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    1. Tentori, L; Balduzzi, A; Portarena, I; Levati, L; Vernole, P; Gold, B; Bonmassar, E; Graziani, G
      Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester

      CELL DEATH AND DIFFERENTIATION
    2. Tentori, L; Portarena, I; Bonmassar, E; Graziani, G
      Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells

      CELL DEATH AND DIFFERENTIATION
    3. Franzese, O; Comandini, A; Lombardi, A; Saponiero, A; Bonmassar, E
      Saquinavir up-regulates telomerase activity in lymphocytes activated with monoclonal antibodies against CD3/CD28

      JOURNAL OF CHEMOTHERAPY
    4. Prete, SP; Giuliani, A; Iona, E; Fattorini, L; Orefici, G; Franzese, O; Bonmassar, E; Graziani, G
      Bacillus Calmette-Guerin down-regulates CD1B induction by granulocyte-macrophage colony stimulating factor in human peripheral blood monocytes

      JOURNAL OF CHEMOTHERAPY
    5. Tentori, L; Portarena, I; Vernole, P; De Fabritiis, P; Madaio, R; Balduzzi, A; Roy, R; Bonmassar, E; Graziani, G
      Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    6. Pepponi, R; Graziani, G; Falcinelli, S; Vernole, P; Levati, L; Lacal, PM; Pagani, E; Bonmassar, E; Jiricny, J; D'Atri, S
      hMSH3 overexpression and cellular response to cytotoxic anticancer agents

      CARCINOGENESIS
    7. Franzese, O; Lombardi, A; Comandini, A; Cannavo, E; Testorelli, C; Cirello, I; Bonmassar, E
      Effect of Saquinavir on proliferation and telomerase activity of human peripheral blood mononuclear cells

      LIFE SCIENCES
    8. Giuliani, A; Prete, SP; Graziani, G; Aquino, A; Balduzzi, A; Sugita, M; Brenner, MB; Iona, E; Fattorini, L; Orefici, G; Porcelli, SA; Bonmassar, E
      Influence of Mycobacterium bovis bacillus Calmette Guerin on in vitro induction of CD1 molecules in human adherent mononuclear cells

      INFECTION AND IMMUNITY
    9. Faraoni, I; Bonmassar, E; Graziani, G
      Clinical applications of telomerase in cancer treatment

      DRUG RESISTANCE UPDATES
    10. Aquino, A; Prete, SP; Baier, S; Cappelletti, D; Greiner, JW; De Vecchis, L; Graziani, G; Bonmassar, E
      Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line

      JOURNAL OF CHEMOTHERAPY
    11. Tentori, L; Vernole, P; Lacal, PM; Madaio, R; Portarena, I; Levati, L; Balduzzi, A; Turriziani, M; Dande, P; Gold, B; Bonmassar, E; Graziani, G
      Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells

      LEUKEMIA
    12. Cappelletti, D; Cardillo, A; Bonanno, E; Prete, SP; Cucchiara, G; Turriziani, M; Greiner, JW; Cottarelli, A; Breda, E; Aquino, A; Bonmassar, E; De Vecchis, L
      Drug-induced modulation of carcinoembryonic antigen (CEA) expression in neoplastic cells from a patient with rectal cancer

      JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
    13. Aquino, A; Prete, SP; Guadagni, F; Greiner, JW; Giuliani, A; Orlando, L; Masci, G; De Santis, S; Bonmassar, E; Graziani, G
      Effect of 5-fluorouracil on carcinoembryonic antigen expression and shedding at clonal level in colon cancer cells

      ANTICANCER RESEARCH
    14. Fuggetta, MP; Alvino, E; Tricarico, M; D'Atri, S; Pepponi, R; Prete, SP; Bonmassar, E
      In vitro effect of hyperthermia on natural cell-mediated cytotoxicity

      ANTICANCER RESEARCH
    15. D'Atri, S; Graziani, G; Lacal, PM; Nistico, V; Gilberti, S; Faraoni, I; Watson, AJ; Bonmassar, E; Margison, GP
      Attenuation of O-6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    16. Sigala, S; Faraoni, I; Botticini, D; Paez-Pereda, M; Missale, C; Bonmassar, E; Spano, P
      Suppression of telomerase, reexpression of KAI1, and abrogation of tumorigenicity by nerve growth factor in prostate cancer cell lines

      CLINICAL CANCER RESEARCH
    17. Tentori, L; Turriziani, M; Franco, D; Serafino, A; Levati, L; Roy, R; Bonmassar, E; Graziani, G
      Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts inleukemic cells resistant to triazene compounds

      LEUKEMIA
    18. Tricarico, M; Macchi, B; D'Atri, S; Morrone, S; Bonmassar, E; Fuggetta, MP; Graziani, G
      In vitro infection of CD4(+) T lymphocytes with HTLV-I generates immortalized cell lines coexpressing lymphoid and myeloid cell markers

      LEUKEMIA
    19. Tricarico, M; Rinaldi, M; Bonmassar, E; Fuggetta, MP; Barrera, G; Fazio, VM
      Effect of 4-hydroxynonenal, a product of lipid peroxidation, on natural cell mediated cytotoxicity

      ANTICANCER RESEARCH
    20. Faraoni, I; Graziani, G; Turriziani, M; Masci, G; Mezzetti, M; Testori, A; Veronesi, U; Bonmassar, E
      Suppression of telomerase activity as an indicator of drug-induced cytotoxicity against cancer cells: In vitro studies with fresh human tumor samples

      LABORATORY INVESTIGATION
    21. Alvino, E; Pepponi, R; Pagani, E; Lacal, PM; Nunziata, C; Bonmassar, E; D'Atri, S
      O-6-benzylguanine enhances the in vitro immunotoxic activity of temozolomide on natural or antigen-dependent immunity

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    22. BONMASSAR E
      XII NATIONAL CONGRESS OF THE ITALIAN-ASSOCIATION-OF-IMMUNOPHARMACOLOGY - VERONA, OCTOBER 23-24, 1997 - PREFACE

      Journal of chemotherapy
    23. AQUINO A; PRETE SP; GREINER JW; GIULIANI A; GRAZIANI G; TURRIZIANI M; DEFILIPPI R; MASCI G; BONMASSAR E; DEVECCHIS L
      EFFECT OF THE COMBINED TREATMENT WITH 5-FLUOROURACIL, GAMMA-INTERFERON OR FOLINIC ACID ON CARCINOEMBRYONIC ANTIGEN EXPRESSION IN COLON-CANCER CELLS

      Clinical cancer research
    24. LEVATI L; MARRA G; LETTIERI T; DATRI S; VERNOLE P; TENTORI L; LACAL PM; PAGANI E; BONMASSAR E; JIRICNY J; GRAZIANI G
      MUTATION OF THE MISMATCH REPAIR GENE HMSH2 AND HMSH6 IN A HUMAN T-CELL LEUKEMIA LINE TOLERANT TO METHYLATING AGENTS

      Genes, chromosomes & cancer
    25. LAMA G; ANGELUCCI C; BRUZZESE N; IACOPINO F; NORI SL; DATRI S; TURRIZIANI M; BONMASSAR E; SICA G
      SENSITIVITY OF HUMAN-MELANOMA CELLS TO ESTROGENS, TAMOXIFEN AND QUERCETIN - IS THERE ANY RELATIONSHIP WITH TYPE-I AND TYPE-II ESTROGEN-BINDING SITE EXPRESSION

      Melanoma research
    26. FRANZESE O; COMANDINI A; CANNAVO E; PEPPONI R; FALCINELLI S; GRAZIANI G; BONMASSAR E
      EFFECT OF PROSTAGLANDIN A(1) ON PROLIFERATION AND TELOMERASE ACTIVITYOF HUMAN-MELANOMA CELLS IN-VITRO

      Melanoma research
    27. FUGGETTA MP; TRICARICO M; STARACE G; PEPPONI R; BONMASSAR E
      INTERFERONS ANTAGONIZE GAMMA-RAY-INDUCED DEPRESSION OF NATURAL IMMUNITY

      International journal of radiation oncology, biology, physics
    28. TONINI G; NUNZIATA C; PRETE SP; PEPPONI R; TURRIZIANI M; MASCI G; GRAZIANI G; BONMASSAR E; DEVECCHIS L
      ADJUVANT TREATMENT OF BREAST-CANCER - A PILOT IMMUNOCHEMOTHERAPY STUDY WITH CMF, INTERLEUKIN-2 AND INTERFERON-ALPHA

      Cancer immunology and immunotherapy
    29. Rinaldi, M; Tricarico, M; Bonmassar, E; Parrella, P; Barrera, G; Fazio, VM
      Effect of 4-hydroxynonenal, a product of lipid peroxidation, on NK susceptibility of human K562 target cells

      ANTICANCER RESEARCH
    30. Alvino, E; Fuggetta, MP; Tricarico, M; Bonmassar, E
      2 '-2 '-Difluorodeoxycytidine: In vitro effects on cell-mediated immune response

      ANTICANCER RESEARCH
    31. TENTORI L; GRAZIANI G; PORCELLI SA; SUGITA M; BRENNER MB; MADAIO R; BONMASSAR E; GIULIANI A; AQUINO A
      RIFAMPIN INCREASES CYTOKINE-INDUCED EXPRESSION OF THE CD1B MOLECULE IN HUMAN PERIPHERAL-BLOOD MONOCYTES

      Antimicrobial agents and chemotherapy
    32. DATRI S; TENTORI L; LACAL PM; GRAZIANI G; PAGANI E; BENINCASA E; ZAMBRUNO G; BONMASSAR E; JIRICNY J
      INVOLVEMENT OF THE MISMATCH REPAIR SYSTEM IN TEMOZOLOMIDE-INDUCED APOPTOSIS

      Molecular pharmacology
    33. GIULIANI A; PORCELLI SA; TENTORI L; GRAZIANI G; TESTORELLI C; PRETE SP; BUSSINI S; CAPPELLETTI D; BRENNER MB; BONMASSAR E; AQUINO A
      EFFECT OF RIFAMPIN ON CD1B EXPRESSION AND DOUBLE-NEGATIVE T-CELL RESPONSES AGAINST MYCOBACTERIA-DERIVED GLYCOLIPID ANTIGEN

      Life sciences (1973)
    34. TENTORI L; LACAL PM; BENINCASA E; FRANCO D; FARAONI I; BONMASSAR E; GRAZIANI G
      ROLE OF WILD-TYPE P53 ON THE ANTINEOPLASTIC ACTIVITY OF TEMOZOLOMIDE ALONE OR COMBINED WITH INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE

      The Journal of pharmacology and experimental therapeutics
    35. FARAONI I; TURRIZIANI M; MASCI G; DEVECCHIS L; SHAY JW; BONMASSAR E; GRAZIANI G
      DECLINE IN TELOMERASE ACTIVITY AS A MEASURE OF TUMOR-CELL KILLING BY ANTINEOPLASTIC AGENTS IN-VITRO

      Clinical cancer research
    36. GIULIANI A; TENTORI L; PEPPONI R; PORCELLI SA; AQUINO A; ORLANDO L; SUGITA M; BRENNER MB; BONMASSAR E; GRAZIANI G
      CYTOKINE-INDUCED EXPRESSION OF CD1B MOLECULES BY PERIPHERAL-BLOOD MONOCYTES - INFLUENCE OF 3'-AZIDO-3'-DEOXYTHYMIDINE

      Pharmacological research
    37. TESTORELLI C; BUSSINI S; DEFILIPPI R; MARELLI O; ORLANDO L; GREINER JW; GROHMANN U; TENTORI L; GIULIANI A; BONMASSAR E; GRAZIANI G
      DACARBAZINE-INDUCED IMMUNOGENICITY OF A MURINE LEUKEMIA IS ATTENUATEDIN CELLS TRANSFECTED WITH MUTATED K-RAS GENE

      Journal of experimental & clinical cancer research
    38. ALVINO E; GILBERTI S; CANTAGALLO D; MASSOUD R; GATTESCHI A; TENTORI L; BONMASSAR E; DATRI S
      IN-VITRO ANTITUMOR-ACTIVITY OF 3'-DESAMINO-3'(2-METHOXY-4-MORPHOLINYL) DOXORUBICIN ON HUMAN-MELANOMA CELLS SENSITIVE OR RESISTANT TO TRIAZENE COMPOUNDS

      Cancer chemotherapy and pharmacology
    39. TENTORI L; ORLANDO L; LACAL PM; BENINCASA E; FARAONI I; BONMASSAR E; DATRI S; GRAZIANI G
      INHIBITION OF O-6-ALKYLGUANINE DNA-ALKYLTRANSFERASE OR POLY(ADP-RIBOSE) POLYMERASE INCREASES SUSCEPTIBILITY OF LEUKEMIC COILS TO APOPTOSIS INDUCED BY TEMOZOLOMIDE

      Molecular pharmacology
    40. MACCHI B; FARAONI I; ZHANG J; GRELLI S; FAVALLI C; MASTINO A; BONMASSAR E
      AZT INHIBITS THE TRANSMISSION OF HUMAN T-CELL LEUKAEMIA LYMPHOMA VIRUS TYPE-I TO ADULT PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN-VITRO/

      Journal of General Virology
    41. BONMASSAR E; CILIBERTO G; CORTESE R; FINAZZIAGRO A; MELINO G; PIACENTINI M
      DONOFRIO,CHIARA (1953-1996) - OBITUARY

      Cell death and differentiation
    42. FARAONI I; TURRIZIANI M; GRAZIANI G; DEVECCHIS L; BONMASSAR E
      TELOMERASE AS A MARKER OF TUMOR-CELL VIABILITY - A NEW APPROACH FOR IN-VITRO CHEMOSENSITIVITY ASSAYS

      Journal of experimental & clinical cancer research
    43. BONMASSAR E
      IN-MEMORIAM DONOFRIO,CHIARA - OBITUARY

      Cancer immunology and immunotherapy
    44. FRANZESE O; BONMASSAR E; MARCUCCI A; DONOFRIO C
      FUNCTIONAL ANTAGONISM BETWEEN IL-2 AND PGA(1) OR PGJ(2) IN THE CONTROL OF PROLIFERATION OF HUMAN CORD BLOOD-DERIVED MONONUCLEAR-CELLS

      International journal of immunopharmacology
    45. PRETE SP; AQUINO A; MASCI G; ORLANDO L; GIULIANI A; DESANTIS S; DEVECCHIS L; DEFILIPPI R; GREINER JW; BONMASSAR E; GRAZIANI G
      DRUG-INDUCED CHANGES OF CARCINOEMBRYONIC ANTIGEN EXPRESSION IN HUMAN CANCER-CELLS - EFFECT OF 5-FLUOROURACIL

      The Journal of pharmacology and experimental therapeutics
    46. LACAL PM; DATRI S; ORLANDO L; BONMASSAR E; GRAZIANI G
      IN-VITRO INACTIVATION OF HUMAN O-6-ALKYLGUANINE DNA ALKYLTRANSFERASE BY ANTITUMOR TRIAZENE COMPOUNDS

      The Journal of pharmacology and experimental therapeutics
    47. PICA F; FRANZESE O; DONOFRIO C; BONMASSAR E; FAVALLI C; GARACI E
      PROSTAGLANDIN E(2) INDUCES APOPTOSIS IN RESTING IMMATURE AND MATURE HUMAN-LYMPHOCYTES - A C-MYC-DEPENDENT AND BCL-2-INDEPENDENT ASSOCIATED PATHWAY

      The Journal of pharmacology and experimental therapeutics
    48. PICCIONI D; DATRI S; PAPA G; CARAVITA T; FRANCHI A; BONMASSAR E; GRAZIANI G
      CISPLATIN INCREASES SENSITIVITY OF HUMAN LEUKEMIC BLASTS TO TRIAZENE COMPOUNDS

      Journal of chemotherapy
    49. DATRI S; PICCIONI D; CASTELLANO A; TUORTO V; FRANCHI A; LU K; CHRISTIANSEN N; FRANKEL S; RUSTUM YM; PAPA G; MANDELLI F; BONMASSAR E
      CHEMOSENSITIVITY TO TRIAZENE COMPOUNDS AND O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE LEVELS - STUDIES WITH BLASTS OF LEUKEMIC PATIENTS

      Annals of oncology
    50. GIULIANI A; VERNOLE P; DATRI S; DELPOETA G; DONOFRIO C; FARAONI I; GREINER JW; BONMASSAR E; GRAZIANI G
      IN-VITRO INFECTION OF LEUKEMIC BONE-MARROW WITH HTLV-I GENERATES IMMORTALIZED CELL-LINES EXPRESSING T OR MYELOID CELL PHENOTYPE

      Leukemia
    51. TENTORI L; GRAZIANI G; GILBERTI S; LACAL PM; BONMASSAR E; DATRI S
      TRIAZENE COMPOUNDS INDUCE APOPTOSIS IN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE DEFICIENT LEUKEMIA-CELL LINES

      Leukemia
    52. TENTORI L; LEONETTI C; LOZUPONE F; BONMASSAR E
      ANTITUMOR AND ANTIMETASTATIC EFFECTS OF DACARBAZINE COMBINED WITH CYCLOPHOSPHAMIDE AND INTERLEUKIN-2 IN LEWIS LUNG-CARCINOMA (3LL)

      Cancer immunology and immunotherapy
    53. DONOFRIO C; PUGLIANIELLO A; AMICI C; FARAONI I; LANZILLI G; BONMASSAR E
      HSP70 PRODUCTION AND INHIBITION OF CELL-PROLIFERATION IN MOLT-4 T-CELLS AFTER CELL-TO-CELL TRANSMISSION OF HTLV-I - EFFECT OF PGA(1)

      Leukemia research
    54. GRAZIANI G; FARAONI I; GROHMANN U; BIANCHI R; BINAGLIA L; MARGISON GP; WATSON AJ; ORIANDO L; BONMASSAR E; DATRI S
      O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ATTENUATES TRIAZENE-INDUCED CYTOTOXICITY AND TUMOR-CELL IMMUNOGENICITY IN MURINE L1210 LEUKEMIA

      Cancer research
    55. LU K; YIN MB; MCGUIRE JJ; BONMASSAR E; RUSTUM YM
      MECHANISMS OF RESISTANCE TO N-6-YLMETHYL)-N-METHYLAMINO]-2-THENOYL]-L-GLUTAMIC ACID (ZD1694), A FOLATE-BASED THYMIDYLATE SYNTHASE INHIBITOR, IN THE HCT-8 HUMAN ILEOCECAL ADENOCARCINOMA CELL-LINE

      Biochemical pharmacology
    56. DEFILIPPI R; PRETE SP; GIULIANI A; BEI R; YAMAUE H; GREINER JW; DEVECCHIS L; BONMASSAR E
      COMBINED EFFECTS OF INTERFERON-ALPHA AND 5-FLUOROURACIL ON NORMAL LYMPHOCYTES OR COLON-CANCER CELLS

      The FASEB journal
    57. GRAZIANI G; FARAONI I; ZHANG J; CARONTI B; LAURO G; BONMASSAR E; MACCHI B
      TRANSIENT HTLV-I INFECTION OF A HUMAN GLIOMA CELL-LINE FOLLOWING CELL-FREE EXPOSURE

      AIDS research and human retroviruses
    58. DONOFRIO C; FRANZESE O; DEMARCO A; BONMASSAR E; AMICI C
      ANTIPROLIFERATIVE ACTIVITY OF CYCLOPENTENONE PROSTAGLANDINS IN EARLY HTLV-1 INFECTION IS INDEPENDENT OF IL-2 AND IS ASSOCIATED WITH HSP70 INDUCTION

      Leukemia
    59. DEFILIPPI R; PRETE SP; GIULIANI A; SILVI E; YAMAUE H; NIERODA CA; GREINER JW; DEVECCHIS L; BONMASSAR E
      DIFFERENTIAL-EFFECTS OF RECOMBINANT INTERFERON-ALPHA AND 5-FLUOROURACIL AGAINST COLON-CANCER CELLS OR AGAINST PERIPHERAL-BLOOD MONONUCLEAR-CELLS

      Anticancer research
    60. DATRI S; ROMANI L; BONMASSAR E; GROHMANN U; TRICARICO M; CHRISTMAS SE; MOORE M
      UNTREATED OR DRUG-TREATED TUMOR-CELLS ARE DIFFERENTIALLY RECOGNIZED BY ALLOGENEIC LYMPHOCYTES

      International journal of immunopharmacology
    61. LACAL PM; PUGLIANIELLO A; BONMASSAR E; DONOFRIO C
      EFFECTS OF CYCLOPENTENONE PROSTAGLANDINS ON MYELOID CELLS DURING EARLY INFECTION WITH HTLV-I .1. CELL-DIFFERENTIATION DETERMINES SENSITIVITY TO PROSTAGLANDINS AND VIRUS-INFECTION

      The Journal of pharmacology and experimental therapeutics
    62. LACAL PM; AMICI C; BONMASSAR E; DONOFRIO C
      EFFECTS OF CYCLOPENTENONE PROSTAGLANDINS ON MYELOID CELLS DURING EARLY INFECTION WITH HTLV-I .2. REGULATION OF SYNTHESIS OF INDUCIBLE P72 HEAT-SHOCK PROTEIN

      The Journal of pharmacology and experimental therapeutics
    63. DONOFRIO C; FRANZESE O; DEMARCO A; AMICI C; BONMASSAR E
      CONTROL OF PROLIFERATION OF HTLV-I-INFECTED MONONUCLEAR-CELLS BY CYCLO-PENTENONE PGS IS INDEPENDENT OF INTERLEUKIN-2 AUTOCRINE REGULATION AND IS ASSOCIATED WITH HSP70 INDUCTION

      British Journal of Pharmacology
    64. NERI M; ZEI T; TENTORI L; BONMASSAR E; AFFABRIS E; IORIO AM
      ACUTE REJECTION OF INTERFERON-TREATED LEUKEMIA-CELLS INJECTED INTO LETHALLY IRRADIATED SYNGENEIC MICE

      Natural immunity
    65. FUGGETTA MP; ALVINO E; PEPPONI R; DEFILIPPI R; MARINI S; BONMASSAR E
      IN-VITRO TUMOR-CELL GROWTH-INHIBITION - A COMPARATIVE-STUDY BETWEEN ALLOSENSITIZED CYTOTOXIC T-LYMPHOCYTES AND LYMPHOKINE-ACTIVATED KILLER-CELLS

      Cell proliferation
    66. VERDECCHIA MC; PRETE SP; MARCOTULLIO D; BONMASSAR E; DEVECCHIS L
      NK-CELL ACTIVITY AFTER SURGERY IN HEAD-NECK CANCER-PATIENTS

      Journal of experimental & clinical cancer research
    67. MACCHI B; FARAONI I; MASTINO A; DONOFRIO C; ROMEO G; BONMASSAR E
      PROTECTIVE EFFECT OF INTERFERON-BETA ON HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I INFECTION OF CD4-CELLS ISOLATED FROM HUMAN CORD-BLOOD( T)

      Cancer immunology and immunotherapy
    68. GRAZIANI G; FARAONI I; ZHANG J; CARONTI B; LAURO G; BONMASSAR E; MACCHI B
      TRANSIENT HTLV-1 INFECTION OF A HUMAN GLIOMA CELL-LINE FOLLOWING CELL-FREE EXPOSURE

      Virology


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Documento generato il 22/10/20 alle ore 20:58:07