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    1. Wood, MD; Reavill, C; Trail, B; Wilson, A; Stean, T; Kennett, GA; Lightowler, S; Blackburn, TP; Thomas, D; Gager, TL; Riley, G; Holland, V; Bromidge, SM; Forbes, IT; Middlemiss, DN
      SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety

      NEUROPHARMACOLOGY
    2. Bromidge, SM; Dabbs, S; Davies, S; Duckworth, DM; Forbes, IT; Jones, GE; Jones, J; King, FD; Saunders, DV; Blackburn, TP; Holland, V; Kennett, GA; Lightowler, S; Middlemiss, DN; Riley, GJ; Trail, B; Wood, MD
      1-[2-[(heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolyticagents

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    3. Bromidge, SM; Davies, S; Duckworth, DM; Forbes, IT; Jones, GE; Jones, J; King, FD; Blackburn, TP; Holland, V; Kennett, GA; Lightowler, S; Middlemiss, DN; Riley, GJ; Trail, B; Wood, MD
      1-[2-[(heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orallyactive 5-HT2C receptor inverse agonists

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    4. Branchek, TA; Blackburn, TP
      5-HT6 receptors as emerging targets for drug discovery

      ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
    5. Clemett, DA; Punhani, T; Duxon, MS; Blackburn, TP; Fone, KCF
      Immunohistochemical localisation of the 5-HT2C receptor protein in the ratCNS

      NEUROPHARMACOLOGY
    6. Bromidge, SM; Dabbs, S; Davies, DT; Davies, S; Duckworth, DM; Forbes, IT; Gaster, LM; Ham, P; Jones, GE; King, FD; Mulholland, KR; Saunders, DV; Wyman, PA; Blaney, FE; Clarke, SE; Blackburn, TP; Holland, V; Kennett, GA; Lightowler, S; Middlemiss, DN; Trail, B; Riley, GJ; Wood, MD
      Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent

      JOURNAL OF MEDICINAL CHEMISTRY
    7. Bromidge, SM; Dabbs, S; Davies, DT; Davies, S; Duckworth, DM; Forbes, IT; Gadre, A; Ham, P; Jones, GE; King, FD; Saunders, DV; Thewlis, KM; Vyas, D; Blackburn, TP; Holland, V; Kennett, GA; Riley, GJ; Wood, MD
      Model studies on a synthetically facile series of N-substituted phenyl-N '-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists

      BIOORGANIC & MEDICINAL CHEMISTRY
    8. Reavill, C; Kettle, A; Holland, V; Riley, G; Blackburn, TP
      Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist

      BRITISH JOURNAL OF PHARMACOLOGY
    9. BLACKBURN TP
      THE 5-HT2C RECEPTOR GENE - FROM MOUSE TO MAN - NOVEL THERAPEUTIC OPPORTUNITIES

      European journal of neuroscience
    10. BROMIDGE SM; DABBS S; DAVIES DT; DUCKWORTH DM; FORBES IT; HAM P; JONES GE; KING FD; SAUNDERS DV; STARR S; THEWLIS KM; WYMAN PA; BLANEY FE; NAYLOR CB; BAILEY F; BLACKBURN TP; HOLLAND V; KENNETT GA; RILEY GJ; WOOD MD
      NOVEL AND SELECTIVE 5-HT2C 2B RECEPTOR ANTAGONISTS AS POTENTIAL ANXIOLYTIC AGENTS - SYNTHESIS, QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS, AND MOLECULAR MODELING OF SUBSTITUTED 1-(3-PYRIDYLCARBAMOYL)INDOLINES/

      Journal of medicinal chemistry
    11. MEADOWS HJ; KUMAR CS; PRITCHETT DB; BLACKBURN TP; BENHAM CD
      SB-205384 - A GABA(A) RECEPTOR MODULATOR WITH NOVEL MECHANISM OF ACTION THAT SHOWS SUBUNIT SELECTIVITY

      British Journal of Pharmacology
    12. DUXON MS; FLANIGAN TP; REAVLEY AC; BAXTER GS; BLACKBURN TP; FONE KCF
      EVIDENCE FOR EXPRESSION OF THE 5-HYDROXYTRYPTAMINE-2B RECEPTOR PROTEIN IN THE RAT CENTRAL-NERVOUS-SYSTEM

      Neuroscience
    13. DUXON MS; KENNETT GA; LIGHTOWLER S; BLACKBURN TP; FONE KCF
      ACTIVATION OF 5-HT2B RECEPTORS IN THE MEDIAL AMYGDALA CAUSES ANXIOLYSIS IN THE SOCIAL-INTERACTION TEST IN THE RAT

      Neuropharmacology
    14. KENNETT GA; WOOD MD; BRIGHT F; TRAIL B; RILEY G; HOLLAND V; AVENELL KY; STEAN T; UPTON N; BROMIDGE S; FORBES IT; BROWN AM; MIDDLEMISS DN; BLACKBURN TP
      SB-242084, A SELECTIVE AND BRAIN PENETRANT 5-HT2C RECEPTOR ANTAGONIST

      Neuropharmacology
    15. KENNETT GA; BRIGHT F; TRAIL B; BLACKBURN TP; SANGER GJ
      ANXIOLYTIC-LIKE ACTIONS OF THE SELECTIVE 5-HT4 RECEPTOR ANTAGONISTS SB-204070A AND SB-207266A IN RATS

      Neuropharmacology
    16. KENNETT GA; AINSWORTH K; TRAIL B; BLACKBURN TP
      BW 723C86, A 5-HT2B RECEPTOR AGONIST, CAUSES HYPERPHAGIA AND REDUCED GROOMING IN RATS

      Neuropharmacology
    17. BROMIDGE SM; DUCKWORTH M; FORBES IT; HAM P; KING FD; THEWLIS KM; BLANEY FE; NAYLOR CB; BLACKBURN TP; KENNETT GA; WOOD MD; CLARKE SE
      ETHYL-3-PYRIDYL)OXY]-5-PYRIDYL]CARBAMOYL]-INDOLINE (SB-242084) - THE FIRST SELECTIVE AND BRAIN PENETRANT 5-HT2C RECEPTOR ANTAGONIST

      Journal of medicinal chemistry
    18. UPTON N; BLACKBURN TP; CAMPBELL CA; COOPER D; EVANS ML; HERDON HJ; KING PD; RAY AM; STEAN TO; CHAN WN; EVANS JM; THOMPSON M
      PROFILE OF SB-204269, A MECHANISTICALLY NOVEL ANTICONVULSANT DRUG, INRAT MODELS OF FOCAL AND GENERALIZED EPILEPTIC SEIZURES

      British Journal of Pharmacology
    19. KENNETT GA; BRIGHT F; TRAIL B; BLACKBURN TP; SANGER GJ
      EFFECTS OF SB-204070A AND SB-207266A, SELECTIVE 5-HT4 RECEPTOR ANTAGONISTS, IN 3 RAT MODELS OF ANXIETY

      British Journal of Pharmacology
    20. BRIGHT F; TRAIL B; BLACKBURN TP; KENNETT GA
      EFFECTS OF CLOZAPINE AND MDL-100,907 IN THE RAT GELLER-SEIFTER MODEL OF ANXIETY

      British Journal of Pharmacology
    21. LIGHTOWLER S; BRIGHT F; STEVENS NC; DEBIASI V; BLACKBURN TP; KENNETT GA
      EFFECT OF PAROXETINE AND MIANSERIN ON AMPHETAMINE-INDUCED HYPERLOCOMOTION

      British Journal of Pharmacology
    22. FORBES IT; DABBS S; DUCKWORTH DM; HAM P; JONES GE; KING FD; SAUNDERS DV; BLANEY FE; NAYLOR CB; BAXTER GS; BLACKBURN TP; KENNETT GA; WOOD MD
      SYNTHESIS, BIOLOGICAL-ACTIVITY, AND MOLECULAR MODELING STUDIES OF SELECTIVE 5-HT2C 2B RECEPTOR ANTAGONISTS/

      Journal of medicinal chemistry
    23. HOPE AG; PETERS JA; BROWN AM; LAMBERT JJ; BLACKBURN TP
      CHARACTERIZATION OF A HUMAN 5-HYDROXYTRYPTAMINE(3) RECEPTOR-TYPE-A (H5-HT(3)R-A(S)) SUBUNIT STABLY EXPRESSED IN HEK-293 CELLS

      British Journal of Pharmacology
    24. KENNETT GA; BRIGHT F; TRAIL B; BAXTER GS; BLACKBURN TP
      EFFECTS OF THE 5-HT2B RECEPTOR AGONIST, BW-723C86, ON 3 RAT MODELS OFANXIETY

      British Journal of Pharmacology
    25. KENNETT GA; WOOD MD; BRIGHT F; CILIA J; PIPER DC; GAGER T; THOMAS D; BAXTER GS; FORBES IT; HAM P; BLACKBURN TP
      IN-VITRO AND IN-VIVO PROFILE OF SB-206553, A POTENT 5-HT2C 5-HT2B RECEPTOR ANTAGONIST WITH ANXIOLYTIC-LIKE PROPERTIES/

      British Journal of Pharmacology
    26. KENNETT GA; BRIGHT F; DARCY S; BLACKBURN TP
      THE 5HT(2C 2B) RECEPTOR ANTAGONIST, SB-206553, HAS ANXIOLYTIC-LIKE PROPERTIES IN 2 RAT MODELS/

      British Journal of Pharmacology
    27. GAGER TL; HOLLAND V; THOMAS DR; BLACKBURN TP
      THE NOVEL 5-HT2C 2B RECEPTOR ANTAGONIST SB206553 IS A POTENT AND SURMOUNTABLE ANTAGONIST AT CLONED HUMAN RECEPTORS/

      British Journal of Pharmacology
    28. AINSWORTH K; TRAIL B; BLACKBURN TP; BAXTER GS; KENNETT GA
      IS BW 723C86-INDUCED HYPERPHAGIA AN IN-VIVO MODEL OF RAT CENTRAL 5-HT2B RECEPTOR FUNCTION

      British Journal of Pharmacology
    29. WARD JL; LIGHTOWLER S; KENNETT GA; BLACKBURN TP
      EFFECT OF THE SELECTIVE 5-HT2B 2C RECEPTOR ANTAGONIST, SB-206553, ON MCPP-INDUCED AND ENVIRONMENTAL STRESS-INDUCED INCREASE IN PLASMA ADRENOCORTICOTROPIC HORMONE IN RATS/

      British Journal of Pharmacology
    30. BLACKBURN TP; DAVIES DT; FORBES IT; HAYWARD CJ; JOHNSON CN; MARTIN RT; PIPER DC; THOMAS DR; THOMPSON M; UPTON N; WARD RW
      ISOSTERIC REPLACEMENT OF THE INDOLE NUCLEUS BY BENZOTHIOPHENE IN A SERIES OF PYRIDO[2,3-B]INDOLES WITH POTENTIAL ANXIOLYTIC ACTIVITY

      Bioorganic & medicinal chemistry letters
    31. BENHAM CD; BLACKBURN TP; JOHNS A; KOTECHA NR; MARTIN RT; THOMAS DR; THOMPSON M; WARD RW
      THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES

      Bioorganic & medicinal chemistry letters
    32. BLACKBURN TP; BUCKINGHAM RE; CHAN WN; EVANS JM; HADLEY MS; THOMPSON M; UPTON N; STEAN TO; STEMP G; VONG AK
      STEREOCHEMICAL DIFFERENTIATION OF ANTICONVULSANT AND ANTIHYPERTENSIVEEFFECTS IN 4-(FLUOROBENZOYLAMINO)BENZOPYRANS

      Bioorganic & medicinal chemistry letters
    33. BELELLI D; BALCAREK JM; HOPE AG; PETERS JA; LAMBERT JJ; BLACKBURN TP
      CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN 5-HYDROXYTRYPTAMINE TYPE3A(S) RECEPTOR SUBUNIT

      Molecular pharmacology
    34. FORBES IT; HAM P; BOOTH DH; MARTIN RT; THOMPSON M; BAXTER GS; BLACKBURN TP; GLEN A; KENNETT GA; WOOD MD
      LCARBAMOYL)-1,2,3,5-TETRAHYDROPYRROLO[2,3-F]INDOLE - A NOVEL 5-HT2C 5-HT2B RECEPTOR ANTAGONIST WITH IMPROVED AFFINITY, SELECTIVITY, AND ORAL ACTIVITY

      Journal of medicinal chemistry
    35. STEWARD LJ; GE J; BENTLEY KR; BARBER PC; HOPE AG; LAMBERT JJ; PETERS JA; BLACKBURN TP; BARNES NM
      EVIDENCE THAT THE ATYPICAL 5-HT3 RECEPTOR-LIGAND, [H-3] BRL46470, LABELS ADDITIONAL 5-HT3 BINDING SITES COMPARED TO [H-3] GRANISETRON

      British Journal of Pharmacology
    36. HOPE AG; BROWN AM; PETERS JA; LAMBERT JJ; BALCAREK JM; BLACKBURN TP
      CHARACTERIZATION OF A CLONED HUMAN 5-HT3 RECEPTOR SUBUNIT STABLY EXPRESSED IN HEK-293 CELLS

      British Journal of Pharmacology
    37. BELELLI D; HOPE AG; PETERS JA; LAMBERT JJ; BLACKBURN TP; BALCAREK JM
      FUNCTIONAL-PROPERTIES OF A HUMAN RECOMBINANT 5-HT3 RECEPTOR EXPRESSEDIN XENOPUS-LAEVIS OOCYTES

      British Journal of Pharmacology
    38. KENNETT GA; BRIGHT F; TRAIL B; BLACKBURN TP; BAXTER GS
      EFFECTS OF THE 5-HT2B RECEPTOR AGONIST, BW 723C86, IN RAT SOCIAL-INTERACTION, ELEVATED X-MAZE AND GELLER-SEIFTER MODELS OF ANXIETY

      British Journal of Pharmacology
    39. DUXON MS; BECKETT SR; BAXTER GS; BLACKBURN TP; FONE KCF
      INTRAAMYGDALA INJECTION OF THE 5-HT2B RECEPTOR AGONIST BW-72386 PRODUCES ANXIOLYSIS ON THE ELEVATED PLUS-MAZE IN THE RAT

      British Journal of Pharmacology
    40. TRAIL B; AINSWORTH K; BLACKBURN TP; BAXTER GS; KENNETT GA
      ARE MCPP-INDUCED BEHAVIORS 5-HT2C OR 5-HT2B RECEPTOR-MEDIATED

      British Journal of Pharmacology
    41. DUXON MS; REAVLEY AC; FLANIGAN TP; BAXTER G; BLACKBURN TP; FONE KCF
      EXPRESSION OF THE 5-HT2B RECEPTOR PROTEIN IN THE RAT-BRAIN

      British Journal of Pharmacology
    42. BAXTER GS; BLACKBURN TP; CHAPMAN J; TILFORD NS
      CONTRACTILE ACTIONS OF THE MIXED 5-HT2A 2B/2C RECEPTOR ANTAGONIST ICI-169369 IN RAT STOMACH FUNDUS/

      British Journal of Pharmacology
    43. KENNETT GA; GREWAL S; BLACKBURN TP
      EVIDENCE OF TOLERANCE DEVELOPMENT TO THE HYPERPHAGIC BUT NOT ANXIOLYTIC-LIKE ACTIONS OF SB-200646A, A 5-HT2C 5-HT2B RECEPTOR ANTAGONIST, AFTER CHRONIC TREATMENT/

      British Journal of Pharmacology
    44. LIGHTOWLER S; KENNETT GA; TULLOCH IF; BLACKBURN TP
      EFFECT OF 7 DAYS PAROXETINE ADMINISTRATION ON SOCIAL-INTERACTION BEHAVIOR AND 5-HT2C RECEPTOR FUNCTION IN RATS

      British Journal of Pharmacology
    45. KENNETT GA; BAILEY F; PIPER DC; BLACKBURN TP
      EFFECT OF SB 200646A, A 5-HT2C 5-HT2B RECEPTOR ANTAGONIST, IN 2 CONFLICT MODELS OF ANXIETY

      Psychopharmacology
    46. BLACKBURN TP; BOLTON D; FORBES IT; JOHNSON CN; MARTIN RT; THOMAS DR; THOMPSON M; UPTON N
      -DIMETHYL-1,2,3,4-TETRAHYDRO-6H-QUININDOLIN-1-ONE, A NOVEL GABA(A) MODULATOR WITH POTENTIAL ANXIOLYTIC ACTIVITY

      Bioorganic & medicinal chemistry letters
    47. LIGHTOWLER S; KENNETT GA; WILLIAMSON IJR; BLACKBURN TP; TULLOCH IF
      ANXIOLYTIC-LIKE EFFECT OF PAROXETINE IN A RAT SOCIAL-INTERACTION TEST

      Pharmacology, biochemistry and behavior
    48. DOWNIE DL; HOPE AG; LAMBERT JJ; PETERS JA; BLACKBURN TP; JONES BJ
      PHARMACOLOGICAL CHARACTERIZATION OF THE APPARENT SPLICE VARIANTS OF THE MURINE 5-HT3, R-A SUBUNIT EXPRESSED IN XENOPUS-LAEVIS OOCYTES

      Neuropharmacology
    49. KENNETT GA; LIGHTOWLER S; DEBIASI V; STEVENS NC; WOOD MD; TULLOCH IF; BLACKBURN TP
      EFFECT OF CHRONIC ADMINISTRATION OF SELECTIVE 5-HYDROXYTRYPTAMINE ANDNORADRENALINE UPTAKE INHIBITORS ON A PUTATIVE INDEX OF 5-HT2C 2B RECEPTOR FUNCTION/

      Neuropharmacology
    50. BAXTER GS; MURPHY OE; BLACKBURN TP
      FURTHER CHARACTERIZATION OF 5-HYDROXYTRYPTAMINE RECEPTORS (PUTATIVE 5-HT2B) IN RAT STOMACH FUNDUS LONGITUDINAL MUSCLE

      British Journal of Pharmacology
    51. STEWARD LJ; HOPE AG; LAMBERT JJ; BLACKBURN TP; BARNES NM
      EVIDENCE THAT THE 5-HT3 RECEPTOR-LIGAND [H-3] BRL46470 LABELS ADDITIONAL 5-HT3 RECEPTOR-BINDING SITES

      British Journal of Pharmacology
    52. KENNETT GA; LIGHTOWLER S; MURPHY O; DEBIASI V; STEVENS N; TULLOCH LF; BLACKBURN TP
      CHRONIC TREATMENT WITH PAROXETINE AND FLUOXETINE, BUT NOT DESIPRAMINE, DESENSITIZES 5-HT2C RECEPTOR FUNCTION

      British Journal of Pharmacology
    53. LIGHTOWLER S; KENNETT GA; BLACKBURN TP
      AN INVESTIGATION OF THE EFFECTS OF ACUTE FLUOXETINE IN A RAT X-MAZE MODEL OF ANXIETY

      British Journal of Pharmacology
    54. KENNETT GA; BAILEY F; PIPER DC; BLACKBURN TP
      EFFECT OF SB 200646A, A 5-HT2C RECEPTOR ANTAGONIST, ON 2 CONFLICT MODELS OF ANXIETY

      British Journal of Pharmacology
    55. LIGHTOWLER S; KENNETT GA; WOOD MD; BROWN AM; GLEN A; BLACKBURN TP; TULLOCH IF
      HYPOPHAGIC EFFECT OF FLUOXETINE IN RATS IS NOT MEDIATED BY INHIBITIONOF 5-HT REUPTAKE OR AN AGONIST ACTION AT 5-HT2C RECEPTORS

      British Journal of Pharmacology
    56. KENNETT GA; WOOD MD; GLEN A; GREWAL S; FORBES I; GADRE A; BLACKBURN TP
      IN-VIVO PROPERTIES OF SB 200646A, A 5-HT2C 2B RECEPTOR ANTAGONIST/

      British Journal of Pharmacology
    57. WOOD MD; GLEN A; MURPHY O; STEWART BR; BLACKBURN TP
      SB-200646A - A SELECTIVE 5-HT(2C) RECEPTOR ANTAGONIST

      British Journal of Pharmacology
    58. KENNETT GA; PITTAWAY K; BLACKBURN TP
      EVIDENCE THAT 5-HT2C RECEPTOR ANTAGONISTS ARE ANXIOLYTIC IN THE RAT GELLER-SEIFTER MODEL OF ANXIETY

      Psychopharmacology
    59. NEWBERRY NR; WATKINS CJ; SPROSEN TS; BLACKBURN TP; GRAHAMESMITH DG; LESLIE RA
      BRL-46470 POTENTLY ANTAGONIZES NEURAL RESPONSES ACTIVATED BY 5-HT(3) RECEPTORS

      Neuropharmacology
    60. GROWCOTT JW; COX B; BLACKBURN TP
      A PHARMACOLOGICAL COMPARISON OF THE RECEPTORS MEDIATING CONTRACTILE RESPONSES TO 5-HYDROXYTRYPTAMINE IN THE RAT ISOLATED CAUDAL ARTERY AND FUNDIC STRIP

      Journal of Pharmacy and Pharmacology
    61. WOOD MD; GLEN A; CAREY J; ROBINSON J; BLACKBURN TP
      CHARACTERIZATION OF [H-3] MESULERGINE BINDING TO THE CLONED HUMAN 5-HT1C RECEPTOR

      Journal of neurochemistry
    62. FORBES IT; KENNETT GA; GADRE A; HAM P; HAYWARD CJ; MARTIN RT; THOMPSON M; WOOD MD; BAXTER GS; GLEN A; MURPHY OE; STEWART BA; BLACKBURN TP
      N-(1-METHYL-5-INDOLYL)-N'-(3-PYRIDYL)UREA HYDROCHLORIDE - THE 1ST SELECTIVE 5-HT(1C) RECEPTOR ANTAGONIST

      Journal of medicinal chemistry
    63. WOOD MD; GLEN A; BLACKBURN TP; LEE JA; SUTIPHONG JA; KUMAR C; CAREY J; ROBINSON J
      (-)-FLUOXETINE HAS HIGH-AFFINITY FOR THE CLONED RAT AND HUMAN 5-HT(1C) RECEPTOR AND THE HUMAN 5-HT(2) RECEPTOR

      British Journal of Pharmacology
    64. ATTWELL PJE; BOWERY NG; BLACKBURN TP; LESLIE RA
      LOCALIZATION OF NEURONAL-ACTIVITY MEDIATED BY NEUROPEPTIDE-Y IN RAT-BRAIN - THE USE OF C-FOS-LIKE IMMUNOREACTIVITY AS AN ANATOMICAL MARKER OF PEPTIDE RECEPTOR ACTIVATION

      British Journal of Pharmacology


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Documento generato il 27/10/20 alle ore 19:44:21