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    1. Oram, PD; Seibert, K; Leonard, W; Dovletoglou, A
      Modeling the selection of fractions during preparative HPLC of a semisynthetic pneumocandin

      JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
    2. Gotz, A; Gracia, I; Plaza, JA; Cane, C; Roetsch, P; Bottner, H; Seibert, K
      A novel methodology for the manufacturability of robust CMOS semiconductorgas sensor arrays

      SENSORS AND ACTUATORS B-CHEMICAL
    3. Walker, MC; Kurumbail, RG; Kiefer, JR; Moreland, KT; Koboldt, CM; Isakson, PC; Seibert, K; Gierse, JK
      A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

      BIOCHEMICAL JOURNAL
    4. Alshafie, GA; Abou-Issa, HM; Seibert, K; Harris, RE
      Chemotherapeutic evaluation of Celecoxib, a cyclooxygeuase-2 inhibitor, ina rat mammary tumor model

      ONCOLOGY REPORTS
    5. Wittwer, V; Gombert, A; Rose, K; Lobmann, P; Sporn, D; Manns, P; Doll, W; Konz, W; Seibert, K
      Applications of periodically structured surfaces on glass

      GLASS SCIENCE AND TECHNOLOGY-GLASTECHNISCHE BERICHTE
    6. Talley, JJ; Bertenshaw, SR; Brown, DL; Carter, JS; Graneto, MJ; Kellogg, MS; Koboldt, CM; Yuan, JH; Zhang, YY; Seibert, K
      N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl] sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration

      JOURNAL OF MEDICINAL CHEMISTRY
    7. Talley, JJ; Brown, DL; Carter, JS; Graneto, MJ; Koboldt, CM; Masferrer, JL; Perkins, WE; Rogers, RS; Shaffer, AF; Zhang, YY; Zweifel, BS; Seibert, K
      4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2

      JOURNAL OF MEDICINAL CHEMISTRY
    8. Khanna, IK; Yu, Y; Huff, RM; Weier, RM; Xu, XD; Koszyk, FJ; Collins, PW; Cogburn, JN; Isakson, PC; Koboldt, CM; Masferrer, JL; Perkins, WE; Seibert, K; Veenhuizen, AW; Yuan, JH; Yang, DC; Zhang, YY
      Selective cyclooxygenase-2 inhibitors: Heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents

      JOURNAL OF MEDICINAL CHEMISTRY
    9. Harris, RE; Alshafie, GA; Abou-Issa, H; Seibert, K
      Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor

      CANCER RESEARCH
    10. Masferrer, JL; Leahy, KM; Koki, AT; Zweifel, BS; Settle, SL; Woerner, BM; Edwards, DA; Flickinger, AG; Moore, RJ; Seibert, K
      Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors

      CANCER RESEARCH
    11. Grubbs, CJ; Lubet, RA; Koki, AT; Leahy, KM; Masferrer, JL; Steele, VE; Kelloff, GJ; Hill, DL; Seibert, K
      Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats

      CANCER RESEARCH
    12. Reddy, BS; Hirose, Y; Lubet, R; Steele, V; Kelloff, G; Paulson, S; Seibert, K; Rao, CV
      Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis

      CANCER RESEARCH
    13. Jacoby, RF; Seibert, K; Cole, CE; Kelloff, G; Lubet, RA
      The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis

      CANCER RESEARCH
    14. Seibert, K; Lefkowith, J; Tripp, C; Isakson, P; Needleman, P
      COX-2 inhibitors - Is there cause for concern?

      NATURE MEDICINE
    15. Carter, JS; Rogier, DJ; Graneto, MJ; Seibert, K; Koboldt, CM; Zhang, Y; Talley, JJ
      Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    16. Carter, JS; Kramer, S; Talley, JJ; Penning, T; Collins, P; Graneto, MJ; Seibert, K; Koboldt, CM; Masferrer, J; Zweifel, B
      Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    17. Fischer, SM; Lo, HH; Gordon, GB; Seibert, K; Kelloff, G; Lubet, RA; Conti, CJ
      Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

      MOLECULAR CARCINOGENESIS
    18. Gierse, JK; Koboldt, CM; Walker, MC; Seibert, K; Isakson, PC
      Kinetic basis for selective inhibition of cyclo-oxygenases

      BIOCHEMICAL JOURNAL
    19. Talley, JJ; Bertenshaw, SR; Brown, DL; Carter, JS; Graneto, MJ; Koboldt, CM; Masferrer, JL; Norman, BH; Rogier, DJ; Zweifel, BS; Seibert, K
      4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)

      MEDICINAL RESEARCH REVIEWS
    20. MULLERDECKER K; KOPPSCHNEIDER A; MARKS F; SEIBERT K; FURSTENBERGER G
      LOCALIZATION OF PROSTAGLANDIN-H SYNTHASE ISOENZYMES IN MURINE EPIDERMAL TUMORS - SUPPRESSION OF SKIN TUMOR PROMOTION BY INHIBITION OF PROSTAGLANDIN-H SYNTHASE-2

      Molecular carcinogenesis
    21. PAULSON S; MAZIASZ T; SEIBERT K; KHAN N; ISAKSON P
      PRECLINICAL PHARMACOLOGY OF CELECOXIB AND DEMONSTRATION OF SUPERIOR GI SAFETY COMPARED WITH NSAIDS IN DOGS

      The FASEB journal
    22. KALGUTKAR AS; CREWS BC; ROWLINSON SW; GARNER C; SEIBERT K; MARNETT LJ
      ASPIRIN-LIKE MOLECULES THAT COVALENTLY INACTIVATE CYCLOOXYGENASE-2

      Science
    23. MASFERRER JL; LEAHY K; KOBOLT C; PERKINS W; ZWEIFEL B; ZHANG Y; KOKI A; ISAKSON P; SEIBERT K
      CELECOXIB - A SPECIFIC COX-2 INHIBITOR WITH ANTIINFLAMMATORY, ANALGESIC AND ANTICANCER ACTIVITIES

      Naunyn-Schmiedeberg's archives of pharmacology
    24. SMITH CJ; ZHANG Y; KOBOLDT CM; MUHAMMAD J; ZWEIFEL BS; SHAFFER A; TALLEY JJ; MASFERRER JL; SEIBERT K; ISAKSON PC
      PHARMACOLOGICAL ANALYSIS OF CYCLOOXYGENASE-1 IN INFLAMMATION

      Proceedings of the National Academy of Sciences of the United Statesof America
    25. KAWAMORI T; RAO CV; SEIBERT K; REDDY BS
      CHEMOPREVENTIVE ACTIVITY OF CELECOXIB, A SPECIFIC CYCLOOXYGENASE-2 INHIBITOR, AGAINST COLON CARCINOGENESIS

      Cancer research
    26. MILITIANU A; SALACATA A; SEIBERT K; KEHOE R; BAGA JJ; MEISSNER MD; PIRES LA; SCHUGER CD; STEINMAN RT; MOSTELLER RD; PALTI AJ; BENDAVID J; LESSMEIER TJ; LEHMANN MH
      IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR UTILIZATION AMONG DEVICE RECIPIENTS PRESENTING EXCLUSIVELY WITH SYNCOPE OR NEAR-SYNCOPE

      Journal of cardiovascular electrophysiology
    27. PENNING TD; KRAMER SW; LEE LF; COLLINS PW; KOBOLDT CM; SEIBERT K; VEENHUIZEN AW; ZHANG YY; ISAKSON PC
      3,4-DIARYLPYRAZOLES - POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2

      Bioorganic & medicinal chemistry letters
    28. KURUMBAIL RG; STEVENS AM; GIERSE JK; MCDONALD JJ; STEGEMAN RA; PAK JY; GILDEHAUS D; MIYASHIRO JM; PENNING TD; SEIBERT K; ISAKSON PC; STALLINGS WC
      STRUCTURAL BASIS FOR SELECTIVE-INHIBITION OF CYCLOOXYGENASE-2 BY ANTIINFLAMMATORY AGENTS (VOL 384, PG 644, 1996)

      Nature
    29. ZHANG Y; SHAFFER A; PORTANOVA J; SEIBERT K; ISAKSON PC
      INHIBITION OF CYCLOOXYGENASE-2 RAPIDLY REVERSES INFLAMMATORY HYPERALGESIA AND PROSTAGLANDIN E-2 PRODUCTION

      The Journal of pharmacology and experimental therapeutics
    30. PENNING TD; TALLEY JJ; BERTENSHAW SR; CARTER JS; COLLINS PW; DOCTER S; GRANETO MJ; LEE LF; MALECHA JW; MIYASHIRO JM; ROGERS RS; ROGIER DJ; YU SS; ANDERSON GD; BURTON EG; COGBURN JN; GREGORY SA; KOBOLDT CM; PERKINS WE; SEIBERT K; VEENHUIZEN AW; ZHANG YY; ISAKSON PC
      SYNTHESIS AND BIOLOGICAL EVALUATION OF THE 1,5-DIARYLPYRAZOLE CLASS OF CYCLOOXYGENASE-2 INHIBITORS - IDENTIFICATION OF RIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE (SC-58635, CELECOXIB)

      Journal of medicinal chemistry
    31. KHANNA IK; WEIER RM; YU Y; COLLINS PW; MIYASHIRO JM; KOBOLDT CM; VEENHUIZEN AW; CURRIE JL; SEIBERT K; ISAKSON PC
      1,2-DIARYLPYRROLES AS POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2

      Journal of medicinal chemistry
    32. KHANNA IK; WEIER RM; YU Y; XU XD; KOSZYK FJ; COLLINS PW; KOBOLDT CM; VEENHUIZEN AW; PERKINS WE; CASLER JJ; MASFERRER JL; ZHANG YY; GREGORY SA; SEIBERT K; ISAKSON PC
      1,2-DIARYLIMIDAZOLES AS POTENT, CYCLOOXYGENASE-2 SELECTIVE, AND ORALLY-ACTIVE ANTIINFLAMMATORY AGENTS

      Journal of medicinal chemistry
    33. COHN SM; SCHLOEMANN S; TESSNER T; SEIBERT K; STENSON WF
      CRYPT STEM-CELL SURVIVAL IN THE MOUSE INTESTINAL EPITHELIUM IS REGULATED BY PROSTAGLANDINS SYNTHESIZED THROUGH CYCLOOXYGENASE-1

      The Journal of clinical investigation
    34. MAZIASZ T; SEIBERT K; KHAN N; PAULSON S; ISAKSON P
      PRECLINICAL PHARMACOLOGY OF CELECOXIB AND DEMONSTRATION OF SUPERIOR GI SAFETY COMPARED WITH NSAIDS IN DOGS

      Arthritis and rheumatism
    35. MASFERRER JL; ISAKSON PC; SEIBERT K
      CYCLOOXYGENASE-2 INHIBITORS - A NEW CLASS OF ANTIINFLAMMATORY AGENTS THAT SPARE THE GASTROINTESTINAL-TRACT

      Gastroenterology clinics of North America
    36. KURUMBAIL RG; STEVENS AM; GIERSE JK; MCDONALD JJ; STEGEMAN RA; PAK JY; GILDEHAUS D; MIYASHIRO JM; PENNING TD; SEIBERT K; ISAKSON PC; STALLINGS WC
      STRUCTURAL BASIS FOR SELECTIVE-INHIBITION OF CYCLOOXYGENASE-2 BY ANTIINFLAMMATORY AGENTS

      Nature
    37. LI JJ; NORTON MB; REINHARD EJ; ANDERSON GD; GREGORY SA; ISAKSON PC; KOBOLDT CM; MASFERRER JL; PERKINS WE; SEIBERT K; ZHANG Y; ZWEIFEL BS; REITZ DB
      NOVEL TERPHENYLS AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS AND ORALLY-ACTIVE ANTIINFLAMMATORY AGENTS

      Journal of medicinal chemistry
    38. HUANG HC; LI JJ; GARLAND DJ; CHAMBERLAIN TS; REINHARD EJ; MANNING RE; SEIBERT K; KOBOLDT CM; GREGORY SA; ANDERSON GD; VEENHUIZEN AW; ZHANG Y; PERKINS WE; BURTON EG; COGBURN JN; ISAKSON PC; REITZ DB
      DIARYLSPIRO[2.4]HEPTENES AS ORALLY-ACTIVE, HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITORS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS

      Journal of medicinal chemistry
    39. PORTANOVA JP; ZHANG Y; ANDERSON GD; HAUSER SD; MASFERRER JL; SEIBERT K; GREGORY SA; ISAKSON PC
      SELECTIVE NEUTRALIZATION OF PROSTAGLANDIN E(2) BLOCKS INFLAMMATION, HYPERALGESIA, AND INTERLEUKIN-6 PRODUCTION IN-VIVO

      The Journal of experimental medicine
    40. GIERSE JK; MCDONALD JJ; HAUSER SD; RANGWALA SH; KOBOLDT CM; SEIBERT K
      A SINGLE AMINO-ACID DIFFERENCE BETWEEN CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) REVERSES THE SELECTIVITY OF COX-2 SPECIFIC INHIBITORS

      The Journal of biological chemistry
    41. COHN SM; SCHLOEMANN S; TESSNER T; SEIBERT K; STENSON WF
      PROSTAGLANDINS SYNTHESIZED BY CYCLOOXYGENASE-1 MEDIATE CRYPT SURVIVALAFTER RADIATION

      Gastroenterology
    42. REDDY BS; RAO CV; SEIBERT K
      EVALUATION OF CYCLOOXYGENASE-2 INHIBITOR FOR POTENTIAL CHEMOPREVENTIVE PROPERTIES IN COLON CARCINOGENESIS

      Cancer research
    43. SEIBERT K; MASFERRER JL; NEEDLEMAN P; SALVEMINI D
      PHARMACOLOGICAL MANIPULATION OF CYCLO-OXYGENASE-2 IN THE INFLAMED HYDRONEPHROTIC KIDNEY

      British Journal of Pharmacology
    44. REITZ DB; HUANG HC; LI JJ; GARLAND DJ; MANNING RE; ANDERSON GD; GREGORY SA; KOBOLDT CM; PERKINS WE; SEIBERT K; ISAKSON PC
      SELECTIVE CYCLOOXYGENASE INHIBITORS - NOVEL 4-SPIRO 1,2-DIARYLCYCLOPENTENES ARE POTENT AND ORALLY-ACTIVE COX-2 INHIBITORS

      Bioorganic & medicinal chemistry letters
    45. HUANG HC; CHAMBERLAIN TS; SEIBERT K; KOBOLDT CM; ISAKSON PC; REITZ DB
      DIARYL INDENES AND BENZOFURANS - NOVEL CLASSES OF POTENT AND SELECTIVE CYCLOOXYGENASE-2 INHIBITORS

      Bioorganic & medicinal chemistry letters
    46. GIERSE J; ASKONAS L; SEIBERT K; ISAKSON P
      MECHANISM OF DIFFERENTIAL INHIBITION OF THE INDUCIBLE AND CONSTITUTIVE FORMS OF CYCLOOXYGENASE

      The FASEB journal
    47. ZWEIFEL BS; COLBURN SM; ORNBERG RL; ISAKSON PC; SEIBERT K; MASFERRER JL
      THE ROLE OF CYCLOOXYGENASE-2 IN INFLAMMATION

      The FASEB journal
    48. GIERSE JK; HAUSER SD; CREELY DP; KOBOLDT C; RANGWALA SH; ISAKSON PC; SEIBERT K
      EXPRESSION AND SELECTIVE-INHIBITION OF THE CONSTITUTIVE AND INDUCIBLEFORMS OF HUMAN CYCLOOXYGENASE

      Biochemical journal
    49. LI JJ; ANDERSON GD; BURTON EG; COGBURN JN; COLLINS JT; GARLAND DJ; GREGORY SA; HUANG HC; ISAKSON PC; KOBOLDT CM; LOGUSCH EW; NORTON MB; PERKINS WE; REINHARD EJ; SEIBERT K; VEENHUIZEN AW; ZHANG Y; REITZ DB
      1,2-DIARYLCYCLOPENTENES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS AND ORALLY-ACTIVE ANTIINFLAMMATORY AGENTS

      Journal of medicinal chemistry
    50. SALVEMINI D; MANNING PT; ZWEIFEL BS; SEIBERT K; CONNOR J; CURRIE MG; NEEDLEMAN P; MASFERRER JL
      DUAL INHIBITION OF NITRIC-OXIDE AND PROSTAGLANDIN PRODUCTION CONTRIBUTES TO THE ANTIINFLAMMATORY PROPERTIES OF NITRIC-OXIDE SYNTHASE INHIBITORS

      The Journal of clinical investigation
    51. LEDUC LE; SEIBERT K
      REGULATION OF PROSTAGLANDIN PRODUCTION IN A RAT INTESTINAL EPITHELIAL-CELL LINE, IEC-18

      Gastroenterology
    52. LEDUC LE; SEIBERT K
      CYTOKINE MECHANISMS AND INTERACTIONS IN CYCLOOXYGENASE REGULATION IN A RAT INTESTINAL EPITHELIAL-CELL LINE, IEC-18

      Gastroenterology
    53. SALVEMINI D; SETTLE SL; MASFERRER JL; SEIBERT K; CURRIE MG; NEEDLEMAN P
      REGULATION OF PROSTAGLANDIN PRODUCTION BY NITRIC-OXIDE - AN IN-VIVO ANALYSIS

      British Journal of Pharmacology
    54. SEIBERT K; MASFERRER JL
      ROLE OF INDUCIBLE CYCLOOXYGENASE (COX-2) IN INFLAMMATION

      Receptor
    55. MASFERRER JL; SEIBERT K
      REGULATION OF PROSTAGLANDIN SYNTHESIS BY GLUCOCORTICOIDS

      Receptor
    56. SEIBERT K; LARGEAU D; BONVALOT B; ANGELIDIS DT; PARSONS P
      OPTICAL-SYSTEM FOR PRESSURE AND TEMPERATURE SENSING

      Sensors and actuators. A, Physical
    57. GIERSE JK; HAUSER SD; CREELY DP; RANGWALA SH; THIELE BR; ISAKSON PC; SEIBERT K
      EXPRESSION AND SELECTIVE-INHIBITION OF THE CONSTITUTIVE AND INDUCIBLEFORMS OF HUMAN CYCLOOXYGENASE

      The FASEB journal
    58. ZHANG Y; SEIBERT K; HAUSER S; GREGORY S; ISAKSON P
      PHARMACOLOGICAL INHIBITION OF COX-2 PREVENTS ELCOSANOID PRODUCTION AND EDEMA IN-VIVO

      The FASEB journal
    59. MASFERRER JL; ZWEIFEL BS; MANNING PT; HAUSER SD; LEAHY KM; SMITH WG; ISAKSON PC; SEIBERT K
      SELECTIVE-INHIBITION OF INDUCIBLE CYCLOOXYGENASE-2 IN-VIVO IS ANTIINFLAMMATORY AND NONULCEROGENIC

      Proceedings of the National Academy of Sciences of the United Statesof America
    60. SEIBERT K; ZHANG Y; LEAHY K; HAUSER S; MASFERRER J; PERKINS W; LEE L; ISAKSON P
      PHARMACOLOGICAL AND BIOCHEMICAL DEMONSTRATION OF THE ROLE OF CYCLOOXYGENASE-2 IN INFLAMMATION AND PAIN

      Proceedings of the National Academy of Sciences of the United Statesof America
    61. MASFERRER JL; REDDY ST; ZWEIFEL BS; SEIBERT K; NEEDLEMAN P; GILBERT RS; HERSCHMAN HR
      IN-VIVO GLUCOCORTICOIDS REGULATE CYCLOOXYGENASE-2 BUT NOT CYCLOOXYGENASE-1 IN PERITONEAL-MACROPHAGES

      The Journal of pharmacology and experimental therapeutics
    62. REITZ DB; LI JJ; NORTON MB; REINHARD EJ; COLLINS JT; ANDERSON GD; GREGORY SA; KOBOLDT CM; PERKINS WE; SEIBERT K; ISAKSON PC
      SELECTIVE CYCLOOXYGENASE INHIBITORS - NOVEL 1,2-DIARYLCYCLOPENTENES ARE POTENT AND ORALLY-ACTIVE COX-2 INHIBITORS

      Journal of medicinal chemistry
    63. SALVEMINI D; SEIBERT K; MASFERRER JL; MISKO TP; CURRIE MG; NEEDLEMAN P
      ENDOGENOUS NITRIC-OXIDE ENHANCES PROSTAGLANDIN PRODUCTION IN A MODEL OF RENAL INFLAMMATION

      The Journal of clinical investigation
    64. SALVEMINI D; SEIBERT K; MASFERRER J; NEEDLEMAN P
      NITRIC-OXIDE IS AN IMPORTANT MEDIATOR OF THE EXAGGERATED RELEASE OF PROSTAGLANDIN-E(2) IN RABBIT HYDRONEPHROTIC KIDNEY

      British Journal of Pharmacology
    65. SALVEMINI D; MISKO TP; MASFERRER JL; SEIBERT K; CURRIE MG; NEEDLEMAN P
      NITRIC-OXIDE ACTIVATES CYCLOOXYGENASE ENZYMES

      Proceedings of the National Academy of Sciences of the United Statesof America


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Documento generato il 06/08/20 alle ore 16:11:12