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    1. Gu, YX; Liu, YD; Hao, Q; Ealick, SE; Fan, HF
      Direct-method-aided phasing of MAD data

      ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
    2. Appleby, TC; Mathews, II; Porcelli, M; Cacciapuoti, G; Ealick, SE
      Three-dimensional structure of a hyperthermophilic 5 '-deoxy-5 '-methylthioadenosine phosphorylase from Sulfolobus solfataricus

      JOURNAL OF BIOLOGICAL CHEMISTRY
    3. Tolbert, WD; Ekstrom, JL; Mathews, II; Secrist, JA; Kapoor, P; Pegg, AE; Ealick, SE
      The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase (vol 40, pg 9484, 2001)

      BIOCHEMISTRY
    4. Peapus, DH; Chiu, HJ; Campobasso, N; Reddick, JJ; Begley, TP; Ealick, SE
      Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase

      BIOCHEMISTRY
    5. Tolbert, WD; Ekstrom, JL; Mathews, II; Secrist, JA; Kapoor, P; Pegg, AE; Ealick, SE
      The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase

      BIOCHEMISTRY
    6. Ekstrom, JL; Tolbert, WD; Xiong, HS; Pegg, AE; Ealick, SE
      Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant

      BIOCHEMISTRY
    7. Ealick, SE
      Advances in multiple wavelength anomalous diffraction crystallography

      CURRENT OPINION IN CHEMICAL BIOLOGY
    8. Kappock, TJ; Ealick, SE; Stubbe, J
      Modular evolution of the purine biosynthetic pathway

      CURRENT OPINION IN CHEMICAL BIOLOGY
    9. Thiel, DJ; le Du, MH; Walter, RL; D'Arcy, A; Chene, C; Fountoulakis, M; Garotta, G; Winkler, FK; Ealick, SE
      Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex

      STRUCTURE WITH FOLDING & DESIGN
    10. Deacon, AM; Ni, YS; Coleman, WG; Ealick, SE
      The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist

      STRUCTURE WITH FOLDING & DESIGN
    11. Begley, TP; Appleby, TC; Ealick, SE
      The structural basis for the remarkable catalytic proficiency of orotidine5 '-monophosphate decarboxylase

      CURRENT OPINION IN STRUCTURAL BIOLOGY
    12. Appleby, TC; Kinsland, C; Begley, TP; Ealick, SE
      The crystal structure and mechanism of orotidine 5 '-monophosphate decarboxylase

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    13. Schumacher, MA; Scott, DM; Mathews, II; Ealick, SE; Roos, DS; Ullman, B; Brennan, RG
      Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding

      JOURNAL OF MOLECULAR BIOLOGY
    14. Schumacher, MA; Scott, DM; Mathews, II; Ealick, SE; Roos, DS; Ullman, B; Brennan, RG
      Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding

      JOURNAL OF MOLECULAR BIOLOGY
    15. Campobasso, N; Mathews, II; Begley, TP; Ealick, SE
      Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 angstrom resolution

      BIOCHEMISTRY
    16. Li, CL; Kappock, TJ; Stubbe, J; Weaver, TM; Ealick, SE
      X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 angstrom resolution

      STRUCTURE WITH FOLDING & DESIGN
    17. Deacon, AM; Ealick, SE
      Selenium-based MAD phasing: setting the sites on larger structures

      STRUCTURE WITH FOLDING & DESIGN
    18. Appleby, TC; Erion, MD; Ealick, SE
      The structure of human 5 '-deoxy-5 '-methylthioadenosine phosphorylase at 1.7 angstrom resolution provides insights into substrate binding and catalysis

      STRUCTURE WITH FOLDING & DESIGN
    19. Ekstrom, JL; Mathews, II; Stanley, BA; Pegg, AE; Ealick, SE
      The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 angstrom resolution reveals a novel fold

      STRUCTURE WITH FOLDING & DESIGN
    20. Mathews, II; Kappock, TJ; Stubbe, JA; Ealick, SE
      Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway

      STRUCTURE WITH FOLDING & DESIGN
    21. Cassetta, A; Deacon, AM; Ealick, SE; Helliwell, JR; Thompson, AW
      Development of instrumentation and methods for MAD and structural genomicsat the SRS, ESRF, CHESS and Elettra facilities

      JOURNAL OF SYNCHROTRON RADIATION
    22. Ding, L; Zhang, YH; Deacon, AM; Ealick, SE; Ni, YS; Sun, P; Coleman, WG
      Crystallization and preliminary x-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D-mannoheptose 6-epimerasefrom Escherichia coli K-12

      ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
    23. Weaver, TM; Wang, WR; Ealick, SE
      Purification, crystallization and preliminary X-ray diffraction data from selenomethionine glycinamide ribonucleotide synthetase

      ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
    24. Zhou, M; Pugmire, MJ; Vuong, BQ; Ealick, SE
      Cloning, expression and crystallization of pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus

      ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
    25. Secrist, JA; Parker, WB; Allan, PW; Bennett, LL; Waud, WR; Truss, JW; Fowler, AT; Montgomery, JA; Ealick, SE; Wells, AH; Gillespie, GY; Gadi, VK; Sorscher, EJ
      Gene therapy of cancer: Activation of nucleoside prodrugs with E-coli purine nucleoside phosphorylase

      NUCLEOSIDES & NUCLEOTIDES
    26. Begley, TP; Downs, DM; Ealick, SE; McLafferty, FW; Van Loon, APGM; Taylor, S; Campobasso, N; Chiu, HJ; Kinsland, C; Reddick, JJ; Xi, J
      Thiamin biosynthesis in prokaryotes

      ARCHIVES OF MICROBIOLOGY
    27. Mueller, EJ; Oh, S; Kavalerchik, E; Kappock, TJ; Meyer, E; Li, C; Ealick, SE; Stubbe, J
      Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis

      BIOCHEMISTRY
    28. Chiu, HJ; Reddick, JJ; Begley, TP; Ealick, SE
      Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 angstrom resolution

      BIOCHEMISTRY
    29. EALICK SE
      CHALLENGES FACING STRUCTURAL BIOLOGY BEAMLINES

      Nature structural biology
    30. PUGMIRE MJ; EALICK SE
      THE CRYSTAL-STRUCTURE OF PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE IN A CLOSED CONFORMATION

      Structure
    31. DEACON AM; APPLEBY T; BILDERBACK DH; EALICK SE; FONTES E; THIEL DJ
      PROTEIN CRYSTALLOGRAPHY USING A MULTILAYER MONOCHROMATOR

      Journal of synchrotron radiation
    32. CAMPOBASSO N; BEGUN J; COSTELLO CA; BEGLEY TP; EALICK SE
      CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF THIAMINASE-I FROM BACILLUS-THIAMINOLYTICUS - SPACE GROUP CHANGE UPON FREEZING OF CRYSTALS

      Acta crystallographica. Section D, Biological crystallography
    33. VORA RA; PEGG AE; EALICK SE
      A NEW MODEL FOR HOW O-6-METHYLGUANINE-DNA METHYLTRANSFERASE BINDS DNA

      Proteins
    34. DEACON AM; WEEKS CM; MILLER R; EALICK SE
      THE SHAKE-AND-BAKE STRUCTURE DETERMINATION OF TRICLINIC LYSOZYME

      Proceedings of the National Academy of Sciences of the United Statesof America
    35. PUGMIRE WJ; COOK WJ; JASANOFF A; WALTER MR; EALICK SE
      STRUCTURAL AND THEORETICAL-STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE

      Journal of Molecular Biology
    36. SECRIST JA; TIWARI KN; SHORTNACYFOWLER AT; MESSINI L; RIORDAN JM; MONTGOMERY JA; MEYERS SC; EALICK SE
      SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CERTAIN 4'-THIO-D-ARABINOFURANOSYLPURINE NUCLEOSIDES

      Journal of medicinal chemistry
    37. MATHEWS II; ERION MD; EALICK SE
      STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.5 ANGSTROM RESOLUTION

      Biochemistry (Easton)
    38. WANG WR; KAPPOCK TJ; STUBBE J; EALICK SE
      X-RAY CRYSTAL-STRUCTURE OF GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE FROMESCHERICHIA-COLI

      Biochemistry (Easton)
    39. CAMPOBASSO N; COSTELLO CA; KINSLAND C; BEGLEY TP; EALICK SE
      CRYSTAL-STRUCTURE OF THIAMINASE-I FROM BACILLUS-THIAMINOLYTICUS AT 2.0 ANGSTROM RESOLUTION

      Biochemistry (Easton)
    40. MAO C; COOK WJ; ZHOU M; FEDEROV AA; ALMO SC; EALICK SE
      CALF SPLEEN PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH SUBSTRATESAND SUBSTRATE-ANALOGS

      Biochemistry
    41. EALICK SE
      NOW WERE COOKING - NEW SUCCESSES FOR SHAKE-AND-BAKE

      Structure
    42. MAO C; COOK WJ; ZHOU M; KOSZALKA GW; KRENITSKY TA; EALICK SE
      THE CRYSTAL-STRUCTURE OF ESCHERICHIA-COLI PURINE NUCLEOSIDE PHOSPHORYLASE - A COMPARISON WITH THE HUMAN ENZYME REVEALS A CONSERVED TOPOLOGY

      Structure
    43. BAX A; EALICK SE
      BIOPHYSICAL METHODS

      Current opinion in structural biology
    44. SMITH GD; BLESSING RH; EALICK SE; FONTECILLACAMPS JC; HAUPTMAN HA; HOUSSET D; LANGS DA; MILLER R
      AB-INITIO STRUCTURE DETERMINATION AND REFINEMENT OF A SCORPION PROTEIN TOXIN

      Acta crystallographica. Section D, Biological crystallography
    45. NARAYANA SVL; BUGG CE; EALICK SE
      REFINED STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE AT 2.75 ANGSTROMRESOLUTION

      Acta crystallographica. Section D, Biological crystallography
    46. DEACON A; THIEL DJ; EALICK SE; HELLIWELL JR
      ULTRA-HIGH-RESOLUTION PROTEIN CRYSTALLOGRAPHY - DATA-COLLECTION AND APPLICATION

      The FASEB journal
    47. WALL ME; EALICK SE; GRUNER SM
      3-DIMENSIONAL DIFFUSE-X-RAY SCATTERING FROM CRYSTALS OF STAPHYLOCOCCAL NUCLEASE

      Proceedings of the National Academy of Sciences of the United Statesof America
    48. ERION MD; TAKABAYASHI K; SMITH HB; KESSI J; WAGNER S; HONGER S; SHAMES SL; EALICK SE
      PURINE NUCLEOSIDE PHOSPHORYLASE .1. STRUCTURE-FUNCTION STUDIES

      Biochemistry
    49. ERION MD; STOECKLER JD; GUIDA WC; WALTER RL; EALICK SE
      PURINE NUCLEOSIDE PHOSPHORYLASE .2. CATALYTIC MECHANISM

      Biochemistry
    50. STOECKLER JD; POIROT AF; SMITH RM; PARKS RE; EALICK SE; TAKABAYASHI K; ERION MD
      PURINE NUCLEOSIDE PHOSPHORYLASE .3. REVERSAL OF PURINE BASE SPECIFICITY BY SITE-DIRECTED MUTAGENESIS

      Biochemistry
    51. ARMSTRONG SR; COOK WJ; SHORT SA; EALICK SE
      CRYSTAL-STRUCTURES OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE IN NATIVE AND LIGAND-BOUND FORMS REVEAL ARCHITECTURE OF THE ACTIVE-SITE

      Structure
    52. WALTER RL; EALICK SE; FRIEDMAN AM; BLAKE RC; PROCTOR P; SHOHAM M
      MULTIPLE WAVELENGTH ANOMALOUS DIFFRACTION (MAD) CRYSTAL-STRUCTURE OF RUSTICYANIN - A HIGHLY OXIDIZING CUPREDOXIN WITH EXTREME ACID STABILITY

      Journal of Molecular Biology
    53. SHORT SA; ARMSTRONG SR; EALICK SE; PORTER DJT
      ACTIVE-SITE AMINO-ACIDS THAT PARTICIPATE IN THE CATALYTIC MECHANISM OF NUCLEOSIDE 2'-DEOXYRIBOSYLTRANSFERASE

      The Journal of biological chemistry
    54. EALICK SE
      CATALYTIC MECHANISM OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE

      Biochemistry
    55. WALTER RL; THIEL DJ; BARNA SL; TATE MW; WALL ME; EIKENBERRY EF; GRUNER SM; EALICK SE
      HIGH-RESOLUTION MACROMOLECULAR STRUCTURE DETERMINATION USING CCD DETECTORS AND SYNCHROTRON-RADIATION

      Structure
    56. WALTER RL; SLAYBAUGH MC; EALICK SE
      AN INSTRUCTIONAL VIDEO ON THE APPLICATION OF CRYOCRYSTALLOGRAPHIC TECHNIQUES

      Structure
    57. GRUNER SM; EALICK SE
      CHARGE-COUPLED-DEVICE X-RAY-DETECTORS FOR MACROMOLECULAR CRYSTALLOGRAPHY

      Structure
    58. BABU YS; EALICK SE; BUGG CE; ERION MD; GUIDA WC; MONTGOMERY JA; SECRIST JA
      STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE

      Acta crystallographica. Section D, Biological crystallography
    59. THIEL DJ; WALTER RL; EALICK SE; BILDERBACK DH; TATE MW; GRUNER SM; EIKENBERRY EF
      MACROMOLECULAR CRYSTALLOGRAPHIC RESULTS OBTAINED AT CHESS USING A DETECTOR INCORPORATING A CHARGE-COUPLED-DEVICE

      Review of scientific instruments
    60. MORGUNOVA EY; MIKHAILOV AM; KOMISSAROV AA; MAO C; LINKOVA EV; MIRONOV AS; POPOV AN; ARMSTRONG S; BURLAKOVA AA; ROMANOVA DV; BLAGOVA EV; SMIRNOVA EA; DEBABOV VG; EALICK SE
      STRUCTURE-FUNCTIONAL ASPECT OF THE INVEST IGATION OF THE MOLECULAR-STRUCTURE OF URIDINE PHOSPHORYLASE FROM ESCHERICHIA-COLI

      Kristallografia
    61. MORGUNOVA EY; MIKHAILOV AM; POPOV AN; BLAGOVA EV; SMIRNOVA EA; VAINSHTEIN BK; MAO C; ARMSTRONG SR; EALICK SE; KOMISSAROV AA; LINKOVA EV; BURLAKOVA AA; MIRONOV AS; DEBABOV VG
      ATOMIC-STRUCTURE AT 2.5 ANGSTROM RESOLUTION OF URIDINE PHOSPHORYLASE FROM ESCHERICHIA-COLI AS REFINED IN THE MONOCLINIC CRYSTAL-LATTICE

      FEBS letters
    62. MEGATI S; EALICK SE; NAGUIB FNM; ELKOUNI MH; KLEIN RS; OTTER BA
      O-(5',16)-METHANOCYTIDINE - SYNTHESIS, CONFORMATIONAL PROPERTIES AND DEAMINATION BY CYTIDINE DEAMINASE

      Nucleosides & nucleotides
    63. WALTER RL; SYMERSKY J; POIROT AF; STOECKLER JD; ERION MD; EALICK SE
      X-RAY CRYSTALLOGRAPHIC AND KINETIC-ANALYSIS OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXES WITH -BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE AND ETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDINE

      Nucleosides & nucleotides
    64. GUIDA WC; ELLIOTT RD; THOMAS HJ; SECRIST JA; BABU YS; BUGG CE; ERION MD; EALICK SE; MONTGOMERY JA
      STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .4. A STUDY OF PHOSPHATE MIMICS

      Journal of medicinal chemistry
    65. ERION MD; NIWAS S; ROSE JD; ANANTHAN S; ALLEN M; SECRIST JA; BABU YS; BUGG CE; GUIDA WC; EALICK SE; MONTGOMERY JA
      STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .3. 9-ARYLMETHYL DERIVATIVES OF 9-DEAZAGUANINE SUBSTITUTED ON THE METHYLENE GROUP (VOL 36, PG 3773, 1993)

      Journal of medicinal chemistry
    66. EALICK SE; ARMSTRONG SR
      PHARMACOLOGICALLY RELEVANT PROTEINS

      Current opinion in structural biology
    67. EALICK SE; WALTER RL
      SYNCHROTRON BEAMLINES FOR MACROMOLECULAR CRYSTALLOGRAPHY

      Current opinion in structural biology
    68. POIROT AF; SMITH RM; STOECKLER JD; PARKS RE; TAKABAYASHI K; ERION MD; EALICK SE
      KINETICS OF SITE-DIRECTED MUTANTS OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE (PNP) - EFFECTS OF CYSTEINE TO ALANINE SUBSTITUTIONS

      The FASEB journal
    69. ERION MD; NIWAS S; ROSE JD; ANANTHAN S; ALLEN M; SECRIST JA; BABU YS; BUGG CE; GUIDA WC; EALICK SE; MONTGOMERY JA
      STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .3. 9-ARYLMETHYL DERIVATIVES OF 9-DEAZAGUANINE SUBSTITUTED ON THE METHYLENE GROUP

      Journal of medicinal chemistry
    70. SECRIST JA; NIWAS S; ROSE JD; BABU YS; BUGG CE; ERION MD; GUIDA WC; EALICK SE; MONTGOMERY JA
      STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .2. 9-ALICYCLIC AND 9-HETEROALICYCLIC DERIVATIVES OF 9-DEAZAGUANINE

      Journal of medicinal chemistry


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Documento generato il 22/10/20 alle ore 15:10:17