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Impaired liver regeneration after partial hepatectomy in plasminogen deficient mice
FIBRINOLYSIS & PROTEOLYSIS
Growing better blood vessels - A polymer scaffold that delivers two angiogenic factors with distinct kinetics shows promise for engineering mature blood vessels
NATURE BIOTECHNOLOGY
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome
NATURE MEDICINE
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy (vol 7, pg 864,2001)
NATURE MEDICINE
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy
NATURE MEDICINE
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathologicalconditions
NATURE MEDICINE
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
NATURE MEDICINE
Jeffrey Michael Isner 1947-2001 - Obituary
NATURE MEDICINE
The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
NATURE MEDICINE
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
NATURE GENETICS
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects
DEVELOPMENT
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
FASEB JOURNAL
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium
MOLECULAR AND CELLULAR BIOLOGY
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat
BREAST CANCER RESEARCH AND TREATMENT
Cardiovascular biology - Creating unique blood vessels
NATURE
Duodenal calcium absorption in vitamin D receptor-knockout mice: Functional and molecular aspects
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Tissue-type plasminogen activator deficiency exacerbates arthritis
JOURNAL OF IMMUNOLOGY
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin: Implications for antiangiogenic strategies
JOURNAL OF CELL BIOLOGY
Hypoxia-inducible factor-2 alpha (HIF-2 alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia
JOURNAL OF BIOLOGICAL CHEMISTRY
The pathophysiology of pelvic floor disorders: evidence from a histomorphologic study of the perineum and a mouse model of rectal prolapse
JOURNAL OF ANATOMY
Replacement of the muscle-specific sarcoplasmic reticulum Ca2+-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart
CIRCULATION RESEARCH
Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice
CIRCULATION
Molecular mechanisms of blood vessel growth
CARDIOVASCULAR RESEARCH
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: Role of VEGF-receptor 2 and host VEGF-A
CANCER RESEARCH
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) fin the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model
CANCER RESEARCH
Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo
BLOOD
Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Tissue factor is not involved in the mitogenic activity of factor VIIa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Heterogeneous vascular dependence of tumor cell populations
AMERICAN JOURNAL OF PATHOLOGY
Mechanisms of angiogenesis and arteriogenesis
NATURE MEDICINE
PR39, a peptide regulator of angiogenesis (vol 6, pg 49, 2000)
NATURE MEDICINE
VEGF gene therapy: stimulating angiogenesis or angioma-genesis?
NATURE MEDICINE
PR39, a peptide regulator of angiogenesis
NATURE MEDICINE
Blood coagulation factor x deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice
THROMBOSIS AND HAEMOSTASIS
Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine genengn3
MOLECULAR AND CELLULAR BIOLOGY
Developmental biology - One cell, two fates
NATURE
Angiogenesis in cancer and other diseases
NATURE
Transgenic mouse models in angiogenesis and cardiovascular disease
JOURNAL OF PATHOLOGY
Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility
JOURNAL OF CLINICAL INVESTIGATION
Proteinases in cardiovascular aneurysms and rupture: targets for therapy?
JOURNAL OF CLINICAL INVESTIGATION
Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids
JOURNAL OF BIOLOGICAL CHEMISTRY
Fibroblast growth factor-1 stimulates branching and survival of myocardialarteries - A goal for therapeutic angiogenesis?
CIRCULATION RESEARCH
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1 alpha -> hypoxia response element -> VEGF cascade differentially regulates vascular response and growth rate in tumors
CANCER RESEARCH
Roles of urokinase type plasminogen activator in a brain stab wound
BRAIN RESEARCH
Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A
BLOOD
Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction
AMERICAN JOURNAL OF PATHOLOGY
Regulation of cancer invasion and vascularization by plasminogen activatorinhibitor-1
FIBRINOLYSIS & PROTEOLYSIS
Plasminogen and cell migration in vivo
FIBRINOLYSIS & PROTEOLYSIS
Tribute to Werner Risau - December 18, 1953 December 13, 1998 - In Memoriam
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - Studies in tPA-deficient mice and wild-type mice on a matched genetic background
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188)
NATURE MEDICINE
Inhibition of plasminogen activators or matrix metalloproteinases preventscardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure
NATURE MEDICINE
Temporal and topographic matrix metalloproteinase expression after vascular injury in mice
THROMBOSIS AND HAEMOSTASIS
Nigral degeneration following striato-pallidal lesion in tissue type plasminogen activator deficient mice
NEUROSCIENCE LETTERS
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
CELL
New developments in the molecular biology of coagulation and fibrinolysis
ANTITHROMBOTICS
Role of vascular endothelial growth factor and vascular endothelial growthfactor receptors in vascular development
VASCULAR GROWTH FACTORS AND ANGIOGENESIS
Developmental biology - Controlling the cellular brakes
NATURE
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit
JOURNAL OF CLINICAL INVESTIGATION
Ovulation in plasminogen-deficient mice
ENDOCRINOLOGY
Plasminogen is not required for neointima formation in a mouse model of vein graft stenosis
CIRCULATION RESEARCH
Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance
CIRCULATION
Role of plasminogen system components in focal cerebral ischemic infarction - A gene targeting and gene transfer study in mice
CIRCULATION
Structure-function analyses of thrombomodulin by gene-targeting in mice: The cytoplasmic domain is not required for normal fetal development
BLOOD
Targeted gene manipulation and gene transfer to study vascular biology
MODERN VISUALISATION OF THE ENDOTHELIUM
UROKINASE MEDIATES BFGF-INDUCED VASCULAR SMOOTH-MUSCLE CELL-MIGRATIONUNDER THE CONTROL OF TGF-BETA
FIBRINOLYSIS & PROTEOLYSIS
MOLECULES IN FOCUS - TISSUE FACTOR
International journal of biochemistry & cell biology
FUNCTION OF THE PLASMINOGEN PLASMIN AND MATRIX METALLOPROTEINASE SYSTEMS AFTER VASCULAR INJURY IN MICE WITH TARGETED INACTIVATION OF FIBRINOLYTIC SYSTEM GENES/
Arteriosclerosis, thrombosis, and vascular biology
ABSENCE OF HOST PLASMINOGEN-ACTIVATOR INHIBITOR-1 PREVENTS CANCER INVASION AND VASCULARIZATION
Nature medicine
CLONING AND CHARACTERIZATION OF A CDNA-ENCODING MURINE COAGULATION-FACTOR-X
Thrombosis and haemostasis
NUCLEOTIDE STRUCTURE AND CHARACTERIZATION OF THE MURINE GENE ENCODINGANTICOAGULANT PROTEIN-C
Thrombosis and haemostasis
PLASMINOGEN DEFICIENCY LEADS TO STAGNANT WOUND-HEALING FOLLOWING MYOCARDIAL-INFARCTION IN MICE
Hypertension
VASCULAR DEVELOPMENT AND DISORDERS - MOLECULAR ANALYSIS AND PATHOGENIC INSIGHTS
Kidney international
DEVELOPMENT AND DISEASE IN PROTEINASE-DEFICIENT MICE - ROLE OF THE PLASMINOGEN, MATRIX METALLOPROTEINASE AND COAGULATION SYSTEM
Thrombosis research
ROLE OF HIF-1-ALPHA IN HYPOXIA-MEDIATED APOPTOSIS, CELL-PROLIFERATIONAND TUMOR ANGIOGENESIS (VOL 394, PG 485, 1998)
Nature
ROLE OF HIF-1-ALPHA OR IN HYPOXIA-MEDIATED APOPTOSIS, CELL-PROLIFERATION AND TUMOR ANGIOGENESIS
Nature
MOLECULAR ANALYSIS, VIA GENE TARGETING AND GENE-TRANSFER, OF BLOOD-VESSEL FORMATION AND DISORDERS
Journal of physiology
UROKINASE PLASMINOGEN-ACTIVATOR PROMOTES KERATINOCYTE PROLIFERATION IN-VIVO
Journal of investigative dermatology
INACTIVATION OF THE GENE FOR ANTICOAGULANT PROTEIN-C CAUSES LETHAL PERINATAL CONSUMPTIVE COAGULOPATHY IN MICE
The Journal of clinical investigation
COORDINATED INDUCTION OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) AND INHIBITION OF PLASMINOGEN-ACTIVATOR GENE-EXPRESSION BY HYPOXIA PROMOTES PULMONARY VASCULAR FIBRIN DEPOSITION
The Journal of clinical investigation
REDUCED TRANSPLANT ARTERIOSCLEROSIS IN PLASMINOGEN-DEFICIENT MICE
The Journal of clinical investigation
LOW-LEVELS OF TISSUE FACTOR ARE COMPATIBLE WITH DEVELOPMENT AND HEMOSTASIS IN MICE
The Journal of clinical investigation
RECEPTOR-INDEPENDENT ROLE OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR IN PERICELLULAR PLASMIN AND MATRIX METALLOPROTEINASE PROTEOLYSIS DURING VASCULAR WOUND-HEALING IN MICE
The Journal of cell biology
COMPLETE INHIBITION OF CARDIAC WOUND-HEALING AFTER MYOCARDIAL-INFARCTION IN PLASMINOGEN DEFICIENT MICE
Circulation
REGULATION OF ARTERIAL THROMBOLYSIS BY PLASMINOGEN-ACTIVATOR INHIBITOR-1 IN MICE
Circulation
MOUSE MODELS OF ANGIOGENESIS, ARTERIAL-STENOSIS, ATHEROSCLEROSIS AND HEMOSTASIS
Cardiovascular Research
PLASMINOGEN DEFICIENCY DIFFERENTIALLY AFFECTS RECRUITMENT OF INFLAMMATORY CELL-POPULATIONS IN MICE
Blood
INSIGHTS FROM GENE-INACTIVATION STUDIES OF THE COAGULATION AND PLASMINOGEN
Fibrinolysis & proteolysis
UROKINASE-GENERATED PLASMIN ACTIVATES MATRIX METALLOPROTEINASES DURING ANEURYSM FORMATION
Nature genetics
A MOUSE MODEL FOR ZELLWEGER-SYNDROME
Nature genetics
GENETIC-ANALYSIS OF BLOOD-VESSEL FORMATION - ROLE OF ENDOTHELIAL VERSUS SMOOTH-MUSCLE CELLS
Trends in cardiovascular medicine
MOLECULAR-GENETICS OF THE FIBRINOLYTIC AND COAGULATION SYSTEMS IN HEMOSTASIS, THROMBOGENESIS, RESTENOSIS AND ATHEROSCLEROSIS
Current opinion in lipidology
MOLECULAR ANALYSIS OF BLOOD-VESSEL FORMATION AND DISEASE
American journal of physiology. Heart and circulatory physiology
IMPAIRED WOUND-HEALING IN MICE LACKING PLACENTAL GROWTH-FACTOR
Thrombosis and haemostasis
LACK OF ANEURYSM FORMATION IN ATHEROSCLEROTIC AORTA FROM UROKINASE DEFICIENT MICE
Thrombosis and haemostasis
GENERATION AND CHARACTERIZATION OF FVII DEFICIENT MICE
Thrombosis and haemostasis
REDUCED DISSEMINATION OF LEWIS LUNG-CARCINOMA IN MICE GENETICALLY DEFICIENT FOR UROKINASE-TYPE (U-PA) PLASMINOGEN-ACTIVATOR
Thrombosis and haemostasis
NUCLEOTIDE STRUCTURE AND CHARACTERIZATION OF THE MURINE PROTEIN-C GENE FOR TARGETED GENE REPLACEMENT
Thrombosis and haemostasis
THE INFLAMMATORY RESPONSE TO BIOPOLYMER IMPLANTS IN PLASMINOGEN DEFICIENT MICE
Thrombosis and haemostasis