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1. Gelkop, S; Babichev, Y; Isakov, N
   T cell activation induces direct binding of the Crk adapter protein to theregulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein
   JOURNAL OF BIOLOGICAL CHEMISTRY
   
   S. Gelkop et al., "T cell activation induces direct binding of the Crk adapter protein to theregulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein", J BIOL CHEM, 276(39), 2001, pp. 36174-36182
2. Isakov, N; Witte, S; Altman, A
   PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules
   TRENDS IN BIOCHEMICAL SCIENCES
   
   N. Isakov et al., "PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules", TRENDS BIOC, 25(11), 2000, pp. 537-539
3. Altman, A; Isakov, N; Baier, G
   Protein kinase C theta: a new essential superstar on the T-cell stage
   IMMUNOLOGY TODAY
   
   A. Altman et al., "Protein kinase C theta: a new essential superstar on the T-cell stage", IMMUNOL TOD, 21(11), 2000, pp. 567-573
4. Witte, S; Villalba, M; Bi, K; Liu, YH; Isakov, N; Altman, A
   Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappa B pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
   JOURNAL OF BIOLOGICAL CHEMISTRY
   
   S. Witte et al., "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappa B pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain", J BIOL CHEM, 275(3), 2000, pp. 1902-1909
5. Isakov, N; Biesinger, B
   Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products
   EUROPEAN JOURNAL OF BIOCHEMISTRY
   
   N. Isakov e B. Biesinger, "Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products", EUR J BIOCH, 267(12), 2000, pp. 3413-3421
6. Gelkop, S; Isakov, N
   T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins
   JOURNAL OF BIOLOGICAL CHEMISTRY
   
   S. Gelkop e N. Isakov, "T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins", J BIOL CHEM, 274(31), 1999, pp. 21519-21527
7. Meller, N; Elitzur, Y; Isakov, N
   Protein kinase C-theta (PKC theta) distribution analysis in hematopoietic cells: Proliferating T cells exhibit high proportions of PKC theta in the particulate fraction
   CELLULAR IMMUNOLOGY
   
   N. Meller et al., "Protein kinase C-theta (PKC theta) distribution analysis in hematopoietic cells: Proliferating T cells exhibit high proportions of PKC theta in the particulate fraction", CELL IMMUN, 193(2), 1999, pp. 185-193
8. MELLER N; ALTMAN A; ISAKOV N
   NEW PERSPECTIVES ON PKC-THETA, A MEMBER OF THE NOVEL SUBFAMILY OF PROTEIN-KINASE-C
   Stem cells
   
   N. Meller et al., "NEW PERSPECTIVES ON PKC-THETA, A MEMBER OF THE NOVEL SUBFAMILY OF PROTEIN-KINASE-C", Stem cells, 16(3), 1998, pp. 178-192
9. ISAKOV N
   ITAMS - IMMUNOREGULATORY SCAFFOLDS THAT LINK IMMUNORECEPTORS TO THEIRINTRACELLULAR SIGNALING PATHWAYS
   Receptors & channels
   
   N. Isakov, "ITAMS - IMMUNOREGULATORY SCAFFOLDS THAT LINK IMMUNORECEPTORS TO THEIRINTRACELLULAR SIGNALING PATHWAYS", Receptors & channels, 5(5), 1998, pp. 243-253
10. Isakov, N
    Role of immunoreceptor tyrosine-based activation motif in signal transduction from antigen and Fc receptors
    ADVANCES IN IMMUNOLOGY, VOL 69
    
    N. Isakov, "Role of immunoreceptor tyrosine-based activation motif in signal transduction from antigen and Fc receptors", ADV IMMUNOL, 69, 1998, pp. 183-247
11. BAZARSKY E; WOLFSON M; GALRON D; GRANOT Y; ARGOV S; ISAKOV N; RAGERZISMAN B
    PERSISTENT MEASLES-VIRUS INFECTION OF MURINE NEUROBLASTOMA-CELLS DIFFERENTIALLY AFFECTS THE EXPRESSION OF PKC INDIVIDUAL ISOENZYMES
    Virus genes
    
    E. Bazarsky et al., "PERSISTENT MEASLES-VIRUS INFECTION OF MURINE NEUROBLASTOMA-CELLS DIFFERENTIALLY AFFECTS THE EXPRESSION OF PKC INDIVIDUAL ISOENZYMES", Virus genes, 15(3), 1997, pp. 227-234
12. ISAKOV N
    IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF (ITAM), A UNIQUE MODULE LINKING ANTIGEN AND FC-RECEPTORS TO THEIR SIGNALING CASCADES
    Journal of leukocyte biology
    
    N. Isakov, "IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF (ITAM), A UNIQUE MODULE LINKING ANTIGEN AND FC-RECEPTORS TO THEIR SIGNALING CASCADES", Journal of leukocyte biology, 61(1), 1997, pp. 6-16
13. ISAKOV N
    ITIMS AND ITAMS - THE YIN AND YANG OF ANTIGEN AND FC RECEPTOR-LINKED SIGNALING MACHINERY
    Immunologic research
    
    N. Isakov, "ITIMS AND ITAMS - THE YIN AND YANG OF ANTIGEN AND FC RECEPTOR-LINKED SIGNALING MACHINERY", Immunologic research, 16(1), 1997, pp. 85-100
14. GALRON D; ANSOTEGUI IJ; ISAKOV N
    POSTTRANSLATIONAL REGULATION OF LCK AND A P36-38 PROTEIN BY ACTIVATORS OF PROTEIN-KINASE-C - DIFFERENTIAL-EFFECTS OF THE TUMOR PROMOTER, PMA, AND THE NON-TUMOR-PROMOTER, BRYOSTATIN
    Cellular immunology
    
    D. Galron et al., "POSTTRANSLATIONAL REGULATION OF LCK AND A P36-38 PROTEIN BY ACTIVATORS OF PROTEIN-KINASE-C - DIFFERENTIAL-EFFECTS OF THE TUMOR PROMOTER, PMA, AND THE NON-TUMOR-PROMOTER, BRYOSTATIN", Cellular immunology, 178(2), 1997, pp. 141-151
15. MELLER N; LIU YC; COLLINS TL; BONNEFOYBERARD N; BAIER G; ISAKOV N; ALTMAN A
    DIRECT INTERACTION BETWEEN PROTEIN-KINASE C-THETA (PKC-THETA) AND 14-3-3-TAU IN T-CELLS - 14-3-3 OVEREXPRESSION RESULTS IN INHIBITION OF PKC-THETA TRANSLOCATION AND FUNCTION
    Molecular and cellular biology
    
    N. Meller et al., "DIRECT INTERACTION BETWEEN PROTEIN-KINASE C-THETA (PKC-THETA) AND 14-3-3-TAU IN T-CELLS - 14-3-3 OVEREXPRESSION RESULTS IN INHIBITION OF PKC-THETA TRANSLOCATION AND FUNCTION", Molecular and cellular biology, 16(10), 1996, pp. 5782-5791
16. TAMIR A; GRANOT Y; ISAKOV N
    INHIBITION OF T-LYMPHOCYTE ACTIVATION BY CAMP IS ASSOCIATED WITH DOWN-REGULATION OF 2 PARALLEL MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAYS, THE EXTRACELLULAR SIGNAL-RELATED KINASE AND C-JUN N-TERMINAL KINASE
    The Journal of immunology
    
    A. Tamir et al., "INHIBITION OF T-LYMPHOCYTE ACTIVATION BY CAMP IS ASSOCIATED WITH DOWN-REGULATION OF 2 PARALLEL MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAYS, THE EXTRACELLULAR SIGNAL-RELATED KINASE AND C-JUN N-TERMINAL KINASE", The Journal of immunology, 157(4), 1996, pp. 1514-1522
17. ISAKOV N; WANGE RL; WATTS JD; AEBERSOLD R; SAMELSON LE
    PURIFICATION AND CHARACTERIZATION OF HUMAN ZAP-70 PROTEIN-TYROSINE KINASE FROM A BACULOVIRUS EXPRESSION SYSTEM
    The Journal of biological chemistry
    
    N. Isakov et al., "PURIFICATION AND CHARACTERIZATION OF HUMAN ZAP-70 PROTEIN-TYROSINE KINASE FROM A BACULOVIRUS EXPRESSION SYSTEM", The Journal of biological chemistry, 271(26), 1996, pp. 15753-15761
18. TAMIR A; GALRON D; GRANOT Y; ISAKOV N
    INHIBITION OF T-CELL ACTIVATION BY CAMP ASSOCIATE WITH ABROGATION OF C-JUN N-TERMINAL-KINASES AND MAP-KINASES ACTIVITY
    The FASEB journal
    
    A. Tamir et al., "INHIBITION OF T-CELL ACTIVATION BY CAMP ASSOCIATE WITH ABROGATION OF C-JUN N-TERMINAL-KINASES AND MAP-KINASES ACTIVITY", The FASEB journal, 9(3), 1995, pp. 235-235
19. ERDEL M; BAIERBITTERLICH G; DUBA C; ISAKOV N; ALTMAN A; UTERMANN G; BAIER G
    MAPPING OF THE HUMAN PROTEIN-KINASE C-THETA (PRKCQ) GENE LOCUS TO THESHORT ARM OF CHROMOSOME-10 (10P15) BY FISH
    Genomics
    
    M. Erdel et al., "MAPPING OF THE HUMAN PROTEIN-KINASE C-THETA (PRKCQ) GENE LOCUS TO THESHORT ARM OF CHROMOSOME-10 (10P15) BY FISH", Genomics, 25(2), 1995, pp. 595-597
20. GERMAIN RN; CASTELLINO F; ROMAGNOLI P; MADRENAS J; WANGE R; ISAKOV N; SAMELSON LE
    FORMATION AND FUNCTION OF PEPTIDE - MHC MOLECULE LIGANDS FOR THE TCR
    Journal of cellular biochemistry
    
    R.N. Germain et al., "FORMATION AND FUNCTION OF PEPTIDE - MHC MOLECULE LIGANDS FOR THE TCR", Journal of cellular biochemistry, 1995, pp. 4-4
21. DOUVDEVANI A; ABRAMSON O; TAMIR A; KONFORTY A; ISAKOV N; CHAIMOVITZ C
    COMMERCIAL DIALYSATE INHIBITS TNF-ALPHA MESSENGER-RNA EXPRESSION AND NF-KAPPA-B DNA-BINDING ACTIVITY IN LPS-STIMULATED MACROPHAGES
    Kidney international
    
    A. Douvdevani et al., "COMMERCIAL DIALYSATE INHIBITS TNF-ALPHA MESSENGER-RNA EXPRESSION AND NF-KAPPA-B DNA-BINDING ACTIVITY IN LPS-STIMULATED MACROPHAGES", Kidney international, 47(6), 1995, pp. 1537-1545
22. MADRENAS J; WANGE RL; WANG JL; ISAKOV N; SAMELSON LE; GERMAIN RN
    ZETA-PHOSPHORYLATION WITHOUT ZAP-70 ACTIVATION-INDUCED BY TCR ANTAGONISTS OR PARTIAL AGONISTS
    Science
    
    J. Madrenas et al., "ZETA-PHOSPHORYLATION WITHOUT ZAP-70 ACTIVATION-INDUCED BY TCR ANTAGONISTS OR PARTIAL AGONISTS", Science, 267(5197), 1995, pp. 515-518
23. SEGEV Y; OFIR R; SALZBERG S; HELLER A; WEINSTEIN Y; ISAKOV N; UDEM S; WOLFSON M; RAGERZISMAN B
    TYROSINE PHOSPHORYLATION OF MEASLES-VIRUS NUCLEOCAPSID PROTEIN IN PERSISTENTLY INFECTED NEUROBLASTOMA-CELLS
    Journal of virology
    
    Y. Segev et al., "TYROSINE PHOSPHORYLATION OF MEASLES-VIRUS NUCLEOCAPSID PROTEIN IN PERSISTENTLY INFECTED NEUROBLASTOMA-CELLS", Journal of virology, 69(4), 1995, pp. 2480-2485
24. ISAKOV N; WANGE RL; BURGESS WH; WATTS JD; AEBERSOLD R; SAMELSON LE
    ZAP-70 BINDING-SPECIFICITY TO T-CELL RECEPTOR TYROSINE-BASED ACTIVATION MOTIFS - THE TANDEM SH2 DOMAINS OF ZAP-70 BIND DISTINCT TYROSINE-BASED ACTIVATION MOTIFS WITH VARYING AFFINITY
    The Journal of experimental medicine
    
    N. Isakov et al., "ZAP-70 BINDING-SPECIFICITY TO T-CELL RECEPTOR TYROSINE-BASED ACTIVATION MOTIFS - THE TANDEM SH2 DOMAINS OF ZAP-70 BIND DISTINCT TYROSINE-BASED ACTIVATION MOTIFS WITH VARYING AFFINITY", The Journal of experimental medicine, 181(1), 1995, pp. 375-380
25. WANGE RL; GUITIAN R; ISAKOV N; WATTS JD; AEBERSOLD R; SAMELSON LE
    ACTIVATING AND INHIBITORY MUTATIONS IN ADJACENT TYROSINES IN THE KINASE DOMAIN OF ZAP-70
    The Journal of biological chemistry
    
    R.L. Wange et al., "ACTIVATING AND INHIBITORY MUTATIONS IN ADJACENT TYROSINES IN THE KINASE DOMAIN OF ZAP-70", The Journal of biological chemistry, 270(32), 1995, pp. 18730-18733
26. WANGE RL; ISAKOV N; BURKE TR; OTAKA A; ROLLER PP; WATTS JD; AEBERSOLD R; SAMELSON LE
    F-2(PMP)(2)-TAM-ZETA(3), A NOVEL COMPETITIVE INHIBITOR OF THE BINDINGOF ZAP-70 TO THE T-CELL ANTIGEN RECEPTOR, BLOCKS EARLY T-CELL SIGNALING
    The Journal of biological chemistry
    
    R.L. Wange et al., "F-2(PMP)(2)-TAM-ZETA(3), A NOVEL COMPETITIVE INHIBITOR OF THE BINDINGOF ZAP-70 TO THE T-CELL ANTIGEN RECEPTOR, BLOCKS EARLY T-CELL SIGNALING", The Journal of biological chemistry, 270(2), 1995, pp. 944-948
27. GELKOP S; PRIEL E; ISAKOV N
    T-CELL MITOGENS INDUCE INCREASED DNA TOPOISOMERASE-I PROTEIN-LEVELS AND ITS TRANSLOCATION TO THE NUCLEUS WHERE ACTIVATION OF THE ENZYME OCCURS
    Biochemical and biophysical research communications
    
    S. Gelkop et al., "T-CELL MITOGENS INDUCE INCREASED DNA TOPOISOMERASE-I PROTEIN-LEVELS AND ITS TRANSLOCATION TO THE NUCLEUS WHERE ACTIVATION OF THE ENZYME OCCURS", Biochemical and biophysical research communications, 211(3), 1995, pp. 872-877
28. WANGE RL; ISAKOV N; WATTS JD; AEBERSOLD R; SAMELSON LE
    LOCALIZATION OF ZAP-70 TO THE TCR IS MEDIATED BY BINDING OF TYROSINE-PHOSPHORYLATED TAMS TO THE TANDEM SH2 DOMAINS OF ZAP-70
    The FASEB journal
    
    R.L. Wange et al., "LOCALIZATION OF ZAP-70 TO THE TCR IS MEDIATED BY BINDING OF TYROSINE-PHOSPHORYLATED TAMS TO THE TANDEM SH2 DOMAINS OF ZAP-70", The FASEB journal, 8(7), 1994, pp. 10001228-10001228
29. ISAKOV N; WANGE RL; SAMELSON LE
    THE ROLE OF TYROSINE KINASES AND PHOSPHOTYROSINE-CONTAINING RECOGNITION MOTIFS IN REGULATION OF THE T-CELL-ANTIGEN RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION PATHWAY
    Journal of leukocyte biology
    
    N. Isakov et al., "THE ROLE OF TYROSINE KINASES AND PHOSPHOTYROSINE-CONTAINING RECOGNITION MOTIFS IN REGULATION OF THE T-CELL-ANTIGEN RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION PATHWAY", Journal of leukocyte biology, 55(2), 1994, pp. 265-271
30. TAMIR A; ISAKOV N
    CYCLIC-AMP INHIBITS PHOSPHATIDYLINOSITOL-COUPLED AND PHOSPHATIDYLINOSITOL-UNCOUPLED MITOGENIC SIGNALS IN T-LYMPHOCYTES - EVIDENCE THAT CAMPALTERS PKC-INDUCED TRANSCRIPTION REGULATION OF MEMBERS OF THE JUN ANDFOS FAMILY OF GENES
    The Journal of immunology
    
    A. Tamir e N. Isakov, "CYCLIC-AMP INHIBITS PHOSPHATIDYLINOSITOL-COUPLED AND PHOSPHATIDYLINOSITOL-UNCOUPLED MITOGENIC SIGNALS IN T-LYMPHOCYTES - EVIDENCE THAT CAMPALTERS PKC-INDUCED TRANSCRIPTION REGULATION OF MEMBERS OF THE JUN ANDFOS FAMILY OF GENES", The Journal of immunology, 152(7), 1994, pp. 3391-3399
31. SEGEV Y; RAGERZISMAN B; ISAKOV N; SCHNEIDERSCHAULIES S; TERMEULEN V; UDEM S; SEGAL S; WOLFSON M
    REVERSAL OF THE MEASLES VIRUS-MEDIATED INCREASE OF PHOSPHORYLATING ACTIVITY IN PERSISTENTLY INFECTED-MOUSE NEUROBLASTOMA-CELLS BY ANTI-MEASLES VIRUS-ANTIBODIES
    Journal of General Virology
    
    Y. Segev et al., "REVERSAL OF THE MEASLES VIRUS-MEDIATED INCREASE OF PHOSPHORYLATING ACTIVITY IN PERSISTENTLY INFECTED-MOUSE NEUROBLASTOMA-CELLS BY ANTI-MEASLES VIRUS-ANTIBODIES", Journal of General Virology, 75, 1994, pp. 819-827
32. ISAKOV N; TAMIR A; ELON J
    SUPPRESSION OF ANTIGEN-SPECIFIC T-CELL RESPONSES BY LEISHMANIA-MAJOR EXCRETED FACTOR - INHIBITION OF ACTIVATION SIGNALS LINKED TO THE T-CELL ANTIGEN RECEPTOR AND INTERLEUKIN-2 RECEPTOR
    Israel journal of medical sciences
    
    N. Isakov et al., "SUPPRESSION OF ANTIGEN-SPECIFIC T-CELL RESPONSES BY LEISHMANIA-MAJOR EXCRETED FACTOR - INHIBITION OF ACTIVATION SIGNALS LINKED TO THE T-CELL ANTIGEN RECEPTOR AND INTERLEUKIN-2 RECEPTOR", Israel journal of medical sciences, 30(9), 1994, pp. 673-679
33. BAIER G; BAIERBITTERLICH G; MELLER N; COGGESHALL KM; GIAMPA L; TELFORD D; ISAKOV N; ALTMAN A
    EXPRESSION AND BIOCHEMICAL-CHARACTERIZATION OF HUMAN PROTEIN-KINASE C-THETA
    European journal of biochemistry
    
    G. Baier et al., "EXPRESSION AND BIOCHEMICAL-CHARACTERIZATION OF HUMAN PROTEIN-KINASE C-THETA", European journal of biochemistry, 225(1), 1994, pp. 195-203
34. GALRON D; TAMIR A; ALTMAN A; ISAKOV N
    INHIBITION OF PMA-INDUCED HUMAN T-CELL PROLIFERATION BY BRYOSTATIN ISASSOCIATED WITH ENHANCED DEGRADATION OF CONVENTIONAL PROTEIN-KINASE-C(CPKC) - CA2+ SIGNALS RESTORE MITOGENIC ACTIVITY WITHOUT ABROGATING ENHANCED CPKC DEGRADATION
    Cellular immunology
    
    D. Galron et al., "INHIBITION OF PMA-INDUCED HUMAN T-CELL PROLIFERATION BY BRYOSTATIN ISASSOCIATED WITH ENHANCED DEGRADATION OF CONVENTIONAL PROTEIN-KINASE-C(CPKC) - CA2+ SIGNALS RESTORE MITOGENIC ACTIVITY WITHOUT ABROGATING ENHANCED CPKC DEGRADATION", Cellular immunology, 158(1), 1994, pp. 195-207
35. EHRLICH T; WISHNIAK O; ISAKOV N; COHEN O; SEGAL S; RAGERZISMAN B; GOPAS J
    THE EFFECT OF H-RAS EXPRESSION ON TUMORIGENICITY AND IMMUNOGENICITY OF BALB C 3T3 FIBROBLASTS/
    Immunology letters
    
    T. Ehrlich et al., "THE EFFECT OF H-RAS EXPRESSION ON TUMORIGENICITY AND IMMUNOGENICITY OF BALB C 3T3 FIBROBLASTS/", Immunology letters, 39(1), 1993, pp. 3-8
36. GALRON D; TAMIR A; GELKOP S; GROSSMAN N; ISAKOV N
    THE EFFECT OF BRYOSTATIN ON PROTEIN-KINASE C-REGULATED FUNCTIONS IN HUMAN T-LYMPHOCYTES AND EPIDERMAL-KERATINOCYTES
    Immunology letters
    
    D. Galron et al., "THE EFFECT OF BRYOSTATIN ON PROTEIN-KINASE C-REGULATED FUNCTIONS IN HUMAN T-LYMPHOCYTES AND EPIDERMAL-KERATINOCYTES", Immunology letters, 39(1), 1993, pp. 17-22
37. GUERON E; ISAKOV N; ELON J
    LEISHMANIA-MAJOR - RESPIRATORY BURST RESPONSE OF INFECTED MURINE MACROPHAGES TREATED WITH PAROMOMYCIN
    Experimental parasitology
    
    E. Gueron et al., "LEISHMANIA-MAJOR - RESPIRATORY BURST RESPONSE OF INFECTED MURINE MACROPHAGES TREATED WITH PAROMOMYCIN", Experimental parasitology, 76(4), 1993, pp. 371-376
38. ISAKOV N
    ACTIVATION OF MURINE LYMPHOCYTES BY EXOGENOUS PHOSPHATIDYLETHANOLAMINE-SPECIFIC AND PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE-C
    Cellular immunology
    
    N. Isakov, "ACTIVATION OF MURINE LYMPHOCYTES BY EXOGENOUS PHOSPHATIDYLETHANOLAMINE-SPECIFIC AND PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE-C", Cellular immunology, 152(1), 1993, pp. 72-81