Per ulteriori informazioni selezionare i riferimenti di interesse.
APL, a model disease for cancer therapies?
ONCOGENE
Pathways of retinoic acid- or arsenic trioxide-induced PML/RAR alpha catabolism, role of oncogene degradation in disease remission
ONCOGENE
Promyelocytic leukemia, a unique model to design treatments targeting oncogenes
M S-MEDECINE SCIENCES
PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator
EMBO JOURNAL
Allelic loss detection in inflammatory breast cancer: Improvement with laser microdissection
LABORATORY INVESTIGATION
Human foamy virus capsid formation requires an interaction domain in the Nterminus of Gag
JOURNAL OF VIROLOGY
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation,11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation
JOURNAL OF EXPERIMENTAL MEDICINE
Responding to allegations of scientific misconduct: The procedure at the French National Medical and Health-Research Institute
SCIENCE AND ENGINEERING ETHICS
Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF
ONCOGENE
Microdissection and breast cancer
JOURNAL OF MOLECULAR MEDICINE-JMM
Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma
LEUKEMIA
Isolation and characterization of an equine foamy virus
JOURNAL OF VIROLOGY
Dimerization with retinoid x receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-kappa B activation
BLOOD
Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-kappa B activation
BLOOD
Stress-induced aberrant splicing of TSG101: association to high tumor grade and p53 status in breast cancers
ONCOGENE
TIF1 gamma, a novel member of the transcriptional intermediary factor 1 family
ONCOGENE
Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins
ONCOGENE
Retinoic acid, but not arsenic trioxide, degrades the PLZF/RAR alpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient
ONCOGENE
In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RAR alpha protein and the PML retargeting on PML-nuclear bodies
LEUKEMIA
Deletion of the fiber gene induces the storage of hexon and penton base proteins in PML/Sp100-containing inclusions during adenovirus infection
BIOLOGY OF THE CELL
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RAR alpha) and oncogenic RAR alpha fusion proteins
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Retinoic acid and arsenic synergize to eradicate leukemic cells in a mousemodel of acute promyelocytic leukemia
JOURNAL OF EXPERIMENTAL MEDICINE
SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation
JOURNAL OF CELL SCIENCE
Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells
BLOOD
Arsenic trioxide, a novel mitochondriotoxic anticancer agent?
JOURNAL OF THE NATIONAL CANCER INSTITUTE