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    1. Fodde, R; Smits, R
      Disease model: familial adenomatous polyposis

      TRENDS IN MOLECULAR MEDICINE
    2. Fodde, R; Kuipers, J; Rosenberg, C; Smits, R; Kielman, M; Gaspar, C; van Es, JH; Bruekel, C; Wiegant, J; Giles, RH; Clevers, H
      Mutations in the APC tumour suppressor gene cause chromosomal instability

      NATURE CELL BIOLOGY
    3. Poon, R; Smits, R; Li, C; Jagmohan-Changur, S; Kong, M; Cheon, S; Yu, CY; Fodde, R; Alman, BA
      Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

      ONCOGENE
    4. Hohenstein, P; Kielman, MF; Breukel, C; Bennett, LM; Wiseman, R; Krimpenfort, P; Cornelisse, G; van Ommen, GJ; Devilee, P; Fodde, R
      A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

      ONCOGENE
    5. Wagner, A; Hendriks, Y; Meijers-Heijboer, EJ; de Leeuw, WJF; Morreau, H; Hofstra, R; Tops, C; Bik, E; Brocker-Vriends, AHJT; van der Meer, C; Lindhout, D; Vasen, HFA; Breuning, MH; Cornelisse, CJ; van Krimpen, C; Niermeijer, MF; Zwinderman, AH; Wijnen, J; Fodde, R
      Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutchpedigree

      JOURNAL OF MEDICAL GENETICS
    6. Stella, A; Wagner, A; Shito, K; Lipkin, SM; Watson, P; Guanti, G; Lynch, HT; Fodde, R; Liu, B
      A nonsense mutation in MLH1 causes exon skipping in three unrelated HNPCC families

      CANCER RESEARCH
    7. Sijmons, R; Hofstra, R; Hollema, H; Mensink, R; van der Hout, A; Hoekstra, H; Kleibeuker, J; Molenaar, W; Wijnen, J; Fodde, R; Vasen, H; Buys, C
      Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer

      GENES CHROMOSOMES & CANCER
    8. Smits, R; Hofland, N; Edelmann, W; Geugien, M; Jagmohan-Changur, S; Albuquerque, C; Breukel, C; Kucherlapati, R; Kielman, MF; Fodde, R
      Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

      GENES CHROMOSOMES & CANCER
    9. Calin, G; Fodde, R
      FAP and Marfanoid habitus - Reply

      EUROPEAN JOURNAL OF HUMAN GENETICS
    10. Fidalgo, P; Almeida, MR; West, S; Gaspar, C; Maia, L; Wijnen, J; Albuquerque, C; Curtis, A; Cravo, M; Fodde, R; Leitao, CN; Burn, J
      Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach

      EUROPEAN JOURNAL OF HUMAN GENETICS
    11. Peelen, T; de Leeuw, W; van Lent, K; Morreau, H; van Eijk, R; van Vliet, M; Wijnen, J; Ligtenberg, M; Ginjaar, HB; Zweemer, R; Menko, F; Fodde, R; van Ommen, GJB; Vasen, HFA; Cornelisse, CJ; Devilee, P
      Genetic analysis of a breast-ovarian cancer family, with 7 cases of colorectal cancer linked to BRCA1, fails to support a role for BRCA1 in colorectal tumorigenesis

      INTERNATIONAL JOURNAL OF CANCER
    12. Smits, R; Ruiz, P; Diaz-Cano, S; Luz, A; Jagmohan-Changur, S; Breukel, C; Birchmeier, C; Birchmeier, W; Fodde, R
      E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

      GASTROENTEROLOGY
    13. Couture, J; Mitri, A; Lagace, R; Smits, R; Berk, T; Bouchard, HL; Fodde, R; Alman, B; Bapat, B
      A germline mutation at the extreme 3 ' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor

      CLINICAL GENETICS
    14. Bouffler, SD; Hofland, N; Cox, R; Fodde, R
      Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis

      BRITISH JOURNAL OF CANCER
    15. Meijers-Heijboer, H; Lindhout, D; Menko, F; Vossen, S; Moslein, G; Tops, C; Brocker-Vriends, A; Wu, Y; Hofstra, R; Sijmons, R; Cornelisse, C; Morreau, H; Fodde, R
      Familial endometrial cancer in female carriers of MSH6 germline mutations

      NATURE GENETICS
    16. van Oordt, CWVH; Smits, R; Schouten, TG; Houwing-Duistermaat, JJ; Williamson, SLH; Luz, A; Khan, PM; van der Eb, A; Breuer, ML; Fodde, R
      The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc 1638N mouse model

      GENES CHROMOSOMES & CANCER
    17. Calin, G; Wijnen, J; van der Klift, H; Ionita, A; Mulder, A; Breukel, C; Smits, R; Dauwerse, H; Hansson, K; Calin, S; Stefanescu, D; Oproiu, A; Fodde, R
      Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association?

      EUROPEAN JOURNAL OF HUMAN GENETICS
    18. Smits, R; Kielman, MF; Breukel, C; Zurcher, C; Neufeld, K; Jagmohan-Changur, S; Hofland, N; van Dijk, J; White, R; Edelmann, W; Kucherlapati, R; Khan, PM; Fodde, R
      Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

      GENES & DEVELOPMENT
    19. Fodde, R; Smits, R; Hofland, N; Kielman, M; Khan, PM
      Mechanisms of APC-driven tumorigenesis: lessons from mouse models

      CYTOGENETICS AND CELL GENETICS
    20. Williamson, SLH; Kartheuser, A; Coaker, J; Kooshkghazi, MD; Fodde, R; Burn, J; Mathers, JC
      Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months

      CARCINOGENESIS
    21. Kartheuser, A; Walon, C; West, S; Breukel, C; Detry, R; Gribomont, AC; Hamzehloei, T; Hoang, P; Maiter, D; Pringot, J; Rahier, J; Khan, PM; Curtis, A; Burn, J; Fodde, R; Verellen-Dumoulin, C
      Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3 ' APC mutation

      JOURNAL OF MEDICAL GENETICS
    22. Boland, CR; Thibodeau, SN; Hamilton, SR; Sidransky, D; Burt, RW; Meltzer, SJ; Rodriguez-Bigas, MA; Fodde, R; Ranzani, GN; Srivastava, S
      Correspondence re: C. R. Boland et al., a National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer. Cancer Res., 58 : 5248-5257, 1998. Reply

      CANCER RESEARCH
    23. Wielenga, VJM; Smits, R; Korinek, V; Smit, L; Kielman, M; Fodde, R; Clevers, H; Pals, ST
      Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

      AMERICAN JOURNAL OF PATHOLOGY
    24. WIJNEN J; VANDERKLIFT H; VASEN H; KHAN PM; MENKO F; TOPS C; HEIJBOER HM; LINDHOUT D; MOLLER P; FODDE R
      MSH2 GENOMIC DELETIONS ARE A FREQUENT CAUSE OF HNPCC

      Nature genetics
    25. WIJNEN JT; VASEN HFA; KHAN PM; ZWINDERMAN AH; VANDERKLIFT H; MULDER A; TOPS C; MOLLER P; FODDE R
      MISMATCH REPAIR GENE-MUTATIONS IN 184 KINDREDS WITH CLUSTERING OF COLORECTAL-CANCER - RISK FACTOR-ANALYSIS AND IMPLICATIONS FOR GENETIC TESTING

      European journal of human genetics
    26. Burn, J; Alonso, A; Bertario, L; Bishop, T; Bisgaard, ML; Cummings, J; Davidson, R; Delhanty, J; Demant, P; Dunlop, M; Eccles, D; Ellis, A; Evans, G; Fidalgo, P; Fodde, R; Haites, N; Hodgson, S; Hultcrantz, R; Huson, S; Jarvinen, H; Kartheuser, A; Kleibeuker, J; Lenaerts, C; Lucasson, A; Lunt, P; McDermot, K; McKay, J; McKeown, C; Maher, E; Mathers, J; Mecklin, JP; Moslein, G; Murday, V; Nagengast, F; Northover, JMA; Obrador, A; Parks, TG; Paraskeva, C; Phillips, R; San Roman, C; Ruscheoff, J; Sampson, J; Shepherd, N; Tempesta, A; Trembath, R; Turnpenny, P; Vasen, HFA
      Concerted action polyp prevention, CAPP2: A trial of aspirin and/or resistant starch in people at risk of hereditary non-polyposis colon cancer (HNPCC)

      CANCER RESEARCH SUPPORTED UNDER BIOMED I
    27. WIJNEN JT; VASEN HFA; KHAN PM; ZWINDERMAN AH; VANDERKLIFT H; MULDER A; TOPS C; MOLLER P; FODDE R; MENKO F; TAAL B; NAGENGAST F; BRUNNER H; KLEIBEUKER J; SIJMONS R; GRIFFIOEN G; BROCKERVRIENDS A; BAKKER E; VANLEEUWENCORNELISSE I; MEIJERSHEIJBOER A; LINDHOUT D; BREUNING M; POST J; SCHAAP C; APOLD J; HEIMDAL K; BERTARIO L; BISGAARD ML; GOETZ P
      CLINICAL FINDINGS WITH IMPLICATIONS FOR GENETIC TESTING IN FAMILIES WITH CLUSTERING OF COLORECTAL-CANCER

      The New England journal of medicine
    28. SMITS R; VANOORDT WVH; LUZ A; ZURCHER C; JAGMOHANCHANGUR S; BREUKEL C; KHAN PM; FODDE R
      APC1638N - A MOUSE MODEL FOR FAMILIAL ADENOMATOUS POLYPOSIS-ASSOCIATED DESMOID TUMORS AND CUTANEOUS CYSTS

      Gastroenterology
    29. VANDERLUIJT RB; KHAN PM; VASEN HFA; TOPS CMJ; VANLEEUWENCORNELISSE ISJ; WIJNEN JT; VANDERKLIFT HM; PLUG RJ; GRIFFIOEN G; FODDE R
      MOLECULAR ANALYSIS OF THE APC GENE IN 105 DUTCH KINDREDS WITH FAMILIAL ADENOMATOUS POLYPOSIS - 67 GERMLINE MUTATIONS IDENTIFIED BY DGGE, PTT, AND SOUTHERN ANALYSIS

      Human mutation
    30. HARTEVELD KL; LOSEKOOT M; FODDE R; GIORDANO PC; BERNINI LF
      THE INVOLVEMENT OF ALU REPEATS IN RECOMBINATION EVENTS AT THE ALPHA-GLOBIN GENE-CLUSTER - CHARACTERIZATION OF 2 ALPHA(O)-THALASSEMIA DELETION BREAKPOINTS

      Human genetics
    31. SORENSEN IK; KRISTIANSEN E; MORTENSEN A; VANKRANEN H; VANKREIJL C; FODDE R; THORGEIRSSON SS
      SHORT-TERM CARCINOGENICITY TESTING OF A POTENT MURINE INTESTINAL MUTAGEN, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE (PHIP), IN APC1638N TRANSGENIC MICE

      Carcinogenesis
    32. SMITS R; KARTHEUSER A; JAGMOHANCHANGUR S; LEBLANC V; BREUKEL C; DEVRIES A; VANKRANEN H; VANKRIEKEN JH; WILLIAMSON S; EDELMANN W; KUCHERLAPATI R; KAN PM; FODDE R
      LOSS OF APC AND THE ENTIRE CHROMOSOME-18 BUT ABSENCE OF MUTATIONS AT THE RAS AND TP53 GENES IN INTESTINAL TUMORS FROM APC1638N, A MOUSE MODEL FOR APC-DRIVEN CARCINOGENESIS

      Carcinogenesis
    33. VANOORDT CWV; SMITS R; WILLIAMSON SLH; LUZ A; KHAN PM; FODDE R; VANDEREB AJ; BREUER ML
      INTESTINAL AND EXTRAINTESTINAL TUMOR MULTIPLICITIES IN THE APC1638N MOUSE MODEL AFTER EXPOSURE TO X-RAYS

      Carcinogenesis
    34. YANG K; EDELMANN W; FAN KH; LAU K; KOLLI V; FODDE R; KHAN PM; KUCHERLAPATI R; LIPKIN M
      A MOUSE MODEL OF HUMAN FAMILIAL ADENOMATOUS POLYPOSIS

      The Journal of experimental zoology
    35. SMITH AM; WATSON SA; COAKER J; CLARKE P; MATHERS JC; FODDE R; VARRO A; HARDCASTLE JD
      GASTRIN IS EXPRESSED IN ADENOMAS IN THE TRANSGENIC MOUSE POLYPOSIS-COLI MODEL APC 1638N

      Gastroenterology
    36. ROGAN PK; SCHNEIDER TD; FAUX B; WIJNEN J; RADICE P; BABA S; SCOTT R; VIEL A; GENUARDI M; KHAN PM; FODDE R
      INFORMATION THEORY-BASED ANALYSIS OF SPLICE JUNCTION MUTATIONS IN HEREDITARY NONPOLYPOSIS COLON-CANCER (HNPCC)

      American journal of human genetics
    37. WIJNEN J; KHAN PM; VASEN H; VANDERKLIFT H; MULDER A; VANLEEUWENCORNELISSE I; BAKKER B; LOSEKOOT M; MOLLER P; FODDE R
      HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER FAMILIES NOT COMPLYING WITHTHE AMSTERDAM CRITERIA SHOW EXTREMELY-LOW-FREQUENCY OF MISMATCH-REPAIR-GENE MUTATIONS

      American journal of human genetics
    38. VANDERLUIJT RB; KHAN PM; VASEN HFA; BREUKEL C; TOPS CMJ; SCOTT RJ; FODDE R
      GERMLINE MUTATIONS IN THE 3'-PART OF APC EXON-15 DO NOT RESULT IN TRUNCATED PROTEINS AND ARE ASSOCIATED WITH ATTENUATED ADENOMATOUS POLYPOSIS-COLI

      Human genetics
    39. VASEN HFA; WIJNEN JT; MENKO FH; KLEIBEUKER JH; TAAL BG; GRIFFIOEN G; NAGENGAST FM; MEIJERSHEIJBOER EH; BERTARIO L; VARESCO L; BISGAARD ML; MOHR J; FODDE R; KHAN PM
      CANCER RISK IN FAMILIES WITH HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER DIAGNOSED BY MUTATION ANALYSIS (VOL 110, PG 1020, 1996)

      Gastroenterology
    40. VASEN HFA; WIJNEN JT; MENKO FH; KLEIBEUKER JH; TAAL BG; GRIFFIOEN G; NAGENGAST FM; MEIJERSHEIJBOER EH; BERTARIO L; VARESCO L; BISGAARD ML; MOHR J; FODDE R; KHAN PM
      CANCER RISK IN FAMILIES WITH HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER DIAGNOSED BY MUTATION ANALYSIS

      Gastroenterology
    41. ECCLES DM; VANDERLUIJT R; BREUKEL C; BULLMAN H; BUNYAN D; FISHER A; BARBER J; DUBOULAY C; PRIMROSE J; BURN J; FODDE R
      HEREDITARY DESMOID DISEASE DUE TO A FRAMESHIFT MUTATION AT CODON-1924OF THE APC GENE

      American journal of human genetics
    42. WIJNEN J; KHAN PM; VASEN H; MENKO F; VANDERKLIFT H; VANDENBROEK M; VANLEEUWENCORNELISSE I; NAGENGAST F; MEIJERSHEIJBOER EJ; LINDHOUT D; GRIFFIOEN G; CATS A; KLEIBEUKER J; VARESCO L; BERTARIO L; BISGAARD ML; MOHR J; KOLODNER R; FODDE R
      MAJORITY OF HMLH1 MUTATIONS RESPONSIBLE FOR HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER CLUSTER AT THE EXONIC REGION 15-16

      American journal of human genetics
    43. VANDERLUIJT RB; TOPS CMJ; KHAN PM; VANDERKLIFT HM; BREUKEL C; VANLEEUWENCORNELISSE ISJ; DAUWERSE HG; BEVERSTOCK GC; VANNOORT E; SNEL P; SLORS FJM; VASEN HFA; FODDE R
      MOLECULAR, CYTOGENETIC, AND PHENOTYPIC STUDIES OF A CONSTITUTIONAL RECIPROCAL TRANSLOCATION T(5-10)(Q22-Q25) RESPONSIBLE FOR FAMILIAL ADENOMATOUS POLYPOSIS IN A DUTCH PEDIGREE

      Genes, chromosomes & cancer
    44. VANDERLUIJT RB; VASEN HFA; TOPS CMJ; BREUKEL C; FODDE R; KHAN PM
      APC MUTATION IN THE ALTERNATIVELY SPLICED REGION OF EXON-9 ASSOCIATEDWITH LATE-ONSET FAMILIAL ADENOMATOUS POLYPOSIS

      Human genetics
    45. WIJNEN J; VASEN H; KHAN PM; MENKO FH; VANDERKLIFT H; VANLEEUWEN C; VANDENBROEK M; VANLEEUWENCORNELISSE I; NAGENGAST F; MEIJERSHEIJBOER A; LINDHOUT D; GRIFFIOEN G; CATS A; KLEIBEUKER J; VARESCO L; BERTARIO L; BISGAARD ML; MOHR J; FODDE R
      7 NEW MUTATIONS IN HMSH2, AN HNPCC GENE, IDENTIFIED BY DENATURING GRADIENT-GEL ELECTROPHORESIS

      American journal of human genetics
    46. FODDE R; LOSEKOOT M
      MUTATION DETECTION BY DENATURING GRADIENT ELECTROPHORESIS (DGGE)

      Human mutation
    47. WIJNEN J; FODDE R; KHAN PM
      DGGE POLYMORPHISM IN INTRON-10 OF MSH2, THE HNPCC GENE

      Human molecular genetics
    48. VANDERLUIJT R; KHAN PM; VASEN H; VANLEEUWEN C; TOPS C; ROEST P; DENDUNNEN J; FODDE R
      RAPID DETECTION OF TRANSLATION-TERMINATING MUTATIONS AT THE ADENOMATOUS POLYPOSIS-COLI (APC) GENE BY DIRECT PROTEIN TRUNCATION TEST

      Genomics
    49. BRAHE C; VELONA I; VANDERSTEEGE G; ZAPPATA S; VANDEVEEN AY; OSINGA J; TOPS CMJ; FODDE R; KHAN PM; BUYS CHCM; NERI G
      MAPPING OF 2 NEW MARKERS WITHIN THE SMALLEST INTERVAL HARBORING THE SPINAL MUSCULAR-ATROPHY LOCUS BY FAMILY AND RADIATION HYBRID ANALYSIS

      Human genetics
    50. FODDE R; EDELMANN W; YANG K; VANLEEUWEN C; CARLSON C; RENAULT B; BREUKEL C; ALT E; LIPKIN M; KHAN PM; KUCHERLAPATI R
      A TARGETED CHAIN-TERMINATION MUTATION IN THE MOUSE APC GENE RESULTS IN MULTIPLE INTESTINAL TUMORS

      Proceedings of the National Academy of Sciences of the United Statesof America
    51. VELONA I; ZAPPATA S; TOPS CMJ; FODDE R; KHAN PM; NERI G; BRAHE C
      DINUCLEOTIDE REPEAT POLYMORPHISM PROXIMAL TO THE SPINAL MUSCULAR-ATROPHY REGION AT THE D5S524 LOCUS

      Human molecular genetics
    52. KIELMAN MF; SMITS R; DEVI TS; FODDE R; BERNINI LF
      HOMOLOGY OF A 130-KB REGION ENCLOSING THE ALPHA-GLOBIN GENE-CLUSTER, THE ALPHA-LOCUS CONTROLLING REGION, AND 2 NON-GLOBIN GENES IN HUMAN AND MOUSE

      Mammalian genome
    53. VANDENBROEK MH; JHANWAR SC; FODDE R; CHAGANTI RSK; KHAN PM
      P53 MUTATIONS IN COLORECTAL CANCERS IN THE PATIENTS OF METROPOLITAN NEW-YORK

      Anticancer research
    54. VANDENBROEK MH; RENAULT B; FODDE R; VERSPAGET H; GRIFFIOEN G; KHAN PM
      SITES AND TYPES OF P53 MUTATIONS IN AN UNSELECTED SERIES OF COLORECTAL CANCERS IN THE NETHERLANDS

      Anticancer research
    55. RENAULT B; VANDENBROEK M; FODDE R; WIJNEN J; PELLEGATA NS; AMADORI D; KHAN PM; RANZANI GN
      BASE TRANSITIONS ARE THE MOST FREQUENT GENETIC CHANGES AT P53 IN GASTRIC-CANCER

      Cancer research
    56. FODDE R; EDELMANN W; YANG K; RENAULT B; BREUKEL C; VANLEEUWEN C; LIPKIN M; KHAN PM; KUCHERLAPATI R
      TARGETED MODIFICATION OF EXON-15 OF THE MOUSE APC GENE RESULTS IN MULTIPLE INTESTINAL ADENOCARCINOMAS

      American journal of human genetics


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Documento generato il 24/10/20 alle ore 13:53:14