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    1. Davies, TG; Tunnah, P; Meijer, L; Marko, D; Eisenbrand, G; Endicott, JA; Noble, MEM
      Inhibitor binding to active and inactive CDK2: The crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

      STRUCTURE
    2. Loukaci, A; Le Saout, I; Samadi, M; Leclerc, S; Damiens, E; Meijer, L; Debitus, C; Guyot, M
      Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinodermamathewsi

      BIOORGANIC & MEDICINAL CHEMISTRY
    3. Damiens, E; Baratte, B; Marie, D; Eisenbrand, G; Meijer, L
      Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest

      ONCOGENE
    4. Escargueil, AE; Plisov, SY; Skladanowski, A; Borgne, A; Meijer, L; Gorbsky, GJ; Larsen, AK
      Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatinremodeling

      FASEB JOURNAL
    5. Naik, S; Kelly, EJ; Meijer, L; Pettersson, T; Sanderson, IR
      Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium

      JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
    6. Ouarzane-Amara, M; Franetich, JF; Pettit, GR; Meijer, L; Doerig, C; Desportes-Livage, I
      In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    7. van Wuijckhuise, L; Frankena, K; van Oijen, MAAJ; Meijer, L
      Analysis of symptoms of disease after a BHV1 vaccination

      TIJDSCHRIFT VOOR DIERGENEESKUNDE
    8. Wang, D; de la Fuente, C; Deng, LW; Wang, L; Zilberman, I; Eadie, C; Healey, M; Stein, D; Denny, T; Harrison, LE; Meijer, L; Kashanchi, F
      Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors

      JOURNAL OF VIROLOGY
    9. Legraverend, M; Ludwig, O; Leclerc, S; Meijer, L
      Synthesis of a new series of purine derivatives and their anti-cyclin-dependent kinase activities

      JOURNAL OF HETEROCYCLIC CHEMISTRY
    10. Leclerc, S; Garnier, M; Hoessel, R; Marko, D; Bibb, JA; Snyder, GL; Greengard, P; Biernat, J; Wu, YZ; Mandelkow, EM; Eisenbrand, G; Meijer, L
      Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease - A property common to most cycline-dependent kinase inhibitors?

      JOURNAL OF BIOLOGICAL CHEMISTRY
    11. Dorin, D; Le Roch, K; Sallicandro, P; Alano, P; Parzy, D; Poullet, P; Meijer, L; Doerig, C
      Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum - Biochemical properties and possible involvement in MAPK regulation

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    12. Meijer, L; Knockaert, M; Damiens, E
      Prevention of chemotherapy-induced alopecia by cyclin-dependant kinase inhibitors

      BULLETIN DU CANCER
    13. Marko, D; Schatzle, S; Friedel, A; Genzlinger, A; Zankl, H; Meijer, L; Eisenbrand, G
      Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives inhuman tumour cells

      BRITISH JOURNAL OF CANCER
    14. Harmse, L; van Zyl, R; Gray, N; Schultz, P; Leclerc, S; Meijer, L; Doerig, C; Havlik, I
      Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum

      BIOCHEMICAL PHARMACOLOGY
    15. Meijer, L
      Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents

      DRUG RESISTANCE UPDATES
    16. Knockaert, M; Gray, N; Damiens, E; Chang, YT; Grellier, P; Grant, K; Fergusson, D; Mottram, J; Soete, M; Dubremetz, JF; Le Roch, K; Doerig, C; Schultz, PG; Meijer, L
      Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors

      CHEMISTRY & BIOLOGY
    17. Meijer, L; Thunnissen, AMWH; White, AW; Garnier, M; Nikolic, M; Tsai, LH; Walter, J; Cleverley, KE; Salinas, PC; Wu, YZ; Biernat, J; Mandelkow, EM; Kim, SH; Pettit, GR
      Inhibition of cyclin-dependent kinases, GSK-3 beta and CK1 by hymenialdisine, a marine sponge constituent

      CHEMISTRY & BIOLOGY
    18. Primot, A; Baratte, B; Gompel, M; Borgne, A; Liabeuf, S; Romette, JL; Jho, EH; Costantini, F; Meijer, L
      Purification of GSK-3 by affinity chromatography on immobilized axin

      PROTEIN EXPRESSION AND PURIFICATION
    19. Mermillod, P; Tomanek, M; Marchal, R; Meijer, L
      High developmental competence of cattle oocytes maintained at the germinalvesicle stage for 24 hours in culture by specific inhibition of MPF kinaseactivity

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    20. Kunick, C; Schultz, C; Lemcke, T; Zaharevitz, DW; Gussio, R; Jalluri, RK; Sausville, EA; Leost, M; Meijer, L
      2-substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    21. Jeong, HW; Kim, MR; Son, KH; Han, MY; Ha, JH; Garnier, M; Meijer, L; Kwon, BM
      Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    22. Corellou, F; Bisgrove, SR; Kropf, DL; Meijer, L; Kloareg, B; Bouget, FY
      A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes

      DEVELOPMENT
    23. Damiens, E; Meijer, L
      Chemical inhibitors of cyclin-dependent kinases: preclinical and clinical studies.

      PATHOLOGIE BIOLOGIE
    24. Andreani, A; Cavalli, A; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Recanatini, M; Garnier, M; Meijer, L
      Imidazo[2,1-b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition

      ANTI-CANCER DRUG DESIGN
    25. Gussio, R; Zaharevitz, DW; McGrath, CF; Pattabiraman, N; Kellogg, GE; Schultz, C; Link, A; Kunick, C; Leost, M; Meijer, L; Sausville, EA
      Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition

      ANTI-CANCER DRUG DESIGN
    26. Legraverend, M; Tunnah, P; Noble, M; Ducrot, P; Ludwig, O; Grierson, DS; Leost, M; Meijer, L; Endicott, J
      Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex

      JOURNAL OF MEDICINAL CHEMISTRY
    27. Le Roch, K; Sestier, C; Dorin, D; Waters, N; Kappes, B; Chakrabarti, D; Meijer, L; Doerig, C
      Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H - Functional characterization of a P. falciparum cyclin homologue

      JOURNAL OF BIOLOGICAL CHEMISTRY
    28. Okochi, M; Walter, J; Koyama, A; Nakajo, S; Baba, M; Iwatsubo, T; Meijer, L; Kahle, PJ; Haass, C
      Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

      JOURNAL OF BIOLOGICAL CHEMISTRY
    29. Tintignac, LA; Leibovitch, MP; Kitzmann, M; Fernandez, A; Ducommun, B; Meijer, L; Leibovitch, SA
      Cyclin E-Cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells

      EXPERIMENTAL CELL RESEARCH
    30. Leost, M; Schultz, C; Link, A; Wu, YZ; Biernat, J; Mandelkow, EM; Bibb, JA; Snyder, GL; Greengard, P; Zaharevitz, DW; Gussio, R; Senderowicz, AM; Sausville, EA; Kunick, C; Meijer, L
      Paullones are potent inhibitors of glycogen synthase kinase-3 beta and cyclin-dependent kinase 5/p25

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    31. Hoessel, R; Leclerc, S; Endicott, JA; Nobel, MEM; Lawrie, A; Tunnah, P; Leost, M; Damiens, E; Marie, D; Marko, D; Niederberger, E; Tang, WC; Eisenbrand, G; Meijer, L
      Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

      NATURE CELL BIOLOGY
    32. Chang, YT; Gray, NS; Rosania, GR; Sutherlin, DP; Kwon, S; Norman, TC; Sarohia, R; Leost, M; Meijer, L; Schultz, PG
      Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

      CHEMISTRY & BIOLOGY
    33. Legraverend, M; Ludwig, O; Bisagni, E; Leclerc, S; Meijer, L; Giocanti, N; Sadri, R; Favaudon, V
      Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors

      BIOORGANIC & MEDICINAL CHEMISTRY
    34. Gray, N; Detivaud, L; Doerig, C; Meijer, L
      ATP-site directed inhibitors of cyclin-dependent kinases

      CURRENT MEDICINAL CHEMISTRY
    35. Paterson, LA; Meijer, L; Bentley, MG
      Regulation of M-phase promoting factor (MPF) in Nereis virens oocytes during meiotic maturation

      INVERTEBRATE REPRODUCTION & DEVELOPMENT
    36. Borgne, A; Meijer, L
      The search for and potential therapeutic applications of chemical inhibitors of cyclin-dependent kinases

      M S-MEDECINE SCIENCES
    37. Collin, O; Meijer, L
      KID, a Kinase Inhibitor Database project

      PHARMACOLOGY & THERAPEUTICS
    38. Meijer, L; Leclerc, S; Leost, M
      Properties and potential applications of chemical inhibitors of cyclin-dependent kinases

      PHARMACOLOGY & THERAPEUTICS
    39. Sausville, EA; Zaharevitz, D; Gussio, R; Meijer, L; Louarn-Leost, M; Kunick, C; Schultz, R; Lahusen, T; Headlee, D; Stinson, S; Arbuck, SG; Senderowicz, A
      Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target

      PHARMACOLOGY & THERAPEUTICS
    40. Bibb, JA; Snyder, GL; Nishi, A; Yan, Z; Meijer, L; Fienberg, AA; Tsai, LH; Kwon, YT; Girault, JA; Czernik, AJ; Huganir, RL; Hemmings, HC; Nairn, AC; Greengard, P
      Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

      NATURE
    41. Schultz, C; Link, A; Leost, M; Zaharevitz, DW; Gussio, R; Sausville, EA; Meijer, L; Kunick, C
      Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity

      JOURNAL OF MEDICINAL CHEMISTRY
    42. Borgne, A; Ostvold, AC; Flament, S; Meijer, L
      Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase/metaphase transition

      JOURNAL OF BIOLOGICAL CHEMISTRY
    43. Detivaud, L; Pettit, GR; Meijer, L
      Characterization of a novel cdk1-related kinase

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    44. Zaharevitz, DW; Gussio, R; Leost, M; Senderowicz, AM; Lahusen, T; Kunick, C; Meijer, L; Sausville, EA
      Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases

      CANCER RESEARCH
    45. ROBERTS MH; VANBROCKLIN ML; DONALDSON JL; MEIJER L
      A NOVEL KINASE RELATED TO PCTAIRE-3 AND INVOLVED IN THE REGULATION OFCIRCADIAN-RHYTHMS

      Molecular biology of the cell
    46. LEGRAVEREND M; LUDWIG O; BISAGNI E; LECLERC S; MEIJER L
      SYNTHESIS OF C2 ALKYNYLATED PURINES, A NEW FAMILY OF POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES

      Bioorganic & medicinal chemistry letters
    47. MEIJER L; LECLERC S; LEOST M
      CYCLIN-DEPENDENT KINASES AS MOLECULAR TARGETS IN SCREENING FOR NEW ANTI-MITOTIC AGENTS

      Annals of oncology
    48. MEIJER L; LECLERC S; LEOST M
      CYCLIN-DEPENDENT KINASES AS MOLECULAR TARGETS IN SCREENING FOR NEW ANTI-MITOTIC AGENTS

      Annals of oncology
    49. COX GB; WALKER RD; FRENG SA; SHORT BA; MEIJER L; GILCHRIST L
      OUTCOME OF A CONTROLLED TRIAL OF THE EFFECTIVENESS OF INTENSIVE CASE-MANAGEMENT FOR CHRONIC PUBLIC INEBRIATES

      Journal of studies on alcohol
    50. GRAY NS; WODICKA L; THUNNISSEN AMWH; NORMAN TC; KWON SJ; ESPINOZA FH; MORGAN DO; BARNES G; LECLERC S; MEIJER L; KIM SH; LOCKHART DJ; SCHULTZ PG
      EXPLOITING CHEMICAL LIBRARIES, STRUCTURE, AND GENOMICS IN THE SEARCH FOR KINASE INHIBITORS

      Science
    51. Alessi, F; Quarta, S; Savio, M; Riva, F; Rossi, L; Stivala, LA; Scovassi, AI; Meijer, L; Prosperi, E
      The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity

      EXPERIMENTAL CELL RESEARCH
    52. ROBERTS MH; MEIJER L
      PURIFICATION OF A MOLLUSCAN OCULAR PROTEIN RELATED TO THE CYCLIN-DEPENDENT-KINASES (CDKS) AND INVOLVED IN CIRCADIAN-RHYTHM REGULATION

      Molecular biology of the cell
    53. AN B; DINELEY KE; ZHANG LL; TERMIN TA; MEIJER L; DOU QP
      INVOLVEMENT OF RB KINASES AND PHOSPHATASES IN LIFE AND DEATH DECISIONS

      Oncology Reports
    54. PLANCHAIS S; GLAB N; TREHIN C; PERENNES C; BUREAU JM; MEIJER L; BERGOUNIOUX C
      ROSCOVITINE, A NOVEL CYCLIN-DEPENDENT KINASE INHIBITOR, CHARACTERIZESRESTRICTION POINT AND G2 M TRANSITION IN TOBACCO BY-2 CELL-SUSPENSION/

      Plant journal
    55. KRUCHER NA; MEIJER L; ROBERTS MH
      THE CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS, OLOMOUCINE AND ROSCOVITINE, ALTER THE EXPRESSION OF A MOLLUSCAN CIRCADIAN PACEMAKER

      Cellular and molecular neurobiology
    56. STIVALA LA; CAZZALINI O; VANNINI V; SCOVASSI IA; MEIJER L; PROSPERI E
      THE CYCLIN-DEPENDENT KINASE INHIBITORS OLOMOUCINE AND ROSCOVITINE ARREST HUMAN FIBROBLASTS IN G1 PHASE AT A DIFFERENT POINT THAN STAUROSPORINE

      European journal of cell biology
    57. HAVLICEK L; HANUS J; VESELY J; LECLERC S; MEIJER L; SHAW G; STRNAD M
      CYTOKININ-DERIVED CYCLIN-DEPENDENT KINASE INHIBITORS - SYNTHESIS AND CDC2 INHIBITORY ACTIVITY OF OLOMOUCINE AND RELATED-COMPOUNDS

      Journal of medicinal chemistry
    58. PIPPIN JW; QU QY; MEIJER L; SHANKLAND SJ
      DIRECT IN-VIVO INHIBITION OF THE NUCLEAR-CELL CYCLE CASCADE IN EXPERIMENTAL MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS WITH ROSCOVITINE, A NOVEL CYCLIN-DEPENDENT KINASE ANTAGONIST

      The Journal of clinical investigation
    59. SCHUTTE B; NIELAND L; VANENGELAND M; HENFLING MER; MEIJER L; RAMAEKERS FCS
      THE EFFECT OF THE CYCLIN-DEPENDENT KINASE INHIBITOR OLOMOUCINE ON CELL-CYCLE KINETICS

      Experimental cell research
    60. DEAZEVEDO WF; LECLERC S; MEIJER L; HAVLICEK L; STRNAD M; KIM SH
      INHIBITION OF CYCLIN-DEPENDENT KINASES BY PURINE ANALOGS - CRYSTAL-STRUCTURE OF HUMAN CDK2 COMPLEXED WITH ROSCOVITINE

      European journal of biochemistry
    61. MEIJER L; BORGNE A; MULNER O; CHONG JPJ; BLOW JJ; INAGAKI N; INAGAKI M; DELCROS JG; MOULINOUX JP
      BIOCHEMICAL AND CELLULAR EFFECTS OF ROSCOVITINE, A POTENT AND SELECTIVE INHIBITOR OF THE CYCLIN-DEPENDENT KINASES CDC2, CDK2 AND CDK5

      European journal of biochemistry
    62. ROBERTS MH; KRUCHER NA; MEIJER L
      CYCLIN-DEPENDENT KINASES (CDKS) AND THE REGULATION OF CIRCADIAN-RHYTHMS

      Molecular biology of the cell
    63. MEIJER L
      CHEMICAL INHIBITORS OF CYCLIN-DEPENDENT KINASES

      Trends in cell biology
    64. BORGNE A; MEIJER L
      SEQUENTIAL DEPHOSPHORYLATION OF P34(CDC2) ON THR-14 AND TYR-15 AT THEPROPHASE METAPHASE TRANSITION/

      The Journal of biological chemistry
    65. SCHULZEGAHMEN U; BRANDSEN J; JONES HD; MORGAN DO; MEIJER L; VESELY J; KIM SH
      MULTIPLE-MODES OF LIGAND RECOGNITION - CRYSTAL-STRUCTURES OF CYCLIN-DEPENDENT PROTEIN-KINASE-2 IN COMPLEX WITH ATP AND 2 INHIBITORS, OLOMOUCINE AND ISOPENTENYLADENINE

      Proteins
    66. ABRAHAM RT; ACQUARONE M; ANDERSEN A; ASENSI A; BELLE R; BERGER F; BERGOUNIOUX C; BRUNN G; BUQUETFAGOT C; FAGOT D; GLAB N; GOUDEAU H; GOUDEAU M; GUERRIER P; HOUGHTON P; HENDRIKS H; KLOAREG B; LIPPAI M; MARIE D; MARO B; MEIJER L; MESTER J; MULNERLORILLON O; POULET SA; SCHIERENBERG E; SCHUTTE B; VAULOT D; VERLHAC MH
      CELLULAR EFFECTS OF OLOMOUCINE, AN INHIBITOR OF CYCLIN-DEPENDENT KINASES

      Biology of the cell
    67. POULET SA; IANORA A; MIRALTO A; MEIJER L
      DO DIATOMS ARREST EMBRYONIC-DEVELOPMENT IN COPEPODS

      Marine ecology. Progress series
    68. LOYER P; GLAISE D; CARIOU S; BAFFET G; MEIJER L; GUGUENGUILLOUZO C
      EXPRESSION AND ACTIVATION OF CDK-1 AND CDK-2 AND CYCLINS IN THE CELL-CYCLE PROGRESSION DURING LIVER-REGENERATION

      The Journal of biological chemistry
    69. AZZI L; MEIJER L; OSTVOLD AC; LEW J; WANG JH
      PURIFICATION OF A 15-KDA CDK4-BINDING AND CDK5-BINDING PROTEIN

      The Journal of biological chemistry
    70. GLAB N; LABIDI B; QIN LX; TREHIN C; BERGOUNIOUX C; MEIJER L
      OLOMOUCINE, AN INHIBITOR OF THE CDC2 CDK2 KINASES ACTIVITY, BLOCKS PLANT-CELLS AT THE G1 TO S AND G2 TO M CELL-CYCLE TRANSITIONS/

      FEBS letters
    71. VESELY J; HAVLICEK L; STRNAD M; BLOW JJ; DONELLADEANA A; PINNA L; LETHAM DS; KATO J; DETIVAUD L; LECLERC S; MEIJER L
      INHIBITION OF CYCLIN-DEPENDENT KINASES BY PURINE ANALOGS

      European journal of biochemistry
    72. HENKENS K; MEIJER L; SIEGERS J
      THE LABOR SUPPLY OF MARRIED AND COHABITING WOMEN IN THE NETHERLANDS, 1981-1989

      European journal of population


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Documento generato il 26/01/21 alle ore 22:54:11