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Titolo:
WHOLE-BODY KINETICS AND DOSIMETRY OF L-3-[I-123]IODO-ALPHA-METHYLTYROSINE
Autore:
SCHMIDT D; LANGEN KJ; HERZOG H; WIRTHS J; HOLSCHBACH M; KIWIT JCW; ZIEMONS K; COENEN HH; MULLERGARTNER HW;
Indirizzi:
RES CTR JULICH,INST MED D-52426 JULICH GERMANY RES CTR JULICH,INST MED D-52426 JULICH GERMANY RES CTR JULICH,INST NUCL MED D-52426 JULICH GERMANY UNIV DUSSELDORF,DEPT NEUROSURG D-4000 DUSSELDORF GERMANY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 9, volume: 24, anno: 1997,
pagine: 1162 - 1166
SICI:
0340-6997(1997)24:9<1162:WKADOL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-METHYL TYROSINE; AMINO-ACID-TRANSPORT; BRAIN-TUMORS; GLIOMAS; SPECT; PET; MICE;
Keywords:
L-3-[I-123]IODO-ALPHA-METHYLTYROSINE; DOSIMETRY; BRAIN TUMORS; AMINO ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D. Schmidt et al., "WHOLE-BODY KINETICS AND DOSIMETRY OF L-3-[I-123]IODO-ALPHA-METHYLTYROSINE", European journal of nuclear medicine, 24(9), 1997, pp. 1162-1166

Abstract

The synthetic amino acid L-3-[I-123]iodo-alpha-methyltyrosine (IMT) is currently under clinical evaluation as a single-photon emission tomography (SPET) tracer of amino acid uptake in brain rumours, So far, dosimetric data in respect of IMT are not available, Therefore we investigated the whole-body distribution of IMT in six patients with cerebral gliomas and the radiation doses were estimated. Whole-body scans were acquired at 1.5, 3 and 5 h after i.v. injection of 370-550 MBq IMT, The bladder was voided prior to each scan and the radioactivity excreted in the urine was measured. Based on the MIRD-11 method and the updated MIRDOSE3, the moan absorbed doses for various organs and the effective dose were calculated from geometric means of the anterior and posterior whole-body scans using seven source organs and the residence time. IMT was predominantly excreted by the kidneys (52.8%+/-11.5% at 1.5 h p.i,, 63.0%+/-15.7% at 3 h p.i. and 74.6%+/-9.8% at 5 h p.i.). No organ system other than the urinary tract showed significant retentionof the tracer. Early whole-body scans revealed slightly increased tracer uptake in the liver and in the bowel. Highest absorbed doses were found for the urinary bladder wall (0.047 mGy/MBq), the kidneys (0.010mGy/MBq), the lower large intestinal wall (0.011 mGy/MBq) and the upper large intestinal wall (0.008 mGy/MBq), The effective dose accordingto ICRP 60 was estimated to be 0.0073 mSv/MBq for adults. This leads to an effective dose of 3.65 mSv in a typical brain SPET study using 500 MBq IMT. The MIRDOSE3 scheme yielded similar results, Thus, in spite of the relatively high tracer dose required for optimal brain scanning, radiation exposure in SPET studies with IMT is in the normal rangeof routine nuclear medicine investigations.

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Documento generato il 26/01/21 alle ore 03:13:42