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    1. Abraham, RT
      Cell cycle checkpoint signaling through the ATM and ATR kinases

      GENES & DEVELOPMENT
    2. Peng, HR; Otterness, DM; Abraham, RT; Zalkow, LH
      Cdc25A Protein phosphatase inhibitors from anomalous ozonolysis of 5,6-seco-5-oxo-3-cholesten-6-oic acid

      TETRAHEDRON
    3. Bao, SD; Tibbetts, RS; Brumbaugh, KM; Fang, YN; Richardson, DA; Ali, A; Chen, SM; Abraham, RT; Wang, XF
      ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

      NATURE
    4. Peng, HR; Xie, WG; Otterness, DM; Cogswell, JP; McConnell, RT; Carter, HL; Powis, G; Abraham, RT; Zalkow, LH
      Syntheses and biological activities of a novel group of steroidal derived inhibitors for human CDC25A protein phosphatase

      JOURNAL OF MEDICINAL CHEMISTRY
    5. Livolsi, A; Busuttil, V; Imbert, V; Abraham, RT; Peyron, JF
      Tyrosine phosphorylation-dependent activation of NF-kappa B - Requirement for p56 LCK and ZAP-70 protein tyrosine kinases

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    6. Peng, HR; Xie, WG; Kim, DI; Zalkow, LH; Powis, G; Otterness, DM; Abraham, RT
      Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase

      BIOORGANIC & MEDICINAL CHEMISTRY
    7. Tibbetts, RS; Cortez, D; Brumbaugh, KM; Scully, R; Livingston, D; Elledge, SJ; Abraham, RT
      Functional interactions between BRCA1 and the checkpoint kinase ATR duringgenotoxic stress

      GENES & DEVELOPMENT
    8. Irvin, BJ; Williams, BL; Nilson, AE; Maynor, HO; Abraham, RT
      Pleiotropic contributions of phospholipase C-gamma 1 (PLC-gamma 1) to T-cell antigen receptor-mediated signaling: Reconstitution studies of a PLC-gamma 1-deficient Jurkat T-cell line

      MOLECULAR AND CELLULAR BIOLOGY
    9. Abraham, RT
      Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways

      IMMUNOLOGIC RESEARCH
    10. Busby, EC; Leistritz, DF; Abraham, RT; Karnitz, LM; Sarkaria, JN
      The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

      CANCER RESEARCH
    11. Sekulic, A; Hudson, CC; Homme, JL; Yin, P; Otterness, DM; Karnitz, LM; Abraham, RT
      A direct linkage between the phosphoinositide 3-Kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

      CANCER RESEARCH
    12. Tibbetts, RS; Abraham, RT
      PI3K-related kinases - Roles in cell-cycle regulation and DNA damage responses

      SIGNALING NETWORKS AND CELL CYCLE CONTROL
    13. Binstadt, BA; Williams, BL; Abraham, RT; Leibson, PJ
      Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways

      NATURAL KILLER CELL PROTOCOLS
    14. Zhang, WG; Irvin, BJ; Trible, RP; Abraham, RT; Samelson, LE
      Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

      INTERNATIONAL IMMUNOLOGY
    15. Tibbetts, RS; Brumbaugh, KM; Williams, JM; Sarkaria, JN; Cliby, WA; Shieh, SY; Taya, Y; Prives, C; Abraham, RT
      A role for ATR in the DNA damage-induced phosphorylation of p53

      GENES & DEVELOPMENT
    16. Gingras, AC; Gygi, SP; Raught, B; Polakiewicz, RD; Abraham, RT; Hoekstra, MF; Aebersold, R; Sonenberg, N
      Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

      GENES & DEVELOPMENT
    17. Zhao, QH; Williams, BL; Abraham, RT; Weiss, A
      Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signalingfunction in lymphocytes

      MOLECULAR AND CELLULAR BIOLOGY
    18. Williams, BL; Irvin, BJ; Sutor, SL; Chini, CCS; Yacyshyn, E; Wardenburg, JB; Dalton, M; Chan, AC; Abraham, RT
      Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma 1 and Ras activation

      EMBO JOURNAL
    19. Peng, HR; Zalkow, LH; Abraham, RT; Powis, G
      Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel (vol 41, pg 4678, 1998)

      JOURNAL OF MEDICINAL CHEMISTRY
    20. Jevremovic, D; Billadeau, DD; Scoon, RA; Dick, CJ; Irvin, BJ; Zhang, WG; Samelson, LE; Abraham, RT; Leibson, PJ
      Cutting edge: A role for the adaptor protein LAT in human NK cell-mediatedcytotoxicity

      JOURNAL OF IMMUNOLOGY
    21. Iiboshi, Y; Papst, PJ; Kawasome, H; Hosoi, H; Abraham, RT; Houghton, PJ; Terada, N
      Amino acid-dependent control of p70(s6k) - Involvement of tRNA aminoacylation in the regulation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    22. Sutor, SL; Vroman, BT; Armstrong, EA; Abraham, RT; Karnitz, LM
      A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

      JOURNAL OF BIOLOGICAL CHEMISTRY
    23. Hosoi, H; Dilling, MB; Shikata, T; Liu, LN; Shu, L; Ashmun, RA; Germain, GS; Abraham, RT; Houghton, PJ
      Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells

      CANCER RESEARCH
    24. Sarkaria, JN; Busby, EC; Tibbetts, RS; Roos, P; Taya, Y; Karnitz, LM; Abraham, RT
      Inhibition of ATM and ATR kinase activities by the radiosensitizing agent,caffeine

      CANCER RESEARCH
    25. KATO M; ABRAHAM RT; OKADA S; KITA H
      LIGATION OF THE BETA(2) INTEGRIN TRIGGERS ACTIVATION AND DEGRANULATION OF HUMAN EOSINOPHILS

      American journal of respiratory cell and molecular biology
    26. ABRAHAM RT
      MAMMALIAN TARGET OF RAPAMYCIN - IMMUNOSUPPRESSIVE DRUGS UNCOVER A NOVEL PATHWAY OF CYTOKINE RECEPTOR SIGNALING

      Current opinion in immunology
    27. LIU LN; HOSOI H; DILLING MB; SHIKATA T; GERMAIN GS; ABRAHAM RT; HOUGHTON PJ
      INHIBITION OF THE MAMMALIAN TARGET OF RAPAMYCIN SELECTIVELY INDUCES APOPTOSIS IN CELLS LACKING P53 TUMOR-SUPPRESSOR FUNCTION

      Annals of oncology
    28. WILLIAMS BL; SCHREIBER KL; ZHANG WG; WANGE RL; SAMELSON LE; LEIBSON PJ; ABRAHAM RT
      GENETIC-EVIDENCE FOR DIFFERENTIAL COUPLING OF SYK FAMILY KINASES TO THE T-CELL RECEPTOR - RECONSTITUTION STUDIES IN A ZAP-70-DEFICIENT JURKAT T-CELL LINE

      Molecular and cellular biology
    29. HOSOI H; DILLING MB; LIU LN; DANKS MK; SHIKATA T; SEKULIC A; ABRAHAM RT; LAWRENCE JC; HOUGHTON PJ
      STUDIES ON THE MECHANISM OF RESISTANCE TO RAPAMYCIN IN HUMAN CANCER-CELLS

      Molecular pharmacology
    30. PENG HR; ZALKOW LH; ABRAHAM RT; POWIS G
      NOVEL CDC25A PHOSPHATASE INHIBITORS FROM PYROLYSIS OF 3-ALPHA-AZIDO-B-HOMO-6-OXA-4-CHOLESTEN-7-ONE ON SILICA-GEL

      Journal of medicinal chemistry
    31. BINSTADT BA; BILLADEAU DD; JEVREMOVIC D; WILLIAMS BL; FANG N; YI TL; KORETZKY GA; ABRAHAM RT; LEIBSON PJ
      SLP-76 IS A DIRECT SUBSTRATE OF SHP-1 RECRUITED TO KILLER-CELL INHIBITORY RECEPTORS

      The Journal of biological chemistry
    32. KENNEDY AP; SEKULIC A; IRVIN BJ; NILSON AE; DILWORTH SM; ABRAHAM RT
      POLYOMAVIRUS MIDDLE T-ANTIGEN AS A PROBE FOR T-CELL ANTIGEN RECEPTOR-COUPLED SIGNALING PATHWAYS

      The Journal of biological chemistry
    33. SARKARIA JN; TIBBETTS RS; BUSBY EC; KENNEDY AP; HILL DE; ABRAHAM RT
      INHIBITION OF PHOSPHOINOSITIDE 3-KINASE RELATED KINASES BY THE RADIOSENSITIZING AGENT WORTMANNIN

      Cancer research
    34. LAWRENCE JC; ABRAHAM RT
      PHAS 4E-BPS AS REGULATORS OF MESSENGER-RNA TRANSLATION AND CELL-PROLIFERATION/

      Trends in biochemical sciences
    35. POWIS G; GALLEGOS A; ABRAHAM RT; ASHENDEL CL; ZALKOW LH; DORR R; DVORAKOVA K; SALMON S; HARRISON S; WORZALLA J
      INHIBITION OF INTRACELLULAR CA2-ACTIVITY OF THE HERBICIDE ORYZALIN AND ITS ANALOGS( SIGNALING, CYTOTOXICITY AND ANTITUMOR)

      Cancer chemotherapy and pharmacology
    36. BRUNN GJ; HUDSON CC; SEKULIC A; WILLIAMS JM; HOSOI H; HOUGHTON PJ; LAWRENCE JC; ABRAHAM RT
      PHOSPHORYLATION OF THE TRANSLATIONAL REPRESSOR PHAS-I BY THE MAMMALIAN TARGET OF RAPAMYCIN

      Science
    37. EISCHEN CM; WILLIAMS BL; ZHANG WG; SAMELSON LE; LYNCH DH; ABRAHAM RT; LEIBSON PJ
      ZAP-70 TYROSINE KINASE IS REQUIRED FOR THE UP-REGULATION OF FAS LIGAND IN ACTIVATION-INDUCED T-CELL APOPTOSIS

      The Journal of immunology
    38. SLOANLANCASTER J; ZHANG WG; PRESLEY J; WILLIAMS BL; ABRAHAM RT; LIPPINCOTTSCHWARTZ J; SAMELSON LE
      REGULATION OF ZAP-70 INTRACELLULAR-LOCALIZATION - VISUALIZATION WITH THE GREEN FLUORESCENT PROTEIN

      The Journal of experimental medicine
    39. BINSTADT BA; BRUMBAUGH KM; DICK CJ; SCHARENBERG AM; WILLIAMS BL; COLONNA M; LANIER LL; KINET JP; ABRAHAM RT; LEIBSON PJ
      SEQUENTIAL INVOLVEMENT OF LCK AND SHP-1 WITH MHC-RECOGNIZING RECEPTORS ON NK CELLS INHIBITS FCR-INITIATED TYROSINE KINASE ACTIVATION

      Immunity
    40. ABRAHAM RT
      PHOSPHATIDYLINOSITOL 3-KINASE RELATED KINASES

      Current opinion in immunology
    41. KENNEDY AP; SEKULIC A; ABRAHAM RT
      POLYOMA-VIRUS MIDDLE T-ANTIGEN (MT) - A NOVEL TOOL FOR THE DISSECTIONOF T-CELL ANTIGEN RECEPTOR (TCR)-LINKED SIGNALING PATHWAYS

      The FASEB journal
    42. SEKULIC A; ABRAHAM RT
      DISSECTION OF CYTOKINE RECEPTOR-LINKED MITOGENIC SIGNALING PATHWAYS BY COMPLEMENTATION WITH POLYOMAVIRUS MIDDLE T-ANTIGEN (MT)

      The FASEB journal
    43. ABRAHAM RT; WIEDERRECHT GJ
      IMMUNOPHARMACOLOGY OF RAPAMYCIN

      Annual review of immunology
    44. BRUNN GJ; WILLIAMS J; SABERS C; WIEDERRECHT G; LAWRENCE JC; ABRAHAM RT
      DIRECT INHIBITION OF THE SIGNALING FUNCTIONS OF THE MAMMALIAN TARGET OF RAPAMYCIN BY THE PHOSPHOINOSITIDE 3-KINASE INHIBITORS, WORTMANNIN AND LY294002

      EMBO journal
    45. LIM KK; SU WPD; SCHROETER AL; SABERS CJ; ABRAHAM RT; PITTELKOW MR
      CYCLOSPORINE IN THE TREATMENT OF DERMATOLOGICAL DISEASE - AN UPDATE

      Mayo Clinic proceedings
    46. KARNITZ LM; ABRAHAM RT
      CYTOKINE RECEPTOR SIGNALING MECHANISMS

      Current opinion in immunology
    47. KARNITZ LM; BURNS LA; SUTOR SL; BLENIS J; ABRAHAM RT
      INTERLEUKIN-2 TRIGGERS A NOVEL PHOSPHATIDYLINOSITOL 3-KINASE-DEPENDENT MEK ACTIVATION PATHWAY

      Molecular and cellular biology
    48. FREW T; POWIS G; BERGGREN M; GALLEGOS A; ABRAHAM RT; ASHENDEL CL; ZALKOW LH; HUDSON C; GRUSZECKAKOWALIK E; BURGESS EM; BENEDETTIDOCTOROVICH V; KERRIGAN JE; LAMBROPOULOS J; MERRIMAN R; BONJOUKLIAN R
      NOVEL QUINONE ANTIPROLIFERATIVE INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE

      Anti-cancer drug design
    49. ABRAHAM RT; ACQUARONE M; ANDERSEN A; ASENSI A; BELLE R; BERGER F; BERGOUNIOUX C; BRUNN G; BUQUETFAGOT C; FAGOT D; GLAB N; GOUDEAU H; GOUDEAU M; GUERRIER P; HOUGHTON P; HENDRIKS H; KLOAREG B; LIPPAI M; MARIE D; MARO B; MEIJER L; MESTER J; MULNERLORILLON O; POULET SA; SCHIERENBERG E; SCHUTTE B; VAULOT D; VERLHAC MH
      CELLULAR EFFECTS OF OLOMOUCINE, AN INHIBITOR OF CYCLIN-DEPENDENT KINASES

      Biology of the cell
    50. KATO M; ABRAHAM RT; GLEICH GJ; KITA H
      ENHANCED PHOSPHOINOSITIDE TURNOVER AND PROTEIN-TYROSINE PHOSPHORYLATION IN ADHERENT EOSINOPHILS

      Journal of allergy and clinical immunology
    51. KATO M; ABRAHAM RT; KITA H
      TYROSINE PHOSPHORYLATION IS REQUIRED FOR EOSINOPHIL DEGRANULATION INDUCED BY IMMOBILIZED IMMUNOGLOBULINS

      The Journal of immunology
    52. EVANS GA; GOLDSMITH MA; JOHNSTON JA; XU WD; WEILER SR; ERWIN R; HOWARD OMZ; ABRAHAM RT; OSHEA JJ; GREENE WC; FARRAR WL
      ANALYSIS OF INTERLEUKIN-2 DEPENDENT SIGNAL-TRANSDUCTION THROUGH THE SHC GRB2 ADAPTER PATHWAY - INTERLEUKIN-2-DEPENDENT MITOGENESIS DOES NOTREQUIRE SHC PHOSPHORYLATION OR RECEPTOR ASSOCIATION/

      The Journal of biological chemistry
    53. LAM E; MARTIN MM; TIMERMAN AP; SABERS C; FLEISCHER S; LUKAS T; ABRAHAM RT; OKEEFE SJ; ONEILL EA; WIEDERRECHT GJ
      A NOVEL FK506 BINDING-PROTEIN CAN MEDIATE THE IMMUNOSUPPRESSIVE EFFECTS OF FK506 AND IS ASSOCIATED WITH THE CARDIAC RYANODINE RECEPTOR

      The Journal of biological chemistry
    54. TING AT; DICK CJ; SCHOON RA; KARNITZ LR; ABRAHAM RT; LEIBSON PJ
      INTERACTION BETWEEN LCK AND SYK FAMILY TYROSINE KINASES IN FC-GAMMA RECEPTOR-INITIATED ACTIVATION OF NATURAL-KILLER-CELLS

      The Journal of biological chemistry
    55. SABERS CJ; MARTIN MM; BRUNN GJ; WILLIAMS JM; DUMONT FJ; WIEDERRECHT G; ABRAHAM RT
      ISOLATION OF A PROTEIN TARGET OF THE FKBP12-RAPAMYCIN COMPLEX IN MAMMALIAN-CELLS

      The Journal of biological chemistry
    56. BRUNN GJ; FALLS EL; NILSON AE; ABRAHAM RT
      PROTEIN-TYROSINE KINASE-DEPENDENT ACTIVATION OF STAT TRANSCRIPTION FACTORS IN INTERLEUKIN-2-STIMULATED OR INTERLEUKIN-4-STIMULATED T-LYMPHOCYTES

      The Journal of biological chemistry
    57. KATO M; ABRAHAM RT; GLEICH GJ; KITA H
      ROLE OF TYROSINE KINASES IN HUMAN EOSINOPHIL DEGRANULATION

      The FASEB journal
    58. POWIS G; GALLEGOS A; ABRAHAM RT; ASHENDEL CL; ZALKOW LH; GRINDEY GB; BONJOUKLIAN R
      INCREASED INTRACELLULAR CA2+ SIGNALING CAUSED BY THE ANTITUMOR AGENT HELENALIN AND ITS ANALOGS

      Cancer chemotherapy and pharmacology
    59. HILL SR; BONJOUKLIAN R; POWIS G; ABRAHAM RT; ASHENDEL CL; ZALKOW LH
      A MULTISAMPLE ASSAY FOR INHIBITORS OF PHOSPHATIDYLINOSITOL PHOSPHOLIPASE-C - IDENTIFICATION OF NATURALLY-OCCURRING PEPTIDE INHIBITORS WITH ANTIPROLIFERATIVE ACTIVITY

      Anti-cancer drug design
    60. FREW T; POWIS G; BERGGREN M; ABRAHAM RT; ASHENDEL CL; ZALKOW LH; HUDSON C; QAZIA S; GRUSZECKAKOWALIK E; MERRIMAN R; BONJOUKLIAN R
      A MULTIWELL ASSAY FOR INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE ANDTHE IDENTIFICATION OF NATURAL PRODUCT INHIBITORS

      Anticancer research
    61. KITA H; KATO M; GLEICH GJ; ABRAHAM RT
      TYROSINE PHOSPHORYLATION AND INOSITOL PHOSPHATE PRODUCTION - ARE EARLY EVENTS IN HUMAN EOSINOPHIL ACTIVATION STIMULATED BY IMMOBILIZED SECRETORY IGA AND IGG

      Journal of allergy and clinical immunology
    62. BONNEMA JD; RIVLIN KA; TING AT; SCHOON RA; ABRAHAM RT; LEIBSON PJ
      CYTOKINE-ENHANCED NK CELL-MEDIATED CYTOTOXICITY - POSITIVE MODULATORYEFFECTS OF IL-2 AND IL-12 ON STIMULUS-DEPENDENT GRANULE EXOCYTOSIS

      The Journal of immunology
    63. BONNEMA JD; KARNITZ LM; SCHOON RA; ABRAHAM RT; LEIBSON PJ
      FC RECEPTOR STIMULATION OF PHOSPHATIDYLINOSITOL 3-KINASE IN NATURAL-KILLER-CELLS IS ASSOCIATED WITH PROTEIN-KINASE C-INDEPENDENT GRANULE RELEASE AND CELL-MEDIATED CYTOTOXICITY

      The Journal of experimental medicine
    64. KARNITZ LM; SUTOR SL; ABRAHAM RT
      THE SRC-FAMILY KINASE, FYN, REGULATES THE ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE IN AN INTERLEUKIN 2-RESPONSIVE T-CELL LINE

      The Journal of experimental medicine
    65. BONNEMA JD; RIVLIN KA; SCHOON RA; ABRAHAM RT; LEIBSON PJ
      IL-2 AND IL-12 ENHANCE THE COUPLING OF THE STIMULUS-SECRETION RESPONSE IN HUMAN NATURAL-KILLER-CELLS

      The Journal of immunology
    66. MORICE WG; WIEDERRECHT G; BRUNN GJ; SIEKIERKA JJ; ABRAHAM RT
      RAPAMYCIN INHIBITION OF INTERLEUKIN-2-DEPENDENT P33CDK2 AND P34CDC2 KINASE ACTIVATION IN T-LYMPHOCYTES

      The Journal of biological chemistry
    67. BURNS LA; KARNITZ LM; SUTOR SL; ABRAHAM RT
      INTERLEUKIN-2-INDUCED TYROSINE PHOSPHORYLATION OF P52(SHC) IN T-LYMPHOCYTES

      The Journal of biological chemistry
    68. LUTZ MP; SUTOR SL; ABRAHAM RT; MILLER LJ
      A ROLE FOR CHOLECYSTOKININ-STIMULATED PROTEIN-TYROSINE PHOSPHORYLATION IN REGULATED SECRETION BY THE PANCREATIC ACINAR CELL

      The Journal of biological chemistry
    69. BERGGREN MM; BURNS LA; ABRAHAM RT; POWIS G
      INHIBITION OF PROTEIN TYROSINE PHOSPHATASE BY THE ANTITUMOR AGENT GALLIUM NITRATE

      Cancer research


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Documento generato il 17/01/21 alle ore 10:19:02