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    1. Takebayashi, Y; Pourquier, P; Zimonjic, DB; Nakayama, K; Emmert, S; Ueda, T; Urasaki, Y; Kanzaki, A; Akiyama, S; Popescu, N; Kraemer, KH; Pommier, Y
      Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

      NATURE MEDICINE
    2. Takebayashi, Y; Goldwasser, F; Urasaki, Y; Kohlhagen, G; Pommier, Y
      Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression

      CLINICAL CANCER RESEARCH
    3. Jing, NJ; Marchand, C; Guan, YL; Liu, J; Pallansch, L; Lackman-Smith, C; De Clercq, E; Pommier, Y
      Structure-activity of inhibition of HIV-1 integrase and virus replication by G-quartet oligonucleotides

      DNA AND CELL BIOLOGY
    4. Zhang, XC; Neamati, N; Lee, YK; Orr, A; Brown, RD; Whitaker, N; Pommier, Y; Burke, TR
      Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase

      BIOORGANIC & MEDICINAL CHEMISTRY
    5. Taktakishvili, M; Neamati, N; Pommier, Y; Nair, V
      Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    6. Shao, RG; Cao, CX; Nieves-Neira, W; Dimanche-Boitrel, MT; Solary, E; Pommier, Y
      Activation of the Fas pathway independently of Fas ligand during apoptosisinduced by camptothecin in p53 mutant human colon carcinoma cells

      ONCOGENE
    7. Takebayashi, Y; Nakayama, K; Kanzaki, A; Miyashita, H; Ogura, O; Mori, S; Mutoh, M; Miyazaki, K; Fukumoto, M; Pommier, Y
      Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors

      CANCER LETTERS
    8. Marchand, C; Neamati, N; Pommier, Y
      In vitro human immunodeficiency virus type 1 integrase assays

      DRUG-NUCLEIC ACID INTERACTIONS
    9. Pourquier, P; Pommier, Y
      Topoisomerase I-mediated DNA damage

      ADVANCES IN CANCER RESEARCH, VOL 80
    10. Zhang, HL; Barcelo, JM; Lee, B; Kohlhagen, G; Zimonjic, DB; Popescu, NC; Pommier, Y
      Human mitochondrial topoisomerase I

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    11. Pluymers, W; Neamati, N; Pannecouque, C; Fikkert, V; Marchand, C; Burke, TR; Pommier, Y; Schols, D; De Clercq, E; Debyser, Z; Witvrouw, M
      Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters (vol 58, pg 641, 2000)

      MOLECULAR PHARMACOLOGY
    12. Fan, Y; Shi, LM; Kohn, KW; Pommier, Y; Weinstein, JN
      Quantitative structure-antitumor activity relationships of camptothecin analogues: Cluster analysis and genetic algorithm-based studies

      JOURNAL OF MEDICINAL CHEMISTRY
    13. Yu, Q; La Rose, JH; Zhang, HL; Pommier, Y
      Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

      FEBS LETTERS
    14. Urasaki, Y; Laco, GS; Pourquier, P; Takebayashi, Y; Kohlhagen, G; Gioffre, C; Zhang, HL; Chatterjee, D; Pantazis, P; Pommier, Y
      Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line

      CANCER RESEARCH
    15. Urasaki, Y; Laco, G; Takebayashi, Y; Bailly, C; Kohlhagen, G; Pommier, Y
      Use of camptothecin-resistant mammalian cell lines to evaluate the role oftopoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site

      CANCER RESEARCH
    16. Pourquier, P; Waltman, JL; Urasaki, Y; Loktionova, NA; Pegg, AE; Nitiss, JL; Pommier, Y
      Topoisomerase I-mediated cytotoxicity of N-methyl-N '-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O-6-methylguanine

      CANCER RESEARCH
    17. Neamati, N; Marchand, C; Winslow, HE; Pommier, Y
      Human immunodeficiency virus type 1 integrase-targeted inhibitor design

      ANTIRETROVIRAL THERAPY
    18. Scherf, U; Ross, DT; Waltham, M; Smith, LH; Lee, JK; Tanabe, L; Kohn, KW; Reinhold, WC; Myers, TG; Andrews, DT; Scudiero, DA; Eisen, MB; Sausville, EA; Pommier, Y; Botstein, D; Brown, PO; Weinstein, JN
      A gene expression database for the molecular pharmacology of cancer

      NATURE GENETICS
    19. Jerina, DM; Sayer, JM; Kroth, H; Kohlhagen, G; Laco, GS; Pommier, Y
      Bay-region diol epoxides of benzo[a]pyrene are stealth poisons of topoisomerase I

      POLYCYCLIC AROMATIC COMPOUNDS
    20. Chen, IJ; Neamati, N; Nicklaus, MC; Orr, A; Anderson, L; Barchi, JJ; Kelley, JA; Pommier, Y; MacKerell, AD
      Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets

      BIOORGANIC & MEDICINAL CHEMISTRY
    21. Taktakishvili, M; Neamati, N; Pommier, Y; Nair, V
      Recognition and inhibition of HIV integrase by a novel dinucleotide

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    22. Pilon, AA; Marchand, C; Kavlick, MF; Bajaj, K; Owen, J; Mitsuya, H; Pommier, Y
      Mutations in the HIV type 1 integrase of patients receiving long-term dideoxynucleoside therapy do not confer resistance to zidovudine

      AIDS RESEARCH AND HUMAN RETROVIRUSES
    23. Voeller, DM; Grem, JL; Pommier, Y; Paull, K; Allegra, CJ
      Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    24. Strumberg, D; Pilon, AA; Smith, M; Hickey, R; Malkas, L; Pommier, Y
      Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5 '-phosphorylated DNA double-strand breaks by replication runoff

      MOLECULAR AND CELLULAR BIOLOGY
    25. Pommier, Y; Marchand, C; Neamati, N
      Retroviral integrase inhibitors year 2000: update and perspectives

      ANTIVIRAL RESEARCH
    26. Pommier, Y; Kohlhagen, G; Pourquier, P; Sayer, JM; Kroth, H; Jerina, DM
      Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    27. Pourquier, P; Takebayashi, Y; Urasaki, Y; Gioffre, C; Kohlhagen, G; Pommier, Y
      Induction of topoisomerase I cleavage complexes by 1-beta-D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    28. Pommier, Y; Laco, GS; Kohlhagen, G; Sayer, JM; Kroth, H; Jerina, DM
      Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]pyrene diol epoxide adducts at the 6-amino group of adenine

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    29. Pluymers, W; Neamati, N; Pannecouque, C; Fikkert, V; Marchand, C; Burke, TR; Pommier, Y; Schols, D; De Clercq, E; Debyser, Z; Witvrouw, M
      Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters

      MOLECULAR PHARMACOLOGY
    30. Bom, D; Curran, DP; Kruszewski, S; Zimmer, SG; Strode, JT; Kohlhagen, G; Du, W; Chavan, AJ; Fraley, KA; Bingcang, AL; Latus, LJ; Pommier, Y; Burke, TG
      The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

      JOURNAL OF MEDICINAL CHEMISTRY
    31. Cushman, M; Jayaraman, M; Vroman, JA; Fukunaga, AK; Fox, BM; Kohlhagen, G; Strumberg, D; Pommier, Y
      Synthesis of new indeno[1,2-c]isoquinolines: Cytotoxic non-camptothecin topoisomerase I inhibitors

      JOURNAL OF MEDICINAL CHEMISTRY
    32. Jing, NJ; Marchand, C; Liu, J; Mitra, R; Hogan, ME; Pommier, Y
      Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in vitro

      JOURNAL OF BIOLOGICAL CHEMISTRY
    33. Fertala, J; Vance, JR; Pourquier, P; Pommier, Y; Bjornsti, MA
      Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate

      JOURNAL OF BIOLOGICAL CHEMISTRY
    34. Rogakou, EP; Nieves-Neira, W; Boon, C; Pommier, Y; Bonner, WM
      Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

      JOURNAL OF BIOLOGICAL CHEMISTRY
    35. Urasaki, Y; Takebayashi, Y; Pommier, Y
      Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations

      CANCER RESEARCH
    36. Taktakishvili, M; Neamati, N; Pommier, Y; Pal, S; Nair, V
      Recognition and inhibition of HIV integrase by novel dinucleotides

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    37. Kreuzer, KN; Freudenreich, CH; Pommier, Y
      Analysis of cleavage complexes using reactive inhibitor derivatives

      DNA TOPOISOMERASE PROTOCOLS, PT II
    38. Mazumder, A; Neamati, N; Sunder, S; Owen, J; Pommier, Y
      Retroviral integrase - A novel target in antiviral drug development and basic in vitro assays with the purified enzyme

      ANTIVIRAL METHODS AND PROTOCOLS
    39. Pommier, Y; Pourquier, P; Urasaki, Y; Wu, JX; Laco, GS
      Topoisomerase I inhibitors: selectivity and cellular resistance

      DRUG RESISTANCE UPDATES
    40. Pourquier, P; Jensen, AD; Gong, SS; Pommier, Y; Rogler, CE
      Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro

      NUCLEIC ACIDS RESEARCH
    41. Carrier, F; Georgel, PT; Pourquier, P; Blake, M; Kontny, HU; Antinore, MJ; Gariboldi, M; Myers, TG; Weinstein, JN; Pommier, Y; Fornace, AJ
      Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin

      MOLECULAR AND CELLULAR BIOLOGY
    42. Shao, RG; Cao, CX; Zhang, HL; Kohn, KW; Wold, MS; Pommier, Y
      Replication-mediated DNA damage by camptothecin induces phosphorylation ofRPA by DNA-dependent protein kinase and dissociates RPA : DNA-PK complexes

      EMBO JOURNAL
    43. Goldwasser, F; Bae, I; Pommier, Y; Fornace, AJ
      Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation

      ANTICANCER RESEARCH
    44. Wang, YX; Neamati, N; Jacob, J; Palmer, I; Stahl, SJ; Kaufman, JD; Huang, PL; Huang, PL; Winslow, HE; Pommier, Y; Wingfield, PT; Lee-Huang, S; Bax, A; Torchia, DA
      Solution structure of anti-HIV-1 and anti-tumor protein MAP30: Structural insights into its multiple functions

      CELL
    45. Pommier, Y; Neamati, N
      Inhibitors of human immunodeficiency virus integrase

      ADVANCES IN VIRUS RESEARCH, VOL 52
    46. Takebayashi, Y; Pourquier, P; Yoshida, A; Kohlhagen, G; Pommier, Y
      Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancerdrug that selectively alkylates DNA in the minor groove

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    47. Nieves-Neira, W; Rivera, MI; Kohlhagen, G; Hursey, ML; Pourquier, P; Sausville, EA; Pommier, Y
      DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells

      MOLECULAR PHARMACOLOGY
    48. Guano, F; Pourquier, P; Tinelli, S; Binaschi, M; Bigioni, M; Animati, F; Manzini, S; Zunino, F; Kohlhagen, G; Pommier, Y; Capranico, G
      Topoisomerase poisoning activity of novel disaccharide anthracyclines

      MOLECULAR PHARMACOLOGY
    49. Lin, ZW; Neamati, N; Zhao, H; Kiryu, Y; Turpin, JA; Aberham, C; Strebel, K; Kohn, K; Witvrouw, M; Pannecouque, C; Debyser, Z; De Clercq, E; Rice, WG; Pommier, Y; Burke, TR
      Chicoric acid analogues as HIV-1 integrase inhibitors

      JOURNAL OF MEDICINAL CHEMISTRY
    50. Strumberg, D; Pommier, Y; Paull, K; Jayaraman, M; Nagafuji, P; Cushman, M
      Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons

      JOURNAL OF MEDICINAL CHEMISTRY
    51. Neamati, N; Turpin, JA; Winslow, HE; Christensen, JL; Williamson, K; Orr, A; Rice, WG; Pommier, Y; Garofalo, A; Brizzi, A; Campiani, G; Fiorini, I; Nacci, V
      Thiazolothiazepine inhibitors of HIV-1 integrase

      JOURNAL OF MEDICINAL CHEMISTRY
    52. Strumberg, D; Nitiss, JL; Dong, JW; Kohn, KW; Pommier, Y
      Molecular analysis of yeast and human type II topoisomerases - Enzyme-DNA and drug interactions

      JOURNAL OF BIOLOGICAL CHEMISTRY
    53. Pourquier, P; Ueng, LM; Fertala, J; Wang, D; Park, HJ; Essigmann, JM; Bjornsti, MA; Pommier, Y
      Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages - 7,8-dihydro-8-oxoguanine and 5-hydroxycytosine

      JOURNAL OF BIOLOGICAL CHEMISTRY
    54. Strumberg, D; Nitiss, JL; Rose, A; Nicklaus, MC; Pommier, Y
      Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions

      JOURNAL OF BIOLOGICAL CHEMISTRY
    55. Nieves-Neira, W; Pommier, Y
      Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI anticancer drug screen: Multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways

      INTERNATIONAL JOURNAL OF CANCER
    56. Brangi, M; Litman, T; Ciotti, M; Nishiyama, K; Kohlhagen, G; Takimoto, C; Robey, R; Pommier, Y; Fojo, T; Bates, SE
      Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation inMXR-expressing cells

      CANCER RESEARCH
    57. Koo, HM; Gray-Goodrich, M; Kohlhagen, G; McWilliams, MJ; Jeffers, M; Vaigro-Wolff, A; Alvord, WG; Monks, A; Paull, KD; Pommier, Y; Vande Woude, GF
      The ras oncogene-mediated sensitization of human cells to topoisomerase IIinhibitor-induced apoptosis

      JOURNAL OF THE NATIONAL CANCER INSTITUTE
    58. Pourquier, P; Kohlhagen, G; Ueng, LM; Pommier, Y
      Topoisomerase I and II activity assays

      CYTOTOXIC DRUG RESISTANCE MECHANISMS
    59. ROGAKOU EP; NIEVESNIERA W; BOON C; POMMIER Y; BONNER WM
      HISTONE H2AX SERINE-139 PHOSPHORYLATION IS INDUCED BY THE INTRODUCTION OF THE INITIAL BREAKS INTO DNA AS A RESULT OF THE APOPTOTIC ENDONUCLEASE

      Molecular biology of the cell
    60. ZHANG JZ; NEAMATI N; POMMIER Y; NAIR V
      INHIBITION OF HIV INTEGRASE BY NOVEL NUCLEOTIDES BEARING TRICYCLIC BASES

      Bioorganic & medicinal chemistry letters
    61. Hong, H; Neamati, N; Winslow, HE; Christensen, JL; Orr, A; Pommier, Y; Milne, GWA
      Identification of HIV-1 integrase inhibitors based on a four-point pharmacophore

      ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
    62. TAKEBAYASHI Y; GOLDWASSER F; POMMIER Y
      PROTEIN-LINKED DNA BREAKS INDUCED BY ECTEINASCIDIN-743 IN HUMAN COLON-CARCINOMA CELLS

      Annals of oncology
    63. POMMIER Y
      DIVERSITY OF DNA TOPOISOMERASE-I AND INHIBITORS

      Biochimie
    64. POURQUIER P; JENSEN AD; GONG SS; POMMIER Y; ROGLER CE
      TOPOISOMERASE-I ACTIVITIES OF LINEARIZATION, CIRCULARIZATION AND RELAXATION OF DUCK HEPATITIS-B VIRUS-DNA PROVIDE MECHANISMS FOR REGULATIONOF VIRAL REPLICATION

      Hepatology
    65. POMMIER Y; POURQUIER P; FAN Y; STRUMBERG D
      MECHANISM OF ACTION OF EUKARYOTIC DNA TOPOISOMERASE-I AND DRUGS TARGETED TO THE ENZYME

      Biochimica et biophysica acta, N. Gene structure and expression
    66. LUBKOWSKI J; YANG F; ALEXANDRATOS J; WLODAWER A; ZHAO H; BURKE TR; NEAMATI N; POMMIER Y; MERKEL G; SKALKA AM
      STRUCTURE OF THE CATALYTIC DOMAIN OF AVIAN-SARCOMA VIRUS INTEGRASE WITH A BOUND HIV-1 INTEGRASE-TARGETED INHIBITOR

      Proceedings of the National Academy of Sciences of the United Statesof America
    67. DRAKE RR; NEAMATI N; HONG HX; PILON AA; SUNTHANKAR P; HUME SD; MILNE GWA; POMMIER Y
      IDENTIFICATION OF A NUCLEOTIDE-BINDING SITE IN HTV-1 INTEGRASE

      Proceedings of the National Academy of Sciences of the United Statesof America
    68. NEAMATI N; MAZUMDER A; SUNDER S; OWEN JM; TANDON M; LOWN JW; POMMIER Y
      HIGHLY POTENT SYNTHETIC POLYAMIDES, BISDISTAMYCINS, AND LEXITROPSINS AS INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE

      Molecular pharmacology
    69. KOHLHAGEN G; PAULL KD; CUSHMAN M; NAGAFUJI P; POMMIER Y
      PROTEIN-LINKED DNA STRAND BREAKS INDUCED BY NSC-314622, A NOVEL NONCAMPTOTHECIN TOPOISOMERASE-I POISON

      Molecular pharmacology
    70. NEAMATI N; HONG HX; OWEN JM; SUNDER S; WINSLOW HE; CHRISTENSEN JL; ZHAO H; BURKE TR; MILNE GWA; POMMIER Y
      SALICYLHYDRAZINE-CONTAINING INHIBITORS OF HIV-1 INTEGRASE - IMPLICATION FOR A SELECTIVE CHELATION IN THE INTEGRASE ACTIVE-SITE

      Journal of medicinal chemistry
    71. FAN Y; WEINSTEIN JN; KOHN KW; SHI LM; POMMIER Y
      MOLECULAR MODELING STUDIES OF THE DNA-TOPOISOMERASE-I TERNARY CLEAVABLE COMPLEX WITH CAMPTOTHECIN

      Journal of medicinal chemistry
    72. Hiraoka, W; Vazquez, N; Nieves-Neira, W; Chanock, SJ; Pommier, Y
      Role of oxygen radicals generated by NADPH oxidase in apoptosis induced inhuman leukemia cells

      JOURNAL OF CLINICAL INVESTIGATION
    73. POURQUIER P; BJORNSTI MA; POMMIER Y
      INDUCTION OF TOPOISOMERASE-I CLEAVAGE COMPLEXES BY THE VINYL-CHLORIDEADDUCT 1,N-6-ETHENOADENINE

      The Journal of biological chemistry
    74. SHIMIZU T; CAO CX; SHAO RG; POMMIER Y
      LAMIN-B PHOSPHORYLATION BY PROTEIN-KINASE-C-ALPHA AND PROTEOLYSIS DURING APOPTOSIS IN HUMAN LEUKEMIA HL60 CELLS

      The Journal of biological chemistry
    75. YOSHIDA A; POURQUIER P; POMMIER Y
      PURIFICATION AND CHARACTERIZATION OF A MG2-DEPENDENT ENDONUCLEASE (AN34) FROM ETOPOSIDE-TREATED HUMAN LEUKEMIA HL-60 CELLS UNDERGOING APOPTOSIS()

      Cancer research
    76. Pourquier, P; Pommier, Y
      Topoisomerases I: New targets for cancer chemotherapy and mechanisms of resistance

      BULLETIN DU CANCER
    77. PARKER BW; KAUR G; NIEVESNEIRA W; TAIMI M; KOHLHAGEN G; SHIMIZU T; LOSIEWICZ MD; POMMIER Y; SAUSVILLE EA; SENDEROWICZ AM
      EARLY INDUCTION OF APOPTOSIS IN HEMATOPOIETIC-CELL LINES AFTER EXPOSURE TO FLAVOPIRIDOL

      Blood
    78. CHOURPA I; RIOU JF; MILLOT JM; POMMIER Y; MANFAIT M
      MODULATION IN KINETICS OF LACTONE RING HYDROLYSIS OF CAMPTOTHECINS UPON INTERACTION WITH TOPOISOMERASE-I CLEAVAGE SITES ON DNA

      Biochemistry
    79. POMMIER Y; KOHLHAGEN G; WU CX; SIMMONS DT
      MAMMALIAN DNA TOPOISOMERASE-I ACTIVITY AND POISONING BY CAMPTOTHECIN ARE INHIBITED BY SIMIAN-VIRUS-40 LARGE T-ANTIGEN

      Biochemistry
    80. NABIEV I; FLEURY F; KUDELINA I; POMMIER Y; CHARTON F; RIOU JF; ALIX AJP; MANFAIT M
      SPECTROSCOPIC AND BIOCHEMICAL-CHARACTERIZATION OF SELF-AGGREGATES FORMED BY ANTITUMOR DRUGS OF THE CAMPTOTHECIN FAMILY - THEIR POSSIBLE ROLE IN THE UNIQUE MODE OF DRUG-ACTION

      Biochemical pharmacology
    81. NEAMATI N; SUNDER S; POMMIER Y
      DESIGN AND DISCOVERY OF HIV-1 INTEGRASE INHIBITORS

      Drug discovery today
    82. GUPTA M; FAN SJ; ZHAN QM; KOHN KW; OCONNOR PM; POMMIER Y
      INACTIVATION OF P53 INCREASES THE CYTOTOXICITY OF CAMPTOTHECIN IN HUMAN COLON HCT116 AND BREAST MCF-7 CANCER-CELLS

      Clinical cancer research
    83. BAGULEY BC; LETEURTRE F; RIOU JF; FINLAY GJ; POMMIER Y
      A CARBAMATE ANALOG OF AMSACRINE WITH ACTIVITY AGAINST NON-CYCLING CELLS STIMULATES TOPOISOMERASE-II CLEAVAGE AT DNA SITES DISTINCT FROM THOSE OF AMSACRINE

      European journal of cancer
    84. POMMIER Y; PILON AA; BAJAJ K; MAZUMDER A; NEAMATI N
      HIV-1 INTEGRASE AS A TARGET FOR ANTIVIRAL DRUGS

      Antiviral chemistry & chemotherapy
    85. NEAMATI N; MAZUMDER A; SUNDER S; OWEN JM; SCHULTZ RJ; POMMIER Y
      2-MERCAPTOBENZENESULPHONAMIDES AS NOVEL INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE AND REPLICATION

      Antiviral chemistry & chemotherapy
    86. SHIMIZU T; POMMIER Y
      CAMPTOTHECIN-INDUCED APOPTOSIS IN P53-NULL HUMAN LEUKEMIA HL60 CELLS AND THEIR ISOLATED-NUCLEI - EFFECTS OF THE PROTEASE INHIBITORS Z-VAD-FMK AND DICHLOROISOCOUMARIN SUGGEST AN INVOLVEMENT OF BOTH CASPASES ANDSERINE PROTEASES

      Leukemia
    87. ZHAO H; NEAMATI N; POMMIER Y; BURKE TR
      DESIGN AND SYNTHESIS OF PHOTOACTIVATABLE COUMARIN-CONTAINING HIV-1 INTEGRASE INHIBITORS

      Heterocycles
    88. HOKI Y; FUJIMORI A; POMMIER Y
      DIFFERENTIAL CYTOTOXICITY OF CLINICALLY IMPORTANT CAMPTOTHECIN DERIVATIVES IN P-GLYCOPROTEIN OVEREXPRESSING CELL-LINES

      Cancer chemotherapy and pharmacology
    89. PONDARRE C; STRUMBERG D; FUJIMORI A; TORRESLEON R; POMMIER Y
      IN-VIVO SEQUENCING OF CAMPTOTHECIN-INDUCED TOPOISOMERASE-I CLEAVAGE SITES IN HUMAN COLON-CARCINOMA CELLS

      Nucleic acids research
    90. NEAMATI N; MAZUMDER A; ZHAO H; SUNDER S; BURKE TR; SCHULTZ RJ; POMMIER Y
      DIARYLSULFONES, A NOVEL CLASS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE INHIBITORS

      Antimicrobial agents and chemotherapy
    91. GOODARZI G; CHIU R; BRACKMANN K; KOHN K; POMMIER Y; GRANDGENETT DP
      HOST SITE SELECTION FOR CONCERTED INTEGRATION BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS IN-VITRO

      Virology
    92. NEAMATI N; HONG HX; SUNDER S; MILNE GWA; POMMIER Y
      POTENT INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE - IDENTIFICATION OF A NOVEL 4-POINT PHARMACOPHORE AND TETRACYCLINES AS NOVEL INHIBITORS

      Molecular pharmacology
    93. VALENTI M; NIEVESNEIRA W; KOHLHAGEN G; KOHN KW; WALL ME; WANI MC; POMMIER Y
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ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 20:09:37