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1. El-Deiry, WS
   Akt takes centre stage in cell-cycle deregulation
   NATURE CELL BIOLOGY
   
   W.S. El-Deiry, "Akt takes centre stage in cell-cycle deregulation", NAT CELL BI, 3(3), 2001, pp. E71-E73
2. El-Deiry, WS
   Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
   CELL DEATH AND DIFFERENTIATION
   
   W.S. El-Deiry, "Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling", CELL DEAT D, 8(11), 2001, pp. 1066-1075
3. Fisher, MJ; Virmani, AK; Wu, L; Aplenc, R; Harper, JC; Powell, SM; Rebbeck, TR; Sidransky, D; Gazdar, AF; El-Deiry, WS
   Nucleotide substitution in the ectodomain of TRAIL receptor DR4 is associated with lung cancer and head and neck cancer
   CLINICAL CANCER RESEARCH
   
   M.J. Fisher et al., "Nucleotide substitution in the ectodomain of TRAIL receptor DR4 is associated with lung cancer and head and neck cancer", CLIN CANC R, 7(6), 2001, pp. 1688-1697
4. Kim, K; Takimoto, R; Dicker, DT; Chen, YH; Gazitt, Y; El-Deiry, WS
   Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines
   INTERNATIONAL JOURNAL OF ONCOLOGY
   
   K. Kim et al., "Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines", INT J ONCOL, 18(2), 2001, pp. 241-247
5. Burns, TF; Bernhard, EJ; El-Deiry, WS
   Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
   ONCOGENE
   
   T.F. Burns et al., "Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo", ONCOGENE, 20(34), 2001, pp. 4601-4612
6. McDonald, ER; El-Deiry, WS
   Checkpoint genes in cancer
   ANNALS OF MEDICINE
   
   E.R. McDonald e W.S. El-Deiry, "Checkpoint genes in cancer", ANN MED, 33(2), 2001, pp. 113-122
7. Liu, Q; El-Deiry, WS; Gazitt, Y
   Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosisin myeloma cell lines
   EXPERIMENTAL HEMATOLOGY
   
   Q. Liu et al., "Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosisin myeloma cell lines", EXP HEMATOL, 29(8), 2001, pp. 962-970
8. Wang, T; Kobayashi, T; Takimoto, R; Denes, AE; Snyder, EL; el-Deiry, WS; Brachmann, RK
   hADA3 is required for p53 activity
   EMBO JOURNAL
   
   T. Wang et al., "hADA3 is required for p53 activity", EMBO J, 20(22), 2001, pp. 6404-6413
9. Takimoto, R; El-Deiry, WS
   DNA replication blockade impairs p53-transactivation
   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
   
   R. Takimoto e W.S. El-Deiry, "DNA replication blockade impairs p53-transactivation", P NAS US, 98(3), 2001, pp. 781-783
10. Burns, TF; El-Deiry, WS
    Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    T.F. Burns e W.S. El-Deiry, "Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach", J BIOL CHEM, 276(41), 2001, pp. 37879-37886
11. McDonald, ER; Chui, PC; Martelli, PF; Dicker, DT; El-Deiry, WS
    Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    E.R. McDonald et al., "Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling", J BIOL CHEM, 276(18), 2001, pp. 14939-14945
12. Meng, RD; El-Deiry, WS
    p53-Independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma
    EXPERIMENTAL CELL RESEARCH
    
    R.D. Meng e W.S. El-Deiry, "p53-Independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma", EXP CELL RE, 262(2), 2001, pp. 154-169
13. Goke, R; Goke, A; Goke, B; El-Deiry, WS; Chen, YH
    Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-inducedapoptosis by induction of p21(waf1/cip1)
    DIGESTION
    
    R. Goke et al., "Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-inducedapoptosis by induction of p21(waf1/cip1)", DIGESTION, 64(2), 2001, pp. 75-80
14. Goldberg, GS; Jin, ZY; Ichikawa, H; Naito, A; Ohki, M; El-Deiry, WS; Tsuda, H
    Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis
    CANCER RESEARCH
    
    G.S. Goldberg et al., "Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis", CANCER RES, 61(4), 2001, pp. 1334-1337
15. Meng, RD; McDonald, ER; Sheikh, MS; Fornace, AJ; El-Deiry, WS
    The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis
    MOLECULAR THERAPY
    
    R.D. Meng et al., "The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis", MOL THER, 1(2), 2000, pp. 130-144
16. Somasundaram, K; El-Deiry, WS
    Tumor suppressor P53: Regulation and function
    FRONTIERS IN BIOSCIENCE
    
    K. Somasundaram e W.S. El-Deiry, "Tumor suppressor P53: Regulation and function", FRONT BIOSC, 5, 2000, pp. D424-D437
17. MacLachlan, TK; El-Deiry, WS
    Pointing (zinc) fingers at BRCA1 targets
    NATURE MEDICINE
    
    T.K. MacLachlan e W.S. El-Deiry, "Pointing (zinc) fingers at BRCA1 targets", NAT MED, 6(12), 2000, pp. 1318-1319
18. Kim, KH; Fisher, MJ; Xu, SQ; El-Deiry, WS
    Molecular determinants of response to TRAIL in killing of normal and cancer cells
    CLINICAL CANCER RESEARCH
    
    K.H. Kim et al., "Molecular determinants of response to TRAIL in killing of normal and cancer cells", CLIN CANC R, 6(2), 2000, pp. 335-346
19. Satyamoorthy, K; Chehab, NH; Waterman, MJF; Lien, MC; El-Deiry, WS; Herlyn, M; Halazonetis, TD
    Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells
    CELL GROWTH & DIFFERENTIATION
    
    K. Satyamoorthy et al., "Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells", CELL GROWTH, 11(9), 2000, pp. 467-474
20. McDonald, ER; El-Deiry, WS
    Cell cycle control as a basis for cancer drug development (review)
    INTERNATIONAL JOURNAL OF ONCOLOGY
    
    E.R. McDonald e W.S. El-Deiry, "Cell cycle control as a basis for cancer drug development (review)", INT J ONCOL, 16(5), 2000, pp. 871-886
21. Ozoren, N; Fisher, MJ; Kim, K; Liu, CX; Genin, A; Shifman, Y; Dicker, DT; Spinner, NB; Lisitsyn, NA; El-Deiry, WS
    Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance
    INTERNATIONAL JOURNAL OF ONCOLOGY
    
    N. Ozoren et al., "Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance", INT J ONCOL, 16(5), 2000, pp. 917-925
22. Takimoto, R; El-Deiry, WS
    Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site
    ONCOGENE
    
    R. Takimoto e W.S. El-Deiry, "Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site", ONCOGENE, 19(14), 2000, pp. 1735-1743
23. Wu, GS; Kim, K; El-Deiry, WS
    Killer/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death
    CANCER GENE THERAPY
    
    G.S. Wu et al., "Killer/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death", ADV EXP MED, 465, 2000, pp. 143-151
24. MacLachlan, TK; Dash, BC; Dicker, DT; El Deiry, WS
    Repression of BRCA1 through a feedback loop involving p53
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    T.K. MacLachlan et al., "Repression of BRCA1 through a feedback loop involving p53", J BIOL CHEM, 275(41), 2000, pp. 31869-31875
25. MacLachlan, TK; Somasundaram, K; Sgagias, M; Shifman, Y; Muschel, RJ; Cowan, KH; El-Deiry, WS
    BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    T.K. MacLachlan et al., "BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression", J BIOL CHEM, 275(4), 2000, pp. 2777-2785
26. Ozoren, N; Kim, KH; Burns, TF; Dicker, DT; Moscioni, AD; El-Deiry, WS
    The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand
    CANCER RESEARCH
    
    N. Ozoren et al., "The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand", CANCER RES, 60(22), 2000, pp. 6259-6265
27. Mitchell, KO; Ricci, MS; Miyashita, T; Dicker, DT; Jin, ZY; Reed, JC; El-Deiry, WS
    Bax is a transcriptional target and mediator of c-Myc-induced apoptosis
    CANCER RESEARCH
    
    K.O. Mitchell et al., "Bax is a transcriptional target and mediator of c-Myc-induced apoptosis", CANCER RES, 60(22), 2000, pp. 6318-6325
28. Xu, SQ; El-Deiry, WS
    p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptorDR4
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    
    S.Q. Xu e W.S. El-Deiry, "p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptorDR4", BIOC BIOP R, 269(1), 2000, pp. 179-190
29. El-Deiry, WS
    The TRAIL to an anticancer agent
    DRUG RESISTANCE UPDATES
    
    W.S. El-Deiry, "The TRAIL to an anticancer agent", DRUG RESIST, 2(2), 1999, pp. 79-80
30. Mitchell, KO; El-Deiry, WS
    Overexpression of c-Myc inhibits p(21WAF1/CIP1) expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells
    CELL GROWTH & DIFFERENTIATION
    
    K.O. Mitchell e W.S. El-Deiry, "Overexpression of c-Myc inhibits p(21WAF1/CIP1) expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells", CELL GROWTH, 10(4), 1999, pp. 223-230
31. Prabhu, NS; Somasundaram, K; Tian, H; Enders, GH; Satyamoorthy, K; Herlyn, M; El-Deiry, WS
    The administration schedule of cyclin-dependent kinase inhibitor gene therapy and etoposide chemotherapy is a major determinant of cytotoxicity
    INTERNATIONAL JOURNAL OF ONCOLOGY
    
    N.S. Prabhu et al., "The administration schedule of cyclin-dependent kinase inhibitor gene therapy and etoposide chemotherapy is a major determinant of cytotoxicity", INT J ONCOL, 15(2), 1999, pp. 209-216
32. Meng, RD; Phillips, P; El-Deiry, WS
    P53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin
    INTERNATIONAL JOURNAL OF ONCOLOGY
    
    R.D. Meng et al., "P53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin", INT J ONCOL, 14(1), 1999, pp. 5-14
33. Wu, GS; Burns, TF; McDonald, ER; Meng, RD; Kao, G; Muschel, R; Yen, T; El-Deiry, WS
    Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest
    ONCOGENE
    
    G.S. Wu et al., "Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest", ONCOGENE, 18(47), 1999, pp. 6411-6418
34. Somasundaram, K; MacLachlan, TK; Burns, TF; Sgagias, M; Cowan, KH; Weber, BL; El-Deiry, WS
    BRCA1 signals ARF-dependent stabilization and coactivation of p53
    ONCOGENE
    
    K. Somasundaram et al., "BRCA1 signals ARF-dependent stabilization and coactivation of p53", ONCOGENE, 18(47), 1999, pp. 6605-6614
35. Sheikh, MS; Huang, Y; Fernandez-Salas, EA; El-Deiry, WS; Friess, H; Amundson, S; Yin, J; Meltzer, SJ; Holbrook, NJ; Fornace, AJ
    The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
    ONCOGENE
    
    M.S. Sheikh et al., "The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract", ONCOGENE, 18(28), 1999, pp. 4153-4159
36. Sun, SY; Yue, P; Wu, GS; El-Deiry, WS; Shroot, B; Hong, WK; Lotan, R
    Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells
    ONCOGENE
    
    S.Y. Sun et al., "Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells", ONCOGENE, 18(14), 1999, pp. 2357-2365
37. Mitra, J; Dai, CY; Somasundaram, K; El-Deiry, WS; Satyamoorthy, K; Herlyn, M; Enders, GH
    Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)
    MOLECULAR AND CELLULAR BIOLOGY
    
    J. Mitra et al., "Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)", MOL CELL B, 19(5), 1999, pp. 3916-3928
38. Burns, TF; El-Deiry, WS
    The p53 pathway and apoptosis
    JOURNAL OF CELLULAR PHYSIOLOGY
    
    T.F. Burns e W.S. El-Deiry, "The p53 pathway and apoptosis", J CELL PHYS, 181(2), 1999, pp. 231-239
39. Wu, GS; Burns, TF; Zhan, Y; Alnemri, ES; El-Deiry, WS
    Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor
    CANCER RESEARCH
    
    G.S. Wu et al., "Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor", CANCER RES, 59(12), 1999, pp. 2770-2775
40. Sun, SY; Yue, P; Wu, GS; El-Deiry, WS; Shroot, B; Hong, WK; Lotan, R
    Implication of p53 in growth arrest and apoptosis induced hy the syntheticretinoid CD437 in human lung cancer cells
    CANCER RESEARCH
    
    S.Y. Sun et al., "Implication of p53 in growth arrest and apoptosis induced hy the syntheticretinoid CD437 in human lung cancer cells", CANCER RES, 59(12), 1999, pp. 2829-2833
41. Song, SS; MacLachlan, TK; Meng, RD; El-Deiry, WS
    Comparative gene expression profiling in response to p53 in a human lung cancer cell line
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    
    S.S. Song et al., "Comparative gene expression profiling in response to p53 in a human lung cancer cell line", BIOC BIOP R, 264(3), 1999, pp. 891-895
42. El-Deiry, WS
    The role of p53 in chemosensitivity
    APOPTOSIS AND CANCER CHEMOTHERAPY
    
    W.S. El-Deiry, "The role of p53 in chemosensitivity", CANC DRUG, 5, 1999, pp. 37-52
43. El-Deiry, WS
    Regulation of p53 downstream genes
    SEMINARS IN CANCER BIOLOGY
    
    W.S. El-Deiry, "Regulation of p53 downstream genes", SEM CANC B, 8(5), 1998, pp. 345-357