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    1. Rasmussen, T; Fink-Jensen, A; Sauerberg, P; Swedberg, MDB; Thomsen, C; Sheardown, MJ; Jeppesen, L; Calligaro, DO; DeLapp, NW; Whitesitt, C; Ward, JS; Shannon, HE; Bymaster, FP
      The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

      SCHIZOPHRENIA RESEARCH
    2. Christopoulos, A; Grant, MKO; Ayoubzadeh, N; Kim, ON; Sauerberg, P; Jeppesen, L; El-Fakahany, EE
      Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    3. Shannon, HE; Rasmussen, K; Bymaster, FP; Hart, JC; Peters, SC; Swedberg, MDB; Jeppesen, L; Sheardown, MJ; Sauerberg, P; Fink-Jensen, A
      Xanomeline, an M-1/M-4 preferring muscarinic cholinergic receptor agonist,produces antipsychotic-like activity in rats and mice

      SCHIZOPHRENIA RESEARCH
    4. Rasmussen, T; Sauerberg, P; Nielsen, EB; Swedberg, MDB; Thomsen, C; Sheardown, MJ; Jeppesen, L; Calligaro, DO; DeLapp, NW; Whitesitt, C; Ward, JS; Shannon, HE; Bymaster, FP; Fink-Jensen, A
      Muscarinic receptor agonists decrease cocaine self-administration rates indrug-naive mice

      EUROPEAN JOURNAL OF PHARMACOLOGY
    5. Thor, KB; Muhlhauser, MA; Sauerberg, P; Shannon, H; Springer, JP
      Central muscarinic inhibition of lower urinary tract nociception

      BRAIN RESEARCH
    6. Ahren, B; Sauerberg, P; Thomsen, C
      Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    7. Bymaster, FP; Shannon, HE; Rasmussen, K; DeLapp, NW; Ward, JS; Calligaro, DO; Mitch, CH; Whitesitt, C; Ludvigsen, TS; Sheardown, M; Swedberg, M; Rasmussen, T; Olesen, PH; Jeppesen, L; Sauerberg, P; Fink-Jensen, A
      Potential role of muscarinic receptors in schizophrenia

      LIFE SCIENCES
    8. Shannon, HE; Hart, JC; Bymaster, FP; Calligaro, DO; Delapp, NW; Mitch, CH; Ward, JS; Fink-Jensen, A; Sauerberg, P; Jeppesen, L; Sheardown, MJ; Swedberg, MDB
      Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    9. Jeppesen, L; Olesen, PH; Hansen, L; Sheardown, MJ; Thomsen, C; Rasmussen, T; Jensen, AF; Christensen, MS; Rimvall, K; Ward, JS; Whitesitt, C; Calligaro, DO; Bymaster, FP; Delapp, NW; Felder, CC; Shannon, HE; Sauerberg, P
      1-(1,2,5-thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M-1 agonists: Structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives

      JOURNAL OF MEDICINAL CHEMISTRY
    10. SAUERBERG P; JEPPESEN L; OLESEN PH; SHEARDOWN MJ; FINKJENSEN A; RASMUSSEN T; RIMVALL K; SHANNON HE; BYMASTER FP; DELAPP NW; CALLIGARO DO; WARD JS; WHITESITT CA; THOMSEN C
      IDENTIFICATION OF SIDE-CHAINS ON 1,2,5-THIADIAZOLE-AZACYCLES OPTIMAL FOR MUSCARINIC M1 RECEPTOR ACTIVATION

      Bioorganic & medicinal chemistry letters
    11. Fink-Jensen, A; Kristensen, P; Shannon, HE; Calligaro, DO; Delapp, NW; Whitesitt, C; Ward, JS; Thomsen, C; Rasmusseen, T; Sheardown, MJ; Jeppesen, L; Sauerberg, P; Bymaster, FP
      Muscarinic agonists exhibit functional dopamine antagonism in unilaterally6-OHDA lesioned rats

      NEUROREPORT
    12. SHANNON HE; BYMASTER FP; BODICK NW; OFFEN WW; DELAPP NC; PERRY KW; RASMUSSEN K; WARD JS; WHITESITT CA; FINKJENSEN A; OLESEN P; RASMUSSEN T; SHEARDOWN M; SWEDBERG M; SAUERBERG P
      MUSCARINIC AGENTS - A NEW APPROACH TO THE TREATMENT OF PSYCHOSIS

      Schizophrenia research
    13. WARD JS; MERRITT L; CALLIGARO DO; BYMASTER FP; SHANNON HE; MITCH CH; WHITESITT C; BRUNSTING D; SHEARDOWN MJ; OLESEN PH; SWEDBERG MDB; JEPPESEN L; SAUERBERG P
      1,2,5-THIADIAZOLE ANALOGS OF ACECLIDINE AS POTENT M(1) MUSCARINIC AGONISTS

      Journal of medicinal chemistry
    14. SAUERBERG P; JEPPESEN L; OLESEN PH; RASMUSSEN T; SWEDBERG MDB; SHEARDOWN MJ; FINKJENSEN A; THOMSEN C; THOGERSEN H; RIMVALL K; WARD JS; CALLIGARO DO; DELAPP NW; BYMASTER FP; SHANNON HE
      MUSCARINIC AGONISTS WITH ANTIPSYCHOTIC-LIKE ACTIVITY - STRUCTURE-ACTIVITY-RELATIONSHIPS OF 1,2,5-THIADIAZOLE ANALOGS WITH FUNCTIONAL DOPAMINE ANTAGONIST ACTIVITY

      Journal of medicinal chemistry
    15. SAUERBERG P; OLESEN PH; SHEARDOWN MJ; RIMVALL K; THOGERSEN H; SHANNON HE; SAWYER BD; WARD JS; BYMASTER FP; DELAPP NW; CALLIGARO DO; SWEDBERG MDB
      CONFORMATIONALLY CONSTRAINED ANALOGS OF THE MUSCARINIC AGONIST IADIAZOL-3-YL)-1,2,5,6-TETRAHYDRO-1-METHYLPYRIDINE - SYNTHESIS, RECEPTOR AFFINITY, AND ANTINOCICEPTIVE ACTIVITY

      Journal of medicinal chemistry
    16. BYMASTER FP; SHANNON HE; RASMUSSEN K; DELAPP NW; MITCH CH; WARD JS; CALLIGARO DO; LUDVIGSEN TS; SHEARDOWN MJ; OLESEN PH; SWEDBERG MDB; SAUERBERG P; FINKJENSEN A
      UNEXPECTED ANTIPSYCHOTIC-LIKE ACTIVITY WITH THE MUSCARINIC RECEPTOR-LIGAND O-1,2,5-THIADIAZOL-4-YL)-1-AZABICYCLO[3.2.1]OCTANE

      European journal of pharmacology
    17. BYMASTER FP; CARTER PA; PETERS SC; ZHANG W; WARD JS; MITCH CH; CALLIGARO DO; WHITESITT CA; DELAPP N; SHANNON HE; RIMVALL K; JEPPESEN L; SHEARDOWN MJ; FINKJENSEN A; SAUERBERG P
      XANOMELINE COMPARED TO OTHER MUSCARINIC AGENTS ON STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS IN-VIVO AND OTHER CHOLINOMIMETIC EFFECTS

      Brain research
    18. DELAPP N; WU S; BELAGAJE R; JOHNSTONE E; LITTLE S; SHANNON H; BYMASTER F; CALLIGARO D; MITCH C; WHITESITT C; WARD J; SHEARDOWN M; FINKJENSEN A; JEPPESEN L; THOMSEN C; SAUERBERG P
      EFFECTS OF THE M1 AGONIST XANOMELINE ON PROCESSING OF HUMAN BETA-AMYLOID PRECURSOR PROTEIN (FAD, SWEDISH MUTANT) TRANSFECTED INTO CHINESE-HAMSTER OVARY-M1 CELLS

      Biochemical and biophysical research communications
    19. OLESEN PH; SAUERBERG P; PETERSEN TG; TREPPENDAHL S; BENTZEN B; DEETER J; WARD JS; MITCH CH; LEHMANN SNV
      SYNTHESIS AND STRUCTURAL DETERMINATION OF STEREOISOMERS OF MUSCARINICLIGANDS OF THE OPYLTHIO-1,2,5-THIADIAZOL-4-YL)-1-AZABICYCLOALKANE TYPE

      Chirality
    20. BYMASTER FP; WHITESITT CA; SHANNON HE; DELAPP N; WARD JS; CALLIGARO DO; SHIPLEY LA; BUELKESAM JL; BODICK NC; FARDE L; SHEARDOWN MJ; OLESEN PH; HANSEN KT; SUZDAK PD; SWEDBERG MDB; SAUERBERG P; MITCH CH
      XANOMELINE - A SELECTIVE MUSCARINIC AGONIST FOR THE TREATMENT OF ALZHEIMERS-DISEASE

      Drug development research
    21. SAUERBERG P; OLESEN PH; THOGERSEN H; NIELSEN S; SHEARDOWN MJ; RIMVALL K; SHANNON HE; WARD JS; MITCH CH; BYMASTER FP; SWEDBERG MDB
      CONFORMATIONALLY CONSTRAINED ANALOGS OF THE MUSCARINIC AGONIST METHYLTHIO-TZTP - SYNTHESIS, RECEPTOR AFFINITY AND ANALGESIC ACTIVITY

      Life sciences
    22. BYMASTER F; CARTER P; SHANNON H; DELAPP N; WHITESITT C; WARD J; CALLIGARO D; MITCH C; SHEARDOWN M; SWEDBERG M; RIMVALL K; FINKJENSEN A; JEPPESEN L; SAUERBERG P
      STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS IN-VIVO BY XANOMELINE AND OTHER MUSCARINIC AGENTS

      Life sciences
    23. WARD JS; MERRITT L; STRATFORD R; BROWN TJ; WIJAYARATNE R; SZEWCZYK SP; CALLIGARO DO; BYMASTER FP; SHANNON HE; MITCH CH; JOHNSON DW; WIKEL JH; OLESEN MJ; SHEARDOWN MJ; SWEDBERG MDB; SAUERBERG P
      THE TETRAHYDROPYRIDINE RING CONFERS OPTIMAL M(1) SELECTIVITY AND BLOOD-BRAIN-BARRIER PENETRATION AMONG HEXYLOXY-1,2,5-THIADIAZOLE AZACYCLES

      Life sciences
    24. SHANNON HE; WOMER DE; DELAPP NW; BYMASTER FP; MITCH CH; WARD JS; WHITESITT C; CALLIGARO D; SWEDBERG MDB; SHEARDOWN MJ; SAUERBERG P; RIMVALL K; FINKJENSEN A; JEPPESEN L
      MUSCARINIC AGONISTS PRODUCE ANALGESIA THROUGH PERTUSSIS-TOXIN-SENSITIVE MUSCARINIC RECEPTORS IN THE SPINAL-CORD

      Life sciences
    25. SWEDBERG MDB; SHANNON HE; SHEARDOWN MJ; KLITGAARD H; BYMASTER FP; WARD JS; MITCH CH; OLESEN PH; ESKESEN K; SUZDAK PD; CALLIGARO DO; SAUERBERG P
      ANTICONVULSANT EFFECTS OF MUSCARINICS

      Life sciences
    26. SHANNON HE; WOMER DE; BYMASTER FP; CALLIGARO DO; DELAPP NC; MITCH CH; WARD JS; WHITESITT CA; SWEDBERG MDB; SHEARDOWN MJ; FINKJENSEN A; OLESEN PH; RIMVALL K; SAUERBERG P
      IN-VIVO PHARMACOLOGY OF BUTYLTHIO[2.2.2] (LY297802 NNC11-1053), AN ORALLY ACTING ANTINOCICEPTIVE MUSCARINIC AGONIST/

      Life sciences
    27. SHEARDOWN MJ; SHANNON HE; SWEDBERG MDB; SUZDAK PD; BYMASTER FP; OLESEN PH; MITCH CH; WARD JS; SAUERBERG P
      M-1 RECEPTOR AGONIST ACTIVITY IS NOT A REQUIREMENT FOR MUSCARINIC ANTINOCICEPTION

      The Journal of pharmacology and experimental therapeutics
    28. SWEDBERG MDB; SHEARDOWN MJ; SAUERBERG P; OLESEN PH; SUZDAK PD; HANSEN KT; BYMASTER FP; WARD JS; MITCH CH; CALLIGARO DO; DELAPP NW; SHANNON HE
      BUTYLTHIO[2.2.2] (NNC 11-1053 LY297802) - AN ORALLY-ACTIVE MUSCARINICAGONIST ANALGESIC/

      The Journal of pharmacology and experimental therapeutics
    29. SHANNON HE; SHEARDOWN MJ; BYMASTER FP; CALLIGARO DO; DELAPP NW; GIDDA J; MITCH CH; SAWYER BD; STENGEL PW; WARD JS; WONG DT; OLESEN PH; SUZDAK PD; SAUERBERG P; SWEDBERG MDB
      PHARMACOLOGY OF BUTYLTHIO[2.2.2] (LY297802 NNC11-1053) - A NOVEL ANALGESIC WITH MIXED MUSCARINIC RECEPTOR AGONIST AND ANTAGONIST ACTIVITY/

      The Journal of pharmacology and experimental therapeutics
    30. MITCH CH; BROWN TJ; BYMASTER FP; CALLIGARO DO; DIECKMAN D; MERRIT L; PETERS SC; QUIMBY SJ; SHANNON HE; SHIPLEY LA; WARD JS; HANSEN K; OLESEN PH; SAUERBERG P; SHEARDOWN MJ; SWEDBERG MDB; SUZDAK P; GREENWOOD B
      MUSCARINIC ANALGESICS WITH POTENT AND SELECTIVE EFFECTS ON THE GASTROINTESTINAL-TRACT - POTENTIAL APPLICATION FOR THE TREATMENT OF IRRITABLE-BOWEL-SYNDROME

      Journal of medicinal chemistry
    31. FARDE L; SUHARA T; HALLDIN C; NYBACK H; NAKASHIMA Y; SWAHN CG; KARLSSON P; GINOVART N; BYMASTER FP; SHANNON HE; FOGED C; SUZDAK PD; SAUERBERG P
      PET STUDY OF THE M(1)-AGONISTS [C-11] XANOMELINE AND [C-11] BUTYLTHIO-TZTP IN MONKEY AND MAN

      Dementia
    32. OLESEN PH; SAUERBERG P; TREPPENDAHL S; LARSSON O; SHEARDOWN MJ; SUZDAK PD; MITCH CH; WARD JS; BYMASTER FP; SHANNON HE; SWEDBERG MDB
      3-(3-ALKYLTHIO-1,2,5-THIADIAZOL-4-YL)1-AZABICYCLE - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR ANTINOCICEPTION MEDIATED BY CENTRAL MUSCARINIC RECEPTORS

      European journal of medicinal chemistry
    33. SAUERBERG P; OLESEN PH; SHEARDOWN MJ; SUZDAK PD; SHANNON HE; BYMASTER FP; CALLIGARO DO; MITCH CH; WARD JS; SWEDBERG MDB
      MUSCARINIC AGONISTS AS ANALGESICS - ANTINOCICEPTIVE ACTIVITY VERSUS M(1) ACTIVITY - SAR OF ALKYLTHIO-TZTPS AND RELATED 1,2,5-THIADIAZOLE ANALOGS

      Life sciences
    34. MITCH CH; BYMASTER FP; CALLIGARO DO; QUIMBY SJ; SAWYER BD; WARD JS; OLESEN PH; SAUERBERG P; SHEARDOWN MJ; SUZDAK PD; SWEDBERG M; SHANNON HE
      SIDE-CHAIN STERIC BULK AND MUSCARINIC AGONIST SAR IN ALKOXY-TZTPS

      Life sciences
    35. SAWYER BD; SHANNON HE; WARD JS; MITCH CH; SHEARDOWN MJ; OLESEN PH; SAUERBERG P
      MUSCARINIC RECEPTOR CHARACTERIZATION AND EVALUATION OF A SERIES OF NOVEL MUSCARINIC LIGANDS IN THE ISOLATED RABBIT THORACIC AORTA

      Life sciences
    36. SHANNON HE; BYMASTER FP; CALLIGARO DO; MITCH CH; SAWYER BD; WARD JS; SHEARDOWN MJ; OLESEN PH; SAUERBERG P; SUZDAK PD; SWEDBERG MDB
      IN-VITRO PHARMACOLOGY OF THE MUSCARINIC ANALGESIC LY297802 NNC111053/

      Life sciences
    37. SWEDBERG MDB; SHEARDOWN MJ; SAUERBERG P; OLESEN P; SUZDAK PD; BYMASTER FP; WARD JS; MITCH CH; CALLIGARO DO; SHANNON HE
      NNC-11-1053 LY-297802 - AN ANTINOCICEPTIVE ORALLY ACTING MUSCARINIC AGONIST IN MOUSE AND RAT

      Life sciences
    38. WARD JS; MERRITT L; CALLIGARO DO; BYMASTER FP; SHANNON HE; SAWYER BD; MITCH CH; DEETER JB; PETERS SC; SHEARDOWN MJ; OLESEN PH; SWEDBERG MDB; SAUERBERG P
      FUNCTIONALLY SELECTIVE M(1) MUSCARINIC AGONISTS .3. SIDE-CHAINS AND AZACYCLES CONTRIBUTING TO FUNCTIONAL MUSCARINIC SELECTIVITY AMONG PYRAZINYLAZACYCLES

      Journal of medicinal chemistry
    39. PERIYASAMY S; MESSER WS; ROKNICH S; SAUERBERG P; HOSS W
      1,2,5-THIADIAZOLE DERIVATIVES OF ARECOLINE STIMULATE M(1) RECEPTORS COUPLED TO PHOSPHOINOSITIDE TURNOVER

      Brain research
    40. QUIMBY SJ; SHANNON HE; BYMASTER FP; SAUERBERG P; OLESEN PH; SHEARDOWN MJ; SUZDAK PD; MITCH CH
      SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ALKYL SUBSTITUTED ANALOGS OF THE FUNCTIONAL M(1) SELECTIVE MUSCARINIC RECEPTOR AGONIST XANOMELINE

      Bioorganic & medicinal chemistry letters
    41. MITCH CH; BYMASTER FP; CALLIGARO DO; QUIMBY SJ; SAWYER BD; SHANNON HE; WARD JS; OLESEN PH; SAUERBERG P; SHEARDOWN MJ; SUZDAK PD
      XANOMELINE - A POTENT AND SELECTIVE M1 MUSCARINIC AGONIST IN-VITRO

      Neurobiology of aging
    42. FARDE L; SUHARA T; HALLDIN C; KARLSSON P; NYBACK H; MULLER L; FOGED C; SAUERBERG P; LUCAS R
      NEW RADIOLIGANDS FOR PET-EXAMINATION OF CENTRAL MUSCARINIC RECEPTORS

      Neurobiology of aging
    43. SHANNON HE; BYMASTER FP; CALLIGARO DO; GREENWOOD B; MITCH CH; SAWYER BD; WARD JS; WONG DT; OLESEN PH; SHEARDOWN MJ; SWEDBERG MDB; SUZDAK PD; SAUERBERG P
      XANOMELINE - A NOVEL MUSCARINIC RECEPTOR AGONIST WITH FUNCTIONAL SELECTIVITY FOR M(1) RECEPTORS

      The Journal of pharmacology and experimental therapeutics
    44. BYMASTER FP; WONG DT; MITCH CH; WARD JS; CALLIGARO DO; SCHOEPP DD; SHANNON HE; SHEARDOWN MJ; OLESEN PH; SUZDAK PD; SWEDBERG MDB; SAUERBERG P
      NEUROCHEMICAL EFFECTS OF THE M(1) MUSCARINIC AGONIST XANOMELINE (LY246708 NNC11-0232)/

      The Journal of pharmacology and experimental therapeutics
    45. HALLDIN C; MULLER L; FOGED C; SAUERBERG P; KARLSSON P; SWAHN CG; HALL H; FARDE L
      PREPARATION OF 3 C-11 LABELED NOVEL FUNCTIONAL M1 SELECTIVE MUSCARINIC AGONISTS

      The Journal of nuclear medicine


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Documento generato il 28/05/20 alle ore 08:25:43