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Titolo:
CENTRAL LEVODOPA METABOLISM IN PARKINSONS-DISEASE AFTER ADMINISTRATION OF STABLE ISOTOPE-LABELED LEVODOPA
Autore:
DURSO R; EVANS JE; JOSEPHS E; SZABO GK; EVANS BA; HANDLER JS; JENNINGS D; BROWNE TR;
Indirizzi:
BOSTON UNIV,SCH MED,BOSTON VAMC,DEPT NEUROL,150 S HUNTINGTON AVE BOSTON MA 02130 EUNICE KENNEDY SHRIVER CTR MENTAL RETARDAT INC,MASS SPECTROMETRY LAB WALTHAM MA 02154
Titolo Testata:
Annals of neurology
fascicolo: 3, volume: 42, anno: 1997,
pagine: 300 - 304
SICI:
0364-5134(1997)42:3<300:CLMIPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; DOPAMINE METABOLISM; HOMOVANILLIC-ACID; BRAIN; PHARMACOKINETICS; PLASMA; RAT; NEUROCHEMISTRY; MAGNITUDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R. Durso et al., "CENTRAL LEVODOPA METABOLISM IN PARKINSONS-DISEASE AFTER ADMINISTRATION OF STABLE ISOTOPE-LABELED LEVODOPA", Annals of neurology, 42(3), 1997, pp. 300-304

Abstract

We report the use of a new stable isotope-labeled form of levodopa (LD) to examine in vivo central LD metabolism in Parkinson's disease (PD). Eight patients representing a wide spectrum of disease severity were administered 50 mg of carbidopa orally followed in 1 hour by an intravenous bolus of 150 mg of stable isotope-labeled LD (ring-1',2',3',4',5',6'-(13)C6). Serial blood samples were taken every 30 to 60 minutesand a lumbar puncture was performed 6 hours after the infusion, The average percentage of labeled homovanillic acid (HVA) in lumbar cerebrospinal fluid (CSF) was 54% (SD, 9%; range, 34-67%). The mean CSF labeled HVA concentration was 34.7 ng/ml (SD, 20.2 ng/ml; range, 11.3-67.9 ng/ml). Area under the curve for labeled serum LD closely predicted CSF labeled HVA concentrations (r = 0.747, p = 0.033), Labeled CSF HVA levels did not significantly correlate with either quality or duration of response to the labeled LD dose, In a similar manner, labeled CSF HVA concentrations were not influenced by duration of disease or previous daily LD dosage, These findings support the hypothesis that levodopa-induced benefit in PD is not severely limited by a defect in centrallevodopa metabolism.

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Documento generato il 06/04/20 alle ore 01:38:44