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    1. Hom, GJ; Forrest, MJ; Bach, TJ; Brady, E; Candelore, MR; Cascieri, MA; Fletcher, DJ; Fisher, MH; Iliff, SA; Mathvink, R; Metzger, J; Pecore, V; Saperstein, R; Shih, T; Weber, AE; Wyvratt, M; Zafian, P; Macintyre, DE
      beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, racial flushing, and reflex tachycardia in anesthetized rhesus monkeys

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    2. DeVita, RJ; Walsh, TF; Young, JR; Jiang, JL; Ujjainwalla, F; Toupence, RB; Parikh, M; Huang, SX; Fair, JA; Goulet, MT; Wyvratt, MJ; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Cui, JS; Mount, G; Rohrer, SP; Schaeffer, JM; Rhodes, L; Drisko, JE; McGowan, E; MacIntyre, DE; Vincent, S; Carlin, JR; Cameron, J; Smith, RG
      A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor

      JOURNAL OF MEDICINAL CHEMISTRY
    3. Chen, AS; Marsh, DJ; Trumbauer, ME; Frazier, EG; Guan, XM; Yu, H; Rosenblum, CI; Vongs, A; Feng, Y; Cao, LH; Metzger, JM; Strack, AM; Camacho, RE; Mellin, TN; Nunes, CN; Min, W; Fisher, J; Gopal-Truter, S; MacIntyre, DE; Chen, HY; Van der Ploeg, LHT
      Inactivation of the mouse melanocortin-3 receptor results in increased fatmass and reduced lean body mass

      NATURE GENETICS
    4. Chen, AS; Metzger, JM; Trumbauer, ME; Guan, XM; Yu, H; Frazier, EG; Marsh, DJ; Forrest, MJ; Gopal-Truter, S; Fisher, J; Camacho, RE; Strack, AM; Mellin, TN; MacIntyre, DE; Chen, HY; Van der Ploeg, LHT
      Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

      TRANSGENIC RESEARCH
    5. Brockunier, LL; Parmee, ER; Ok, HO; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
      Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    6. Mathvink, RJ; Tolman, JS; Chitty, D; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
      Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    7. Ok, HO; Reigle, LB; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, L; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Strader, CD; Tota, L; Wang, P; Wyvratt, MJ; Fisher, MH; Weber, AE
      Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    8. Feng, DQD; Biftu, T; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Strader, CD; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
      Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    9. Biftu, T; Feng, DD; Liang, GB; Kuo, H; Qian, XX; Naylor, EM; Colandrea, VJ; Candelore, MR; Cascieri, MA; Colwell, LF; Forrest, MJ; Hom, GJ; MacIntyre, DE; Stearns, RA; Strader, CD; Wyvratt, MJ; Fisher, MH; Weber, AE
      Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    10. Tattersall, FD; Rycroft, W; Cumberbatch, M; Mason, G; Tye, S; Williamson, DJ; Hale, JJ; Mills, SG; Finke, PE; MacCoss, M; Sadowski, S; Ber, E; Cascieri, M; Hill, RG; MacIntyre, DE; Hargreaves, RJ
      The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L758,298, inhibit acute and delayed cisplatin-inducedemesis in ferrets

      NEUROPHARMACOLOGY
    11. Hale, JJ; Mills, SG; MacCoss, M; Dorn, CP; Finke, PE; Budhu, RJ; Reamer, RA; Huskey, SEW; Luffer-Atlas, D; Dean, BJ; McGowan, EM; Feeney, WP; Chiu, SHL; Cascieri, MA; Chicchi, GG; Kurtz, MM; Sadowski, S; Ber, E; Tattersall, FD; Rupniak, NMJ; Williams, AR; Rycroft, W; Hargreaves, R; Metzger, JM; MacIntyre, DE
      Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs

      JOURNAL OF MEDICINAL CHEMISTRY
    12. Mathvink, RJ; Tolman, JS; Chitty, D; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
      Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

      JOURNAL OF MEDICINAL CHEMISTRY
    13. Shih, TL; Candelore, MR; Cascieri, MA; Chiu, SHL; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Strader, CD; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
      L-770,644: A potent and selective human beta(3) adrenergic receptor agonist with improved oral bioavailability

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    14. Parmee, ER; Naylor, EM; Perkins, L; Colandrea, VJ; Ok, HO; Candelore, MR; Cascieri, MA; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Miller, RR; Stearns, RA; Strader, CD; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE
      Human beta(3) adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    15. Naylor, EM; Parmee, ER; Colandrea, VJ; Perkins, L; Brockunier, L; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, LP; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Strader, CD; Tota, L; Wang, PR; Wyvratt, MJ; Fisher, MH; Weber, AE
      Human beta(3) adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    16. Meurer, RD; Forrest, MJ; MacIntyre, DE
      The effects of IB4, a monoclonal antibody to the CD18 leukocyte integrin on phorbol myristate acetate (PMA)-induced polymorphonuclear leukocyte (PMN)accumulation and endothelial injury in rabbit lungs

      INFLAMMATION
    17. Varnerin, JP; Smith, T; Rosenblum, CI; Vongs, A; Murphy, BA; Nunes, C; Mellin, TN; King, JJ; Burgess, BW; Junker, B; Chou, M; Hey, P; Frazier, E; MacIntyre, DE; Van der Ploeg, LHT; Tota, MR
      Production of leptin in Escherichia coli: A comparison of methods

      PROTEIN EXPRESSION AND PURIFICATION
    18. NAYLOR EM; COLANDREA VJ; CANDELORE MR; CASCIERI MA; COLWELL LF; DENG LP; FEENEY WP; FORREST MJ; HOM GJ; MACINTYRE DE; STRADER CD; TOTA L; WANG PR; WYVRATT MJ; FISHER MH; WEBER AE
      3-PYRIDYLETHANOLAMINES - POTENT AND SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONISTS

      Bioorganic & medicinal chemistry letters
    19. WEBER AE; OK HO; ALVARO RF; CANDELORE MR; CASCIERI MA; CHIU SHL; DENG LP; FORREST MJ; HOM GJ; HUTCHINS JE; KAO J; MACINTYRE DE; MATHVINK RJ; MCLOUGHLIN D; MILLER RR; NEWBOLD RC; OLAH TV; PARMEE ER; PERKINS L; STEARNS RA; STRADER CD; SZUMILOSKI J; TANG YS; TOTA L; VICARIO PP; WYVRATT MJ; FISHER MH
      3-PYRIDYLOXYPROPANOLAMINE AGONISTS OF THE BETA(3) ADRENERGIC-RECEPTORWITH IMPROVED PHARMACOKINETIC PROPERTIES

      Bioorganic & medicinal chemistry letters
    20. Murphy, B; Nunes, CN; Ronan, JJ; Harper, CM; Beall, MJ; Hanaway, M; Fairhurst, AM; Van der Ploeg, LHT; MacIntyre, DE; Mellin, TN
      Melanocortin mediated inhibition of feeding behavior in rats

      NEUROPEPTIDES
    21. VICARIO PP; CANDELORE MR; SCHAEFFER MT; KELLY L; THOMPSON GM; BRADY EJ; SAPERSTEIN R; MACINTYRE DE; TOTA LM; CASCIERI MA
      DESENSITIZATION OF BETA(3)-ADRENERGIC RECEPTOR-STIMULATED ADENYLYL-CYCLASE ACTIVITY AND LIPOLYSIS IN RATS

      Life sciences
    22. FLETCHER DS; CANDELORE MR; GRUJIC D; LOWELL BB; LUELL S; SUSULIC VS; MACINTYRE DE
      BETA-3 ADRENERGIC-RECEPTOR AGONISTS CAUSE AN INCREASE IN GASTROINTESTINAL TRANSIT-TIME IN WILD-TYPE MICE, BUT NOT IN MICE LACKING THE BETA-3 ADRENERGIC-RECEPTOR

      The Journal of pharmacology and experimental therapeutics
    23. HALE JJ; MILLS SG; MACCOSS M; FINKE PE; CASCIERI MA; SADOWSKI S; BER E; CHICCHI GG; KURTZ M; METZGER J; EIERMANN G; TSOU NN; TATTERSALL FD; RUPNIAK NMJ; WILLIAMS AR; RYCROFT W; HARGREAVES R; MACINTYRE DE
      STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST

      Journal of medicinal chemistry
    24. STEVENSON GI; HUSCROFT I; MACLEOD AM; SWAIN CJ; CASCIERI MA; CHICCHI GG; GRAHAM MI; HARRISON T; KELLEHER FJ; KURTZ M; LADDUWAHETTY T; MERCHANT KJ; METZGER JM; MACINTYRE DE; SADOWSKI S; SOHAL B; OWENS AP
      4,4-DISUBSTITUTED PIPERIDINE HIGH-AFFINITY NK1 ANTAGONISTS - STRUCTURE-ACTIVITY-RELATIONSHIPS AND IN-VIVO ACTIVITY

      Journal of medicinal chemistry
    25. FISHER MH; AMEND AM; BACH TJ; BARKER JM; BRADY EJ; CANDELORE MR; CARROLL D; CASCIERI MA; CHIU SHL; DENG LP; FORREST MJ; HEGARTYFRISCINO B; GUAN XM; HOM GJ; HUTCHINS JE; KELLY LJ; MATHVINK RJ; METZGER JM; MILLER RR; OK HO; PARMEE ER; SAPERSTEIN R; STRADER CD; STEARNS RA; THOMPSON GM; TOTA L; VICARIO PP; WEBER AE; WOODS JW; WYVRATT MJ; ZAFIAN PT; MACINTYRE DE
      A SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONIST INCREASES METABOLIC-RATE IN RHESUS-MONKEYS

      The Journal of clinical investigation
    26. CHALLET E; NAYLOR E; METZGER JM; MACINTYRE DE; TUREK FW
      AN NK1 RECEPTOR ANTAGONIST AFFECTS THE CIRCADIAN REGULATION OF LOCOMOTOR-ACTIVITY IN GOLDEN-HAMSTERS

      Brain research
    27. STRADER CD; MACINTYRE DE; CANDELORE MR; PARKER EM
      MOLECULAR APPROACHES TO THE DISCOVERY OF NEW TREATMENTS FOR OBESITY

      CURRENT OPINION IN CHEMICAL BIOLOGY
    28. SWAIN CJ; WILLIAMS BJ; BAKER R; CASCIERI MA; CHICCHI G; FORREST M; HERBERT R; KEOWN L; LADDUWAHETTY T; LUELL S; MACINTYRE DE; METZGER J; MORTON S; OWENS AP; SADOWSKI S; WATT AP
      3-BENZYLOXY-2-PHENYLPIPERIDINE NK1 ANTAGONISTS - THE INFLUENCE OF ALPHA-METHYL SUBSTITUTION

      Bioorganic & medicinal chemistry letters
    29. TATTERSALL FD; RYCROFT W; FRANCIS B; PEARCE D; MERCHANT K; MACLEOD AM; LADDUWAHETTY T; KEOWN L; SWAIN C; BAKER R; CASCIERI M; BER E; METZGER J; MACINTYRE DE; HILL RG; HARGREAVES RJ
      TACHYKININ NK1 RECEPTOR ANTAGONISTS ACT CENTRALLY TO INHIBIT EMESIS INDUCED BY THE CHEMOTHERAPEUTIC AGENT CISPLATIN IN FERRETS

      Neuropharmacology
    30. HALE JJ; MILLS SG; MACCOSS M; SHAH SK; QI HB; MATHRE DJ; CASCIERI MA; SADOWSKI S; STRADER CD; MACINTYRE DE; METZGER JM
      NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST

      Journal of medicinal chemistry
    31. LADDUWAHETTY T; BAKER R; CASCIERI MA; CHAMBERS MS; HAWORTH K; KEOWN LE; MACINTYRE DE; METZGER JM; OWEN S; RYCROFT W; SADOWSKI S; SEWARD EM; SHEPHEARD SL; SWAIN CJ; TATTERSALL FD; WATT AP; WILLIAMSON DW; HARGREAVES RJ
      N-HETEROARYL-2-PHENYL-3-(BENZYLOXY)PIPERIDINES - A NOVEL CLASS OF POTENT ORALLY-ACTIVE HUMAN NK1 ANTAGONISTS

      Journal of medicinal chemistry
    32. FLETCHER DS; AGARWAL L; CHAPMAN KT; CHIN J; EGGER LA; LIMJUCO G; LUELL S; MACINTYRE DE; PETERSON EP; THORNBERRY NA; KOSTURA MJ
      A SYNTHETIC INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING-ENZYME PREVENTS ENDOTOXIN-INDUCED INTERLEUKIN-1-BETA PRODUCTION IN-VITRO AND IN-VIVO

      Journal of interferon & cytokine research
    33. HOM GJ; GRANT SK; WOLFE G; BACH TJ; MACINTYRE DE; HUTCHINSON NI
      LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION AND VASCULAR HYPOREACTIVITY INTHE RAT - TISSUE-ANALYSIS OF NITRIC-OXIDE SYNTHASE MESSENGER-RNA AND PROTEIN EXPRESSION IN THE PRESENCE AND ABSENCE OF DEXAMETHASONE, N-G-MONOMETHYL-L-ARGININE OR INDOMETHACIN

      The Journal of pharmacology and experimental therapeutics
    34. MACLEOD AM; CASCIERI MA; MERCHANT KJ; SADOWSKI S; HARDWICKE S; LEWIS RT; MACINTYRE DE; METZGER JM; FONG TM; SHEPHEARD S; TATTERSALL FD; HARGREAVES R; BAKER R
      SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN

      Journal of medicinal chemistry
    35. SWAIN CJ; SEWARD EM; CASCIERI MA; FONG TM; HERBERT R; MACINTYRE DE; MERCHANT KJ; OWEN SN; OWENS AP; SABIN V; TEALL M; VANNIEL MB; WILLIAMS BJ; SADOWSKI S; STRADER C; BALL RG; BAKER R
      IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANEHUMAN NK1 ANTAGONISTS

      Journal of medicinal chemistry
    36. MACLEOD M; MERCHANT KJ; BROOKFIELD F; KELLEHER F; STEVENSON G; OWENS AP; SWAIN CJ; BAKER R; CASCIERI MA; SADOWSKI S; BER E; STRADER CD; MACINTYRE DE; METZGER JM; BALL RG
      IDENTIFICATION OF L-TRYPTOPHAN DERIVATIVES WITH POTENT AND SELECTIVE ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR

      Journal of medicinal chemistry
    37. HWANG SB; LAM MH; SZALKOWSKI DM; MACINTYRE DE; BACH TJ; LUELL S; MEUER R; SAHOO SP; ALBERTS AW; CHABALA JC
      MK 287 - A POTENT, SPECIFIC, AND ORALLY-ACTIVE RECEPTOR ANTAGONIST OFPLATELET-ACTIVATING-FACTOR

      Journal of lipid mediators
    38. MEURER R; VANRIPER G; FEENEY W; CUNNINGHAM P; HORA D; SPRINGER MS; MACINTYRE DE; ROSEN H
      FORMATION OF EOSINOPHILIC AND MONOCYTIC INTRADERMAL INFLAMMATORY SITES IN THE DOG BY INJECTION OF HUMAN RANTES BUT NOT HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN-1, HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1-ALPHA, OR HUMAN INTERLEUKIN-8

      The Journal of experimental medicine
    39. PETERSON LB; WILLIAMS D; METZGER J; GREEN B; KNIGHT WB; MACINTYRE DE
      THE USE OF ENZYME-COATED BEADS TO MONITOR INHIBITION OF HUMAN-LEUKOCYTE ELASTASE IN THE LARGE AIRWAYS OF THE RAT BY ORALLY-ADMINISTERED MONOCYCLIC BETA-LACTAMS

      The American review of respiratory disease


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 16:23:14