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1. Hom, GJ; Forrest, MJ; Bach, TJ; Brady, E; Candelore, MR; Cascieri, MA; Fletcher, DJ; Fisher, MH; Iliff, SA; Mathvink, R; Metzger, J; Pecore, V; Saperstein, R; Shih, T; Weber, AE; Wyvratt, M; Zafian, P; Macintyre, DE
   beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, racial flushing, and reflex tachycardia in anesthetized rhesus monkeys
   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
   
   G.J. Hom et al., "beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, racial flushing, and reflex tachycardia in anesthetized rhesus monkeys", J PHARM EXP, 297(1), 2001, pp. 299-307
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   A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor
   JOURNAL OF MEDICINAL CHEMISTRY
   
   R.J. DeVita et al., "A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor", J MED CHEM, 44(6), 2001, pp. 917-922
3. Chen, AS; Marsh, DJ; Trumbauer, ME; Frazier, EG; Guan, XM; Yu, H; Rosenblum, CI; Vongs, A; Feng, Y; Cao, LH; Metzger, JM; Strack, AM; Camacho, RE; Mellin, TN; Nunes, CN; Min, W; Fisher, J; Gopal-Truter, S; MacIntyre, DE; Chen, HY; Van der Ploeg, LHT
   Inactivation of the mouse melanocortin-3 receptor results in increased fatmass and reduced lean body mass
   NATURE GENETICS
   
   A.S. Chen et al., "Inactivation of the mouse melanocortin-3 receptor results in increased fatmass and reduced lean body mass", NAT GENET, 26(1), 2000, pp. 97-102
4. Chen, AS; Metzger, JM; Trumbauer, ME; Guan, XM; Yu, H; Frazier, EG; Marsh, DJ; Forrest, MJ; Gopal-Truter, S; Fisher, J; Camacho, RE; Strack, AM; Mellin, TN; MacIntyre, DE; Chen, HY; Van der Ploeg, LHT
   Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
   TRANSGENIC RESEARCH
   
   A.S. Chen et al., "Role of the melanocortin-4 receptor in metabolic rate and food intake in mice", TRANSGEN RE, 9(2), 2000, pp. 145-154
5. Brockunier, LL; Parmee, ER; Ok, HO; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
   Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   L.L. Brockunier et al., "Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides", BIOORG MED, 10(18), 2000, pp. 2111-2114
6. Mathvink, RJ; Tolman, JS; Chitty, D; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
   Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   R.J. Mathvink et al., "Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore", BIOORG MED, 10(17), 2000, pp. 1971-1973
7. Ok, HO; Reigle, LB; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, L; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Strader, CD; Tota, L; Wang, P; Wyvratt, MJ; Fisher, MH; Weber, AE
   Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   H.O. Ok et al., "Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists", BIOORG MED, 10(14), 2000, pp. 1531-1534
8. Feng, DQD; Biftu, T; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Strader, CD; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
   Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   D.Q.D. Feng et al., "Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist", BIOORG MED, 10(13), 2000, pp. 1427-1429
9. Biftu, T; Feng, DD; Liang, GB; Kuo, H; Qian, XX; Naylor, EM; Colandrea, VJ; Candelore, MR; Cascieri, MA; Colwell, LF; Forrest, MJ; Hom, GJ; MacIntyre, DE; Stearns, RA; Strader, CD; Wyvratt, MJ; Fisher, MH; Weber, AE
   Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents
   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   
   T. Biftu et al., "Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents", BIOORG MED, 10(13), 2000, pp. 1431-1434
10. Tattersall, FD; Rycroft, W; Cumberbatch, M; Mason, G; Tye, S; Williamson, DJ; Hale, JJ; Mills, SG; Finke, PE; MacCoss, M; Sadowski, S; Ber, E; Cascieri, M; Hill, RG; MacIntyre, DE; Hargreaves, RJ
    The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L758,298, inhibit acute and delayed cisplatin-inducedemesis in ferrets
    NEUROPHARMACOLOGY
    
    F.D. Tattersall et al., "The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L758,298, inhibit acute and delayed cisplatin-inducedemesis in ferrets", NEUROPHARM, 39(4), 2000, pp. 652-663
11. Hale, JJ; Mills, SG; MacCoss, M; Dorn, CP; Finke, PE; Budhu, RJ; Reamer, RA; Huskey, SEW; Luffer-Atlas, D; Dean, BJ; McGowan, EM; Feeney, WP; Chiu, SHL; Cascieri, MA; Chicchi, GG; Kurtz, MM; Sadowski, S; Ber, E; Tattersall, FD; Rupniak, NMJ; Williams, AR; Rycroft, W; Hargreaves, R; Metzger, JM; MacIntyre, DE
    Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs
    JOURNAL OF MEDICINAL CHEMISTRY
    
    J.J. Hale et al., "Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs", J MED CHEM, 43(6), 2000, pp. 1234-1241
12. Mathvink, RJ; Tolman, JS; Chitty, D; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
    Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
    JOURNAL OF MEDICINAL CHEMISTRY
    
    R.J. Mathvink et al., "Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide", J MED CHEM, 43(21), 2000, pp. 3832-3836
13. Shih, TL; Candelore, MR; Cascieri, MA; Chiu, SHL; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Strader, CD; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
    L-770,644: A potent and selective human beta(3) adrenergic receptor agonist with improved oral bioavailability
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    T.L. Shih et al., "L-770,644: A potent and selective human beta(3) adrenergic receptor agonist with improved oral bioavailability", BIOORG MED, 9(9), 1999, pp. 1251-1254
14. Parmee, ER; Naylor, EM; Perkins, L; Colandrea, VJ; Ok, HO; Candelore, MR; Cascieri, MA; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Strader, CD; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
    Human beta(3) adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    E.R. Parmee et al., "Human beta(3) adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides", BIOORG MED, 9(5), 1999, pp. 749-754
15. Naylor, EM; Parmee, ER; Colandrea, VJ; Perkins, L; Brockunier, L; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Strader, CD; Tota, L; Wang, PR; Wyvratt, MJ; Fisher, MH; Weber, AE
    Human beta(3) adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
    E.M. Naylor et al., "Human beta(3) adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides", BIOORG MED, 9(5), 1999, pp. 755-758
16. Meurer, RD; Forrest, MJ; MacIntyre, DE
    The effects of IB4, a monoclonal antibody to the CD18 leukocyte integrin on phorbol myristate acetate (PMA)-induced polymorphonuclear leukocyte (PMN)accumulation and endothelial injury in rabbit lungs
    INFLAMMATION
    
    R.D. Meurer et al., "The effects of IB4, a monoclonal antibody to the CD18 leukocyte integrin on phorbol myristate acetate (PMA)-induced polymorphonuclear leukocyte (PMN)accumulation and endothelial injury in rabbit lungs", INFLAMMATIO, 23(1), 1999, pp. 51-62
17. Varnerin, JP; Smith, T; Rosenblum, CI; Vongs, A; Murphy, BA; Nunes, C; Mellin, TN; King, JJ; Burgess, BW; Junker, B; Chou, M; Hey, P; Frazier, E; MacIntyre, DE; Van der Ploeg, LHT; Tota, MR
    Production of leptin in Escherichia coli: A comparison of methods
    PROTEIN EXPRESSION AND PURIFICATION
    
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18. NAYLOR EM; COLANDREA VJ; CANDELORE MR; CASCIERI MA; COLWELL LF; DENG LP; FEENEY WP; FORREST MJ; HOM GJ; MACINTYRE DE; STRADER CD; TOTA L; WANG PR; WYVRATT MJ; FISHER MH; WEBER AE
    3-PYRIDYLETHANOLAMINES - POTENT AND SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONISTS
    Bioorganic & medicinal chemistry letters
    
    E.M. Naylor et al., "3-PYRIDYLETHANOLAMINES - POTENT AND SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONISTS", Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3087-3092
19. WEBER AE; OK HO; ALVARO RF; CANDELORE MR; CASCIERI MA; CHIU SHL; DENG LP; FORREST MJ; HOM GJ; HUTCHINS JE; KAO J; MACINTYRE DE; MATHVINK RJ; MCLOUGHLIN D; MILLER RR; NEWBOLD RC; OLAH TV; PARMEE ER; PERKINS L; STEARNS RA; STRADER CD; SZUMILOSKI J; TANG YS; TOTA L; VICARIO PP; WYVRATT MJ; FISHER MH
    3-PYRIDYLOXYPROPANOLAMINE AGONISTS OF THE BETA(3) ADRENERGIC-RECEPTORWITH IMPROVED PHARMACOKINETIC PROPERTIES
    Bioorganic & medicinal chemistry letters
    
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20. Murphy, B; Nunes, CN; Ronan, JJ; Harper, CM; Beall, MJ; Hanaway, M; Fairhurst, AM; Van der Ploeg, LHT; MacIntyre, DE; Mellin, TN
    Melanocortin mediated inhibition of feeding behavior in rats
    NEUROPEPTIDES
    
    B. Murphy et al., "Melanocortin mediated inhibition of feeding behavior in rats", NEUROPEPTID, 32(6), 1998, pp. 491-497
21. VICARIO PP; CANDELORE MR; SCHAEFFER MT; KELLY L; THOMPSON GM; BRADY EJ; SAPERSTEIN R; MACINTYRE DE; TOTA LM; CASCIERI MA
    DESENSITIZATION OF BETA(3)-ADRENERGIC RECEPTOR-STIMULATED ADENYLYL-CYCLASE ACTIVITY AND LIPOLYSIS IN RATS
    Life sciences
    
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22. FLETCHER DS; CANDELORE MR; GRUJIC D; LOWELL BB; LUELL S; SUSULIC VS; MACINTYRE DE
    BETA-3 ADRENERGIC-RECEPTOR AGONISTS CAUSE AN INCREASE IN GASTROINTESTINAL TRANSIT-TIME IN WILD-TYPE MICE, BUT NOT IN MICE LACKING THE BETA-3 ADRENERGIC-RECEPTOR
    The Journal of pharmacology and experimental therapeutics
    
    D.S. Fletcher et al., "BETA-3 ADRENERGIC-RECEPTOR AGONISTS CAUSE AN INCREASE IN GASTROINTESTINAL TRANSIT-TIME IN WILD-TYPE MICE, BUT NOT IN MICE LACKING THE BETA-3 ADRENERGIC-RECEPTOR", The Journal of pharmacology and experimental therapeutics, 287(2), 1998, pp. 720-724
23. HALE JJ; MILLS SG; MACCOSS M; FINKE PE; CASCIERI MA; SADOWSKI S; BER E; CHICCHI GG; KURTZ M; METZGER J; EIERMANN G; TSOU NN; TATTERSALL FD; RUPNIAK NMJ; WILLIAMS AR; RYCROFT W; HARGREAVES R; MACINTYRE DE
    STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST
    Journal of medicinal chemistry
    
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24. STEVENSON GI; HUSCROFT I; MACLEOD AM; SWAIN CJ; CASCIERI MA; CHICCHI GG; GRAHAM MI; HARRISON T; KELLEHER FJ; KURTZ M; LADDUWAHETTY T; MERCHANT KJ; METZGER JM; MACINTYRE DE; SADOWSKI S; SOHAL B; OWENS AP
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25. FISHER MH; AMEND AM; BACH TJ; BARKER JM; BRADY EJ; CANDELORE MR; CARROLL D; CASCIERI MA; CHIU SHL; DENG LP; FORREST MJ; HEGARTYFRISCINO B; GUAN XM; HOM GJ; HUTCHINS JE; KELLY LJ; MATHVINK RJ; METZGER JM; MILLER RR; OK HO; PARMEE ER; SAPERSTEIN R; STRADER CD; STEARNS RA; THOMPSON GM; TOTA L; VICARIO PP; WEBER AE; WOODS JW; WYVRATT MJ; ZAFIAN PT; MACINTYRE DE
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26. CHALLET E; NAYLOR E; METZGER JM; MACINTYRE DE; TUREK FW
    AN NK1 RECEPTOR ANTAGONIST AFFECTS THE CIRCADIAN REGULATION OF LOCOMOTOR-ACTIVITY IN GOLDEN-HAMSTERS
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27. STRADER CD; MACINTYRE DE; CANDELORE MR; PARKER EM
    MOLECULAR APPROACHES TO THE DISCOVERY OF NEW TREATMENTS FOR OBESITY
    CURRENT OPINION IN CHEMICAL BIOLOGY
    
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28. SWAIN CJ; WILLIAMS BJ; BAKER R; CASCIERI MA; CHICCHI G; FORREST M; HERBERT R; KEOWN L; LADDUWAHETTY T; LUELL S; MACINTYRE DE; METZGER J; MORTON S; OWENS AP; SADOWSKI S; WATT AP
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29. TATTERSALL FD; RYCROFT W; FRANCIS B; PEARCE D; MERCHANT K; MACLEOD AM; LADDUWAHETTY T; KEOWN L; SWAIN C; BAKER R; CASCIERI M; BER E; METZGER J; MACINTYRE DE; HILL RG; HARGREAVES RJ
    TACHYKININ NK1 RECEPTOR ANTAGONISTS ACT CENTRALLY TO INHIBIT EMESIS INDUCED BY THE CHEMOTHERAPEUTIC AGENT CISPLATIN IN FERRETS
    Neuropharmacology
    
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30. HALE JJ; MILLS SG; MACCOSS M; SHAH SK; QI HB; MATHRE DJ; CASCIERI MA; SADOWSKI S; STRADER CD; MACINTYRE DE; METZGER JM
    NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST
    Journal of medicinal chemistry
    
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31. LADDUWAHETTY T; BAKER R; CASCIERI MA; CHAMBERS MS; HAWORTH K; KEOWN LE; MACINTYRE DE; METZGER JM; OWEN S; RYCROFT W; SADOWSKI S; SEWARD EM; SHEPHEARD SL; SWAIN CJ; TATTERSALL FD; WATT AP; WILLIAMSON DW; HARGREAVES RJ
    N-HETEROARYL-2-PHENYL-3-(BENZYLOXY)PIPERIDINES - A NOVEL CLASS OF POTENT ORALLY-ACTIVE HUMAN NK1 ANTAGONISTS
    Journal of medicinal chemistry
    
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    A SYNTHETIC INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING-ENZYME PREVENTS ENDOTOXIN-INDUCED INTERLEUKIN-1-BETA PRODUCTION IN-VITRO AND IN-VIVO
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33. HOM GJ; GRANT SK; WOLFE G; BACH TJ; MACINTYRE DE; HUTCHINSON NI
    LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION AND VASCULAR HYPOREACTIVITY INTHE RAT - TISSUE-ANALYSIS OF NITRIC-OXIDE SYNTHASE MESSENGER-RNA AND PROTEIN EXPRESSION IN THE PRESENCE AND ABSENCE OF DEXAMETHASONE, N-G-MONOMETHYL-L-ARGININE OR INDOMETHACIN
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34. MACLEOD AM; CASCIERI MA; MERCHANT KJ; SADOWSKI S; HARDWICKE S; LEWIS RT; MACINTYRE DE; METZGER JM; FONG TM; SHEPHEARD S; TATTERSALL FD; HARGREAVES R; BAKER R
    SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN
    Journal of medicinal chemistry
    
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    IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANEHUMAN NK1 ANTAGONISTS
    Journal of medicinal chemistry
    
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36. MACLEOD M; MERCHANT KJ; BROOKFIELD F; KELLEHER F; STEVENSON G; OWENS AP; SWAIN CJ; BAKER R; CASCIERI MA; SADOWSKI S; BER E; STRADER CD; MACINTYRE DE; METZGER JM; BALL RG
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    Journal of medicinal chemistry
    
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37. HWANG SB; LAM MH; SZALKOWSKI DM; MACINTYRE DE; BACH TJ; LUELL S; MEUER R; SAHOO SP; ALBERTS AW; CHABALA JC
    MK 287 - A POTENT, SPECIFIC, AND ORALLY-ACTIVE RECEPTOR ANTAGONIST OFPLATELET-ACTIVATING-FACTOR
    Journal of lipid mediators
    
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38. MEURER R; VANRIPER G; FEENEY W; CUNNINGHAM P; HORA D; SPRINGER MS; MACINTYRE DE; ROSEN H
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