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1. Owens, TD; Semple, JE
   Atom-economical synthesis of the N(10)-C(17) fragment of cyclotheonamides via a novel passerini reaction-deprotection-acyl migration strategy
   ORGANIC LETTERS
   
   T.D. Owens e J.E. Semple, "Atom-economical synthesis of the N(10)-C(17) fragment of cyclotheonamides via a novel passerini reaction-deprotection-acyl migration strategy", ORG LETT, 3(21), 2001, pp. 3301-3304
2. Owens, TD; Araldi, GL; Nutt, RF; Semple, JE
   Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin Avia a novel Passerini reaction-deprotection-acyl migration strategy
   TETRAHEDRON LETTERS
   
   T.D. Owens et al., "Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin Avia a novel Passerini reaction-deprotection-acyl migration strategy", TETRAHEDR L, 42(36), 2001, pp. 6271-6274
3. Semple, JE; Owens, TD; Nguyen, K; Levy, OE
   New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction
   ORGANIC LETTERS
   
   J.E. Semple et al., "New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction", ORG LETT, 2(18), 2000, pp. 2769-2772
4. Siev, DV; Semple, JE
   Novel Hydrazino-Carbonyl-Amino-Methylated polystyrene (HCAM) resin methodology for the synthesis of P-1-aldehyde protease inhibitor candidates
   ORGANIC LETTERS
   
   D.V. Siev e J.E. Semple, "Novel Hydrazino-Carbonyl-Amino-Methylated polystyrene (HCAM) resin methodology for the synthesis of P-1-aldehyde protease inhibitor candidates", ORG LETT, 2(1), 2000, pp. 19-22
5. Tamura, SY; Levy, OE; Uong, TH; Reiner, JE; Goldman, EA; Ho, JZ; Cohen, CR; Bergum, PW; Nutt, RF; Brunck, TK; Semple, JE
   Guanylpiperidine peptidomimetics: Potent and selective bis-cation inhibitors of factor Xa
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   S.Y. Tamura et al., "Guanylpiperidine peptidomimetics: Potent and selective bis-cation inhibitors of factor Xa", BIOORG MED, 10(8), 2000, pp. 745-749
6. Semple, JE; Levy, OE; Minami, NK; Owens, TD; Siev, DV
   Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P-1-ketoamide moieties
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   J.E. Semple et al., "Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P-1-ketoamide moieties", BIOORG MED, 10(20), 2000, pp. 2305-2309
7. Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY
   Investigation of the S-3 site of thrombin: Design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P-1-argininals
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   J.E. Reiner et al., "Investigation of the S-3 site of thrombin: Design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P-1-argininals", BIOORG MED, 9(6), 1999, pp. 895-900
8. Ho, JZ; Levy, OE; Gibson, TS; Nguyen, K; Semple, JE
   Exploratory solid-phase synthesis of factor Xa inhibitors: Discovery and application of P-3-heterocyclic amides as novel types of non-basic arginine surrogates
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   J.Z. Ho et al., "Exploratory solid-phase synthesis of factor Xa inhibitors: Discovery and application of P-3-heterocyclic amides as novel types of non-basic arginine surrogates", BIOORG MED, 9(24), 1999, pp. 3459-3464
9. Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE
   Novel benzo-fused lactam scaffolds as factor Xa inhibitors
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   S.Y. Tamura et al., "Novel benzo-fused lactam scaffolds as factor Xa inhibitors", BIOORG MED, 9(17), 1999, pp. 2573-2578
10. Minami, NK; Reiner, JE; Semple, JE
    Asymmetric synthesis of novel quaternary alpha-hydroxy-delta-lactam dipeptide surrogates
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    N.K. Minami et al., "Asymmetric synthesis of novel quaternary alpha-hydroxy-delta-lactam dipeptide surrogates", BIOORG MED, 9(17), 1999, pp. 2625-2628
11. Siev, DV; Gaudette, JA; Semple, JE
    Novel protocol for the solid-phase synthesis of peptidyl and peptidomimetic P-1-argininal derivatives
    TETRAHEDRON LETTERS
    
    D.V. Siev et al., "Novel protocol for the solid-phase synthesis of peptidyl and peptidomimetic P-1-argininal derivatives", TETRAHEDR L, 40(28), 1999, pp. 5123-5127
12. SEMPLE JE
    DESIGN AND CONSTRUCTION OF NOVEL THROMBIN INHIBITORS FEATURING P-3-P-4 QUATERNARY LACTAM DIPEPTIDE SURROGATES
    Bioorganic & medicinal chemistry letters
    
    J.E. Semple, "DESIGN AND CONSTRUCTION OF NOVEL THROMBIN INHIBITORS FEATURING P-3-P-4 QUATERNARY LACTAM DIPEPTIDE SURROGATES", Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2501-2506
13. Semple, JE; Rowley, DC; Owens, TD; Minami, NK; Uong, TH; Brunck, TK
    Potent and selective thrombin inhibitors featuring hydrophobic, basic P-3-P-4-aminoalkyllactam moieties
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    J.E. Semple et al., "Potent and selective thrombin inhibitors featuring hydrophobic, basic P-3-P-4-aminoalkyllactam moieties", BIOORG MED, 8(24), 1998, pp. 3525-3530
14. Owens, TD; Semple, JE
    Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: Synthesis of potent, selective P-3-lactam thrombin inhibitors containing P-4-o-alkoxycarbonylbenzylsulfonamide residues'
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    T.D. Owens e J.E. Semple, "Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: Synthesis of potent, selective P-3-lactam thrombin inhibitors containing P-4-o-alkoxycarbonylbenzylsulfonamide residues'", BIOORG MED, 8(24), 1998, pp. 3683-3688
15. SEMPLE JE
    EFFICIENT CONSTRUCTION OF NOVEL QUATERNARY LACTAM DIPEPTIDE SURROGATES
    Tetrahedron letters
    
    J.E. Semple, "EFFICIENT CONSTRUCTION OF NOVEL QUATERNARY LACTAM DIPEPTIDE SURROGATES", Tetrahedron letters, 39(37), 1998, pp. 6645-6648
16. ROTHERHAM LW; SEMPLE JE
    A PRACTICAL AND EFFICIENT SYNTHETIC ROUTE TO DIHYDROPIPERCIDE AND PIPERCIDE
    Journal of organic chemistry
    
    L.W. Rotherham e J.E. Semple, "A PRACTICAL AND EFFICIENT SYNTHETIC ROUTE TO DIHYDROPIPERCIDE AND PIPERCIDE", Journal of organic chemistry, 63(19), 1998, pp. 6667-6672
17. KRISHNAN R; ZHANG E; HAKANSSON K; ARNI RK; TULINSKY A; LIMWILBY MSL; LEVY OE; SEMPLE JE; BRUNCK TK
    HIGHLY SELECTIVE MECHANISM-BASED THROMBIN INHIBITORS - STRUCTURES OF THROMBIN AND TRYPSIN INHIBITED WITH RIGID PEPTIDYL ALDEHYDES
    Biochemistry
    
    R. Krishnan et al., "HIGHLY SELECTIVE MECHANISM-BASED THROMBIN INHIBITORS - STRUCTURES OF THROMBIN AND TRYPSIN INHIBITED WITH RIGID PEPTIDYL ALDEHYDES", Biochemistry, 37(35), 1998, pp. 12094-12103
18. SEMPLE JE; ROWLEY DC; BRUNCK TK; RIPKA WC
    SYNTHESIS AND BIOLOGICAL-ACTIVITY OF P-2-P-4 AZAPEPTIDOMIMETIC P-1-ARGININAL AND P-1-KETOARGININAMIDE DERIVATIVES - A NOVEL CLASS OF SERINE-PROTEASE INHIBITORS
    Bioorganic & medicinal chemistry letters
    
    J.E. Semple et al., "SYNTHESIS AND BIOLOGICAL-ACTIVITY OF P-2-P-4 AZAPEPTIDOMIMETIC P-1-ARGININAL AND P-1-KETOARGININAMIDE DERIVATIVES - A NOVEL CLASS OF SERINE-PROTEASE INHIBITORS", Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 315-320
19. TAMURA SY; GOLDMAN EA; BRUNCK TK; RIPKA WC; SEMPLE JE
    RATIONAL DESIGN, SYNTHESIS, AND SERINE-PROTEASE INHIBITORY ACTIVITY OF A NOVEL P-1-ARGININAL DERIVATIVE FEATURING A CONFORMATIONALLY CONSTRAINED P-2-P-3-BICYCLIC LACTAM MOIETY
    Bioorganic & medicinal chemistry letters
    
    S.Y. Tamura et al., "RATIONAL DESIGN, SYNTHESIS, AND SERINE-PROTEASE INHIBITORY ACTIVITY OF A NOVEL P-1-ARGININAL DERIVATIVE FEATURING A CONFORMATIONALLY CONSTRAINED P-2-P-3-BICYCLIC LACTAM MOIETY", Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 331-336
20. SEMPLE JE; MINAMI NK; TAMURA SY; BRUNCK TK; NUTT RF; RIPKA WC
    RATIONAL DESIGN AND SYNTHESIS OF A NOVEL, SELECTIVE CLASS OF THROMBININHIBITORS - P-1-ARGININAL DERIVATIVES INCORPORATING P-3-P-4 QUATERNARY LACTAM DIPEPTIDE SURROGATES
    Bioorganic & medicinal chemistry letters
    
    J.E. Semple et al., "RATIONAL DESIGN AND SYNTHESIS OF A NOVEL, SELECTIVE CLASS OF THROMBININHIBITORS - P-1-ARGININAL DERIVATIVES INCORPORATING P-3-P-4 QUATERNARY LACTAM DIPEPTIDE SURROGATES", Bioorganic & medicinal chemistry letters, 7(18), 1997, pp. 2421-2426
21. TAMURA SY; SEMPLE JE; REINER JE; GOLDMAN EA; BRUNCK TK; LIMWILBY MS; CARPENTER SH; ROTE WE; OLDESHULTE GL; RICHARD BM; NUTT RF; RIPKA WC
    DESIGN AND SYNTHESIS OF A NOVEL CLASS OF THROMBIN INHIBITORS INCORPORATING HETEROCYCLIC DIPEPTIDE SURROGATES
    Bioorganic & medicinal chemistry letters
    
    S.Y. Tamura et al., "DESIGN AND SYNTHESIS OF A NOVEL CLASS OF THROMBIN INHIBITORS INCORPORATING HETEROCYCLIC DIPEPTIDE SURROGATES", Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1543-1548
22. MURRAY WM; SEMPLE JE
    FACILE ACCESS TO NOVEL 1,4-DIHYDROXYNAPHTHALENE-2,3-DICARBOXIMIDES AND HETEROFUSED ANALOGS
    Synthesis
    
    W.M. Murray e J.E. Semple, "FACILE ACCESS TO NOVEL 1,4-DIHYDROXYNAPHTHALENE-2,3-DICARBOXIMIDES AND HETEROFUSED ANALOGS", Synthesis, (10), 1996, pp. 1180
23. SEMPLE JE; RYDZEWSKI RM; GARDNER G
    AN EFFICIENT SYNTHETIC ROUTE TO ETHYL YDROXY-1,3(2H,4H)-DIOXOISOQUINOLINE-4-CARBOXYLATES
    Journal of organic chemistry
    
    J.E. Semple et al., "AN EFFICIENT SYNTHETIC ROUTE TO ETHYL YDROXY-1,3(2H,4H)-DIOXOISOQUINOLINE-4-CARBOXYLATES", Journal of organic chemistry, 61(22), 1996, pp. 7967-7972
24. LEVY OE; SEMPLE JE; LIM ML; REINER J; ROTE WE; DEMPSEY E; RICHARD BM; ZHANG E; TULINSKY A; RIPKA WC; NUTT RF
    POTENT AND SELECTIVE THROMBIN INHIBITORS INCORPORATING THE CONSTRAINED ARGININE MIMIC L-3-PIPERIDYL(N-GUANIDINO)ALANINE AT P-1
    Journal of medicinal chemistry
    
    O.E. Levy et al., "POTENT AND SELECTIVE THROMBIN INHIBITORS INCORPORATING THE CONSTRAINED ARGININE MIMIC L-3-PIPERIDYL(N-GUANIDINO)ALANINE AT P-1", Journal of medicinal chemistry, 39(23), 1996, pp. 4527-4530
25. SEMPLE JE; ROWLEY DC; BRUNCK TK; HAUONG T; MINAMI NK; OWENS TD; TAMURA SY; GOLDMAN EA; SIEV DV; ARDECKY RJ; CARPENTER SH; GE Y; RICHARD BM; NOLAN TG; HAKANSON K; TULINSKY A; NUTT RF; RIPKA WC
    DESIGN, SYNTHESIS, AND EVOLUTION OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS - P1-ARGININAL DERIVATIVES INCORPORATING P3-P4 LACTAM SULFONAMIDE MOIETIES
    Journal of medicinal chemistry
    
    J.E. Semple et al., "DESIGN, SYNTHESIS, AND EVOLUTION OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS - P1-ARGININAL DERIVATIVES INCORPORATING P3-P4 LACTAM SULFONAMIDE MOIETIES", Journal of medicinal chemistry, 39(23), 1996, pp. 4531-4536
26. SEMPLE JE
    A CONCISE SYNTHESIS OF PELLITORINE
    Organic preparations and procedures international
    
    J.E. Semple, "A CONCISE SYNTHESIS OF PELLITORINE", Organic preparations and procedures international, 27(5), 1995, pp. 582-586