Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXTENDED PRESERVATION OF ISCHEMIC PULMONARY GRAFT BY POSTMORTEM ALVEOLAR EXPANSION
Autore:
VANRAEMDONCK DEM; JANNIS NCP; REGA FRL; DELEYN PRJ; FLAMENG WJ; LERUT TE;
Indirizzi:
UNIV HOSP GASTHUISBERG,DEPT THORAC SURG,HERESTR 49 B-3000 LOUVAIN BELGIUM KATHOLIEKE UNIV LEUVEN,CTR EXPT SURG & ANESTHESIOL B-3001 LOUVAIN BELGIUM
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 3, volume: 64, anno: 1997,
pagine: 801 - 808
SICI:
0003-4975(1997)64:3<801:EPOIPG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-BEATING DONORS; LUNG TRANSPLANTATION; CADAVER LUNGS; RABBIT LUNG; DEATH; VIABILITY; VENTILATION; SURFACTANT; DIE; REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.E.M. Vanraemdonck et al., "EXTENDED PRESERVATION OF ISCHEMIC PULMONARY GRAFT BY POSTMORTEM ALVEOLAR EXPANSION", The Annals of thoracic surgery, 64(3), 1997, pp. 801-808

Abstract

Background. If lungs could be retrieved for transplantation from non-heart-beating cadavers, the shortage of donors might be significantly alleviated. Methods. Peak airway pressure, mean pulmonary artery pressure, pulmonary vascular resistance, and wet to dry weight ratio were measured during delayed hypothermic crystalloid flush in rabbit lungs (n = 6) at successive intervals after death comparing cadavers with lungs left deflated (group 1), inflated with room air (group 2) or 100% oxygen (group 4), or ventilated with room air (group 3), or 100% nitrogen (group 5), or 100% oxygen (group 6). Results. There was a gradual increase in mean pulmonary artery pressure and pulmonary vascular resistance with longer postmortem intervals in all study groups (p = not significant, group 1 versus group 2 versus group 3). There was also a gradual increase in peak airway pressure and wet-to-dry weight ratio over time in all groups, which reflected edema formation during flush (airway pressure, from 14.5 +/- 1.0 cm H2O to 53.7 +/- 12.2 cm H2O, and wet-to-dry weight ratio, from 3.6 +/- 0.1 to 11.5 +/- 1.2, in group 1 at 0 and 6 hours postmortem, respectively; p < 0.05). Compared with group 1, however, the increase in groups 2 and 3 was much slower (airway pressure, 20.9 +/- 0.5 cm H2O and 18.8 +/- 1.2 cm H2O, and wet-to-dry weight ratio, 5.2 +/- 0.3 and 4.6 +/- 0.4 at 6 hours postmortem, respectively; p < 0.05 versus group 1 and p = not significant, group 2 versus group 3). Airway pressure and wet-to-dry weight ratio did not differ between groups 2 and 4 or between groups 3, 5, and 6. Conclusions. These data suggest that (1) pulmonary edema will develop in atelectaticlungs if hypothermic flush is delayed for 2 hours after death, (2) postmortem inflation is as good as ventilation in prolonging warm ischemic tolerance, (3) inflation with oxygen or ventilation with nitrogen or oxygen is no different from that with room air, and (4) therefore, prevention of alveolar collapse appears to be the critical factor in protecting the lung from warm ischemic damage independent of continued oxygen delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:13:24