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    1. Holmes, MC; Kotelevtsev, Y; Mullins, JJ; Seckl, JR
      Phenotypic analysis of mice bearing targeted deletions of 11 beta-hydroxysteroid dehydrogenases 1 and 2 genes

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    2. Masuzaki, H; Paterson, J; Shinyama, H; Morton, NM; Mullins, JJ; Seckl, JR; Flier, JS
      A transgenic model of visceral obesity and the metabolic syndrome

      SCIENCE
    3. Yau, JLW; Noble, J; Kenyon, CJ; Hibberd, C; Kotelevtsev, Y; Mullins, JJ; Seckl, JR
      Lack of tissue glucocorticoid reactivation in 11 beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    4. Ryding, ADS; Sharp, MGF; Mullins, JJ
      Conditional transgenic technologies

      JOURNAL OF ENDOCRINOLOGY
    5. Morton, NM; Holmes, MC; Fievet, C; Staels, B; Tailleux, A; Mullins, JJ; Seckl, JR
      Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11 beta-hydroxysteroid dehydrogenase type 1 null mice.

      JOURNAL OF BIOLOGICAL CHEMISTRY
    6. Kantachuvesiri, S; Fleming, S; Peters, J; Peters, B; Brooker, G; Lammie, AG; McGrath, I; Kotelevtsev, Y; Mullins, JJ
      Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease

      JOURNAL OF BIOLOGICAL CHEMISTRY
    7. Harris, HJ; Kotelevtsev, Y; Mullins, JJ; Seckl, JR; Holmes, MC
      Intracellular regeneration of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: Analysis of 11 beta-HSD-1-deficient mice

      ENDOCRINOLOGY
    8. Hadoke, PWF; Christy, C; Kotelevtsev, YV; Williams, BC; Kenyon, CJ; Seckl, JR; Mullins, JJ; Walker, BR
      Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11 beta-hydromysteroid dehydrogenase

      CIRCULATION
    9. Mullins, LJ; Payne, CM; Kotelevtseva, N; Brooker, G; Fleming, S; Harris, S; Mullins, JJ
      Granulation rescue and developmental marking of juxtaglomerular cells using "piggy-BAC" recombination of the mouse Ren locus

      JOURNAL OF BIOLOGICAL CHEMISTRY
    10. Mullins, JJ
      Commentary: Understanding the regulation of renin gene expression through in vitro and in vivo models

      DRUGS, ENZYMES AND RECEPTORS OF THE RENIN-ANGIOTENSIN SYSTEM: CELEBRATING A CENTURY OF DISCOVERY
    11. Payne, CM; Mullins, LJ; Mullins, JJ
      Manipulating large genomic clones via in vivo recombination in bacteria

      JOURNAL OF HUMAN HYPERTENSION
    12. Brosnan, MJ; Devlin, AM; Clark, JS; Mullins, JJ; Dominiczak, AF
      Different effects of antihypertensive agents on cardiac and vascular hypertrophy in the transgenic rat line TGR(mRen2)27

      AMERICAN JOURNAL OF HYPERTENSION
    13. Jacinto, SM; Mullins, JJ; Mitchell, KD
      Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats

      AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
    14. Kantachuvesiri, S; Haley, CS; Fleming, S; Kurian, K; Whitworth, CE; Wenham, P; Kotelevtsev, Y; Mullins, JJ
      Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats

      KIDNEY INTERNATIONAL
    15. JACINTO SM; MULLINS JJ; MITCHELL KD
      DECREASED RENAL VASCULAR RESPONSIVENESS TO NOREPINEPHRINE IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      The FASEB journal
    16. MONTGOMERY HE; KIERNAN LA; WHITWORTH CE; FLEMING S; UNGER T; GOHLKE P; MULLINS JJ; MCEWAN JR
      INHIBITION OF TISSUE ANGIOTENSIN-CONVERTING ENZYME-ACTIVITY PREVENTS MALIGNANT HYPERTENSION IN TGR(MREN2)27

      Journal of hypertension
    17. KOTELEVTSEV YV; BROWN RW; FLEMING S; EDWARDS CRW; SECKL JR; MULLINS JJ
      HYPERTENSION IN MICE CAUSED BY INACTIVATION OF 11-BETA-HYDROXYSTEROIDDEHYDROGENASE TYPE-2

      Journal of hypertension
    18. SHARP MGF; CLARK AF; FLEMING S; PETERS J; MULLINS JJ
      GENE TARGETING DEMONSTRATES DIFFERENT FUNCTIONS IN RENAL MORPHOLOGY AND PRESSURE HOMEOSTASIS FOR THE MOUSE RENIN GENES

      Journal of hypertension
    19. KANTACHUVESIRI S; HALEY C; FLEMING S; FETTES D; KOTELEVTSEV Y; MULLINS JJ
      THE GENETIC-MAPPING OF CHROMOSOMAL LOCI CONTRIBUTING TO MORTALITY IN A RAT MODEL OF MALIGNANT HYPERTENSION

      Journal of hypertension
    20. MULLINS LJ; KOTELEVTSEVA N; MULLINS JJ
      INVESTIGATION OF RENIN LOCUS-CONTROL IN TRANSGENIC MICE CARRYING 150KB TRANSGENE SPANNING REN1 AND REN2

      Journal of hypertension
    21. KANTACHUVESIRI S; BROOKER G; PETERS J; FLEMING S; KOTELEVTSEV Y; MULLINS JJ
      INDUCIBLE HYPERTENSION IN RATS CARRYING A CYP1A1-REN2 TRANSGENE

      Hypertension
    22. FLEMING S; KANTACHUVERSIRI S; HALEY C; KURIAN K; WENHAM P; KOTELEVTSEV Y; MULLINS JJ
      GENETIC-LOCI AND MORTALITY FROM MALIGNANT HYPERTENSION IN A TRANSGENERAT MODEL

      Journal of pathology
    23. SHARP MGF; KANTACHUVESIRI S; MULLINS JJ
      GENOTYPE AND CARDIOVASCULAR PHENOTYPE - LESSONS FROM GENETICALLY MANIPULATED ANIMALS AND DISEASED HUMANS

      Current opinion in nephrology and hypertension
    24. JACINTO SM; MULLINS JJ; MITCHELL KD
      ENHANCED RENAL VASCULAR RESPONSIVENESS TO ENDOTHELIUM-DEPENDENT VASODILATORS IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      Journal of the American Society of Nephrology
    25. JACINTO SM; MULLINS JJ; MITCHELL KD
      ENHANCED RENAL VASCULAR RESPONSIVENESS TO ANGIOTENSIN-II IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      The FASEB journal
    26. MITCHELL KD; JACINTO SM; MULLINS JJ
      PROXIMAL TUBULAR FLUID, KIDNEY, AND PLASMA-LEVELS OF ANGIOTENSIN-II IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      American journal of physiology. Renal, fluid and electrolyte physiology
    27. MULLINS LJ; KOTELEVTSEVA N; BOYD AC; MULLINS JJ
      EFFICIENT CRE-LOX LINEARIZATION OF BACS - APPLICATIONS TO PHYSICAL MAPPING AND GENERATION OF TRANSGENIC ANIMALS

      Nucleic acids research
    28. CHAPMAN KE; KOTELEVTSEV YV; JAMIESON PM; WILLIAMS LJS; MULLINS JJ; SECKL JR
      TISSUE-SPECIFIC MODULATION OF GLUCOCORTICOID ACTION BY THE 11-BETA-HYDROXYSTEROID DEHYDROGENASES

      Biochemical Society transactions
    29. KOTELEVTSEV Y; HOLMES MC; BURCHELL A; HOUSTON PM; SCHMOLL D; JAMIESON P; BEST R; BROWN R; EDWARDS CRW; SECKL JR; MULLINS JJ
      11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 KNOCKOUT MICE SHOW ATTENUATED GLUCOCORTICOID-INDUCIBLE RESPONSES AND RESIST HYPERGLYCEMIA ON OBESITY OR STRESS

      Proceedings of the National Academy of Sciences of the United Statesof America
    30. KURIAN K; WHITWORTH C; MULLINS JJ; FLEMING S
      ENDOTHELIN BLOCKADE FAILS TO PREVENT TISSUE-INJURY IN MALIGNANT HYPERTENSION

      Journal of pathology
    31. CLARK AF; SHARP MGF; MORLEY SD; FLEMING S; PETERS J; MULLINS JJ
      RENIN-1 IS ESSENTIAL FOR NORMAL RENAL JUXTAGLOMERULAR CELL GRANULATION AND MACULA DENSA MORPHOLOGY

      The Journal of biological chemistry
    32. FLYNN PD; MULLINS JJ; LAWN RM; WEISSBERG PL
      TRANSGENIC RATS EXPRESSING HUMAN APOLIPOPROTEIN(A)

      Atherosclerosis
    33. MULLINS LJ; MORLEY SD; MULLINS JJ
      TRANSGENICS AND ESSENTIAL-HYPERTENSION

      Journal of human hypertension
    34. MITCHELL KD; LEWIS L; HYMEL A; MULLINS JJ
      KIDNEY AND PLASMA-LEVELS OF ANGIOTENSIN-II IN PRE-HYPERTENSIVE AND HYPERTENSIVE REN-2 TRANSGENIC RATS

      The FASEB journal
    35. MORLEY SD; VIARD I; CHUNG BC; IKEDA Y; PARKER KL; MULLINS JJ
      VARIEGATED EXPRESSION OF A MOUSE STEROID 21-HYDROXYLASE BETA-GALACTOSIDASE TRANSGENE SUGGESTS CENTRIPETAL MIGRATION OF ADRENOCORTICAL-CELLS/

      Molecular endocrinology
    36. DELL GC; MORLEY SD; MULLINS JJ; WILLIAMS BC; WALKER SW
      MULTIPLE SIGNAL-TRANSDUCTION SYSTEMS REGULATE ANGIOTENSIN-II TYPE-1 (AT(1)) RECEPTOR MESSENGER-RNA EXPRESSION IN BOVINE ADRENOCORTICAL-CELLS

      Endocrine research
    37. MORLEY SD; VIARD I; PARKER KL; MULLINS JJ
      ADRENOCORTICAL-SPECIFIC TRANSGENE EXPRESSION DIRECTED BY STEROID HYDROXYLASE GENE PROMOTERS

      Endocrine research
    38. KOTELEVTSEV YV; JAMIESON PM; BEST R; STEWART F; EDWARDS CRW; SECKL JR; MULLINS JJ
      INACTIVATION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 BY GENE TARGETING IN MICE

      Endocrine research
    39. BROWN RW; CHAPMAN KE; KOTELEVTSEV Y; YAU JLW; LINDSAY RS; BRETT L; LECKIE C; MURAD P; LYONS V; MULLINS JJ; EDWARDS CRW; SECKL JR
      CLONING AND PRODUCTION OF ANTISERA TO HUMAN PLACENTAL 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2

      Biochemical journal
    40. SHARP MGF; FETTES D; BROOKER G; CLARK AF; PETERS J; FLEMING S; MULLINS JJ
      TARGETED INACTIVATION OF THE REN-2 GENE IN MICE

      Hypertension
    41. SHARP MGF; CLARK AF; FETTES D; MORLEY SD; MULLINS JJ
      DISSECTING THE FUNCTION OF THE DUPLICATED MOUSE RENIN GENES BY GENE TARGETING

      Hypertension
    42. LANTELME P; LO M; MULLINS JJ; GHARIB C; BIZOLLON CA; SASSARD J
      COMPARISON BETWEEN CHRONIC CONVERTING-ENZYME INHIBITION AND AT(1) BLOCKADE IN MREN2 TRANSGENIC RATS

      Journal of cardiovascular pharmacology
    43. CLARK AF; SHARP MGF; MULLINS JJ
      GENE TARGETING AND ITS APPLICATION TO BASIC HYPERTENSION RESEARCH

      Clinical science
    44. CLARK AF; MORLEY SD; FETTES D; SHARP MGF; MULLINS JJ
      MINILECTURE-4 - DISRUPTION OF THE REN1(D) GENE USING PCR TO GENERATE HOMOLOGY FOR THE CONSTRUCTION OF A TARGETING VECTOR

      Kidney international
    45. MULLINS LJ; MULLINS JJ
      TRANSGENESIS IN THE RAT AND LARGER MAMMALS

      The Journal of clinical investigation
    46. MULLINS LJ; MULLINS JJ
      TRANSGENESIS IN THE RAT AND LARGER MAMMALS

      The Journal of clinical investigation
    47. CHAPMAN KE; KOTELEVSTEV Y; JAMIESON PM; WILLIAMS LJS; BROWN RD; MULLINS JJ; SECKL JR
      TISSUE-SPECIFIC MODULATION OF GLUCOCORTICOID ACTION BY THE 11-BETA-HYDROXYSTEROID DEHYDROGENASES

      Immunology
    48. BROWN RW; DIAZ R; ROBSON AC; KOTELEVTSEV YV; MULLINS JJ; KAUFMAN MH; SECKL JR
      THE ONTOGENY OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2 AND MINERALOCORTICOID RECEPTOR GENE-EXPRESSION REVEAL INTRICATE CONTROL OF GLUCOCORTICOID ACTION IN DEVELOPMENT

      Endocrinology
    49. WAGNER J; DANSER AHJ; DERKX FHM; DEJONG PTVM; PAUL M; MULLINS JJ; SCHALEKAMP MADH; GANTEN D
      DEMONSTRATION OF RENIN MESSENGER-RNA, ANGIOTENSINOGEN MESSENGER-RNA, AND ANGIOTENSIN-CONVERTING ENZYME MESSENGER-RNA EXPRESSION IN THE HUMAN EYE - EVIDENCE FOR AN INTRAOCULAR RENIN-ANGIOTENSIN SYSTEM

      British journal of ophthalmology
    50. MITCHELL KD; LEWIS L; HYMEL A; MULLINS JJ
      PROXIMAL TUBULAR FLUID, KIDNEY AND PLASMA-LEVELS OF ANGIOTENSIN-II INANESTHETIZED HYPERTENSIVE REN-2 TRANSGENIC RATS

      Journal of the American Society of Nephrology
    51. RAJAN V; CHAPMAN KE; LYONS V; JAMIESON P; MULLINS JJ; EDWARDS CRW; SECKL JR
      CLONING, SEQUENCING AND TISSUE-DISTRIBUTION OF MOUSE 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 CDNA

      Journal of steroid biochemistry and molecular biology
    52. VENIANT M; WHITWORTH CE; MENARD J; SHARP MGF; GONZALES MF; BRUNEVAL P; MULLINS JJ
      DEVELOPMENTAL STUDIES DEMONSTRATE AGE-DEPENDENT ELEVATION OF RENIN-ACTIVITY IN TGR(MREN2)27 RATS

      American journal of hypertension
    53. MITCHELL KD; MULLINS JJ
      ATTENUATION OF TUBULOGLOMERULAR FEEDBACK DURING PERITUBULAR INFUSION OF LOSARTAN IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      The FASEB journal
    54. MORLEY SD; VIARD I; PARKER KL; MULLINS JJ
      ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLYIMMORTAL RAT ADRENOCORTICAL CELL-LINES

      Endocrine research
    55. MITCHELL KD; MULLINS JJ
      ANG-II DEPENDENCE OF TUBULOGLOMERULAR FEEDBACK RESPONSIVENESS IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      American journal of physiology. Renal, fluid and electrolyte physiology
    56. WHITWORTH CE; VENIANT MM; FIRTH JD; CUMMING AD; MULLINS JJ
      ENDOTHELIN IN THE KIDNEY IN MALIGNANT PHASE HYPERTENSION

      Hypertension
    57. WHITWORTH CE; FLEMING S; KOTELEVTSEV Y; MANSON L; BROOKER GA; CUMMING AD; MULLINS JJ
      A GENETIC MODEL OF MALIGNANT PHASE HYPERTENSION IN RATS

      Kidney international
    58. GARDINER SM; MARCH JE; KEMP PA; MULLINS JJ; BENNETT T
      HEMODYNAMIC-EFFECTS OF LOSARTAN AND THE ENDOTHELIN ANTAGONIST, SB-209670, IN CONSCIOUS, TRANSGENIC ((MREN-2)27), HYPERTENSIVE RATS

      British Journal of Pharmacology
    59. GARDINER SM; KEMP PA; MARCH JE; MULLINS JJ; BENNETT T
      HEMODYNAMIC-EFFECTS OF THE NONSELECTIVE ENDOTHELIN ANTAGONIST, SB-209670, IN CONSCIOUS, TRANSGENIC (TGR(MREN-2)27) HYPERTENSIVE RATS

      British Journal of Pharmacology
    60. SHARPE RM; MAGUIRE SM; SAUNDERS PTK; MILLAR MR; RUSSELL LD; GANTEN D; BACHMANN S; MULLINS L; MULLINS JJ
      INFERTILITY IN A TRANSGENIC RAT DUE TO IMPAIRMENT OF CYTOPLASMIC ELIMINATION AND SPERM RELEASE FROM THE SERTOLI CELLS (VOL 53, PG 214, 1995)

      Biology of reproduction
    61. SHARPE RM; MAGUIRE SM; SAUNDERS PTK; MILLAR MR; RUSSELL LD; GANTEN D; BACHMANN S; MULLINS L; MULLINS JJ
      INFERTILITY IN A TRANSGENIC RAT DUE TO IMPAIRMENT OF CYTOPLASMIC ELIMINATION AND SPERM RELEASE FROM THE SERTOLI CELLS

      Biology of reproduction
    62. MITCHELL KD; MULLINS JJ
      TUBULOGLOMERULAR FEEDBACK RESPONSES DURING REDUCED RENAL ARTERIAL-PRESSURE IN HYPERTENSIVE REN-2 TRANSGENIC RATS

      Journal of the American Society of Nephrology
    63. MULLINS JJ; MULLINS LJ
      TRANSGENES, HYPOTHESES, AND HYPERTENSION

      Hypertension
    64. MULLINS JJ; OGG D; BARRETT G; PETERS J; WHITWORTH C
      REDESIGNING TRANSGENICS - EXTRARENAL EXPRESSION OF MOUSE REN-2 PRORENIN

      Regulatory peptides
    65. MULLINS JJ; OGG D; BARRETT G; PETERS J; WHITWORTH C
      REDESIGNING TRANSGENICS - EXTRARENAL EXPRESSION OF MOUSE REN-2 PRORENIN

      Regulatory peptides
    66. WHITWORTH CE; FLEMING S; CUMMING AD; MORTON JJ; BURNS NJT; WILLIAMS BC; MULLINS JJ
      SPONTANEOUS DEVELOPMENT OF MALIGNANT PHASE HYPERTENSION IN TRANSGENICREN-2 RATS

      Kidney international
    67. KOCK K; MORLEY SD; MULLINS JJ; SCHMALE H
      DENATONIUM BITTER-TASTING AMONG TRANSGENIC MICE EXPRESSING RAT VON EBNERS GLAND PROTEIN

      Physiology & behavior
    68. BISHOP JE; KIEMAN LA; MONTGOMERY HE; MULLINS JJ; MCEWAN JR; LAURENT GJ
      A LOW CIRCULATING RENIN MODEL OF HYPERTENSION - ABSENCE OF INCREASED COLLAGEN DEPOSITION IN THE VENTRICLES OF THE TRANSGENIC TGR (MESSENGERREN-2(B))27 RAT

      Circulation
    69. BISHOP JE; KIEMAN LA; MONTGOMERY HE; MULLINS JJ; MCEWAN JR; LAURENT GJ
      A LOW CIRCULATING RENIN MODEL OF HYPERTENSION - ABSENCE OF INCREASED COLLAGEN DEPOSITION IN THE VENTRICLES OF THE TRANSGENIC TGR (MESSENGERREN-2(B))27 RAT

      Circulation
    70. MONTGOMERY HE; KIEMAN LA; BISHOP JE; MULLINS JJ; LAURENT G; MCEWAN JR
      ABSENCE OF AORTIC COLLAGEN ACCUMULATION IN LOW CIRCULATING RENIN HYPERTENSION STUDIES IN THE TRANSGENIC TGR (MREN-2(2))27 RAT

      Circulation
    71. MONTGOMERY HE; KIEMAN LA; BISHOP JE; MULLINS JJ; LAURENT G; MCEWAN JR
      ABSENCE OF AORTIC COLLAGEN ACCUMULATION IN LOW CIRCULATING RENIN HYPERTENSION STUDIES IN THE TRANSGENIC TGR (MREN-2(2))27 RAT

      Circulation
    72. BROSNAN MJ; MULLINS JJ
      TRANSGENIC ANIMALS IN HYPERTENSION AND CARDIOVASCULAR RESEARCH

      Experimental nephrology
    73. LATHE R; MULLINS JJ
      TRANSGENIC ANIMALS AS MODELS FOR HUMAN-DISEASE - REPORT OF AN EC STUDY-GROUP

      Transgenic research
    74. SHARP MGF; MULLINS JJ
      USE OF RIBOZYMES TO DEVELOP AND MODIFY MODELS OF HUMAN-DISEASE

      Journal of cellular biochemistry
    75. SHARP MGF; MULLINS JJ
      LOSS OF GENE-FUNCTION METHODOLOGY

      Journal of hypertension
    76. UNGER T; GANTEN D; JOHNSTON CI; LEVER AF; MULLINS JJ; SASSARD J; VANZWIETEN PA
      ROUND-TABLE-1 - DO TRANSGENIC TECHNIQUES HELP US TO UNDERSTAND HYPERTENSION

      Journal of hypertension
    77. MULLINS JJ; MULLINS LJ
      TRANSGENESIS IN NONMURINE SPECIES

      Hypertension
    78. ZHAO Y; BADER M; KREUTZ R; FERNANDEZALFONSO M; ZIMMERMANN F; GANTEN U; METZGER R; GANTEN D; MULLINS JJ; PETERS J
      ONTOGENIC REGULATION OF MOUSE REN-2(D) RENIN GENE IN TRANSGENIC HYPERTENSIVE RATS, TGR(MREN2)27

      The American journal of physiology
    79. LO M; MEDEIROS IA; MULLINS JJ; GANTEN D; BARRES C; CERUTTI C; VINCENT M; SASSARD J
      HIGH BLOOD-PRESSURE MAINTENANCE IN TRANSGENIC MREN-2 VS LYON GENETICALLY HYPERTENSIVE RATS

      The American journal of physiology


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Documento generato il 11/08/20 alle ore 12:59:59