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    1. Villinger, F; Bucur, S; Chikkala, NF; Brar, SS; Bostik, P; Mayne, AE; Adams, J; Lee, ME; Novembre, FJ; Gately, MK; Ansari, AA; Hillyer, CD
      In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS

      AIDS RESEARCH AND HUMAN RETROVIRUSES
    2. Brombacher, F; Dorfmuller, A; Magram, J; Dai, WJ; Kohler, G; Wunderlin, A; Palmer-Lehmann, K; Gately, MK; Alber, G
      IL-12 is dispensable for innate and adaptive immunity against low doses ofListeria monocytogenes

      INTERNATIONAL IMMUNOLOGY
    3. Rakhit, A; Yeon, MM; Ferrante, J; Fettner, S; Nadeau, R; Motzer, R; Bukowski, R; Carvajal, DM; Wilkinson, VL; Presky, DH; Magram, J; Gately, MK
      Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice

      CLINICAL PHARMACOLOGY & THERAPEUTICS
    4. VANDERMEIDE PH; VILLINGER F; ANSARI AA; GATELY MK; SCHELLEKENS H; WIJDENES J
      INTERLEUKIN-12 STRONGLY POTENTIATES THE IMMUNOGENICITY OF THE CANDIDATE VACCINE MOLECULE HIV-1GP120 IN RHESUS-MONKEYS

      European cytokine network
    5. GATELY MK; RENZETTI LM; MAGRAM J; STERN AS; ADORINI L; GUBLER U; PRESKY DH
      THE INTERLEUKIN-12 INTERLEUKIN-12-RECEPTOR SYSTEM - ROLE IN NORMAL AND PATHOLOGICAL IMMUNE-RESPONSES/

      Annual review of immunology
    6. PRESKY DH; MINETTI LJ; GILLESSEN S; WILKINSON VL; WU CY; GUBLER U; CHIZZONITE R; GATELY MK
      ANALYSIS OF THE MULTIPLE INTERACTIONS BETWEEN IL-12 AND THE HIGH-AFFINITY IL-12 RECEPTOR COMPLEX

      The Journal of immunology
    7. DECKEN K; KOHLER G; PALMERLEHMANN K; WUNDERLIN A; MATTNER F; MAGRAM J; GATELY MK; ALBER G
      INTERLEUKIN-12 IS ESSENTIAL FOR A PROTECTIVE TH1 RESPONSE IN MICE INFECTED WITH CRYPTOCOCCUS-NEOFORMANS

      Infection and immunity
    8. GATELY MK
      INTERLEUKIN-12 - POTENTIAL CLINICAL-APPLICATIONS IN THE TREATMENT OF CHRONIC VIRAL-HEPATITIS

      Journal of viral hepatitis
    9. LIESCHKE GJ; RAO PK; GATELY MK; MULLIGAN RC
      BIOACTIVE MURINE AND HUMAN INTERLEUKIN-12 FUSION PROTEINS WHICH RETAIN ANTITUMOR-ACTIVITY IN-VIVO

      Nature biotechnology
    10. WILKINSON VL; CARVAJAL D; MINETTI LJ; CHUA AO; GUBLER U; GATELY MK; PRESKY DH
      FUNCTIONAL-CHARACTERIZATION OF MOUSE IL-12 RECEPTORS

      Journal of allergy and clinical immunology
    11. WU CY; FERRANTE J; GATELY MK; MAGRAM J
      CHARACTERIZATION OF IL-12 RECEPTOR BETA-1 CHAIN (IL-12R-BETA-1)-DEFICIENT MICE - IL-12R-BETA-1 IS AN ESSENTIAL COMPONENT OF THE FUNCTIONAL-MOUSE IL-12 RECEPTOR

      The Journal of immunology
    12. MATTNER F; OZMEN L; PODLASKI FJ; WILKINSON VL; PRESKY DH; GATELY MK; ALBER G
      TREATMENT WITH HOMODIMERIC INTERLEUKIN-12 (IL-12) P40 PROTECTS MICE FROM IL-12-DEPENDENT SHOCK BUT NOT FROM TUMOR-NECROSIS-FACTOR ALPHA-DEPENDENT SHOCK

      Infection and immunity
    13. TREMBLEAU S; PENNA G; GREGORI S; GATELY MK; ADORINI L
      DEVIATION OF PANCREAS-INFILTRATING CELLS TO TH2 BY INTERLEUKIN-12 ANTAGONIST ADMINISTRATION INHIBITS AUTOIMMUNE DIABETES

      European Journal of Immunology
    14. WU CY; WARRIER RR; WANG X; PRESKY DH; GATELY MK
      REGULATION OF INTERLEUKIN-12 RECEPTOR BETA-1 CHAIN EXPRESSION AND INTERLEUKIN-12 BINDING BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

      European Journal of Immunology
    15. MAGRAM J; CONNAUGHTON SE; WARRIER RR; CARVAJAL DM; WU CY; FERRANTE J; STEWART C; SARMIENTO U; FAHERTY DA; GATELY MK
      IL-12-DEFICIENT MICE ARE DEFECTIVE IN IFN-GAMMA PRODUCTION AND TYPE-1CYTOKINE RESPONSES

      Immunity
    16. MARINARO M; BOYAKA PN; JACKSON RJ; FINKELMAN FD; GATELY MK; KIYONO H; MCGHEE JR
      MUCOSAL ADMINISTRATION OF RMIL-12 TO MICE MODULATES TH2-TYPE RESPONSES INDUCED BY AN ORAL VACCINE

      The FASEB journal
    17. PRESKY DH; MINETTI LJ; GUBLER U; STERN AS; CHIZZONITE R; GATELY MK
      ANALYSIS OF THE MULTIVALENT INTERACTIONS BETWEEN IL-12 AND THE HIGH-AFFINITY IL-12 RECEPTOR (IL-12R) COMPLEX

      The FASEB journal
    18. PRESKY DH; YANG H; MINETTI LJ; CHUA AO; NABAVI N; WU CY; GATELY MK; GUBLER U
      A FUNCTIONAL INTERLEUKIN-12 RECEPTOR COMPLEX IS COMPOSED OF 2 BETA-TYPE CYTOKINE RECEPTOR SUBUNITS

      Proceedings of the National Academy of Sciences of the United Statesof America
    19. URBAN JF; FAYER R; CHEN SJ; GAUSE WC; GATELY MK; FINKELMAN FD
      IL-12 PROTECTS IMMUNOCOMPETENT AND IMMUNODEFICIENT NEONATAL MICE AGAINST INFECTION WITH CRYPTOSPORIDIUM-PARVUM

      The Journal of immunology
    20. WILKINSON VL; WARRIER RR; TRUITT TP; NUNES P; GATELY MK; PRESKY DH
      CHARACTERIZATION OF ANTI-MOUSE IL-12 MONOCLONAL-ANTIBODIES AND MEASUREMENT OF MOUSE IL-12 BY ELISA

      Journal of immunological methods
    21. UYEMURA K; DEMER LL; CASTLE SC; JULLIEN D; BERLINER JA; GATELY MK; WARRIER RR; PHAM N; FOGELMAN AM; MODLIN RL
      CROSS-REGULATORY ROLES OF INTERLEUKIN (IL)-12 AND IL-10 IN ATHEROSCLEROSIS

      The Journal of clinical investigation
    22. MATTNER F; MAGRAM J; FERRANTE J; LAUNOIS P; DIPADOVA K; BEHIN R; GATELY MK; LOUIS JA; ALBER G
      GENETICALLY RESISTANT MICE LACKING INTERLEUKIN-12 ARE SUSCEPTIBLE TO INFECTION WITH LEISHMANIA-MAJOR AND MOUNT A POLARIZED TH2 CELL RESPONSE

      European Journal of Immunology
    23. WU CY; WARRIER RR; CARVAJAL DM; CHUA AO; MINETTI LJ; CHIZZONITE R; MONGINI PKA; STERN AS; GUBLER U; PRESKY DH; GATELY MK
      BIOLOGICAL FUNCTION AND DISTRIBUTION OF HUMAN INTERLEUKIN-12 RECEPTOR-BETA CHAIN

      European Journal of Immunology
    24. MCINTYRE KW; SHUSTER DJ; GILLOOLY KM; WARRIER RR; CONNAUGHTON SE; HALL LB; ARP LH; GATELY MK; MAGRAM J
      REDUCED INCIDENCE AND SEVERITY OF COLLAGEN-INDUCED ARTHRITIS IN INTERLEUKIN-32-DEFICIENT MICE

      European Journal of Immunology
    25. HESS H; GATELY MK; RUDE E; SCHMITT E; SZELIGA J; GERMANN T
      HIGH-DOSES OF INTERLEUKIN-12 INHIBIT THE DEVELOPMENT OF JOINT DISEASEIN DBA 1 MICE IMMUNIZED WITH TYPE-II COLLAGEN IN COMPLETE FREUNDS-ADJUVANT/

      European Journal of Immunology
    26. GATELY MK; MULQUEEN MJ
      INTERLEUKIN-12 - POTENTIAL CLINICAL-APPLICATIONS IN THE TREATMENT ANDPREVENTION OF INFECTIOUS-DISEASES

      Drugs
    27. DURACK DT; GATELY MK; HOIBY N; JOHNNY KV; UTILI R
      INTERLEUKIN-12 - POTENTIAL CLINICAL-APPLICATIONS IN THE TREATMENT ANDPREVENTION OF INFECTIOUS-DISEASES - DISCUSSION

      Drugs
    28. TARE NS; BOWEN S; WARRIER RR; CARVAJAL DM; BENJAMIN WR; RILEY JH; ANDERSON TD; GATELY MK
      ADMINISTRATION OF RECOMBINANT INTERLEUKIN-12 TO MICE SUPPRESSES HEMATOPOIESIS IN THE BONE-MARROW BUT ENHANCES HEMATOPOIESIS IN THE SPLEEN

      Journal of interferon & cytokine research
    29. BRUNDA MJ; LUISTRO L; HENDRZAK JA; FOUNTOULAKIS M; GAROTTA G; GATELY MK
      ROLE OF INTERFERON-GAMMA IN MEDIATING THE ANTITUMOR EFFICACY OF INTERLEUKIN-12

      Journal of immunotherapy with emphasis on tumor immunology
    30. GERMANN T; GUCKES S; BONGARTZ M; DLUGONSKA H; SCHMITT E; KOLBE L; KOLSCH E; PODLASKI FJ; GATELY MK; RUDE E
      ADMINISTRATION OF IL-12 DURING ONGOING IMMUNE-RESPONSES FAILS TO PERMANENTLY SUPPRESS AND CAN EVEN ENHANCE THE SYNTHESIS OF ANTIGEN-SPECIFIC IGE

      International immunology
    31. PRESKY DH; GUBLER U; CHIZZONITE RA; GATELY MK
      IL12 RECEPTORS AND RECEPTOR ANTAGONISTS

      Research in immunology
    32. GERMANN T; SZELIGA J; HESS H; SCHMITT E; PODLASKI FJ; GATELY MK; RUDE E
      ADMINISTRATION OF IL12 TO DBA 1 MICE IMMUNIZED WITH TYPE-II COLLAGEN CAUSES SEVERE ARTHRITIS/

      Journal of cellular biochemistry
    33. TREMBLEAU S; GERMANN T; GATELY MK; ADORINI L
      THE ROLE OF IL-12 IN THE INDUCTION OF ORGAN-SPECIFIC AUTOIMMUNE-DISEASES

      Immunology today
    34. GERMANN T; RUDE E; MATTNER F; GATELY MK
      THE IL-12 P40 HOMODIMER AS A SPECIFIC ANTAGONIST OF THE IL-12 HETERODIMER

      Immunology today
    35. GERMANN T; SZELIGA J; HESS H; STORKEL S; PODLASKI FJ; GATELY MK; SCHMITT E; RUDE E
      ADMINISTRATION OF INTERLEUKIN-12 IN COMBINATION WITH TYPE-II COLLAGENINDUCES SEVERE ARTHRITIS IN DBA 1 MICE/

      Proceedings of the National Academy of Sciences of the United Statesof America
    36. PAPPO I; TAHARA H; ROBBINS PD; GATELY MK; WOLF SF; BARNEA A; LOTZE MT
      ADMINISTRATION OF SYSTEMIC OR LOCAL INTERLEUKIN-2 ENHANCES THE ANTITUMOR EFFECTS OF INTERLEUKIN-12 GENE-THERAPY

      The Journal of surgical research
    37. LING P; GATELY MK; GUBLER U; STERN AS; LIN P; HOLLFELDER K; SU C; PAN YCE; HAKIMI J
      HUMAN IL-12 P40 HOMODIMER BINDS TO THE IL-12 RECEPTOR BUT DOES NOT MEDIATE BIOLOGIC ACTIVITY

      The Journal of immunology
    38. TREMBLEAU S; PENNA G; BOSI E; MORTARA A; GATELY MK; ADORINI L
      INTERLEUKIN-12 ADMINISTRATION INDUCES T-HELPER TYPE-1 CELLS AND ACCELERATES AUTOIMMUNE DIABETES IN NOD MICE

      The Journal of experimental medicine
    39. ZOU JJ; SCHOENHAUT DS; CARVAJAL DM; WARRIER RR; PRESKY DH; GATELY MK; GUBLER U
      STRUCTURE-FUNCTION ANALYSIS OF THE P35 SUBUNIT OF MOUSE INTERLEUKIN-12

      The Journal of biological chemistry
    40. GERMANN T; BONGARTZ M; DLUGONSKA H; HESS H; SCHMITT E; KOLBE L; KOLSCH E; PODLASKI FJ; GATELY MK; RUDE E
      INTERLEUKIN-12 PROFOUNDLY UP-REGULATES THE SYNTHESIS OF ANTIGEN-SPECIFIC COMPLEMENT-FIXING IGG2A, IGG2B AND IGG3 ANTIBODY SUBCLASSES IN-VIVO

      European Journal of Immunology
    41. GILLESSEN S; CARVAJAL D; LING P; PODLASKI FJ; STREMLO DL; FAMILLETTI PC; GUBLER U; PRESKY DH; STERN AS; GATELY MK
      MOUSE INTERLEUKIN-12 (IL-12) P40 HOMODIMER - A POTENT IL-12 ANTAGONIST

      European Journal of Immunology
    42. GATELY MK; WARRIER RR; HONASOGE S; CARVAJAL DM; FAHERTY DA; CONNAUGHTON SE; ANDERSON TD; SARMIENTO U; HUBBARD BR; MURPHY M
      ADMINISTRATION OF RECOMBINANT IL-12 TO NORMAL MICE ENHANCES CYTOLYTICLYMPHOCYTE ACTIVITY AND INDUCES PRODUCTION OF IFN-GAMMA IN-VIVO

      International immunology
    43. LING P; LIN P; GUBLER U; PAN YE; GATELY MK; HAKIMI J
      A HOMODIMER OF THE IL-12 P40 SUBUNIT BINDS TO THE IL-12 RECEPTOR BUT DOES NOT MEDIATE BIOLOGIC ACTIVITY

      The FASEB journal
    44. LESTER MR; GATELY MK; TRUMBLE A; LEUNG DYM
      THE IN-VITRO EFFECTS OF INTERLEUKIN (IL)-12 ON PERIPHERAL-BLOOD MONONUCLEAR-CELLS (PBMC) IN ATOPIC-DERMATITIS (AD)

      Journal of allergy and clinical immunology
    45. BRUNDA MJ; GATELY MK
      ANTITUMOR-ACTIVITY OF INTERLEUKIN-12

      Clinical immunology and immunopathology
    46. SARMIENTO UM; RILEY JH; KNAACK PA; LIPMAN JM; BECKER JM; GATELY MK; CHIZZONITE R; ANDERSON TD
      BIOLOGIC EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN-12 IN SQUIRREL-MONKEYS (SCIUREUS-SAIMIRI)

      Laboratory investigation
    47. VIA CS; RUS V; GATELY MK; FINKELMAN FD
      IL-12 STIMULATES THE DEVELOPMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE IN MICE THAT NORMALLY WOULD DEVELOP CHRONIC, AUTOIMMUNE GRAFT-VERSUS-HOST DISEASE

      The Journal of immunology
    48. SIELING PA; WANG XH; GATELY MK; OLIVEROS JL; MCHUGH T; BARNES PF; WOLF SF; GOLKAR L; YAMAMURA M; YOGI Y; UYEMURA K; REA TH; MODLIN RL
      IL-12 REGULATES T-HELPER TYPE-1 CYTOKINE RESPONSES IN HUMAN INFECTIOUS-DISEASE

      The Journal of immunology
    49. NASTALA CL; EDINGTON HD; MCKINNEY TG; TAHARA H; NALESNIK MA; BRUNDA MJ; GATELY MK; WOLF SF; SCHREIBER RD; STORKUS WJ; LOTZE MT
      RECOMBINANT IL-12 ADMINISTRATION INDUCES TUMOR-REGRESSION IN ASSOCIATION WITH IFN-GAMMA PRODUCTION

      The Journal of immunology
    50. BYUN DG; DEMEURE CE; YANG LP; SHU U; ISHIHARA H; VEZZIO N; GATELY MK; DELESPESSE G
      IN-VITRO MATURATION OF NEONATAL HUMAN CD8 T-LYMPHOCYTES INTO IL-4-PRODUCING AND IL-5-PRODUCING CELLS

      The Journal of immunology
    51. CHUA AO; CHIZZONITE R; DESAI BB; TRUITT TP; NUNES P; MINETTI LJ; WARRIER RR; PRESKY DH; LEVINE JF; GATELY MK; GUBLER U
      EXPRESSION CLONING OF A HUMAN IL-12 RECEPTOR COMPONENT A NEW MEMBER OF THE CYTOKINE RECEPTOR SUPERFAMILY WITH STRONG HOMOLOGY TO GP130

      The Journal of immunology
    52. GODFREY DI; KENNEDY J; GATELY MK; HAKIMI J; HUBBARD BR; ZLOTNIK A
      IL-12 INFLUENCES INTRATHYMIC T-CELL DEVELOPMENT

      The Journal of immunology
    53. TRIPP CS; GATELY MK; HAKIMI J; LING P; UNANUE ER
      NEUTRALIZATION OF IL-12 DECREASES RESISTANCE TO LISTERIA IN SCID AND C.B-17 MICE - REVERSAL BY IFN-GAMMA

      The Journal of immunology
    54. MORRIS SC; MADDEN KB; ADAMOVICZ JJ; GAUSE WC; HUBBARD BR; GATELY MK; FINKELMAN FD
      EFFECTS OF IL-12 ON IN-VIVO CYTOKINE GENE-EXPRESSION AND IG ISOTYPE SELECTION

      The Journal of immunology
    55. FINKELMAN FD; MADDEN KB; CHEEVER AW; KATONA IM; MORRIS SC; GATELY MK; HUBBARD BR; GAUSE WC; URBAN JF
      EFFECTS OF INTERLEUKIN-12 ON IMMUNE-RESPONSES AND HOST PROTECTION IN MICE INFECTED WITH INTESTINAL NEMATODE PARASITES

      The Journal of experimental medicine
    56. ZHANG M; GATELY MK; WANG E; GONG JH; WOLF SF; LU SH; MODLIN RL; BARNES PF
      INTERLEUKIN-12 AT THE SITE OF DISEASE IN TUBERCULOSIS

      The Journal of clinical investigation
    57. GATELY MK
      INTERLEUKIN-12 - A RECENTLY DISCOVERED CYTOKINE WITH POTENTIAL FOR ENHANCING CELL-MEDIATED IMMUNE-RESPONSES TO TUMORS

      Cancer investigation
    58. HAKIMI J; HA VC; LIN P; CAMPBELL E; GATELY MK; TSUDO M; PAYNE PW; WALDMANN TA; GRANT AJ; TSIEN WH; SCHNEIDER WP
      HUMANIZED MIK-BETA-1, A HUMANIZED ANTIBODY TO THE IL-2-RECEPTOR BETA-CHAIN THAT ACTS SYNERGISTICALLY WITH HUMANIZED ANTI-TAC

      The Journal of immunology
    59. HEINZEL FP; SCHOENHAUT DS; LOCKSLEY RM; GATELY MK
      IMMUNOREGULATORY ROLES OF INTERLEUKIN-2 AND INTERLEUKIN-12 DURING MURINE LEISHMANIASIS

      The Journal of immunology
    60. LING P; PILSON R; LIN P; PODLASKI F; GUBLER U; CHIZZONITE R; GATELY MK; HAKIMI J
      DEMONSTRATION OF THE ROLES OF IL-12-SUBUNITS IN RECEPTOR-BINDING AND SIGNAL TRANSDUCTION

      The Journal of immunology
    61. BRUNDA MJ; LUISTRO L; WARRIER RR; WRIGHT RB; HUBBARD BR; MURPHY M; WOLF SF; GATELY MK
      ANTITUMOR AND ANTIMETASTATIC ACTIVITY OF INTERLEUKIN-12 AGAINST MURINE TUMORS

      The Journal of experimental medicine
    62. HEINZEL FP; SCHOENHAUT DS; RERKO RM; ROSSER LE; GATELY MK
      RECOMBINANT INTERLEUKIN-12 CURES MICE INFECTED WITH LEISHMANIA-MAJOR

      The Journal of experimental medicine
    63. GERMANN T; GATELY MK; SCHOENHAUT DS; LOHOFF M; MATTNER F; FISCHER S; JIN SC; SCHMITT E; RUDE E
      INTERLEUKIN-12 T-CELL STIMULATING FACTOR, A CYTOKINE WITH MULTIPLE EFFECTS ON T-HELPER TYPE-1 (TH1) BUT NOT ON TH2 CELLS/

      European Journal of Immunology


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Documento generato il 29/10/20 alle ore 11:50:24