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Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
NEUROBIOLOGY OF DISEASE
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
NEURON
Variable phenotype of Alzheimer's disease with spastic paraparesis
ANNALS OF NEUROLOGY
Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126
JOURNAL OF NEUROSCIENCE RESEARCH
Clioquinol's return: Cautions from Japan - Response
SCIENCE
Memory decline in healthy older people - Implications for identifying mildcognitive impairment
NEUROLOGY
The emerging European epidemic of variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy: lessons for Australia
MEDICAL JOURNAL OF AUSTRALIA
The Worster-Drought syndrome and other syndromes of dementia with spastic paraparesis: The paradox of molecular pathology
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
JOURNAL OF NEUROCHEMISTRY
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
JOURNAL OF NEUROCHEMISTRY
Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma-secretase inhibitor - Implications for presenilin biology
JOURNAL OF BIOLOGICAL CHEMISTRY
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
JOURNAL OF BIOLOGICAL CHEMISTRY
The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Interaction of linear homologous DNA duplexes via Holliday junction formation
EUROPEAN JOURNAL OF BIOCHEMISTRY
Identification of structural variations in the carboxyl terminus of Alzheimer's disease-associated beta A4[1-42] amyloid using a monoclonal antibody
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
BIOCHEMISTRY
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
BIOCHEMISTRY
Statistical evaluation of voltages in distribution systems with embedded wind generation
IEE PROCEEDINGS-GENERATION TRANSMISSION AND DISTRIBUTION
Correct heteroduplex formation for mutation detection analysis
MOLECULAR DIAGNOSIS
Chelation and intercalation: Complementary properties in a compound for the treatment of Alzheimer's disease
JOURNAL OF STRUCTURAL BIOLOGY
Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies
NEUROBIOLOGY OF DISEASE
Recent advances in the pre-mortem diagnosis of Creutzfeldt-Jakob disease
JOURNAL OF CLINICAL NEUROSCIENCE
Creutzfeldt-Jakob disease: diagnostic utility of 14-3-3 protein immunodetection in cerebrospinal fluid
JOURNAL OF CLINICAL NEUROSCIENCE
Presenilin I expression in yeast lowers secretion of the amyloid precursorprotein
NEUROREPORT
Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta 42(43) peptide levels and induces apoptosis
ANNALS OF NEUROLOGY
Amyloidgenicity and neurotoxicity of peptides corresponding to the helicalregions of PrPC
JOURNAL OF NEUROSCIENCE RESEARCH
A beta peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture
JOURNAL OF NEUROSCIENCE RESEARCH
What the evolution of the amyloid protein precursor supergene family tellsus about its function
NEUROCHEMISTRY INTERNATIONAL
Differential effects of zinc on amyloid precursor protein (APP) processingin copper-resistant variants of cultured Chinese hamster ovary cells
CELLULAR AND MOLECULAR BIOLOGY
Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures
JOURNAL OF NEUROCHEMISTRY
Identification of cis-elements regulating exon 15 splicing of the amyloid precursor protein pre-mRNA
JOURNAL OF BIOLOGICAL CHEMISTRY
Presenilin 2 expression in neuronal cells: Induction during differentiation of embryonic carcinoma cells
EXPERIMENTAL CELL RESEARCH
Novel prion protein gene mutation in an octogenarian with Creutzfeldt-Jakob disease
ARCHIVES OF NEUROLOGY
Prospects for pharmacological intervention in Alzheimer disease
ARCHIVES OF NEUROLOGY
Alzheimer disease - Mouse models pave the way for therapeutic opportunities
ARCHIVES OF NEUROLOGY
Genomic neurology
ARCHIVES OF NEUROLOGY
The role of NAC in amyloidogenesis in Alzheimer's disease - Author's reply
AMERICAN JOURNAL OF PATHOLOGY
Interaction of the presenilins with the amyloid precursor protein (APP)
ALZHEIMER'S DISEASE
It all sticks together - the APP-related family of proteins and Alzheimer's disease
MOLECULAR PSYCHIATRY
Amyloid Nomenclature Committee
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
NATURE STRUCTURAL BIOLOGY
Early-onset Alzheimer's disease caused by a novel mutation at codon 219 ofthe presenilin-1 gene
NEUROREPORT
Amyloid precursor protein of Alzheimer's disease: evidence for a stable, full-length, trans-membrane pool in primary neuronal cultures
EUROPEAN JOURNAL OF NEUROSCIENCE
The amyloid precursor protein of Alzheimer disease in human brain and blood
JOURNAL OF LEUKOCYTE BIOLOGY
Soluble pool of A beta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
ANNALS OF NEUROLOGY
Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease
ANNALS OF NEUROLOGY
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies
JOURNAL OF NEUROSCIENCE RESEARCH
alpha-Synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores
NEUROSCIENCE LETTERS
The Alzheimer's disease amyloid precursor protein modulates copper-inducedtoxicity and oxidative stress in primary neuronal cultures
JOURNAL OF NEUROSCIENCE
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion
BIOCHEMICAL JOURNAL
Metal binding and radical generation of proteins in human neurological diseases and aging
METAL IONS IN BIOLOGIAL SYSTEMS, VOL 36
Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study
LANCET
Mitochondrial respiratory chain activity in the human brain as a function of age
MECHANISMS OF AGEING AND DEVELOPMENT
Prion biology and diseases
NATURE
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126
JOURNAL OF NEUROCHEMISTRY
Alzheimer's disease: Correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome
JOURNAL OF NEUROCHEMISTRY
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice
JOURNAL OF NEUROCHEMISTRY
Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione
JOURNAL OF NEUROCHEMISTRY
Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain
JOURNAL OF NEUROCHEMISTRY
Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
JOURNAL OF BIOLOGICAL CHEMISTRY
Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction
JOURNAL OF BIOLOGICAL CHEMISTRY
Aqueous dissolution of Alzheimer's disease A beta amyloid deposits by biometal depletion
JOURNAL OF BIOLOGICAL CHEMISTRY
A novel substrate for analyzing Alzheimer's disease gamma-secretase
FEBS LETTERS
Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth
FEBS LETTERS
The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons
EUROPEAN JOURNAL OF BIOCHEMISTRY
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
BRAIN RESEARCH
Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: Implications for the mechanism of prion formation
BIOCHEMISTRY
Neurobiology of primary dementia
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity
AMERICAN JOURNAL OF PATHOLOGY
Non-A beta component of Alzheimer's disease amyloid (NAC) revisited - NAC and alpha-synuclein are not associated with A beta amyloid
AMERICAN JOURNAL OF PATHOLOGY
Cleavage of the Alzheimer's disease amyloid precursor protein during apoptosis by activated caspases
ALZHEIMER'S DISEASE AND RELATED DISORDERS
Characterization of gamma-secretase candidates from human brain using a new Western blot assay
ALZHEIMER'S DISEASE AND RELATED DISORDERS
Oxidative stress in Alzheimer's disease
ALZHEIMERS REPORTS
SUBCELLULAR-LOCALIZATION OF THE ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN AND DERIVED POLYPEPTIDES EXPRESSED IN A RECOMBINANT YEAST SYSTEM
Amyloid (Carnforth)
COMPARATIVE NEUROPATHOLOGY OF KURU WITH THE NEW VARIANT OF CREUTZFELDT-JAKOB-DISEASE - EVIDENCE FOR STRAIN OF AGENT PREDOMINATING OVER GENOTYPE OF HOST
Brain pathology
SCIENCE, MEDICINE, AND THE FUTURE - ALZHEIMERS-DISEASE
BMJ. British medical journal
2 NOVEL PRESENILIN-1 MUTATIONS (SER169LEU AND PRO436GLN) ASSOCIATED WITH VERY EARLY-ONSET ALZHEIMERS-DISEASE
NeuroReport
NEUROBIOLOGY OF GENES CONTRIBUTING TO ALZHEIMERS-DISEASE (AD)
European journal of neuroscience
THE BETA-AMYLOID PROTEIN INFLUENCES CHOLINESTERASE ASSEMBLY AND GLYCOSYLATION IN THE ALZHEIMER BRAIN
European journal of neuroscience
NO ASSOCIATION OF PRESENILIN-1 INTRONIC POLYMORPHISM AND ALZHEIMERS-DISEASE IN AUSTRALIA
Neuroscience letters
SURVIVAL OF CULTURED NEURONS FROM AMYLOID PRECURSOR PROTEIN KNOCK-OUTMICE AGAINST ALZHEIMERS AMYLOID-BETA TOXICITY AND OXIDATIVE STRESS
The Journal of neuroscience
PHYSIOLOGICAL-FUNCTION OF BETA-AMYLOID DOMAIN IN AXONAL-TRANSPORT OF APP - IMPLICATION ALZHEIMERS-DISEASE
Naunyn-Schmiedeberg's archives of pharmacology
THE TREMBLING MOUNTAIN - A PERSONAL ACCOUNT OF KURU, CANNIBALS AND MAD-COW-DISEASE - KLITZMAN,R
Nature
TRANSGENIC DROSOPHILA EXPRESSING HUMAN AMYLOID PRECURSOR PROTEIN SHOWGAMMA-SECRETASE ACTIVITY AND A BLISTERED-WING PHENOTYPE
Proceedings of the National Academy of Sciences of the United Statesof America
SECRETION OF ALZHEIMERS-DISEASE A-BETA AMYLOID PEPTIDE BY ACTIVATED HUMAN PLATELETS
Laboratory investigation
ACETYLCHOLINESTERASE IS INCREASED IN THE BRAINS OF TRANSGENIC MICE EXPRESSING THE C-TERMINAL FRAGMENT (CT100) OF THE BETA-AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE
Journal of neurochemistry
RELATIVE INCREASE IN ALZHEIMERS-DISEASE OF SOLUBLE FORMS OF CEREBRAL A-BETA AMYLOID PROTEIN-PRECURSOR CONTAINING THE KUNITZ PROTEASE INHIBITORY DOMAIN
The Journal of biological chemistry
EFFECTS OF THE AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE AND OTHER LIGANDS OF THE LDL RECEPTOR-RELATED PROTEIN ON NEURITE OUTGROWTH FROM SYMPATHETIC NEURONS IN CULTURE
FEBS letters
INHIBITION OF PLATELET ACTIVATION BY THE ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN
British Journal of Haematology
PROCESSING OF THE ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN IN PICHIA-PASTORIS - IMMUNODETECTION OF ALPHA-SECRETASE, BETA-SECRETASE, ANDGAMMA-SECRETASE PRODUCTS
Biochemistry (Easton)
COPPER-BINDING AMYLOID PRECURSOR PROTEIN UNDERGOES A SITE-SPECIFIC FRAGMENTATION IN THE REDUCTION OF HYDROGEN-PEROXIDE
Biochemistry
CEREBRAL CHANGES AND CEREBROSPINAL-FLUID BETA-AMYLOID IN ALZHEIMERS-DISEASE - A STUDY WITH QUANTITATIVE MAGNETIC-RESONANCE-IMAGING
Molecular psychiatry
DISTINCT SITES OF INTRACELLULAR PRODUCTION FOR ALZHEIMERS-DISEASE A-BETA-40 42 AMYLOID PEPTIDES/
Nature medicine
SERPENTS ON THE ROAD TO DEMENTIA AND DEATH
Nature medicine
FORMATION OF STABLE COMPLEXES BETWEEN 2 ALZHEIMERS-DISEASE GENE-PRODUCTS - PRESENILIN-2 AND BETA-AMYLOID PRECURSOR PROTEIN
Nature medicine
EXPRESSION OF HUMAN AMYLOID PRECURSOR PROTEIN ECTODOMAINS IN PICHIA-PASTORIS - ANALYSIS OF CULTURE CONDITIONS, PURIFICATION, AND CHARACTERIZATION
Protein expression and purification
CLUES TO THE ETIOLOGY OF ALZHEIMERS-DISEASE THROUGH THE STUDY OF THE AMYLOID PRECURSOR PROTEIN
Brain pathology
COMPARATIVE NEUROPATHOLOGY IN KURU AND NEW VARIANT CJD
Brain pathology
ALZHEIMERS-DISEASE - UNRAVELING THE GENETIC AND ENVIRONMENTAL PATHWAYS TOWARDS PATHOGENESIS
Australian journal on ageing