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    1. Wirsching, J; Voss, J; Adiwidjaja, G; Balzarini, J; De Clercq, E
      Thiosugars. VIII. Preparation of new 41-thio-L-lyxo pyrimidine nucleoside analogues

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    2. Redwane, N; Lazrek, HB; Barascut, JL; Imbach, JL; Balzarini, J; Witvrouw, M; De Clerq, E
      Synthesis and biological activities of (Z) and (E) alpha-ethenyl acyclonucleosides

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    3. De Clercq, E; Andrei, G; Snoeck, R; De Bolle, L; Naesens, L; Degreve, B; Balzarini, J; Zhang, Y; Schols, D; Leyssen, P; Ying, C; Neyts, J
      Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    4. McGuigan, C; Barucki, H; Carangio, A; Blewett, S; Srinivasan, S; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    5. Carangio, A; McGuigan, C; Cahard, D; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Synthesis and in vitro evaluation of novel anti-varicella-zoster virus (VZV) nucleosides

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    6. Lobaton, E; Velazquez, S; Perez-Perez, MJ; Jimeno, ML; San-Felix, A; De Clercq, E; Balzarini, J; Camarasa, MJ
      "Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    7. Lobaton, E; Velazquez, S; San-Felix, A; De Clercq, E; Balzarini, J; Camarasa, MJ
      4 ''-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    8. Huntley, CM; Cotterill, AS; Maillard, JY; Balzarini, J; Simons, C
      Synthesis and biological evaluation of pyridin-2-one nucleosides

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    9. Srinivasan, S; McGuigan, C; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Effect of terminal unsaturation in the side-chain

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    10. Renze, J; Plath, M; Ducho, C; Balzarini, J; De Clercq, E; Meier, C
      Benzyl-functionalized cycloSal-d4T monophosphates

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    11. Blewett, S; McGuigan, C; Barucki, H; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective Varicella-Zoster Virus inhibitors

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    12. Fernandez, F; Hergueta, AR; Lopez, C; De Clercq, E; Balzarini, J
      Modified cyclobutane carbonucleosides: Synthesis and evaluation of their antiviral activity

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    13. Lopez, C; Balo, C; Blanco, JM; Fernandez, F; De Clercq, E; Balzarini, J
      A cyclobutane carbonucleoside with marked selectivity against TK+ and TK- varicella zoster virus

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    14. Caamano, O; Figueira, AJ; Fernandez, F; Garcia, MD; Nieto, MI; De Clercq, E; Balzarini, J
      Synthesis and evaluation of antiviral activity of higher homologues of xylo-carbocyclic nucleosides

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    15. Wang, ZX; Duan, WL; Wiebe, LI; Balzarini, J; De Clercq, E; Knaus, EE
      Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene thymidine mimics, some related alpha-anomers, and their evaluation as antiviral and anticancer agents

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    16. Wang, ZX; Duan, WL; Wiebe, LI; Balzarini, J; De Clercq, E; Knaus, EE
      Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "Thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    17. Stephens, CE; Felder, TM; Sowell, JW; Andrei, G; Balzarini, J; Snoeck, R; De Clercq, E
      Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones

      BIOORGANIC & MEDICINAL CHEMISTRY
    18. Wirsching, J; Voss, J; Adiwidjaja, G; Balzarini, J; De Clercq, E
      Thiosugars. Part 9: Synthesis and biological evaluation of some 4 '-thio-L-arabino nucleoside analogues

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    19. Ballatore, C; McGuigan, C; De Clercq, E; Balzarini, J
      Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    20. Srinivasan, S; McGuigan, C; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Bicyclic nucleoside inhibitors of Varicella-Zoster virus (VZV): The effectof terminal unsaturation in the side chain

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    21. Chamorro, C; Lobaton, E; Bonache, MC; De Clercq, E; Balzarini, J; Velazquez, S; San-Felix, A; Camarasa, MJ
      Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    22. Brancale, A; McGuigan, C; Algain, B; Savy, P; Benhida, R; Fourrey, JL; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    23. Barreca, ML; Chimirri, A; De Luca, L; Monforte, AM; Monforte, P; Rao, A; Zappala, M; Balzarini, J; De Clercq, E; Pannecouque, C; Witvrouw, M
      Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    24. Manfredini, S; Baraldi, PG; Durini, E; Porcu, L; Angusti, A; Vertuani, S; Solaroli, N; De Clercq, E; Karlsson, A; Balzarini, J
      Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    25. Spaepen, K; Stroobants, S; Dupont, P; Van Steenweghen, S; Thomas, J; Vandenberghe, P; Vanuytsel, L; Bormans, G; Balzarini, J; De Wolf-Peeters, C; Mortelmans, L; Verhoef, G
      Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([F-18]FDG) after first-line chemotherapy in non-Hodgkin'slymphoma: Is [F-18]FDG-PET a valid alternative to conventional diagnostic methods?

      JOURNAL OF CLINICAL ONCOLOGY
    26. Chaouni-Benabdallah, A; Galtier, C; Allouchi, H; Kherbeche, A; Debouzy, JC; Teulade, JC; Chavignon, O; Witvrouw, M; Pannecouque, C; Balzarini, J; de Clercq, E; Enguehard, C; Gueiffier, A
      Synthesis of 3-nitrosoimidazo[1,2-a]pyridine derivatives as potential antiretroviral agents

      ARCHIV DER PHARMAZIE
    27. Naimi, E; Wiebe, LI; Balzarini, J; De Clercq, E; Knaus, EE
      Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-halo-1-hydroxyethyl)benzenes and related derivatives: "Thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents

      DRUG DEVELOPMENT RESEARCH
    28. Van Laethem, K; Witvrouw, M; Pannecouque, C; Van Remoortel, B; Schmit, JC; Esnouf, R; Kleim, JP; Balzarini, J; Desmyter, J; De Clercq, E; Vandamme, AM
      Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype

      AIDS
    29. Griffon, JF; Mathe, C; Faraj, A; Aubertin, AM; De Clercq, E; Balzarini, J; Sommadossi, JP; Gosselin, G
      Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine

      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    30. Chamorro, C; Perez-Perez, MJ; Rodriguez-Barrios, F; Gago, F; De Clercq, E; Balzarini, J; San-Felix, A; Camarasa, MJ
      Exploring the role of the 5 '-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives

      ANTIVIRAL RESEARCH
    31. Pelemans, H; Esnouf, R; Min, KL; Parniak, M; De Clercq, E; Balzarini, J
      Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a TRP229TYR mutant RT

      VIROLOGY
    32. Pelemans, H; Aertsen, A; Van Laethem, K; Vandamme, AM; De Clercq, E; Perez-Perez, MJ; San-Felix, A; Velazquez, S; Camarasa, MJ; Balzarini, J
      Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138

      VIROLOGY
    33. Damian, F; Blaton, N; Augustijns, P; Naesens, L; Balzarini, J; Kinget, R; Van den Mooter, G
      Thermal characterization of the antiviral drug UC-781 and stability of itsglass

      THERMOCHIMICA ACTA
    34. Degreve, B; Esnouf, R; De Clercq, E; Balzarini, J
      Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase

      MOLECULAR PHARMACOLOGY
    35. Balzarini, J; Camarasa, MJ; Perez-Perez, MJ; San-Fleix, A; Velazquez, S; Perno, CF; De Clercq, E; Anderson, JN; Karlsson, A
      Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV

      JOURNAL OF VIROLOGY
    36. Damian, F; Blaton, N; Desseyn, H; Clou, K; Augustijns, P; Naesens, L; Balzarini, J; Kinget, R; Van den Mooter, G
      Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30)

      JOURNAL OF PHARMACY AND PHARMACOLOGY
    37. Dimmock, JR; Padmanilayam, MP; Puthucode, RN; Nazarali, AJ; Motaganahalli, NL; Zello, GA; Quail, JW; Oloo, EO; Kraatz, HB; Prisciak, JS; Allen, TM; Santos, CL; Balzarini, J; De Clercq, E; Manavathu, EK
      A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues

      JOURNAL OF MEDICINAL CHEMISTRY
    38. Baraldi, PG; Balboni, G; Pavani, MG; Spalluto, G; Tabrizi, MA; De Clercq, E; Balzarini, J; Bando, T; Sugiyama, H; Romagnoli, R
      Design, synthesis, DNA binding, and biological evaluation of water-solublehybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders

      JOURNAL OF MEDICINAL CHEMISTRY
    39. Rodriguez-Barrios, F; Perez, C; Lobaton, E; Velazquez, S; Chamorro, C; San-Felix, A; Perez-Perez, MJ; Camarasa, MJ; Pelemans, H; Balzarini, J; Gago, F
      Identification of a putative binding site for [2 ',5 '-bis-O-(tert-butyldimethylsilyl)beta-D-ribofuranosyl]-3 '-spiro-5 ''-(4 ''-amino-1 '',2 ''-oxathiole-2 '',2 ''-dioxide)thymine (TSAO) derivatives at the p51-p66 interfaceof HIV-1 reverse transcriptase

      JOURNAL OF MEDICINAL CHEMISTRY
    40. Mavromoustakos, T; Calogeropoulou, T; Koufaki, M; Kolocouris, A; Daliani, I; Demetzos, C; Meng, ZX; Makriyannis, A; Balzarini, J; De Clercq, E
      Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers

      JOURNAL OF MEDICINAL CHEMISTRY
    41. Hergueta, AR; Fernandez, F; Lopez, C; Balzarini, J; De Clercq, E
      Novel carbocyclic nucleosides containing a cyclobutyl ring: Adenosine analogues

      CHEMICAL & PHARMACEUTICAL BULLETIN
    42. Chaouni-Benabdallah, A; Galtier, C; Allouchi, H; Kherbeche, A; Chavignon, O; Teulade, JC; Witvrouw, M; Pannecouque, C; Snoeck, R; Andrei, G; Balzarini, J; De Clercq, E; Fauvelle, F; Enguehard, C; Gueiffier, A
      3-benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents

      CHEMICAL & PHARMACEUTICAL BULLETIN
    43. Spaepen, K; Stroobants, S; Dupont, P; Thomas, J; Vandenberghe, P; Balzarini, J; De Wolf-Peeters, C; Mortelmans, L; Verhoef, G
      Can positron emission tomography with [F-18]-fluorodeoxyglucose after first-line treatment distinguish Hodgkin's disease patients who need additionaltherapy from others in whom additional therapy would mean avoidable toxicity?

      BRITISH JOURNAL OF HAEMATOLOGY
    44. Balzarini, J; Degreve, B; Zhu, CY; Durini, E; Porcu, L; De Clercq, E; Karlsson, A; Manfredini, S
      2 '-O-acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of humanmitochondrial thymidine kinase

      BIOCHEMICAL PHARMACOLOGY
    45. Curbo, S; Zhu, CY; Johansson, M; Balzarini, J; Karlsson, A
      Dual mechanisms of 9-beta-D-arabinofuranosylguanine resistance in CEM T-lymphoblast leukemia cells

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    46. Mavel, S; Renou, JL; Galtier, C; Snoeck, R; Andrei, G; Balzarini, J; De Clercq, E; Gueiffier, A
      Synthesis of imidazo[1,2-a] pyridine derivatives as antiviral agents

      ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
    47. Balzarini, J; De Clercq, E
      Nucleoside and nucleotide reverse transcriptase inhibitors

      ANTIRETROVIRAL THERAPY
    48. Balzarini, J; Esnouf, R; De Clercq, E
      Nonnucleoside reverse transcriptase inhibitors

      ANTIRETROVIRAL THERAPY
    49. Wang, ZX; Duan, WL; Wiebe, LI; De Clercq, E; Balzarini, J; Knaus, EE
      Syntheses of 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-derivatives of 5-substituted-2,4-difluorobenzene: Unnatural acyclo thymidine mimics for evaluation as anticancer and antiviral agents

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    50. Tronchet, JMJ; Kovacs, I; Seman, M; Dilda, P; De Clercq, E; Balzarini, J
      Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    51. Degreve, B; De Clercq, E; Balzarini, J
      Selection of HSV-1 TK gene-transfected murine mammary carcinoma coils resistant to (E)-5-(2-bromovinyl)-2 '-deoxyuridine (BVDU) and ganciclovir (GCV)

      GENE THERAPY
    52. Siddiqui, A; McGuigan, C; Ballatore, C; Srinivasan, S; De Clercq, E; Balzarini, J
      Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    53. Knaggs, MH; McGuigan, C; Harris, SA; Heshmati, P; Cahard, D; Gilbert, IH; Balzarini, J
      A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    54. Wirsching, J; Voss, J; Balzarini, J; De Clercq, E
      Thiosugars. Part 5: Synthesis and biological activity of 1-(4-thio-L-arabinofuranosyl)-5-halopyrimidine nucleosides

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    55. Brancale, A; McGuigan, C; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): The effectof a terminal halogen substitution in the side-chain

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    56. Brancale, A; Srinivasan, S; McGuigan, C; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility

      ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
    57. McGuigan, C; Pathirana, RN; Jones, G; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency

      ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
    58. Martinez, A; Esteban, A; Castro, A; Gil, C; Conde, S; Andrei, G; Snoeck, R; Balzarini, J; De Clercq, E
      Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity

      ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
    59. McGuigan, C; Bidois, L; Hiouni, A; Ballatore, C; De Clercq, E; Balzarini, J
      Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine

      ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
    60. Chamorro, C; De Clercq, E; Balzarini, J; Camarasa, MJ; San-Felix, A
      TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesisand anti-human immunodeficiency virus activity

      ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
    61. Candotti, F; Agbaria, R; Mullen, CA; Touraine, R; Balzarini, J; Johns, DG; Blaese, RM
      Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric genefor metabolic suicide gene transfer

      CANCER GENE THERAPY
    62. Grignet-Debrus, C; Cool, V; Baudson, N; Degreve, B; Balzarini, J; De Leval, L; Debrus, S; Velu, T; Calberg-Bacq, CM
      Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2 '-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressingeither the Varicella zoster or the Herpes simplex virus thymidine kinase

      CANCER GENE THERAPY
    63. Damian, F; Blaton, N; Naesens, L; Balzarini, J; Kinget, R; Augustijns, P; Van den Mooter, G
      Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14

      EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
    64. Van Laethem, K; Schmit, JC; Pelemans, H; Balzarini, J; Witvrouw, M; Perez-Perez, MJ; Camarasa, MJ; Esnouf, RM; Aquaro, S; Cenci, A; Perno, CF; Hermans, P; Sprecher, S; Ruiz, L; Clotet, B; Van Wijngaerden, E; Van Ranst, M; Desmyter, J; De Clercq, E; Vandamme, AM
      Presence of 2 ',5 '-bis-O-(tert-butyldimethylsilyl)-3 '-spiro-5 ''-(4 ''-amino-1 '',2 ''-oxathiole-2 '',2 ''-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients

      AIDS RESEARCH AND HUMAN RETROVIRUSES
    65. Balzarini, J; De Clercq, E; Carbonez, A; Burt, V; Kleim, JP
      Long-term exposure of HIV type 1-infected cell cultures to combinations ofthe novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors

      AIDS RESEARCH AND HUMAN RETROVIRUSES
    66. Camarasa, MJ; San-Felix, A; Perez-Perez, MJ; Velazquez, S; Alvarez, R; Chamorro, C; Jimeno, ML; Perez, C; Gago, F; De Clercq, E; Balzarini, J
      HIV-1 specific reverse transcriptase inhibitors: Why are TSAO-nucleosides so unique?

      JOURNAL OF CARBOHYDRATE CHEMISTRY
    67. San-Felix, A; Chamorro, C; Perez-Perez, MJ; Velazquez, S; de Clercq, E; Balzarini, J; Camarasa, MJ
      Synthesis of novel 5 '-substituted TSAO-T analogues with anti-HIV-1 activity

      JOURNAL OF CARBOHYDRATE CHEMISTRY
    68. McGuigan, C; Brancale, A; Barucki, H; Srinivasan, S; Jones, G; Pathirana, R; Blewett, S; Alvarez, R; Yarnold, CJ; Carangio, A; Velazquez, S; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent andselective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles

      DRUGS OF THE FUTURE
    69. Van Laethem, K; Witvrouw, M; Balzarini, J; Schmit, JC; Sprecher, S; Hermans, P; Leal, M; Harrer, T; Ruiz, L; Clotet, B; Van Ranst, M; Desmyter, J; De Clercq, E; Vandamme, AM
      Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir

      AIDS
    70. Verri, A; Focher, F; Duncombe, RJ; Basnak, I; Walker, RT; Coe, PL; De Clercq, E; Andrei, G; Snoeck, R; Balzarini, J; Spadari, S
      Anti-(herpes simplex virus) activity of 4 '-thio-2 '-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

      BIOCHEMICAL JOURNAL
    71. Balzarini, J; Zhu, CY; De Clercq, E; Perez-Perez, MJ; Chamorro, C; Camarasa, MJ; Karlsson, A
      Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2

      BIOCHEMICAL JOURNAL
    72. Dimmock, JR; Kumar, P; Nazarali, AJ; Motaganahalli, NL; Kowalchuk, TP; Beazely, MA; Quail, JW; Oloo, EO; Allen, TM; Szydlowski, J; DeClercq, E; Balzarini, J
      Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds

      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    73. Pierra, C; Imbach, JL; De Clercq, E; Balzarini, J; Van Aerschot, A; Herdewijn, P; Faraj, A; Loi, AG; Sommadossi, JP; Gosselin, G
      Synthesis and antiviral evaluation of some beta-L-2 ',3 '-dideoxy-5-chloropyrimidine nucleosides and pronucleotides

      ANTIVIRAL RESEARCH
    74. Balzarini, J
      Effect of antimetabolite drugs of nucleotide metabolism on the anti-human immunodeficiency virus activity of nucleoside reverse transcriptase inhibitors

      PHARMACOLOGY & THERAPEUTICS
    75. de Vrueh, RLA; Rump, ET; van de Bilt, E; van Veghel, R; Balzarini, J; Biessen, EAL; van Berkel, TJC; Bijsterbosch, MK
      Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    76. Aquaro, S; Wedgwood, O; Yarnold, C; Cahard, D; Pathinara, R; McGuigan, C; Calio', R; De Clercq, E; Balzarini, J; Perno, CF
      Activities of masked 2 ',3 '-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    77. Wijnholds, J; Mol, CAAM; van Deemter, L; de Haas, M; Scheffer, GL; Baas, F; Beijnen, JH; Scheper, RJ; Hatse, S; De Clercq, E; Balzarini, J; Borst, P
      Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    78. Degreve, B; Esnouf, R; De Clercq, E; Balzarini, J
      Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of Alanine-167 to tyrosine

      MOLECULAR PHARMACOLOGY
    79. Balzarini, J; Aquaro, S; Knispel, T; Rampazzo, C; Bianchi, V; Perno, CF; De Clercq, E; Meier, C
      Cyclosaligenyl-2 ',3 '-didehydro-2 ',3 '-dideoxythymidine monophosphate: Efficient intracellular delivery of d4TMP

      MOLECULAR PHARMACOLOGY
    80. Pelemans, H; Esnouf, R; De Clercq, E; Balzarini, J
      Mutational analysis of Trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime targetfor the rational design of new non-nucleoside RT inhibitors

      MOLECULAR PHARMACOLOGY
    81. Balzarini, J; Degreve, B; Hatse, S; De Clercq, E; Breuer, M; Johansson, M; Huybrechts, R; Karlsson, A
      The multifunctional deoxynucleoside kinase of insect cells is a target forthe development of new insecticides

      MOLECULAR PHARMACOLOGY
    82. Wang, ZX; Wiebe, LI; Balzarini, J; De Clercq, E; Knaus, EE
      Chiral synthesis of 4-[1-(2-deoxy-beta-L-ribofuranosyl)] derivatives of 2-substituted 5-fluoroaniline: "Cytosine replacement" analogues of deoxy-beta-L-cytidine

      JOURNAL OF ORGANIC CHEMISTRY
    83. Wnuk, SF; Valdez, CA; Khan, J; Moutinho, P; Robins, MJ; Yang, XD; Borchardt, RT; Balzarini, J; De Clercq, E
      Doubly homologated dihalovinyl and acetylene analogues of adenosine: Synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects

      JOURNAL OF MEDICINAL CHEMISTRY
    84. Esteban-Gamboa, A; Balzarini, J; Esnouf, R; De Clercq, E; Camarasa, MJ; Perez-Perez, MJ
      Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase

      JOURNAL OF MEDICINAL CHEMISTRY
    85. McGuigan, C; Barucki, H; Blewett, S; Carangio, A; Erichsen, JT; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J
      Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain

      JOURNAL OF MEDICINAL CHEMISTRY
    86. Raic-Malic, S; Svedruzic, D; Gazivoda, T; Marunovic, A; Hergold-Brundic, A; Nagl, A; Balzarini, J; De Clercq, E; Mintas, M
      Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6-dideoxy-L-ascorbic acid

      JOURNAL OF MEDICINAL CHEMISTRY
    87. Dimmock, JR; Kandepu, NM; Nazarali, AJ; Motaganahalli, NL; Kowalchuk, TP; Pugazhenthi, U; Prisciak, JS; Quail, JW; Allen, TM; LeClerc, R; Santos, CL; De Clercq, E; Balzarini, J
      Sequential cytotoxicity: A theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds

      JOURNAL OF MEDICINAL CHEMISTRY
    88. Martinez, A; Gil, C; Perez, C; Castro, A; Prieto, C; Otero, J; Andrei, G; Snoeck, R; Balzarini, J; De Clercq, E
      Nonnucleoside human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives

      JOURNAL OF MEDICINAL CHEMISTRY
    89. Ren, JS; Diprose, J; Warren, J; Esnouf, RM; Bird, LE; Ikemizu, S; Slater, M; Milton, J; Balzarini, J; Stuart, DI; Stammers, DK
      Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 andHIV-2 reverse transcriptases - Structural and biochemical analyses

      JOURNAL OF BIOLOGICAL CHEMISTRY
    90. Balzarini, J; Degreve, B; Esteban-Gamboa, A; Esnouf, R; De Clercq, E; Engelborghs, Y; Camarasa, MJ; Perez-Perez, MJ
      Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase

      FEBS LETTERS
    91. Wang, ZX; Wiebe, LI; De Clercq, E; Balzarini, J; Knaus, EE
      Syntheses of 4-[1-(2-deoxy-beta-D-ribofuranosyl)]-derivatives of 2-substituted-5-fluoroaniline: '' cytosine replacement '' analogs of deoxycytidine for evaluation as anticancer and antihuman immunodeficiency virus (anti-HIV)agents

      CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
    92. Sluis-Cremer, N; Dmitrienko, GI; Balzarini, J; Camarasa, MJ; Parniak, MA
      Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-{spiro[4 ''-amino-2 '',2 ''-dioxo-1 '',2 ''-oxathiole-5 '',3 '-[2 ',5 '-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]}-3-ethylthymine

      BIOCHEMISTRY
    93. Vandamme, AM; Witvrouw, M; Pannecouque, C; Balzarini, J; Van Laethem, K; Schmit, JC; Desmyter, J; De Clercq, E
      Evaluating clinical isolates for their phenotypic and genotypic resistanceagainst anti-HIV drugs

      ANTIVIRAL METHODS AND PROTOCOLS
    94. Balzarini, J
      Evaluation of compounds against recombinant HIV reverse transcriptase

      ANTIVIRAL METHODS AND PROTOCOLS
    95. Hatse, S; Schols, D; De Clercq, E; Balzarini, J
      9-(2-phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase

      CELL GROWTH & DIFFERENTIATION
    96. Degreve, B; De Clercq, E; Balzarini, J
      Bystander effect of purine nucleoside analogues in HSV-1tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues

      GENE THERAPY
    97. Martinez, A; Esteban, AI; Herrero, A; Ochoa, C; Andrei, G; Snoeck, R; Balzarini, J; De Clercq, E
      Imidazothiadiazine dioxides: Synthesis and antiviral activity

      BIOORGANIC & MEDICINAL CHEMISTRY
    98. Arranz, ME; Diaz, JA; Ingate, ST; Witvrouw, M; Pannecouque, C; Balzarini, J; De Clercq, E; Vega, S
      Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): A new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors

      BIOORGANIC & MEDICINAL CHEMISTRY
    99. Naesens, L; Hatse, S; Segers, C; Verbeken, E; De Clercq, E; Waer, M; Balzarini, J
      9-(2-phosphonylmethoxyethyl)-N-6-cyclopropyl-2,6-diaminopurine: A novel prodrug of 9-(2-phosphonyl-methoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats

      ONCOLOGY RESEARCH
    100. Siddiqui, AQ; McGuigan, C; Ballatore, C; Wedgwood, O; De Clercq, E; Balzarini, J
      Simple mono-derivatisation of the aryl moiety of d4A and ddA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:28:57