOXICITY IN MICE FOLLOWING PRETREATMENT WITH 2 DIFFERENT LIVER ENZYME-INDUCING AGENTS

      Fundamental and applied toxicology
    46. LAKE BG; GRASSO P
      COMPARISON OF THE HEPATOTOXICITY OF COUMARIN IN THE RAT, MOUSE, AND SYRIAN-HAMSTER - A DOSE AND TIME RESPONSE STUDY

      Fundamental and applied toxicology
    47. BACH PH; VICKERS AEM; FISHER R; BAUMANN A; BRITTEBO E; CARLILE DJ; KOSTER HJ; LAKE BG; SALMON F; SAWYER TW; SKIBINSKI G
      THE USE OF TISSUE-SLICES FOR PHARMACOTOXICOLOGY STUDIES - THE REPORT AND RECOMMENDATIONS OF ECVAM-WORKSHOP-20

      ATLA. Alternatives to laboratory animals
    48. BEAMAND JA; PRICE RJ; PHILLIPS JC; BUTLER WH; JONES CDG; OSIMITZ TG; GABRIEL KL; PREISS FJ; LAKE BG
      LACK OF EFFECT OF PIPERONYL BUTOXIDE ON UNSCHEDULED DNA-SYNTHESIS IN PRECISION-CUT HUMAN LIVER SLICES

      Mutation research. Genetic toxicology testing
    49. LEWIS DFV; LAKE BG
      MOLECULAR MODELING OF CYP1A SUBFAMILY MEMBERS BASED ON AN ALIGNMENT WITH CYP102 - RATIONALIZATION OF CYP1A SUBSTRATE-SPECIFICITY IN TERMS OF ACTIVE-SITE AMINO-ACID-RESIDUES

      Xenobiotica
    50. LAKE BG; CHARZAT C; TREDGER JM; RENWICK AB; BEAMAND JA; PRICE RJ
      INDUCTION OF CYTOCHROME-P450 ISOENZYMES IN CULTURED PRECISION-CUT RATAND HUMAN LIVER SLICES

      Xenobiotica
    51. LAKE BG; BEAMAND JA; WIELD PT; PRICE RJ
      USE OF PRECISION-CUT LIVER SLICES TO EVALUATE SPECIES-DIFFERENCES IN 2-ACETYLAMINOFLUORENE-INDUCED UNSCHEDULED DNA-SYNTHESIS

      Toxicology and applied pharmacology
    52. LAKE BG
      PEROXISOME PROLIFERATION - CURRENT MECHANISMS RELATING TO NONGENOTOXIC CARCINOGENESIS

      Toxicology letters
    53. LAKE BG
      MECHANISMS OF HEPATOCARCINOGENICITY OF PEROXISOME-PROLIFERATING DRUGSAND CHEMICALS

      Annual review of pharmacology and toxicology
    54. PRICE RJ; RENWICK AB; WIELD PT; BEAMAND JA; LAKE BG
      TOXICITY OF 3-METHYLINDOLE, 1-NITRONAPHTHALENE AND PARAQUAT IN PRECISION-CUT RAT LUNG SLICES

      Archives of toxicology
    55. PRICE RJ; RENWICK AB; BEAMAND JA; ESCLANGON F; WIELD PT; WALTERS DG; LAKE BG
      COMPARISON OF THE METABOLISM OF 7-ETHOXYCOUMARIN AND COUMARIN IN PRECISION-CUT RAT-LIVER AND LUNG SLICES

      Food and chemical toxicology
    56. DING SH; LAKE BG; FRIEDBERG T; WOLF CR
      EXPRESSION AND ALTERNATIVE SPLICING OF THE CYTOCHROME-P-450 CYP2A7

      Biochemical journal
    57. COLDHAM NG; MOORE AS; DAVE M; GRAHAM PJ; SIVAPATHASUNDARAM S; LAKE BG; SAUER MJ
      IMIDOCARB RESIDUES IN EDIBLE BOVINE-TISSUES AND IN-VITRO ASSESSMENT OF IMIDOCARB METABOLISM AND CYTOTOXICITY

      Drug metabolism and disposition
    58. LEWIS DFV; LAKE BG
      MOLECULAR MODELING OF MEMBERS OF THE P4502A SUBFAMILY - APPLICATION TO STUDIES OF ENZYME SPECIFICITY

      Xenobiotica
    59. LAKE BG; SAUER MJ; ESCLANGON F; BEAMAND JA; PRICE RJ; WALTERS DG
      METABOLISM OF COUMARIN BY PRECISION-CUT CALF LIVER SLICES AND CALF LIVER-MICROSOMES

      Xenobiotica
    60. LEWIS DFV; LAKE BG; PARKE DV
      MOLECULAR ORBITAL-GENERATED QSARS IN A HOMOLOGOUS SERIES OF ALKOXYRESORUFINS AND STUDIES OF THEIR INTERACTIVE DOCKING WITH P450S

      Xenobiotica
    61. LAKE BG; BEAMAND JA; CUNNINGHAME ME; DAVIES S; MISTRY H; PRICE RJ
      EFFECT OF PEROXISOME PROLIFERATORS AND INDUCERS OF XENOBIOTIC METABOLISM ON MARKER ENZYME-ACTIVITIES IN CULTURED RAT-LIVER SLICES

      Toxicology in vitro
    62. BEAMAND JA; WIELD PT; MORIN CA; MISTRY H; DAVIES S; PRICE RJ; LAKE BG
      INDUCTION OF MIXED-FUNCTION OXIDASE ACTIVITIES IN CYNOMOLGUS MONKEY HEPATOCYTE CULTURES

      Toxicology in vitro
    63. LEWIS DFV; MOEREELS H; LAKE BG; IOANNIDES C; PARKE DV
      MOLECULAR MODELING OF ENZYMES AND RECEPTORS INVOLVED IN CARCINOGENESIS - QSARS AND COMPACT-3D

      Drug metabolism reviews
    64. BEAMAND JA; PRICE RJ; BLOWERS SD; WIELD PT; CUNNINGHAME ME; LAKE BG
      USE OF PRECISION-CUT LIVER SLICES FOR STUDIES OF UNSCHEDULED DNA-SYNTHESIS

      Food and chemical toxicology
    65. LAKE BG; EVANS JG; LEWIS DFV; PRICE RJ
      COMPARISON OF THE HEPATIC-EFFECTS OF COUMARIN, 3,4-DIMETHYLCOUMARIN, DIHYDROCOUMARIN AND 6-METHYLCOUMARIN IN THE RAT

      Food and chemical toxicology
    66. LAKE BG; EVANS JG; LEWIS DFV; PRICE RJ
      STUDIES ON THE ACUTE EFFECTS OF COUMARIN AND SOME COUMARIN DERIVATIVES IN THE RAT

      Food and chemical toxicology
    67. VANIERSEL M; WALTERS DG; PRICE PJ; LOVELL DP; LAKE BG
      SEX AND STRAIN DIFFERENCES IN MOUSE HEPATIC-MICROSOMAL COUMARIN 7-HYDROXYLASE ACTIVITY

      Food and chemical toxicology
    68. RUMSBY PC; DAVIES MJ; PRICE RJ; LAKE BG
      EFFECT OF SOME PEROXISOME PROLIFERATORS ON TRANSFORMING GROWTH FACTOR-BETA(1) GENE-EXPRESSION AND INSULIN-LIKE GROWTH-FACTOR II MANNOSE-6-PHOSPHATE RECEPTOR GENE-EXPRESSION IN RAT-LIVER/

      Carcinogenesis
    69. LEWIS DFV; LAKE BG; IOANNIDES C; PARKE DV
      INHIBITION OF RAT HEPATIC ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY BY A SERIES OF 7-HYDROXY COUMARINS - QSAR STUDIES

      Xenobiotica
    70. STEENSMA A; BEAMAND JA; WALTERS DG; PRICE RJ; LAKE BG
      METABOLISM OF COUMARIN AND 7-ETHOXYCOUMARIN BY RAT, MOUSE, GUINEA-PIG, CYNOMOLGUS MONKEY AND HUMAN PRECISION-CUT LIVER SLICES

      Xenobiotica
    71. VANIERSEL MLPS; HENDERSON CJ; WALTERS DG; PRICE RJ; WOLF CR; LAKE BG
      METABOLISM OF [3-C-14] COUMARIN BY HUMAN LIVER-MICROSOMES

      Xenobiotica
    72. LAKE BG; LEWIS DFV; GRAY TJB; BEAMAND JA
      STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INDUCTION OF PEROXISOMAL ENZYME-ACTIVITIES IN PRIMARY RAT HEPATOCYTE CULTURES

      Toxicology in vitro
    73. LAKE BG; BEAMAND JA; JAPENGA AC; RENWICK A; DAVIES S; PRICE RJ
      INDUCTION OF CYTOCHROME-P-450-DEPENDENT ENZYME-ACTIVITIES IN CULTUREDRAT-LIVER SLICES

      Food and chemical toxicology
    74. LAKE BG; EVANS JG
      EFFECT OF PRETREATMENT WITH SOME MIXED-FUNCTION OXIDASE ENZYME INDUCERS ON THE ACUTE HEPATOTOXICITY OF COUMARIN IN THE RAT

      Food and chemical toxicology
    75. BARRASS NC; PRICE RJ; LAKE BG; ORTON TC
      COMPARISON OF THE ACUTE AND CHRONIC MITOGENIC EFFECTS OF THE PEROXISOME PROLIFERATORS METHYLCLOFENAPATE AND CLOFIBRIC ACID IN RAT-LIVER

      Carcinogenesis
    76. LAKE BG; EVANS JG; CUNNINGHAME ME; PRICE RJ
      COMPARISON OF THE HEPATIC-EFFECTS OF NAFENOPIN AND WY-14,643 ON PEROXISOME PROLIFERATION AND CELL REPLICATION IN THE RAT AND SYRIAN-HAMSTER

      Environmental health perspectives
    77. EVANS JG; COLLINS MA; LAKE BG; BUTLER WH
      THE HISTOLOGY AND DEVELOPMENT OF HEPATIC NODULES AND CARCINOMA IN C3HHE AND C57BL/6 MICE FOLLOWING CHRONIC PHENOBARBITONE ADMINISTRATION/

      Toxicologic pathology


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Documento generato il 24/10/20 alle ore 00:17:43