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Cbl: Many adaptations to regulate protein tyrosine kinases
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosinekinase converts it into a transforming protein
MOLECULAR CELL
RING finger mutations that abolish C-Cbl-directed polyubiquitination and downregulation of the EGF receptor ave insufficient for cell transformation
MOLECULAR CELL
The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction
JOURNAL OF BIOLOGICAL CHEMISTRY
Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl
JOURNAL OF BIOLOGICAL CHEMISTRY
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation
MOLECULAR AND CELLULAR BIOLOGY
The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
c-Cbl localizes to actin lamellae and regulates lamellipodia formation andcell morphology
JOURNAL OF CELL SCIENCE
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes
JOURNAL OF IMMUNOLOGY
ONCOGENIC FORMS OF CBL ABROGATE THE ANCHORAGE REQUIREMENT BUT NOT THEGROWTH-FACTOR REQUIREMENT FOR PROLIFERATION
Oncogene
TYROSINE PHOSPHORYLATION SITES OF C-CBL IN T-CELLS
The FASEB journal
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
GENES & DEVELOPMENT
C-CBL - A REGULATOR OF T-CELL RECEPTOR-MEDIATED SIGNALING
Immunology and cell biology
TISSUE HYPERPLASIA AND ENHANCED T-CELL SIGNALING VIA ZAP-70 IN C-CBL-DEFICIENT MICE
Molecular and cellular biology
FYN, YES, AND SYK PHOSPHORYLATION SITES IN C-CBL MAP TO THE SAME TYROSINE RESIDUES THAT BECOME PHOSPHORYLATED IN ACTIVATED T-CELLS
The Journal of biological chemistry
TYROSINE KINASE-ACTIVITY OF THE EGF RECEPTOR IS ENHANCED BY THE EXPRESSION OF ONCOGENIC 70Z-CBL
Oncogene
TYROSINE PHOSPHORYLATION OF P120(CBL) IN BCR ABL TRANSFORMED HEMATOPOIETIC-CELLS MEDIATES ENHANCED ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE/
Oncogene
EGF RECEPTOR-BINDING AND TRANSFORMATION BY V-CBL IS ABLATED BY THE INTRODUCTION OF A LOSS-OF-FUNCTION MUTATION FROM THE CAENORHABDITIS-ELEGANS SLI-1 GENE
Oncogene
PHOSPHOTYROSINE BINDING DOMAIN-DEPENDENT UP-REGULATION OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR-ALPHA SIGNALING CASCADE BY TRANSFORMING MUTANTS OF CBL - IMPLICATIONS FOR CBL FUNCTION AND ONCOGENICITY
Molecular and cellular biology
RAS-DEPENDENT, CA2-STIMULATED ACTIVATION OF NUCLEAR FACTOR OF ACTIVATED T-CELLS BY A CONSTITUTIVELY ACTIVE CBL MUTANT IN T-CELLS()
The Journal of biological chemistry
A C-CBL YEAST 2 HYBRID SCREEN REVEALS INTERACTIONS WITH 14-3-3-ISOFORMS AND CYTOSKELETAL COMPONENTS
Biochemical and biophysical research communications
THE 2 MAJOR SITES OF CBL TYROSINE PHOSPHORYLATION IN ABL-TRANSFORMED CELLS SELECT THE CRKL SH2 DOMAIN
Oncogene
REGULATION OF THE ASSOCIATION OF P120(CBL) WITH GRB2 IN JURKAT T-CELLS
The Journal of biological chemistry
A NOVEL PHOSPHOTYROSINE-BINDING DOMAIN IN THE N-TERMINAL TRANSFORMINGREGION OF CBL INTERACTS DIRECTLY AND SELECTIVELY ZAP-70 IN T-CELLS
The Journal of biological chemistry
STIMULATION THROUGH THE T-CELL RECEPTOR INDUCES CBL ASSOCIATION WITH CRK PROTEINS AND THE GUANINE-NUCLEOTIDE EXCHANGE PROTEIN C3G
The Journal of biological chemistry
C-CBL IS TRANSIENTLY TYROSINE-PHOSPHORYLATED, UBIQUITINATED, AND MEMBRANE-TARGETED FOLLOWING CSF-1 STIMULATION OF MACROPHAGES
The Journal of biological chemistry
THE PROTEIN PRODUCT OF THE C-CBL ONCOGENE RAPIDLY COMPLEXES WITH THE EGF RECEPTOR AND IS TYROSINE-PHOSPHORYLATED FOLLOWING EGF STIMULATION
Oncogene
TUMOR-INDUCTION BY TYROSINE PHOSPHORYLATION OF THE PRODUCT OF THE CBLONCOGENE
Journal of cellular biochemistry
ASSOCIATION OF A CHROMOSOME DELETION SYNDROME WITH A FRAGILE SITE WITHIN THE PROTOONCOGENE CBL2
Nature
TYROSINE PHOSPHORYLATION OF THE C-CBL PROTOONCOGENE PROTEIN PRODUCT AND ASSOCIATION WITH EPIDERMAL GROWTH-FACTOR (EGF) RECEPTOR UPON EGF STIMULATION
The Journal of biological chemistry
TPO C-MPL LIGAND INDUCES TYROSINE PHOSPHORYLATION OF MULTIPLE CELLULAR PROTEINS INCLUDING PROTOONCOGENE PRODUCTS, VAV AND C-CBL, AND RAS SIGNALING MOLECULES/
Biochemical and biophysical research communications
THE CBL ONCOGENE - A NOVEL SUBSTRATE OF PROTEIN-TYROSINE KINASES
Australian and New Zealand Journal of Medicine
THE FRAGILE SITE FRA11B IS LOCATED WITHIN THE PROTOONCOGENE CBL2 AND IS ASSOCIATED WITH A CHROMOSOME DELETION SYNDROME
American journal of human genetics
PHYSICAL LINKAGE OF THE FRAGILE SITE FRA11B AND A JACOBSEN SYNDROME CHROMOSOME DELETION BREAKPOINT IN 11Q23.3
Human molecular genetics
EXPRESSION OF C-CBL PROTOONCOGENE IS MODULATED DURING DIFFERENTIATIONBUT NOT DURING INDUCTION OF PROLIFERATION
Oncogene
TUMOR-INDUCTION BY ACTIVATED ABL INVOLVES TYROSINE PHOSPHORYLATION OFTHE PRODUCT OF THE CBL ONCOGENE
EMBO journal
THE PROTEIN PRODUCT OF THE C-CBL PROTOONCOGENE IS THE 120-KDA TYROSINE-PHOSPHORYLATED PROTEIN IN JURKAT CELLS ACTIVATED VIA THE T-CELL ANTIGEN RECEPTOR
The Journal of biological chemistry
5 SEQUENCE-TAGGED SITES FOR HUMAN-CHROMOSOME BAND 11Q23
Human molecular genetics
THE CONTRASTING CHARACTERISTICS OF THE V-CBL AND C-CBL ONCOGENES
Journal of leukocyte biology
THE TRUNCATION THAT GENERATED THE V-CBL ONCOGENE REVEALS AN ABILITY FOR NUCLEAR TRANSPORT, DNA-BINDING AND ACUTE TRANSFORMATION
EMBO journal