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    1. Ramamoorthy, Y; Tyndale, RF; Sellers, EM
      Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates

      PHARMACOGENETICS
    2. Wong, JMY; Harper, PA; Meyer, UA; Bock, KW; Morike, K; Lagueux, J; Ayotte, P; Tyndale, RF; Sellers, EM; Manchester, DK; Okey, AB
      Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro

      PHARMACOGENETICS
    3. Petrie, J; Sapp, DW; Tyndale, RF; Park, MK; Fanselow, M; Olsen, RW
      Altered GABA(A) receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    4. Zhang, WJ; Kilicarslan, T; Tyndale, RF; Sellers, EM
      Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific andselective CYP2A6 inhibitors in vitro

      DRUG METABOLISM AND DISPOSITION
    5. Kilicarslan, T; Haining, RL; Rettie, AE; Busto, U; Tyndale, RF; Sellers, EM
      Flunitrazepam metabolism by cytochrome P450S2C19 and 3A4

      DRUG METABOLISM AND DISPOSITION
    6. Tyndale, RF; Sellers, EM
      Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk

      DRUG METABOLISM AND DISPOSITION
    7. Howard, LA; Micu, AL; Sellers, EM; Tyndale, RF
      Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    8. Gaedigk, A; Casley, WL; Tyndale, RF; Sellers, EM; Jurima-Romet, M; Leeder, JS
      Cytochrome P4502C9 (CYP2C9) allele frequencies in canadian native indian and inuit populations

      CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
    9. Schoedel, KA; Sellers, EM; Tyndale, RF
      Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain

      BIOCHEMICAL PHARMACOLOGY
    10. Vandenbergh, DJ; Thompson, MD; Cook, EH; Bendahhou, E; Nguyen, T; Krasowski, MD; Zarrabian, D; Comings, D; Sellers, EM; Tyndale, RF; George, SR; O'Dowd, BF; Uhl, GR
      Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivitydisorder populations

      MOLECULAR PSYCHIATRY
    11. Kathiramalainathan, K; Kaplan, HL; Romach, MK; Busto, UE; Li, NY; Sawe, J; Tyndale, RF; Sellers, EM
      Inhibition of cytochrome P450 2D6 modifies codeine abuse liability

      JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
    12. Romach, MK; Otton, SV; Somer, G; Tyndale, RF; Sellers, EM
      Cytochrome P450 2D6 and treatment of codeine dependence

      JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
    13. Miksys, S; Rao, Y; Sellers, EM; Kwan, M; Mendis, D; Tyndale, RF
      Regional and cellular distribution of CYP2D subfamily members in rat brain

      XENOBIOTICA
    14. Davies, PA; Hoffmann, EB; Carlisle, HJ; Tyndale, RF; Hales, TG
      The influence of an endogenous beta 3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells

      NEUROPHARMACOLOGY
    15. Rao, YS; Hoffmann, E; Zia, M; Bodin, L; Zeman, M; Sellers, EM; Tyndale, RF
      Duplications and defects in the CYP2A6 gene: Identification, genotyping, and in vivo effects on smoking

      MOLECULAR PHARMACOLOGY
    16. Sellers, EM; Kaplan, HL; Tyndale, RF
      Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking

      CLINICAL PHARMACOLOGY & THERAPEUTICS
    17. Miksys, S; Hoffmann, E; Tyndale, RF
      Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

      BIOCHEMICAL PHARMACOLOGY
    18. Tyndale, RF; Tomkins, DM
      Differences in propensity for drinking alcohol are reflected in subunit- and region-specific GABA(A) receptor levels

      ADDICTION BIOLOGY
    19. Ozdemir, V; Tyndale, RF; Reed, K; Herrmann, N; Sellers, EM; Kalow, W; Naranjo, CA
      Paroxetine steady-state plasma concentration in relation to CYP2D6 genotype in extensive metabolizers

      JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
    20. Tyndale, RF; Li, Y; Li, NY; Messina, E; Miksys, S; Sellers, EM
      Characterization of cytochrome P-450 2D1 activity in rat brain: High-affinity kinetics for dextromethorphan

      DRUG METABOLISM AND DISPOSITION
    21. GAEDIGK A; TYNDALE RF; JURIMAROMET M; SELLERS EM; GRANT DM; LEEDER JM
      NAD(P)H-QUINONE OXIDOREDUCTASE - POLYMORPHISMS AND ALLELE FREQUENCIESIN CAUCASIAN, CHINESE AND CANADIAN NATIVE INDIAN AND INUIT POPULATIONS

      Pharmacogenetics
    22. DROLL K; BRUCEMENSAH K; OTTON SV; GAEDIGK A; SELLERS EM; TYNDALE RF
      COMPARISON OF 3 CYP2D6 PROBE SUBSTRATES AND GENOTYPE IN GHANAIANS, CHINESE AND CAUCASIANS

      Pharmacogenetics
    23. Tyndale, RF; Droll, KP; Sellers, EM
      Relevance of deficient CYP2D6 in opiate dependence

      PHARMACOGENETICS
    24. ZAWERTAILO LA; KAPLAN HL; BUSTO UE; TYNDALE RF; SELLERS EM
      PSYCHOTROPIC EFFECTS OF DEXTROMETHORPHAN ARE ALTERED BY THE CYP2D6 POLYMORPHISM - A PILOT-STUDY

      Journal of clinical psychopharmacology
    25. PIANEZZA ML; SELLERS EM; TYNDALE RF
      NICOTINE METABOLISM DEFECT REDUCES SMOKING

      Nature
    26. BRONSTEIN JM; HALES TG; TYNDALE RF; CHARLES AC
      A CONDITIONALLY IMMORTALIZED GLIAL-CELL LINE THAT EXPRESSES MATURE MYELIN PROTEINS AND FUNCTIONAL GABA(A) RECEPTORS

      Journal of neurochemistry
    27. TYNDALE RF; MIKSYS S; HOFFMANN E; TAMPAKERAS M; TOMKINS DM
      DIFFERENT ALCOHOL-DRINKING PROPENSITIES ARE REFLECTED IN SUBUNIT-SPECIFIC AND REGION-SPECIFIC GABA(A) RECEPTORS LEVELS

      Journal of neurochemistry
    28. NOWAK MP; SELLERS EM; TYNDALE RF
      CANADIAN NATIVE INDIANS EXHIBIT UNIQUE CYP2A6 AND CYP2C19 MUTANT ALLELE FREQUENCIES

      Clinical pharmacology and therapeutics
    29. GAEDIGK A; TYNDALE RF; JURIMAROMET M; SELLERS EM; LEEDER JS
      GENETIC POLYMORPHISMS IN THE NAD(P)H - QUINONE OXIDOREDUCTASE (NQO1) GENE LOCUS

      Clinical pharmacology and therapeutics
    30. PIANEZZA ML; SELLERS EM; TYNDALE RF
      GENETICALLY VARIABLE CYP2A6 INFLUENCES SMOKING-BEHAVIOR

      Clinical pharmacology and therapeutics
    31. ZEMAN MV; PIANEZZA ML; LI NY; TYNDALE RF; SELLERS EM
      CHARACTERIZATION OF CYP2A6 ACTIVITY USING PLASMA COUMARIN MEASUREMENTS

      Clinical pharmacology and therapeutics
    32. ZAWERTAILO LA; BUSTO UE; TYNDALE RF; SELLERS EM
      DEXTROMETHORPHANS ACTIVE METABOLITE CONTRIBUTES TO ITS ABUSE LIABILITY

      Clinical pharmacology and therapeutics
    33. KILICARSLAN T; LI NY; BUSTO U; TYNDALE RF; SELLERS EM
      FLUNITRAZEPAM - POLYMORPHIC METABOLISM BY CYP2C19

      Clinical pharmacology and therapeutics
    34. CHEUNG S; NOLTE H; OTTON SV; TYNDALE RF; WU PH; SELLERS EM
      SIMULTANEOUS GAS-CHROMATOGRAPHIC DETERMINATION OF METHAMPHETAMINE, AMPHETAMINE AND THEIR P-HYDROXYLATED METABOLITES IN PLASMA AND URINE

      Journal of chromatography B. Biomedical sciences and applications
    35. TYNDALE RF; DROLL KP; SELLERS EM
      GENETICALLY DEFICIENT CYP2D6 METABOLISM PROVIDES PROTECTION AGAINST ORAL OPIATE DEPENDENCE

      Pharmacogenetics
    36. NOWAK MP; TYNDALE RF; SELLERS EM
      CYP2D6 PHENOTYPE AND GENOTYPE IN A CANADIAN NATIVE INDIAN POPULATION

      Pharmacogenetics
    37. NOWAK MP; TYNDALE RF; SELLERS EM
      CYP2D6 PHENOTYPE AND GENOTYPE IN A CANADIAN NATIVE INDIAN POPULATION

      Pharmacogenetics
    38. TYNDALE RF; BHAVE SV; HOFFMANN E; HOFFMAN PL; TABAKOFF B; TOBIN AJ; OLSEN RW
      PENTOBARBITAL DECREASES THE GAMMA-AMINOBUTYRIC ACID(A) RECEPTOR SUBUNIT GAMMA-2 LONG SHORT MESSENGER-RNA RATIO BY A MECHANISM DISTINCT FROMRECEPTOR OCCUPATION/

      The Journal of pharmacology and experimental therapeutics
    39. MESSINA ES; TYNDALE RF; SELLERS EM
      A MAJOR ROLE FOR CYP2A6 IN NICOTINE C-OXIDATION BY HUMAN LIVER-MICROSOMES

      The Journal of pharmacology and experimental therapeutics
    40. TOMKINS DM; OTTON SV; JOHARCHI N; LI NY; BALSTER RF; TYNDALE RF; SELLERS EM
      EFFECT OF CYTOCHROME-P450 2D1 INHIBITION ON HYDROCODONE METABOLISM AND ITS BEHAVIORAL CONSEQUENCES IN RATS

      The Journal of pharmacology and experimental therapeutics
    41. TYNDALE RF; DROLL K; PAK A; SELLERS EM
      ROLE OF THE CYP2D6 POLYMORPHISM IN TOBACCO DEPENDENCE

      Clinical pharmacology and therapeutics
    42. ROMACH MK; KATHIRAMALAINATHAN K; KAPLAN HL; BUSTO UE; TYNDALE RF; SELLERS EM
      CODEINE ABUSE LIABILITY IS MODIFIED BY CYP2D6 INHIBITION

      Clinical pharmacology and therapeutics
    43. SELLERS EM; KAPLAN HL; SOMER G; TYNDALE RF
      TOBACCO AND OTHER DRUG-DEPENDENCE INCREASES VARIATION IN CYTOCHROME-P450 3A ACTIVITY (CYP3A) IN FEMALES

      Clinical pharmacology and therapeutics
    44. CHARLES AC; KODALI SK; TYNDALE RF
      INTERCELLULAR CALCIUM WAVES IN NEURONS

      Molecular and cellular neurosciences
    45. TYNDALE RF; BHAVE SV; HOFFMAN PL; TABAKOFF B; TOBIN AJ; OLSEN RW
      THE GABA(A) RECEPTOR SUBUNIT-GAMMA-2 L S RATIO IS ALTERED AFTER PENTOBARBITAL TREATMENT/

      Journal of neurochemistry
    46. OCAMPO JA; BUSTO UE; KAPLAN HL; TYNDALE RF; OTTON SV; NOLTE H; SYMANZIK C; SELLERS EM
      DOES EXTENT OF P-HYDROXYLATION ALTER METHAMPHETAMINE KINETICS

      Clinical pharmacology and therapeutics
    47. GREGER V; KNOLL JHM; WOOLF E; GLATT K; TYNDALE RF; DELOREY TM; OLSEN RW; TOBIN AJ; SIKELA JM; NAKATSU Y; BRILLIANT MH; WHITING PJ; LALANDE M
      THE GAMMA-AMINOBUTYRIC-ACID RECEPTOR GAMMA-3 SUBUNIT GENE (GABRG3) ISTIGHTLY LINKED TO THE ALPHA-5 SUBUNIT GENE (GABRA5) ON HUMAN-CHROMOSOME 15Q11-Q13 AND IS TRANSCRIBED IN THE SAME ORIENTATION

      Genomics
    48. BEISCHLAG TV; MARCHESE A; MEADORWOODRUFF JH; DAMASK SP; ODOWD BF; TYNDALE RF; VANTOL HHM; SEEMAN P; NIZNIK HB
      THE HUMAN DOPAMINE D5 RECEPTOR GENE - CLONING AND CHARACTERIZATION OFTHE 5'-FLANKING AND PROMOTER REGION

      Biochemistry
    49. TYNDALE RF; HALES TG; OLSEN RW; TOBIN AJ
      DISTINCTIVE PATTERNS OF GABA(A) RECEPTOR SUBUNIT MESSENGER-RNAS IN 13CELL-LINES

      The Journal of neuroscience
    50. HALES TG; TYNDALE RF
      FEW CELL LINES WITH GABA(A) MESSENGER-RNAS HAVE FUNCTIONAL RECEPTORS

      The Journal of neuroscience
    51. TYNDALE RF; TOBIN AJ; OLSEN RW; CHARLES AC
      GABA(A) RECEPTORS ARE DIFFERENT IN GLIA AND NEURONS

      Journal of neurochemistry
    52. NAKATSU Y; TYNDALE RF; DELOREY TM; DURHAMPIERRE D; GARDNER JM; MCDANEL HJ; NGUYEN Q; WAGSTAFF J; LALANDE M; SIKELA JM; OLSEN RW; TOBIN AJ; BRILLIANT MH
      A CLUSTER OF 3 GABA(A) RECEPTOR SUBUNIT GENES IS DELETED IN A NEUROLOGICAL MUTANT OF THE MOUSE P-LOCUS

      Nature


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Documento generato il 19/02/20 alle ore 20:57:28