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    1. Ito, S; Ieiri, I; Tanabe, M; Suzuki, A; Higuchi, S; Otsubo, K
      Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

      PHARMACOGENETICS
    2. Matsubara, J; Morita, S; Yamashita, H; Otsubo, K; Kitano, K; Ohtani, T; Kawano, Y; Bando, M; Kido, M; Uchida, M; Tabusa, F
      An efficient synthesis of optical isomers of vasopressin V-2 receptor antagonist OPC-41061 by lipase-catalyzed enantioselective transesterification

      HETEROCYCLES
    3. Yajima, A; Tanaka, K; Tominaga, Y; Ogawa, Y; Tanizawa, T; Inou, T; Otsubo, O; Otsubo, K
      Early changes of bone histology and circulating markers of bone turnover after parathyroidectomy in hemodialysis patients with severe hyperparathyroidism

      CLINICAL NEPHROLOGY
    4. Hadama, A; Ieiri, I; Morita, T; Kimura, M; Urae, A; Irie, S; Kaneda, T; Mamiya, K; Tashiro, N; Higuchi, S; Otsubo, K
      P-hydroxylation of phenobarbital: Relationship to (s)-mephenytoin hydroxylation (CYP2C19) polymorphism

      THERAPEUTIC DRUG MONITORING
    5. Ieiri, I; Kishimoto, Y; Okochi, H; Momiyama, K; Morita, T; Kitano, M; Morisawa, T; Fukushima, Y; Nakagawa, K; Hasegawa, J; Otsubo, K; Ishizaki, T
      Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism

      EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
    6. Tanabe, M; Ieiri, I; Nagata, N; Inoue, K; Ito, S; Kanamori, Y; Takahashi, M; Kurata, Y; Kigawa, J; Higuchi, S; Terakawa, N; Otsubo, K
      Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    7. Shintani, M; Ieiri, I; Inoue, K; Mamiya, K; Ninomiya, H; Tashiro, N; Higuchi, S; Otsubo, K
      Genetic polymorphisms and functional characterization of the 5 '-flanking region of the human CYP2C9 gene: In vitro and in vivo studies

      CLINICAL PHARMACOLOGY & THERAPEUTICS
    8. Konagaya, K; Morita, H; Otsubo, K
      Chinese land use predicted by the GTR-model

      LAND USE AND COVER CHANGE
    9. Otsubo, K; Zhang, ZJ; Ishii, T
      Influence of intensive land use on groundwater resources in the Hebei Plain, China

      LAND USE AND COVER CHANGE
    10. Wang, QX; Otsubo, K
      Relationship between agricultural land use change and socioeconomic factors in north-east China in recent decades

      LAND USE AND COVER CHANGE
    11. Li, L; Sato, Y; Otsubo, K
      Modeling city expansion based on remotely sensed images

      URBAN SUSTAINABILITY IN THE CONTEXT OF GLOBAL CHANGE
    12. Sugawara, M; Mukai, K; Nakata, Y; Otsubo, K; Ishikawa, H
      Performance and physics of quantum-dot lasers with self-assembled columnar-shaped and 1.3-mu m emitting InGaAs quantum dots

      IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
    13. Imai, J; Ieiri, I; Mamiya, K; Miyahara, S; Furuumi, H; Nanba, E; Yamane, M; Fukumaki, Y; Ninomiya, H; Tashiro, N; Otsubo, K; Higuchi, S
      Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus

      PHARMACOGENETICS
    14. Saito, M; Tabuchi, F; Otsubo, K; Miyagawa, I
      Treatment of overactive bladder with modified intravesical oxybutynin chloride

      NEUROUROLOGY AND URODYNAMICS
    15. Matsubara, J; Otsubo, K; Kawano, Y; Kitano, K; Ohtani, T; Yamashita, H; Morita, S; Uchida, M
      Kinetic resolution of 5-hydroxy-2,3,4,5-tetrahydrobenzazepines with chiral1,1 '-bi-2-naphthol derived acylating agents

      HETEROCYCLES
    16. Ieiri, I; Tainaka, H; Morita, T; Hadama, A; Mamiya, K; Hayashibara, M; Ninomiya, H; Ohmori, S; Kitada, M; Tashiro, N; Higuchi, S; Otsubo, K
      Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

      THERAPEUTIC DRUG MONITORING
    17. Matsubara, J; Kitano, K; Otsubo, K; Kawano, Y; Ohtani, T; Bando, M; Kido, M; Uchida, M; Tabusa, F
      Enantioselective synthesis of the metabolites of vasopressin V-2 receptor antagonist OPC-31260 via lipase-catalyzed transesterification

      TETRAHEDRON
    18. Shimamoto, J; Ieiri, I; Urae, A; Kimura, M; Irie, S; Kubota, T; Chiba, K; Ishizaki, T; Otsubo, K; Higuchi, S
      Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele

      EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
    19. Mamiya, K; Hadama, A; Yukawa, E; Ieiri, I; Otsubo, K; Ninomiya, H; Tashiro, N; Higuchi, S
      CYP2C19 polymorphism effect on phenobarbitone - Pharmacokineties in Japanese patients with epilepsy: analysis by population pharmacokinetics

      EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
    20. Otsubo, K
      Studies on the efficient syntheses of the drug metabolites

      YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
    21. Nishijima, Y; Nakajima, K; Otsubo, K; Ishikawa, H
      InGaAs single crystal with a uniform composition in the growth direction grown on an InGaAs seed using the multicomponent zone growth method

      JOURNAL OF CRYSTAL GROWTH
    22. Mukai, K; Nakata, Y; Otsubo, K; Sugawara, M; Yokoyama, N; Ishikawa, H
      1.3-mu m CW lasing characteristics of self-assembled InGaAs-GaAs quantum dots

      IEEE JOURNAL OF QUANTUM ELECTRONICS
    23. Mukai, K; Nakata, Y; Otsubo, K; Sugawara, M; Yokoyama, N; Ishikawa, H
      High characteristic temperature of near-1.3-mu m InGaAs/GaAs quantum-dot lasers at room temperature

      APPLIED PHYSICS LETTERS
    24. Mukai, K; Nakata, Y; Otsubo, K; Sugawara, M; Yokoyama, N; Ishikawa, H
      1.3-mu m CW lasing of InGaAs-GaAs quantum dots at room temperature with a threshold current of 8 mA

      IEEE PHOTONICS TECHNOLOGY LETTERS
    25. Kawano, Y; Otsubo, K; Matsubara, J; Kitano, K
      An efficient synthesis of a metabolite of vasopressin V2 receptor antagonist, OPC-31260, by metalloporphyrin-catalyzed demethylation

      HETEROCYCLES
    26. Kimura, M; Ieiri, I; Wada, Y; Mamiya, K; Urae, A; Iimori, E; Sakai, T; Otsubo, K; Higuchi, S
      Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping:possible effect of age, liver disease and length of therapy

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    27. Kitano, K; Matsubara, J; Ohtani, T; Otsubo, K; Kawano, Y; Morita, S; Uchida, M
      An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

      TETRAHEDRON LETTERS
    28. Ueda, M; Hamamoto, M; Nagayama, H; Otsubo, K; Nito, C; Miyazaki, T; Terashi, A; Katayama, Y
      Susceptibility to neuroleptic malignant syndrome in Parkinson's disease

      NEUROLOGY
    29. Nishijima, Y; Nakajima, K; Otsubo, K; Ishikawa, H
      InGaAs single crystal using a GaAs seed grown with the vertical gradient freeze technique

      JOURNAL OF CRYSTAL GROWTH
    30. Otsubo, K; Nishijima, Y; Uchida, T; Shoji, H; Nakajima, K; Ishikawa, H
      1.3 mu m InGaAs/InAlGaAs strained quantum well lasers on InGaAs ternary substrates

      JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS
    31. OTSUBO K; SHOJI H; KUSUNOKI T; SUZUKI T; UCHIDA T; NISHIJIMA Y; NAKAJIMA K; ISHIKAWA H
      LONG-WAVELENGTH STRAINED-QUANTUM-WELL LASERS OSCILLATING UP TO 210 DEGREES-C ON INGAAS TERNARY SUBSTRATES

      IEEE photonics technology letters
    32. MORITA S; KITANO K; MATSUBARA J; OHTANI T; KAWANO Y; OTSUBO K; UCHIDA M
      PRACTICAL APPLICATION OF THE PALLADIUM-CATALYZED AMINATION IN PHENYLPIPERAZINE SYNTHESIS - AN EFFICIENT SYNTHESIS OF A METABOLITE OF THE ANTIPSYCHOTIC AGENT ARIPIPRAZOLE

      Tetrahedron
    33. Otsubo, K; Nishijima, Y; Ishikawa, H
      Long-wavelength semiconductor lasers on InGaAs ternary substrates with excellent temperature characteristics

      FUJITSU SCIENTIFIC & TECHNICAL JOURNAL
    34. Mamiya, K; Ieiri, I; Shimamoto, J; Yukawa, E; Imai, J; Ninomiya, H; Yamada, H; Otsubo, K; Higuchi, S; Tashiro, N
      The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: Studies in stereoselective hydroxylation and population pharmacokinetics

      EPILEPSIA
    35. MORITA S; MATSUBARA J; OTSUBO K; KITANO K; OHTANI T; KAWANO Y; UCHIDA M
      SYNTHESIS OF A KEY INTERMEDIATE, -[(3-HYDROXYPROPYL)SULFINYL]-1-(O-TOLYL)IMIDAZOLE, FOR THE PLATELET-AGGREGATION INHIBITOR, OPC-29030 VIA LIPASE-CATALYZED ENANTIOSELECTIVE TRANSESTERIFICATION

      Tetrahedron : asymmetry
    36. HAYASHI T; YAMAMOTO K; MATSUO A; OTSUBO K; MURAMATSU S; MATSUDA A; KOMATSU K
      CHARACTERIZATION AND CLONING OF AN ENANTIOSELECTIVE AMIDASE FROM COMAMONAS-ACIDOVORANS KPO-2771-4

      Journal of fermentation and bioengineering
    37. NAKAJIMA K; KUSUNOKI T; OTSUBO K
      BRIDGMAN GROWTH OF COMPOSITIONALLY GRADED INXGA1-XAS (X=0.05-0.30) SINGLE-CRYSTALS FOR USE AS SEEDS FOR IN0.25GA0.75AS CRYSTAL-GROWTH

      Journal of crystal growth
    38. SHOJI H; OTSUBO K; FUJII T; ISHIKAWA H
      CALCULATED PERFORMANCES OF 1.3-MU-M VERTICAL-CAVITY SURFACE-EMITTING LASERS ON INGAAS TERNARY SUBSTRATES

      IEEE journal of quantum electronics
    39. OTSUBO K; SHOJI H; KUSUNOKI T; SUZUKI T; UCHIDA T; NISHIJIMA Y; NAKAJIMA K; ISHIKAWA H
      HIGH T-0 (140K) AND LOW-THRESHOLD LONG-WAVELENGTH STRAINED-QUANTUM-WELL LASERS ON INGAAS TERNARY SUBSTRATES

      Electronics Letters
    40. OTSUBO K; MATSUBARA J; KITANO K; KAWANO Y; OHTANI T; MORITA S; SATO S; OSHIRO Y; UCHIDA M
      SYNTHESIS OF METABOLITES OF THE CEREBROPROTECTING AGENT PIPERAZINYL]ACETYL]AMINO]-2,2,4,6-TETRAMETHYLINDAN (OPC-14117)

      Chemical and Pharmaceutical Bulletin
    41. SHIRAHATA S; KABAYAMA S; NAKANO M; MIURA T; KUSUMOTO K; GOTOH M; HAYASHI H; OTSUBO K; MORISAWA S; KATAKURA Y
      ELECTROLYZED-REDUCED WATER SCAVENGES ACTIVE OXYGEN SPECIES AND PROTECTS DNA FROM OXIDATIVE DAMAGE

      Biochemical and biophysical research communications
    42. OTSUBO K; MATSUBARA J; OHTANI T; KAWANO Y; KITANO K; MORITA S; KONDO K; YAMAMURA Y; UCHIDA M
      SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF METABOLITES OF VASOPRESSIN V-1 RECEPTOR ANTAGONIST, OPC-21268

      Heterocycles
    43. MATSUBARA J; OTSUBO K; MORITA S; OHTANI T; KAWANO Y; UCHIDA M
      ABSOLUTE-CONFIGURATION OF OPTICAL ISOMERS OF OBENZOYLAMINO)-3-[2(1H)-QUINOLINON-4-YL]-PROPIONIC ACID (REBAMIPIDE)

      Heterocycles
    44. TANAKA R; OKADA M; KAJIMURA N; OTSUBO K; GYOTOKU M; NAGASAKI K; EKIMOTO H; YAMAGUCHI K
      TRIPLE PARANEOPLASTIC-SYNDROME OF HYPERCALCEMIA, LEUKOCYTOSIS AND CACHEXIA IN 2 HUMAN TUMOR XEROGRAFTS IN NUDE-MICE

      Japanese Journal of Clinical Oncology
    45. NAGASAKI K; OTSUBO K; KAJIMURA N; TANAKA R; WATANABE H; TACHIMORI Y; KATO H; YAMAGUCHI H; SAITO D; WATANABE T; ADACHI I; YAMAGUCHI K
      CIRCULATING PARATHYROID HORMONE-RELATED PROTEIN (109-141) IN MALIGNANCY-ASSOCIATED HYPERCALCEMIA

      Japanese Journal of Clinical Oncology
    46. KAJIMURA N; ISEKI H; TANAKA R; OHUE C; OTSUBO K; GYOUTOKU M; SASAKI K; AKIYAMA Y; YAMAGUCHI K
      TOXOHORMONES RESPONSIBLE FOR CANCER CACHEXIA SYNDROME IN NUDE-MICE BEARING HUMAN CANCER CELL-LINES

      Cancer chemotherapy and pharmacology
    47. SENDO T; ADACHI K; OTSUBO K; AOYAMA T; OISHI R
      IN-LINE FILTER OCCLUSION DURING INTRAVENOUS DELIVERY OF INJECTABLE MENATETRENONE (VITAMIN-K-2)

      Journal of clinical pharmacy and therapeutics
    48. MORISHIGE H; SHUTO H; IEIRI I; OTSUBO K; OISHI R
      INSTABILITY OF STANDARD CALIBRATORS MAY BE INVOLVED IN OVERESTIMATINGVANCOMYCIN CONCENTRATIONS DETERMINED BY FLUORESCENCE POLARIZATION IMMUNOASSAY

      Therapeutic drug monitoring
    49. YAMAMOTO K; OTSUBO K; MATSUO A; HAYASHI T; FUJIMATSU I; KOMATSU K
      PRODUCTION OF R-(-)-KETOPROFEN FROM AN AMIDE COMPOUND BY COMAMONAS-ACIDOVORANS KPO-2771-4

      Applied and environmental microbiology
    50. TANAKA K; OTSUBO K; FUJI K
      ENANTIOSELECTIVE PREPARATION OF ALLENECARBOXYLATES BY ASYMMETRIC HORNER-WADSWORTH-EMMONS REACTION

      Tetrahedron letters
    51. SHOJI H; OTSUBO K; KUSUNOKI T; SUZUKI T; UCHIDA T; ISHIKAWA H
      IN0.38GA0.62AS INALGAAS/INGAP STRAINED DOUBLE-QUANTUM-WELL LASERS ON IN0.21GA0.79AS TERNARY SUBSTRATE/

      JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS
    52. OTSUBO K; SETO H; FUTAGAMI K; OISHI R
      RAPID AND SENSITIVE DETECTION OF BENZODIAZEPINES AND ZOPICLONE IN SERUM USING HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY

      Journal of chromatography B. Biomedical applications
    53. SUEYASU M; IKEDA T; OTSUBO K; TANIYAMA T; AOYAMA T; OISHI R
      ENANTIOSELECTIVE DETERMINATION OF THIAMYLAL IN HUMAN SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

      Journal of chromatography B. Biomedical applications
    54. MORITA S; OTSUBO K; MATSUBARA J; OHTANI T; UCHIDA M
      AN EFFICIENT SYNTHESIS OF A KEY INTERMEDIATE TOWARDS (S)-(-)-NADIFLOXACIN

      Tetrahedron : asymmetry
    55. TANAKA K; OTSUBO K; FUJI K
      ONE-POT PROCEDURE FOR PRODUCING ALLENE CARBOXYLIC ESTERS FROM BHT ESTERS

      Synlett
    56. KAWASHIGE M; SENDO T; OTSUBO K; AOYAMA T; OISHI R
      QUALITY EVALUATION OF COMMERCIAL LYOPHILIZED HUMAN GROWTH-HORMONE PREPARATIONS

      Biological & pharmaceutical bulletin
    57. YAMAGUCHI K; AOYAGI K; URAKAMI K; FUKUTANI T; MAKI N; YAMAMOTO S; OTSUBO K; MIYAKE Y; KODAMA T
      ENZYME-LINKED-IMMUNOSORBENT-ASSAY OF PRO-GASTRIN-RELEASING PEPTIDE FOR SMALL-CELL LUNG-CANCER PATIENTS IN COMPARISON WITH NEURON-SPECIFIC ENOLASE MEASUREMENT

      Japanese journal of cancer research
    58. FUTAGAMI K; OTSUBO K; NAKAO Y; AOYAMA T; IIMORI E; URAKAMI S; IDE M; OISHI R
      ACUTE ORGANOPHOSPHATE POISONING AFTER DISULFOTON INGESTION

      Journal of toxicology. Clinical toxicology
    59. TAKAHASHI H; OTSUBO K; NAGATA H; KOHIYAMA K; GOTO G; AOKI T; ASAMI F
      CONSIDERATIONS FOR SYSTEM-DEVELOPMENT OF ONE-CHIP VIDEO MUSE (HDTV) DECODER

      IEEE transactions on consumer electronics
    60. KIBE S; OTSUBO K; NITTA K
      EVA-RELATED ACTIVITIES IN JAPAN

      Acta astronautica
    61. TANAKA K; OTSUBO K; FUJI K
      TANDEM MICHAEL-HORNER-WADSWORTH-EMMONS REACTION OF ALPHA,BETA-UNSATURATED 2,6-DI-TERT-BUTYL-4-METHYLPHENYL ESTERS AS A CONVENIENT METHOD FOR THE PREPARATION OF DELTA-BRANCHED ALLENE CARBOXYLATES

      Tetrahedron letters
    62. SENDO T; OTSUBO K; HISAZUMI A; AOYAMA T; OISHI R
      PARTICLE CONTAMINATION IN CONTRAST-MEDIA INDUCED BY DISPOSABLE SYRINGES

      Journal of pharmaceutical sciences
    63. UCHIDA M; OTSUBO K; MATSUBARA J; OHTANI T; MORITA S; YAMASAKI K
      SYNTHESIS OF 4-(PHENYLAMINO)QUINOLINE-3-CARBOXAMIDES AS A NOVEL CLASSOF GASTRIC H+ K+-ATPASE INHIBITORS/

      Chemical and Pharmaceutical Bulletin
    64. MORITA S; OTSUBO K; MATSUBARA J; OHTANI T; KAWANO Y; OHMORI K; OHGURO K; UCHIDA M
      SYNTHESIS OF POSSIBLE METABOLITES OF -METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID (GREPAFLOXACIN, OPC-17116)

      Chemical and Pharmaceutical Bulletin
    65. YOSHINAGA M; YUASA Y; HATANO H; KONO Y; NOMURA Y; OKU S; NAKAMURA M; KANEKURA S; OTSUBO K; AKIBA S; MIYATA K
      EFFECT OF TOTAL ADIPOSE WEIGHT AND SYSTEMIC HYPERTENSION ON LEFT-VENTRICULAR MASS IN CHILDREN

      The American journal of cardiology
    66. OTSUBO K; SHOJI H; FUJII T; MATSUDA M; ISHIKAWA H
      HIGH-REFLECTIVITY IN0.29GA0.71AS IN0.28AL0.72AS TERNARY MIRRORS FOR 1.3 MU-M VERTICAL-CAVITY SURFACE-EMITTING LASERS GROWN ON GAAS/

      JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS
    67. TAKAGI M; SHIROKAZE JI; OISHI K; OTSUBO K; YAMAMOTO K; YOSHIDA N; FUJIMATSU I
      PRODUCTION OF S-(-IBUPROFEN WITH HIGH OPTICAL PURITY FROM A NITRILE COMPOUND BY CELLS IMMOBILIZED ON CELLULOSE POROUS BEADS())

      Journal of fermentation and bioengineering
    68. KOHIYAMA K; OTSUBO K; TAKAHASHI H; OGAWA K; OTOBE Y
      DEVELOPMENT OF IMPROVED LOW-POWER MUSE (HDTV) DECODER CHIP SET 2.5TH GENERATION MUSE CHIP SET

      IEICE transactions on electronics
    69. SHOJI H; OTSUBO K; MATSUDA M; ISHIKAWA H
      160-DEGREES-C CW OPERATION OF INGAAS GAAS VERTICAL-CAVITY SURFACE-EMITTING LASERS/

      Electronics Letters
    70. SHOJI H; OTSUBO K; MATSUDA M; ISHIKAWA H
      160-DEGREES-C CW OPERATION OF INGAAS GAAS VERTICAL-CAVITY SURFACE-EMITTING LASERS (VOL 30, PG 409, 1994)/

      Electronics Letters
    71. OTSUBO K; KATAYAMA Y; KASHIWAGI F; MURAMATSU H; TERASHI A
      COMPARISON OF THE EFFECTS OF GLYCEROL, MANNITOL, AND UREA ON ISCHEMICHIPPOCAMPAL DAMAGE IN GERBILS

      Acta neurochirurgica
    72. FUJISAWA Y; FUKUDA T; ARAI F; MURO E; HOSHINO H; MIYAZAKI T; OTSUBO K; UEHARA K
      MECHANISM AND CONTROL OF MAN-ROBOT COOPERATIVE-WORK-TYPE MANIPULATOR

      JSME international journal. Series C, dynamics, control, robotics, design and manufacturing
    73. OTSUBO K; MORITA S; UCHIDA M
      SYNTHESIS OF N-ACETYLHEMIAMINAL METABOLITES OF OPC-21268, VASOPRESSINV1-RECEPTOR ANTAGONIST

      Bioorganic & medicinal chemistry letters


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Documento generato il 26/10/20 alle ore 23:30:48