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SAP: natural inhibitor or grand SLAM of T cell activation?
NATURE IMMUNOLOGY
Notch1 regulates maturation of CD4(+) and CD8(+) thymocytes by modulating TCR signal strength
IMMUNITY
Lymphocyte activation and effector functions - Lymphocyte signaling in year 1 of the postgenomic era - Editorial overview
CURRENT OPINION IN IMMUNOLOGY
The role of the adapter molecule SLP-76 in platelet function
ONCOGENE
Coupling of the TCR to integrin activation by SLAP-130/Fyb
SCIENCE
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
JOURNAL OF EXPERIMENTAL MEDICINE
The molecular adapter SLP-76 relays signals from platelet integrin alpha(IIb)beta(3) to the actin cytoskeleton
JOURNAL OF BIOLOGICAL CHEMISTRY
C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination
BLOOD
Intracellular adapter molecules
SEMINARS IN IMMUNOLOGY
In vitro and in vivo macrophage function can occur independently of SLP-76
INTERNATIONAL IMMUNOLOGY
Adapter proteins in lymphocyte antigen-receptor signaling
CURRENT OPINION IN IMMUNOLOGY
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
The regulation of CD95 (Fas) ligand expression in primary T cells: Induction of promoter activation in CD95LP-Luc transgenic mice
JOURNAL OF IMMUNOLOGY
Cutting edge: A novel function for the SLAP-130/FYB adapter protein in beta(1) integrin signaling and T lymphocyte migration
JOURNAL OF IMMUNOLOGY
Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling
JOURNAL OF EXPERIMENTAL MEDICINE
Functional association between SLAP-130 and SLP-76 in Jurkat T cells
JOURNAL OF BIOLOGICAL CHEMISTRY
T-cell signaling
PRINCIPLES OF MOLECULAR RHEUMATOLOGY
The role of adapter proteins in T cell activation
CELLULAR AND MOLECULAR LIFE SCIENCES
Adapter molecules in T cell receptor signaling
INFLAMMATORY BOWEL DISEASES
TNF-alpha increases ceramide without inducing apoptosis in alveolar type II epithelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
CURRENT BIOLOGY
Integration of T cell receptor-dependent signaling pathways by adapter proteins
ANNUAL REVIEW OF IMMUNOLOGY
Signal transduction in T lymphocytes
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Human fetal retinal pigment epithelial cells induce apoptosis in the T-cell line Jurkat
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide
JOURNAL OF IMMUNOLOGY
Recent developments in lymphocyte activation: linking kinases to downstream signaling events
JOURNAL OF CLINICAL INVESTIGATION
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
JOURNAL OF CLINICAL INVESTIGATION
Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets
JOURNAL OF BIOLOGICAL CHEMISTRY
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity
JOURNAL OF BIOLOGICAL CHEMISTRY
NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein
EUROPEAN JOURNAL OF IMMUNOLOGY
Interaction of SLP adaptors with the SH2 domain of Tec family kinases
EUROPEAN JOURNAL OF IMMUNOLOGY
THE NEED FOR BASIC SCIENCE RESEARCH EDUCATION IN THE MEDICAL-SCHOOL CURRICULUM
Proceedings of the Association of American Physicians
ADAPTER PROTEINS IN LYMPHOCYTE ANTIGEN-RECEPTOR SIGNALING
Current opinion in immunology
ROLE OF THE JNK CASCADE IN STRESS-INDUCED APOPTOSIS OF JURKAT T-CELLS
The FASEB journal
REGULATION OF CD95 (FAS) LIGAND EXPRESSION IN ACTIVATED T-CELLS AND IMMUNE PRIVILEGED TISSUES
The FASEB journal
SLAP-130 INHIBITS NFAT, BUT NOT AP-1 ACTIVITY TO MODULATE SLP-76 FUNCTION
The FASEB journal
STRESS-INDUCED FAS LIGAND EXPRESSION IN T-CELLS IS MEDIATED THROUGH AMEK KINASE 1-REGULATED RESPONSE ELEMENT IN THE FAS LIGAND PROMOTER
Molecular and cellular biology
REQUIREMENT FOR THE LEUKOCYTE-SPECIFIC ADAPTER PROTEIN SLP-76 FOR NORMAL T-CELL DEVELOPMENT
Science
SLP-76 EXPRESSION IS RESTRICTED TO HEMATOPOIETIC-CELLS OF MONOCYTE, GRANULOCYTE, AND T-LYMPHOCYTE LINEAGE AND IS REGULATED DURING T-CELL MATURATION AND ACTIVATION
The Journal of immunology (1950)
EXTRACELLULAR SIGNAL-REGULATED KINASE-2, BUT NOT C-JUN NH2-TERMINAL KINASE, ACTIVATION CORRELATES WITH SURFACE IGM-MEDIATED APOPTOSIS IN THE WEHI-231 B-CELL LINE
The Journal of immunology (1950)
CUTTING EDGE - A NEWLY IDENTIFIED RESPONSE ELEMENT IN THE CD95 LIGANDPROMOTER CONTRIBUTES TO OPTIMAL INDUCIBILITY IN ACTIVATED T-LYMPHOCYTES
The Journal of immunology (1950)
THE C-JUN N-TERMINAL KINASE CASCADE PLAYS A ROLE IN STRESS-INDUCED APOPTOSIS IN JURKAT CELLS BY UP-REGULATING FAS LIGAND EXPRESSION
The Journal of immunology
SLP-76 IS A DIRECT SUBSTRATE OF SHP-1 RECRUITED TO KILLER-CELL INHIBITORY RECEPTORS
The Journal of biological chemistry
MOLECULAR INTERACTION BETWEEN THE FYN-ASSOCIATED PROTEIN SKAP55 AND THE SLP-78-ASSOCIATED PHOSPHOPROTEIN SLAP-130
The Journal of biological chemistry
INSULIN RECEPTOR-MEDIATED DISSOCIATION OF GRB2 FROM SOS INVOLVES PHOSPHORYLATION OF SOS BY KINASE(S) OTHER THAN EXTRACELLULAR SIGNAL-REGULATED KINASE
The Journal of biological chemistry
Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine Blymphocytes
EUROPEAN JOURNAL OF IMMUNOLOGY
SLP-76-CBL-GRB2-SHC INTERACTIONS IN FC-GAMMA-RI SIGNALING
Blood
MOLECULAR CHARACTERIZATION OF A CD95 SIGNALING MUTANT
Arthritis and rheumatism
IDENTIFICATION OF AN OLIGODEOXYNUCLEOTIDE SEQUENCE MOTIF THAT SPECIFICALLY INHIBITS PHOSPHORYLATION BY PROTEIN-TYROSINE KINASES
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
THE ROLE OF GRB2-ASSOCIATED PROTEINS IN T-CELL ACTIVATION
Immunology today
SIGNALING EVENTS IN T-LYMPHOCYTES LEADING TO CELLULAR ACTIVATION OR PROGRAMMED CELL-DEATH
Clinical immunology and immunopathology
REGULATION OF SIGNAL-TRANSDUCTION THROUGH THE T-CELL ANTIGEN RECEPTOR
The Journal of laboratory and clinical medicine
3 DOMAINS OF SLP-76 ARE REQUIRED FOR ITS OPTIMAL FUNCTION IN A T-CELLLINE
The Journal of immunology
SURFACE EXPRESSION OF HEMATOPOIETIC-CELL PHOSPHATASE FAILS TO COMPLEMENT CD45 DEFICIENCY AND INHIBITS TCR-MEDIATED SIGNAL-TRANSDUCTION IN AJURKAT T-CELL CLONE
The Journal of immunology
REGULATION OF CD95 (FAS) LIGAND EXPRESSION BY TCR-MEDIATED SIGNALING EVENTS
The Journal of immunology
2 NFAT TRANSCRIPTION FACTOR-BINDING SITES PARTICIPATE IN THE REGULATION OF CD95 (FAS) LIGAND EXPRESSION IN ACTIVATED HUMAN T-CELLS
The Journal of biological chemistry
T-CELL RECEPTOR-INDUCED PHOSPHORYLATION OF SOS REQUIRES ACTIVITY OF CD45, LCK, AND PROTEIN-KINASE-C, BUT NOT EPK
The Journal of biological chemistry
SLP-76 IS A SUBSTRATE OF THE HIGH-AFFINITY IGE RECEPTOR-STIMULATED PROTEIN-TYROSINE KINASES IN RAT BASOPHILIC LEUKEMIA-CELLS
The Journal of biological chemistry
MOLECULAR-CLONING OF SLAP-130, AN SLP-76-ASSOCIATED SUBSTRATE OF THE T-CELL ANTIGEN RECEPTOR-STIMULATED PROTEIN-TYROSINE KINASES
The Journal of biological chemistry
FUNCTIONAL INTERACTIONS BETWEEN THE THROMBIN RECEPTOR AND THE T-CELL ANTIGEN RECEPTOR IN HUMAN T-CELL LINES
Blood
MOLECULAR-CLONING OF SLAP-130, A SLP-76 ASSOCIATED SUBSTRATE OF THE TCR STIMULATED PROTEIN-TYROSINE KINASES
Arthritis and rheumatism
CHARACTERIZATION OF A CD95 SIGNAL-TRANSDUCTION MUTANT
Arthritis and rheumatism
NFAT BINDING-SITES PARTICIPATE IN REGULATION OF THE CD95 (FAS) LIGANDPROMOTER IN ACTIVATED T-CELLS
Arthritis and rheumatism
CHARACTERIZATION OF A CD95 SIGNAL-TRANSDUCTION MUTANT
Journal of investigative medicine
SLP-76 FUNCTIONS TO ACTIVATE THE RAS ERK KINASE PATHWAY IN T-CELLS/
Journal of investigative medicine
FUNCTIONAL INTERACTIONS BETWEEN THE THROMBIN RECEPTOR AND THE T-CELL RECEPTOR IN HUMAN T-CELL LINES
Journal of investigative medicine
VAV AND SLP-76 INTERACT AND FUNCTIONALLY COOPERATE IN IL-2 GENE ACTIVATION
Immunity
THE LEUKOCYTE SPECIFIC PROTEIN-TYROSINE-PHOSPHATASE CD45 REGULATES LYMPHOCYTE INTEGRIN FUNCTION
Molecular biology of the cell
A COMPLEX BETWEEN P95(VAV) AND SLP-76 IS INVOLVED IN TCR-MEDIATED IL-2 GENE INDUCTION
The FASEB journal
POLYMORPHISM IN AND LOCALIZATION OF THE GENE LCP2 (SLP-76) TO CHROMOSOME 5Q33.1-QTER
Genomics
TYROSINE PHOSPHORYLATION OF GRB2-ASSOCIATED PROTEINS CORRELATES WITH PHOSPHOLIPASE C-GAMMA-1 ACTIVATION IN T-CELLS
Molecular and cellular biology
TYROSINE-113, TYROSINE-128, AND TYROSINE-145 OF SLP-76 ARE REQUIRED FOR OPTIMAL AUGMENTATION OF NFAT PROMOTER ACTIVITY
The Journal of immunology
CD40 LIGATION RESULTS IN PROTEIN-KINASE C-INDEPENDENT ACTIVATION OF ERK AND JNK IN RESTING MURINE SPLENIC B-CELLS
The Journal of immunology
IMPLICATION OF THE GRB2-ASSOCIATED PHOSPHOPROTEIN SLP-76 IN T-CELL RECEPTOR-MEDIATED INTERLEUKIN-2 PRODUCTION
The Journal of experimental medicine
DIFFERENTIAL REGULATION OF ACTIVATION-INDUCED TYROSINE PHOSPHORYLATION AND RECRUITMENT OF SLP-76 TO VAV BY DISTINCT ISOFORMS OF THE CD45 PROTEIN-TYROSINE-PHOSPHATASE
The Journal of biological chemistry
EPIDERMAL GROWTH-FACTOR RECEPTOR TARGETING PREVENTS UNCOUPLING OF THEGRB2-SOS COMPLEX
The Journal of biological chemistry
FAS LIGATION INDUCES APOPTOSIS AND JUN KINASE ACTIVATION INDEPENDENTLY OF CD45 AND LCK IN HUMAN T-CELLS
Blood
MULTIPLE DOMAINS OF SLP-76 ARE REQUIRED FOR OPTIMAL ACTIVATION OF THERAS ERK PATHWAY IN T-CELLS/
Arthritis and rheumatism
IMMUNE-RESPONSE LIMITS ADENOVIRUS-MEDIATED GENE-TRANSFER TO FETAL LUNG IN-VIVO
Pediatric research
CPG MOTIFS IN BACTERIAL-DNA TRIGGER DIRECT B-CELL ACTIVATION
Nature
REGULATION OF CD45 ENGAGEMENT BY THE B-CELL RECEPTOR CD22
Proceedings of the National Academy of Sciences of the United Statesof America
REGULATION BY CD45 OF THE TYROSINE PHOSPHORYLATION OF HIGH-AFFINITY IGE RECEPTOR BETA-CHAINS AND GAMMA-CHAINS
The Journal of immunology
ADENOVIRAL-MEDIATED GENE-TRANSFER TO FETAL PULMONARY EPITHELIA IN-VITRO AND IN-VIVO
The Journal of clinical investigation
IDENTIFICATION OF THE SITES OF INTERACTION BETWEEN LYMPHOCYTE PHOSPHATASE-ASSOCIATED PHOSPHOPROTEIN (LPAP) AND CD45
The Journal of biological chemistry
DESENSITIZATION OF RAS ACTIVATION BY A FEEDBACK DISASSOCIATION OF THESOS-GRB2 COMPLEX
The Journal of biological chemistry
MOLECULAR-CLONING OF SLP-76, A 76-KDA TYROSINE PHOSPHOPROTEIN ASSOCIATED WITH GRB2 IN T-CELLS
The Journal of biological chemistry
FUNCTIONAL INTERACTIONS BETWEEN THE THROMBIN RECEPTOR, PROTEINASE-ACTIVATED RECEPTOR-2, AND THE T-CELL RECEPTOR IN HUMAN T-CELL LINES
Blood
TYROSINE PHOSPHORYLATION OF PP36 IS REQUIRED FOR COUPLING THE T-CELL ANTIGEN RECEPTOR WITH PLC-GAMMA-1
Arthritis and rheumatism
RESTORATION OF CD2-MEDIATED SIGNALING BY A CHIMERIC MEMBRANE-PROTEIN INCLUDING THE CYTOPLASMIC SEQUENCE OF CD45
Human immunology
GLYCOSYL PHOSPHATIDYLINOSITOL MEMBRANE ANCHOR IS NOT REQUIRED FOR T-CELL ACTIVATION THROUGH CD73
The Journal of immunology
SURFACE EXPRESSION OF A HETEROLOGOUS PHOSPHATASE COMPLEMENTS CD45 DEFICIENCY IN A T-CELL CLONE
The Journal of experimental medicine
IN-VIVO ASSOCIATION OF GRB2 WITH PP116, A SUBSTRATE OF THE T-CELL ANTIGEN RECEPTOR-ACTIVATED PROTEIN-TYROSINE KINASE
The Journal of biological chemistry
SURFACE EXPRESSION OF AN HETEROLOGOUS PHOSPHATASE COMPLEMENTS CD45 DEFICIENCY IN A T-CELL CLONE
Clinical research
ANTIIDIOTYPE ANTIBODY INDUCES ACTIVATION SIGNALS AND UP-REGULATES B7-2 EXPRESSION ON A MURINE B-CELL LYMPHOMA
Blood
THE ASSOCIATION BETWEEN CD45 AND LCK DOES NOT REQUIRE CD4 OR CD8 AND IS INDEPENDENT OF T-CELL RECEPTOR STIMULATION
Biochemical and biophysical research communications
CD45 AND THE IMMUNE-RESPONSE
Journal of the American Society of Nephrology
EXPRESSION OF THE CYTOPLASMIC DOMAIN OF THE TYROSINE PHOSPHATASE, CD45, IS SUFFICIENT FOR T-CELL RECEPTOR-MEDIATED SIGNALING
The Journal of immunology
CD45-ASSOCIATED KINASE-ACTIVITY REQUIRES LCK BUT NOT T-CELL RECEPTOR EXPRESSION IN THE JURKAT T-CELL LINE
The Journal of biological chemistry